| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Larotrectinib sulfate perturbation in A549 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Larotrectinib sulfate_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.177095 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.105658 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0901179 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0819748 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0765348 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0726204 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0692426 |
| RNF213 | ring finger protein 213 | 0.0682387 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0642115 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0631354 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0623686 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0619017 |
| NAV2 | neuron navigator 2 | 0.0589605 |
| VIM | vimentin | 0.0583872 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0563438 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0529344 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0524062 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0473101 |
| EFNA5 | ephrin-A5 | 0.0464335 |
| KIRREL3 | kin of IRRE like 3 (Drosophila) | 0.0438425 |
| CDH4 | cadherin 4, type 1, R-cadherin (retinal) | 0.0434317 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0426282 |
| TNS1 | tensin 1 | 0.0423232 |
| AUTS2 | autism susceptibility candidate 2 | 0.0418132 |
| EGFR | epidermal growth factor receptor | 0.0405713 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.039452 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0382367 |
| RND3 | Rho family GTPase 3 | 0.0372261 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.0359278 |
| FMNL2 | formin-like 2 | 0.035685 |
| GPC6 | glypican 6 | 0.0355222 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.035063 |
| DAPK1 | death-associated protein kinase 1 | 0.0347428 |
| LTBP4 | latent transforming growth factor beta binding protein 4 | 0.0339405 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0337459 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0332575 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0329147 |
| RIGI | RNA sensor RIG-I | 0.0326837 |
| PLSCR1 | phospholipid scramblase 1 | 0.0318897 |
| TAPBP | TAP binding protein (tapasin) | 0.0315641 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0304334 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0300635 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0300034 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0297794 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0294348 |
| C1D | C1D nuclear receptor corepressor | 0.0292821 |
| ZFP36 | ZFP36 ring finger protein | 0.02915 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | 0.0291249 |
| KLF6 | Kruppel-like factor 6 | 0.0284511 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0283157 |
| LOXL2 | lysyl oxidase-like 2 | 0.0277338 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0273692 |
| DST | dystonin | 0.0271261 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0264265 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0262262 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | 0.0257794 |
| RAD51B | RAD51 paralog B | 0.0256612 |
| AHNAK | AHNAK nucleoprotein | 0.0251262 |
| CMIP | c-Maf inducing protein | 0.0250252 |
| FLNB | filamin B, beta | 0.0246339 |
| PCBP2 | poly(rC) binding protein 2 | 0.024613 |
| VPS13C | vacuolar protein sorting 13 homolog C (S. cerevisiae) | 0.024429 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0241828 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0235349 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0233793 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0230763 |
| OPTN | optineurin | 0.0230623 |
| MSI2 | musashi RNA-binding protein 2 | 0.0228817 |
| USP47 | ubiquitin specific peptidase 47 | 0.0225438 |
| RHCG | Rh family, C glycoprotein | 0.022353 |
| ANO6 | anoctamin 6 | 0.0219116 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0215664 |
| FNIP1 | folliculin interacting protein 1 | 0.0211807 |
| TGFBR1 | transforming growth factor, beta receptor 1 | 0.0210328 |
| HMGA2 | high mobility group AT-hook 2 | 0.0207083 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0206081 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0205779 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0202136 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | 0.0201546 |
| SP100 | SP100 nuclear antigen | 0.0197722 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0197277 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0195341 |
| KIF16B | kinesin family member 16B | 0.0195034 |
| DIAPH2 | diaphanous-related formin 2 | 0.0193695 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0191396 |
| IGFBP4 | insulin-like growth factor binding protein 4 | 0.0189154 |
| CDC42BPB | CDC42 binding protein kinase beta (DMPK-like) | 0.0188742 |
| ZFHX3 | zinc finger homeobox 3 | 0.0188516 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0181755 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0180108 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0179946 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0179669 |
| FLNA | filamin A, alpha | 0.0177943 |
| MYO1E | myosin IE | 0.0176967 |
| LAMB3 | laminin, beta 3 | 0.0176948 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0175558 |
