| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Larotrectinib sulfate perturbation in A498 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Larotrectinib sulfate_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.255063 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.138061 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.131096 |
| RAI14 | retinoic acid induced 14 | 0.120169 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.114733 |
| VIM | vimentin | 0.0948557 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0934128 |
| CCL2 | chemokine (C-C motif) ligand 2 | 0.0895475 |
| NRP2 | neuropilin 2 | 0.0852829 |
| NAV2 | neuron navigator 2 | 0.0835565 |
| P3H2 | prolyl 3-hydroxylase 2 | 0.0827691 |
| VCAM1 | vascular cell adhesion molecule 1 | 0.0814054 |
| CD44 | CD44 molecule (Indian blood group) | 0.0772721 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0747543 |
| B2M | beta-2-microglobulin | 0.0741981 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0683252 |
| TNS3 | tensin 3 | 0.0678451 |
| RND3 | Rho family GTPase 3 | 0.0675306 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0669799 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0660035 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0638789 |
| GPC6 | glypican 6 | 0.0636242 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0633007 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.063039 |
| SKAP2 | src kinase associated phosphoprotein 2 | 0.062769 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0607159 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0582493 |
| ITGAV | integrin, alpha V | 0.0566954 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0519486 |
| SMAD3 | SMAD family member 3 | 0.0511483 |
| FBXO32 | F-box protein 32 | 0.048911 |
| RPS6 | ribosomal protein S6 | 0.0472654 |
| TAPBP | TAP binding protein (tapasin) | 0.0467519 |
| CSF1 | colony stimulating factor 1 (macrophage) | 0.0464202 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0458866 |
| RNF213 | ring finger protein 213 | 0.0453026 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0443563 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0439301 |
| OPTN | optineurin | 0.043255 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.0431797 |
| CENPF | centromere protein F, 350/400kDa | 0.0426825 |
| ARRDC3 | arrestin domain containing 3 | 0.0424024 |
| APOL1 | apolipoprotein L, 1 | 0.0420317 |
| TGFB2 | transforming growth factor, beta 2 | 0.0419415 |
| RIGI | RNA sensor RIG-I | 0.0405721 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0388742 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.038659 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | 0.0384306 |
| SPECC1 | sperm antigen with calponin homology and coiled-coil domains 1 | 0.0383998 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0377305 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0371242 |
| IFT74 | intraflagellar transport 74 | 0.0367978 |
| EIF2AK1 | eukaryotic translation initiation factor 2-alpha kinase 1 | 0.0361704 |
| MYOF | myoferlin | 0.0357443 |
| HERC5 | HECT and RLD domain containing E3 ubiquitin protein ligase 5 | 0.0355697 |
| ATP13A3 | ATPase type 13A3 | 0.0355501 |
| BICC1 | BicC family RNA binding protein 1 | 0.0353928 |
| FNDC3B | fibronectin type III domain containing 3B | 0.034831 |
| NUB1 | negative regulator of ubiquitin-like proteins 1 | 0.0347321 |
| TMED9 | transmembrane emp24 protein transport domain containing 9 | 0.0344588 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0344042 |
| SBF2 | SET binding factor 2 | 0.0340253 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0338055 |
| PLK2 | polo-like kinase 2 | 0.0336628 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0334272 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0330418 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.0330053 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0329592 |
| LDHA | lactate dehydrogenase A | 0.0321055 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0315652 |
| FLNB | filamin B, beta | 0.0315213 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.031235 |
| MT2A | metallothionein 2A | 0.0311294 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0311292 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0311096 |
| FAM13A | family with sequence similarity 13, member A | 0.0310209 |
| ETV6 | ets variant 6 | 0.0308157 |
| COL4A1 | collagen, type IV, alpha 1 | 0.0308148 |
| B4GALT1 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 | 0.0302037 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0300981 |
| GCC2 | GRIP and coiled-coil domain containing 2 | 0.0297985 |
| CALD1 | caldesmon 1 | 0.0297162 |
| EML4 | echinoderm microtubule associated protein like 4 | 0.0296249 |
| RACK1 | receptor for activated C kinase 1 | 0.0289216 |
| PREX2 | phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 | 0.0288359 |
| AHNAK | AHNAK nucleoprotein | 0.0286821 |
| CD47 | CD47 molecule | 0.0286263 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0285329 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0282272 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0282098 |
| ITIH5 | inter-alpha-trypsin inhibitor heavy chain family, member 5 | 0.0280693 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | 0.0279663 |
| RPS8 | ribosomal protein S8 | 0.0279441 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0278489 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | 0.0276184 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0276052 |
| ZFAND5 | zinc finger, AN1-type domain 5 | 0.026994 |
