Larotrectinib sulfate_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Larotrectinib sulfate perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Larotrectinib sulfate_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
BHLHE40 basic helix-loop-helix family, member e40 0.0563511
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0524004
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0500104
NAV2 neuron navigator 2 0.0485935
AKAP12 A kinase (PRKA) anchor protein 12 0.0437976
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0370382
NDRG1 N-myc downstream regulated 1 0.0346419
FTH1 ferritin, heavy polypeptide 1 0.0309927
SOD2 superoxide dismutase 2, mitochondrial 0.0307147
AUTS2 autism susceptibility candidate 2 0.0269208
TRIO trio Rho guanine nucleotide exchange factor 0.0268818
CD109 CD109 molecule 0.026775
MSI2 musashi RNA-binding protein 2 0.024903
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0245527
SLC39A11 solute carrier family 39, member 11 0.0237199
RND3 Rho family GTPase 3 0.0230046
OPTN optineurin 0.0220438
WDFY1 WD repeat and FYVE domain containing 1 0.0215935
ZFP36L1 ZFP36 ring finger protein-like 1 0.0213693
CYLD cylindromatosis (turban tumor syndrome) 0.0199086
FOSL1 FOS-like antigen 1 0.0191629
FNIP1 folliculin interacting protein 1 0.0190479
AMPD3 adenosine monophosphate deaminase 3 0.0187892
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0185639
ESYT2 extended synaptotagmin-like protein 2 0.0176944
LPCAT2 lysophosphatidylcholine acyltransferase 2 0.0176895
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0166173
TAPBP TAP binding protein (tapasin) 0.0158369
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.0157586
MMP12 matrix metallopeptidase 12 0.0156737
BACE2 beta-site APP-cleaving enzyme 2 0.0156698
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0154756
RNMT RNA (guanine-7-) methyltransferase 0.0153756
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0153328
FMNL2 formin-like 2 0.0153246
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 0.015075
FBXL7 F-box and leucine-rich repeat protein 7 0.0146876
PDXK pyridoxal (pyridoxine, vitamin B6) kinase 0.0141114
RHOBTB3 Rho-related BTB domain containing 3 0.0137167
VEGFA vascular endothelial growth factor A 0.0136925
SLC15A4 solute carrier family 15 (oligopeptide transporter), member 4 0.0134914
L1CAM L1 cell adhesion molecule 0.0132023
ZBTB7C zinc finger and BTB domain containing 7C 0.012988
INSIG2 insulin induced gene 2 0.0129588
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0128532
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0119831
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0118636
ADM adrenomedullin 0.0116617
PCGF5 polycomb group ring finger 5 0.0116062
FAM193B family with sequence similarity 193, member B 0.0115591
SEPTIN9 septin 9 0.011358
FNDC3B fibronectin type III domain containing 3B 0.0112566
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0112297
GOLGA4 golgin A4 0.0111467
FAM107B family with sequence similarity 107, member B 0.0111313
AP3S1 adaptor-related protein complex 3, sigma 1 subunit 0.0110697
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.010813
MNT MAX network transcriptional repressor 0.0107801
ZEB1 zinc finger E-box binding homeobox 1 0.0103001
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0102454
KDM7A lysine (K)-specific demethylase 7A 0.0101998
NCOR2 nuclear receptor corepressor 2 0.0100664
ZMIZ1 zinc finger, MIZ-type containing 1 0.00985183
CDPF1 cysteine-rich, DPF motif domain containing 1 0.00972884
CDK18 cyclin-dependent kinase 18 0.00956812
INSIG1 insulin induced gene 1 0.00953111
ELP2 elongator acetyltransferase complex subunit 2 0.0094807
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.00946958
ATP13A3 ATPase type 13A3 0.00932201
RICTOR RPTOR independent companion of MTOR, complex 2 0.00923664
GDF15 growth differentiation factor 15 0.00922715
NAMPT nicotinamide phosphoribosyltransferase 0.009041
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.00903986
UGCG UDP-glucose ceramide glucosyltransferase 0.00896658
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.00892509
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase 0.00878515
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.00877228
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.00875944
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.00868916
CAMTA1 calmodulin binding transcription activator 1 0.00864576
RIOK3 RIO kinase 3 0.00854662
HELZ helicase with zinc finger 0.008308
STEAP3 STEAP family member 3, metalloreductase 0.0082795
MIMS1 mitochondrial inner membrane scaffold 1 0.00826801
ZFP36 ZFP36 ring finger protein 0.00818974
RFX2 regulatory factor X, 2 (influences HLA class II expression) 0.00818558
CGNL1 cingulin-like 1 0.00816195
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.00814984
MXRA7 matrix-remodelling associated 7 0.00803364
CERT1 ceramide transporter 1 0.00799383
DTNA dystrobrevin, alpha 0.00797042
LIFR leukemia inhibitory factor receptor alpha 0.00795249
C1D C1D nuclear receptor corepressor 0.00795083
