| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Larotrectinib sulfate perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Larotrectinib sulfate_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | 0.185043 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.139371 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.135317 |
| DST | dystonin | 0.0893057 |
| NLGN1 | neuroligin 1 | 0.0801139 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0733173 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0711076 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0613242 |
| PCBP2 | poly(rC) binding protein 2 | 0.0610118 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0608354 |
| TENM3 | teneurin transmembrane protein 3 | 0.0586756 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0571555 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0561603 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0557393 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0522137 |
| MMP12 | matrix metallopeptidase 12 | 0.0482369 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0467179 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0461668 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | 0.0447363 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0444293 |
| TMEM41B | transmembrane protein 41B | 0.044183 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.0440268 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0419297 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.039972 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0395169 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0392293 |
| CMIP | c-Maf inducing protein | 0.0389292 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0380994 |
| TMCC1 | transmembrane and coiled-coil domain family 1 | 0.0359242 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0352456 |
| HDGF | hepatoma-derived growth factor | 0.0348849 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0347187 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0339509 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0330812 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0322253 |
| RASAL2 | RAS protein activator like 2 | 0.0322037 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0321934 |
| PDK4 | pyruvate dehydrogenase kinase, isozyme 4 | 0.0321516 |
| RPS3 | ribosomal protein S3 | 0.0314957 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0312914 |
| YAP1 | Yes-associated protein 1 | 0.0299356 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0297136 |
| EFNA5 | ephrin-A5 | 0.0289596 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0285536 |
| NRXN3 | neurexin 3 | 0.0279173 |
| FNIP1 | folliculin interacting protein 1 | 0.0273629 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0268242 |
| TAPBP | TAP binding protein (tapasin) | 0.0263988 |
| TGM2 | transglutaminase 2 | 0.0263837 |
| SPATS2 | spermatogenesis associated, serine-rich 2 | 0.0263744 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0263214 |
| GABARAPL1 | GABA(A) receptor-associated protein like 1 | 0.0256396 |
| EGFR | epidermal growth factor receptor | 0.0254209 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0250228 |
| AXIN2 | axin 2 | 0.0247747 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0246456 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0244745 |
| ANXA1 | annexin A1 | 0.0243501 |
| NEGR1 | neuronal growth regulator 1 | 0.0235606 |
| KLHL24 | kelch-like family member 24 | 0.0233531 |
| PARD3 | par-3 family cell polarity regulator | 0.0229276 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0228527 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0227217 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0226139 |
| JMJD1C | jumonji domain containing 1C | 0.0225289 |
| TPD52 | tumor protein D52 | 0.0224433 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0222716 |
| NEBL | nebulette | 0.0219089 |
| MPG | N-methylpurine-DNA glycosylase | 0.0218333 |
| SBF2 | SET binding factor 2 | 0.0218214 |
| DSPP | dentin sialophosphoprotein | 0.0217698 |
| RPL14 | ribosomal protein L14 | 0.0217472 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0214991 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0214977 |
| TXNRD1 | thioredoxin reductase 1 | 0.021427 |
| COL5A2 | collagen, type V, alpha 2 | 0.0211115 |
| CELF2 | CUGBP, Elav-like family member 2 | 0.0209182 |
| CALD1 | caldesmon 1 | 0.0206598 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.02058 |
| MSH6 | mutS homolog 6 | 0.0204964 |
| GJA1 | gap junction protein, alpha 1, 43kDa | 0.0204722 |
| MED13L | mediator complex subunit 13-like | 0.0203853 |
| HDAC9 | histone deacetylase 9 | 0.0203194 |
| CDK19 | cyclin-dependent kinase 19 | 0.0202147 |
| FER | fer (fps/fes related) tyrosine kinase | 0.019753 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0194193 |
| DHX40 | DEAH (Asp-Glu-Ala-His) box polypeptide 40 | 0.0192644 |
| FOXM1 | forkhead box M1 | 0.019259 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0190928 |
| CEP250 | centrosomal protein 250kDa | 0.0190681 |
| EZR | ezrin | 0.0190058 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0189605 |
| OLR1 | oxidized low density lipoprotein (lectin-like) receptor 1 | 0.0188805 |
| SERINC1 | serine incorporator 1 | 0.0188773 |
| P3H2 | prolyl 3-hydroxylase 2 | 0.0188437 |
| MSN | moesin | 0.0188074 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0187891 |
| PPP1R21 | protein phosphatase 1, regulatory subunit 21 | 0.0186968 |