| COL4A2 | collagen, type IV, alpha 2 | 0.0269064 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.0267497 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0265618 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ASPH | aspartate beta-hydroxylase | -0.163945 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.163507 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0862821 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0842466 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0773619 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0691622 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0653143 |
| CREB5 | cAMP responsive element binding protein 5 | -0.0636537 |
| INTS6 | integrator complex subunit 6 | -0.0580153 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.055281 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0539326 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.052661 |
| NUP98 | nucleoporin 98kDa | -0.0450061 |
| PKM | pyruvate kinase, muscle | -0.0442277 |
| POTEF | POTE ankyrin domain family, member F | -0.0434392 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0432137 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0430542 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0428452 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0418998 |
| CTSD | cathepsin D | -0.0418056 |
| UBAP2 | ubiquitin associated protein 2 | -0.0401338 |
| RPS2 | ribosomal protein S2 | -0.0381931 |
| PRKCA | protein kinase C, alpha | -0.0376502 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0368613 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | -0.0361852 |
| HM13 | histocompatibility (minor) 13 | -0.0359781 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0354996 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0351103 |
| TUSC3 | tumor suppressor candidate 3 | -0.0350107 |
| RAB10 | RAB10, member RAS oncogene family | -0.0344857 |
| SEC24D | SEC24 family member D | -0.0336846 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0333892 |
| SLC31A1 | solute carrier family 31 (copper transporter), member 1 | -0.0332078 |
| ELOVL5 | ELOVL fatty acid elongase 5 | -0.0321705 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0315355 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0315291 |
| TXNRD1 | thioredoxin reductase 1 | -0.030709 |
| HIPK2 | homeodomain interacting protein kinase 2 | -0.0306599 |
| CRY1 | cryptochrome circadian clock 1 | -0.0305353 |
| COG6 | component of oligomeric golgi complex 6 | -0.0304577 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0301585 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0300273 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0294283 |
| CALR | calreticulin | -0.0293549 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | -0.0278012 |
| SURF4 | surfeit 4 | -0.0277532 |
| CLTC | clathrin, heavy chain (Hc) | -0.0275591 |
| SCFD2 | sec1 family domain containing 2 | -0.0273796 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0273252 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0273049 |
| RPS24 | ribosomal protein S24 | -0.02725 |
| HSD17B12 | hydroxysteroid (17-beta) dehydrogenase 12 | -0.0269106 |
| PCSK5 | proprotein convertase subtilisin/kexin type 5 | -0.0255401 |
| INSIG1 | insulin induced gene 1 | -0.0252338 |
| ZNF207 | zinc finger protein 207 | -0.0252082 |
| SUCO | SUN domain containing ossification factor | -0.0250172 |
| TASOR2 | transcription activation suppressor family member 2 | -0.0248978 |
| AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) | -0.0247488 |
| KDELR2 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 | -0.0247344 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0243236 |
| FBXO11 | F-box protein 11 | -0.0243146 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0242975 |
| BPNT2 | 3'(2'), 5'-bisphosphate nucleotidase 2 | -0.024091 |
| AGO3 | argonaute RISC catalytic component 3 | -0.0239472 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0238231 |
| PDXDC1 | pyridoxal-dependent decarboxylase domain containing 1 | -0.0236592 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.023654 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.023461 |
| GOSR2 | golgi SNAP receptor complex member 2 | -0.0234031 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0231643 |
| GPC5 | glypican 5 | -0.0231059 |
| RPL3 | ribosomal protein L3 | -0.0230307 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0230198 |
| EIF2AK3 | eukaryotic translation initiation factor 2-alpha kinase 3 | -0.0227682 |
| NOLC1 | nucleolar and coiled-body phosphoprotein 1 | -0.0226244 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0226205 |
| PTGES2 | prostaglandin E synthase 2 | -0.0224523 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0222299 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0222171 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0222164 |
| CTBP2 | C-terminal binding protein 2 | -0.0221474 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -0.0220542 |
| CSTF3 | cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa | -0.0219478 |
| ANO10 | anoctamin 10 | -0.0218284 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0217845 |
| NOP58 | NOP58 ribonucleoprotein | -0.0216174 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.021286 |
| GPATCH2 | G patch domain containing 2 | -0.0211705 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0210452 |
| COG5 | component of oligomeric golgi complex 5 | -0.0209597 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.0209345 |
| TAOK1 | TAO kinase 1 | -0.0208534 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0207358 |
| RPS5 | ribosomal protein S5 | -0.0205077 |
| HSPB1 | heat shock 27kDa protein 1 | -0.020396 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0203705 |
| PBX1 | pre-B-cell leukemia homeobox 1 | -0.0203059 |
| TMED3 | transmembrane emp24 protein transport domain containing 3 | -0.0201393 |
| TUBA1C | tubulin, alpha 1c | -0.0201106 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -0.0200433 |