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.00787255
TM4SF19 transmembrane 4 L six family member 19 0.00786204
ARHGAP12 Rho GTPase activating protein 12 0.0078015
ZNF395 zinc finger protein 395 0.00777821
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.00774764
MIDEAS mitotic deacetylase associated SANT domain protein 0.00770969
PHC3 polyhomeotic homolog 3 (Drosophila) 0.00766198

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.251153
TMSB10 thymosin beta 10 -0.188015
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.184029
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.175738
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.155496
AHNAK AHNAK nucleoprotein -0.153581
LOX lysyl oxidase -0.144029
VIM vimentin -0.141027
IGFBP3 insulin-like growth factor binding protein 3 -0.129662
UBC ubiquitin C -0.122536
MAP1B microtubule-associated protein 1B -0.11806
FN1 fibronectin 1 -0.101541
COL5A1 collagen, type V, alpha 1 -0.0972048
S100A10 S100 calcium binding protein A10 -0.0967508
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -0.0934902
ANXA2 annexin A2 -0.0921821
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0919478
COL3A1 collagen, type III, alpha 1 -0.0885336
CD44 CD44 molecule (Indian blood group) -0.0866689
COL8A1 collagen, type VIII, alpha 1 -0.0813029
PLAT plasminogen activator, tissue -0.0786267
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.075697
SAMD9 sterile alpha motif domain containing 9 -0.074287
ABI3BP ABI family, member 3 (NESH) binding protein -0.0738197
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0721161
COL5A2 collagen, type V, alpha 2 -0.0709769
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0704826
CDH13 cadherin 13 -0.0679325
LDHA lactate dehydrogenase A -0.0667596
PKM pyruvate kinase, muscle -0.0654867
LMNA lamin A/C -0.0653393
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0632703
ENO1 enolase 1, (alpha) -0.0627768
THBS2 thrombospondin 2 -0.0621724
HLA-B major histocompatibility complex, class I, B -0.0607299
NAV1 neuron navigator 1 -0.0605923
CALR calreticulin -0.0605667
S100A6 S100 calcium binding protein A6 -0.0602152
LOC112694756 uncharaterized LOC112694756 -0.0591533
PRSS23 protease, serine, 23 -0.0588324
COL1A2 collagen, type I, alpha 2 -0.0575079
ASPH aspartate beta-hydroxylase -0.0571547
B2M beta-2-microglobulin -0.0541768
TPM4 tropomyosin 4 -0.0533593
CANX calnexin -0.0533577
POTEF POTE ankyrin domain family, member F -0.0525605
FSTL1 follistatin-like 1 -0.0513798
TAGLN2 transgelin 2 -0.0509187
SLC38A1 solute carrier family 38, member 1 -0.0504377
PODXL podocalyxin-like -0.0496534
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0489971
PTMA prothymosin, alpha -0.0489839
DCLK2 doublecortin-like kinase 2 -0.0486141
CAVIN1 caveolae associated protein 1 -0.0481493
HLA-C major histocompatibility complex, class I, C -0.0470569
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0453491
RIGI RNA sensor RIG-I -0.0440389
DST dystonin -0.0428287
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0409587
CDK6 cyclin-dependent kinase 6 -0.040451
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.04003
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0391495
MBNL1 muscleblind-like splicing regulator 1 -0.0383835
APP amyloid beta (A4) precursor protein -0.0383821
SH3KBP1 SH3-domain kinase binding protein 1 -0.0377723
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.0375747
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0375087
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0373607
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0370267
PDIA3 protein disulfide isomerase family A, member 3 -0.0365533
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0355912
TMSB4X thymosin beta 4, X-linked -0.0353108
RRBP1 ribosome binding protein 1 -0.0352466
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0349321
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0345787
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0345701
ZNF217 zinc finger protein 217 -0.0343939
CD99 CD99 molecule -0.0340313
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0339409
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0338943
GLIS3 GLIS family zinc finger 3 -0.0337621
IFITM3 interferon induced transmembrane protein 3 -0.0337172
MX2 MX dynamin-like GTPase 2 -0.0335676
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0334167
CSNK1A1 casein kinase 1, alpha 1 -0.0333913
MT2A metallothionein 2A -0.0333482
MEIS2 Meis homeobox 2 -0.0332511
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0327781
SUCNR1 succinate receptor 1 -0.0325753
VCL vinculin -0.0325349
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0323729
GLG1 golgi glycoprotein 1 -0.0318937
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0316111
LRRC17 leucine rich repeat containing 17 -0.0314187
RPS27A ribosomal protein S27a -0.0310471
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0309935
EXT1 exostosin glycosyltransferase 1 -0.0306561
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0303082
CALU calumenin -0.0302434
MACF1 microtubule-actin crosslinking factor 1 -0.0295201