| BNC2 | basonuclin 2 | 0.0175028 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | 0.0173919 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0172044 |
| IRAK2 | interleukin-1 receptor-associated kinase 2 | 0.0170897 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.255596 |
| TMSB10 | thymosin beta 10 | -0.133253 |
| ACTG1 | actin gamma 1 | -0.130257 |
| FTL | ferritin, light polypeptide | -0.124544 |
| ASPH | aspartate beta-hydroxylase | -0.104754 |
| RPS6 | ribosomal protein S6 | -0.0975855 |
| MT2A | metallothionein 2A | -0.0934862 |
| RPLP1 | ribosomal protein, large, P1 | -0.0859269 |
| TXNRD1 | thioredoxin reductase 1 | -0.0833258 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0820725 |
| RPS19 | ribosomal protein S19 | -0.0753218 |
| STC1 | stanniocalcin 1 | -0.0719114 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0670692 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0653529 |
| RPS16 | ribosomal protein S16 | -0.0647003 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.061927 |
| KYNU | kynureninase | -0.0617571 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.061308 |
| PTMA | prothymosin, alpha | -0.0610822 |
| RPS8 | ribosomal protein S8 | -0.0579762 |
| RPS2 | ribosomal protein S2 | -0.0578024 |
| PKM | pyruvate kinase, muscle | -0.0577525 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0572237 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0567987 |
| TNIP1 | TNFAIP3 interacting protein 1 | -0.0566427 |
| RPL26 | ribosomal protein L26 | -0.0553325 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0547507 |
| RPS27A | ribosomal protein S27a | -0.0541117 |
| RPL19 | ribosomal protein L19 | -0.0498707 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0482945 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0478486 |
| RPL28 | ribosomal protein L28 | -0.0477388 |
| RPS13 | ribosomal protein S13 | -0.0474901 |
| RPS5 | ribosomal protein S5 | -0.0471191 |
| RPL7A | ribosomal protein L7a | -0.0459379 |
| RPS24 | ribosomal protein S24 | -0.0451279 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0446605 |
| PLEC | plectin | -0.043308 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0425022 |
| GOLGA4 | golgin A4 | -0.0423582 |
| RPL23 | ribosomal protein L23 | -0.0423467 |
| RPL31 | ribosomal protein L31 | -0.0418144 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | -0.0413005 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0404998 |
| RPL37A | ribosomal protein L37a | -0.0404352 |
| RPL8 | ribosomal protein L8 | -0.0402634 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.039926 |
| RPL12 | ribosomal protein L12 | -0.03806 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0380217 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0377884 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0377509 |
| USP3 | ubiquitin specific peptidase 3 | -0.0375721 |
| KRT81 | keratin 81, type II | -0.0374674 |
| RPS23 | ribosomal protein S23 | -0.0369936 |
| RPS11 | ribosomal protein S11 | -0.0360535 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0354637 |
| RPL35 | ribosomal protein L35 | -0.0354184 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0352157 |
| RPLP0 | ribosomal protein, large, P0 | -0.0344978 |
| S100A10 | S100 calcium binding protein A10 | -0.0341084 |
| RPS17 | ribosomal protein S17 | -0.0339671 |
| UBC | ubiquitin C | -0.0338731 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0335978 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.033369 |
| RPL9 | ribosomal protein L9 | -0.0330458 |
| RPL36A | ribosomal protein L36a | -0.032849 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0324022 |
| MSN | moesin | -0.0323804 |
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | -0.0320695 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.031592 |
| RPL32 | ribosomal protein L32 | -0.0313987 |
| NDRG1 | N-myc downstream regulated 1 | -0.0313586 |
| RPLP2 | ribosomal protein, large, P2 | -0.0312716 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.031025 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0308709 |
| RPS12 | ribosomal protein S12 | -0.0307752 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0306298 |
| RPS27 | ribosomal protein S27 | -0.0305605 |
| SPAG9 | sperm associated antigen 9 | -0.0303007 |
| RPL3 | ribosomal protein L3 | -0.0303004 |
| MT1X | metallothionein 1X | -0.0302096 |
| KCTD9 | potassium channel tetramerization domain containing 9 | -0.0301892 |
| WDR43 | WD repeat domain 43 | -0.030073 |
| RPL38 | ribosomal protein L38 | -0.029818 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0295133 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0293734 |
| RPS21 | ribosomal protein S21 | -0.0293716 |
| RPS25 | ribosomal protein S25 | -0.0293604 |
| RPS29 | ribosomal protein S29 | -0.0291636 |
| RPL11 | ribosomal protein L11 | -0.029158 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0288106 |
| WWC1 | WW and C2 domain containing 1 | -0.0284833 |
| LMNA | lamin A/C | -0.0281872 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0278775 |
| NME2 | NME/NM23 nucleoside diphosphate kinase 2 | -0.0277045 |
| EREG | epiregulin | -0.0276697 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0276113 |
| MKI67 | marker of proliferation Ki-67 | -0.0275288 |
| SETD5 | SET domain containing 5 | -0.027347 |
| ENO1 | enolase 1, (alpha) | -0.0273194 |