| BRD4 | bromodomain containing 4 | 0.0185155 |
| MYPN | myopalladin | 0.0184916 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.305478 |
| TMSB10 | thymosin beta 10 | -0.199733 |
| RPLP1 | ribosomal protein, large, P1 | -0.0673276 |
| MGAT4C | MGAT4 family, member C | -0.0671518 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0662727 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0599505 |
| ACTG1 | actin gamma 1 | -0.0579134 |
| FUS | FUS RNA binding protein | -0.0552753 |
| RPS24 | ribosomal protein S24 | -0.0542644 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | -0.0535442 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.05304 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0517327 |
| FTL | ferritin, light polypeptide | -0.0495537 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.045977 |
| RPS27A | ribosomal protein S27a | -0.0457761 |
| RPL35A | ribosomal protein L35a | -0.0434768 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.042452 |
| RPS21 | ribosomal protein S21 | -0.0413694 |
| FBXO11 | F-box protein 11 | -0.0413499 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0412416 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0401988 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0376906 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0366799 |
| PCDH7 | protocadherin 7 | -0.0364179 |
| ASPH | aspartate beta-hydroxylase | -0.0358563 |
| CCDC88A | coiled-coil domain containing 88A | -0.0358103 |
| RPLP0 | ribosomal protein, large, P0 | -0.0357206 |
| RPS5 | ribosomal protein S5 | -0.0355423 |
| RPLP2 | ribosomal protein, large, P2 | -0.0355033 |
| RPL34 | ribosomal protein L34 | -0.0350986 |
| RPL38 | ribosomal protein L38 | -0.0350421 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0349803 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0339061 |
| RPL23 | ribosomal protein L23 | -0.0336731 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0331848 |
| ZNF638 | zinc finger protein 638 | -0.0326901 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0326868 |
| USP34 | ubiquitin specific peptidase 34 | -0.0324105 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.032189 |
| BCHE | butyrylcholinesterase | -0.0320536 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0320339 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0319779 |
| NHSL1 | NHS-like 1 | -0.0319347 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0315102 |
| GNAS | GNAS complex locus | -0.0311609 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0309924 |
| RPL26 | ribosomal protein L26 | -0.0307006 |
| RPS15 | ribosomal protein S15 | -0.0298533 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0295256 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0293974 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0288609 |
| RPL37 | ribosomal protein L37 | -0.0279708 |
| RPS16 | ribosomal protein S16 | -0.0277409 |
| TMEM123 | transmembrane protein 123 | -0.027724 |
| EGR1 | early growth response 1 | -0.0273101 |
| HMGB1 | high mobility group box 1 | -0.0272621 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0272142 |
| AREG | amphiregulin | -0.0270884 |
| NABP1 | nucleic acid binding protein 1 | -0.0269309 |
| CENPE | centromere protein E, 312kDa | -0.0268468 |
| ZNF217 | zinc finger protein 217 | -0.0268326 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0268172 |
| KRR1 | KRR1, small subunit (SSU) processome component, homolog (yeast) | -0.0267441 |
| RPL19 | ribosomal protein L19 | -0.0264122 |
| RPL8 | ribosomal protein L8 | -0.0262526 |
| CCND1 | cyclin D1 | -0.026162 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0260267 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0258144 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0254603 |
| CCT8 | chaperonin containing TCP1, subunit 8 (theta) | -0.0254111 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0251863 |
| ZNF207 | zinc finger protein 207 | -0.0251583 |
| H3-3B | H3.3 histone B | -0.0250704 |
| NME2 | NME/NM23 nucleoside diphosphate kinase 2 | -0.0249498 |
| NF1 | neurofibromin 1 | -0.0248372 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0248114 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | -0.0246215 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0243777 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0243584 |
| ECT2 | epithelial cell transforming 2 | -0.0240032 |
| PPP2CA | protein phosphatase 2, catalytic subunit, alpha isozyme | -0.0239895 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0239318 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0234043 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.0232948 |
| WDR45B | WD repeat domain 45B | -0.0229315 |
| RPL12 | ribosomal protein L12 | -0.0227948 |
| RPL32 | ribosomal protein L32 | -0.022718 |
| ARF1 | ADP-ribosylation factor 1 | -0.0226839 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.0225167 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0224473 |
| S100A6 | S100 calcium binding protein A6 | -0.0223894 |
| RPL9 | ribosomal protein L9 | -0.0222244 |
| LMO7 | LIM domain 7 | -0.0220699 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.021997 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0219572 |
| HMGA1 | high mobility group AT-hook 1 | -0.0219395 |
| RPS8 | ribosomal protein S8 | -0.0218665 |
| RPS13 | ribosomal protein S13 | -0.0216875 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0213827 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0213419 |
