| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Larotrectinib sulfate perturbation in AN3 CA cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Larotrectinib sulfate_AN3 CA drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PRKG1 | protein kinase, cGMP-dependent, type I | 0.202468 |
| MGP | matrix Gla protein | 0.091261 |
| SEPTIN11 | septin 11 | 0.0856327 |
| PRELID2 | PRELI domain containing 2 | 0.0811023 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0803704 |
| GSE1 | Gse1 coiled-coil protein | 0.0742583 |
| EXOC4 | exocyst complex component 4 | 0.0563059 |
| FNIP1 | folliculin interacting protein 1 | 0.0548791 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0548722 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0504196 |
| TMSB4X | thymosin beta 4, X-linked | 0.047273 |
| RAD51B | RAD51 paralog B | 0.0460144 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0445085 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0431662 |
| H1-4 | H1.4 linker histone, cluster member | 0.0422284 |
| KAZN | kazrin, periplakin interacting protein | 0.0405552 |
| ITGAV | integrin, alpha V | 0.0402977 |
| QKI | QKI, KH domain containing, RNA binding | 0.0399114 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.039754 |
| HOXC6 | homeobox C6 | 0.0397409 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0396631 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0390041 |
| HMGB2 | high mobility group box 2 | 0.0386708 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0385889 |
| SQSTM1 | sequestosome 1 | 0.0380644 |
| VPS13C | vacuolar protein sorting 13 homolog C (S. cerevisiae) | 0.0376521 |
| SOX6 | SRY (sex determining region Y)-box 6 | 0.037252 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0355212 |
| SFTPA2 | surfactant protein A2 | 0.0353453 |
| FGFR2 | fibroblast growth factor receptor 2 | 0.0352815 |
| OGA | O-GlcNAcase | 0.0343044 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.0341619 |
| FER | fer (fps/fes related) tyrosine kinase | 0.0337953 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0337602 |
| UTRN | utrophin | 0.0336478 |
| VEGFA | vascular endothelial growth factor A | 0.033459 |
| SEMA6A | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A | 0.0330594 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0329798 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.0328484 |
| OPTN | optineurin | 0.0324935 |
| HOXA3 | homeobox A3 | 0.0314542 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0314226 |
| RPL3 | ribosomal protein L3 | 0.031219 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0311387 |
| PTMA | prothymosin, alpha | 0.0301994 |
| HSPA8 | heat shock 70kDa protein 8 | 0.029681 |
| CCNG2 | cyclin G2 | 0.0284624 |
| SET | SET nuclear proto-oncogene | 0.0282831 |
| SERPINB6 | serpin peptidase inhibitor, clade B (ovalbumin), member 6 | 0.0267667 |
| ATG10 | autophagy related 10 | 0.026745 |
| TTC17 | tetratricopeptide repeat domain 17 | 0.0267406 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | 0.0264365 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0263008 |
| RAD50 | RAD50 homolog (S. cerevisiae) | 0.0259406 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0258135 |
| WWOX | WW domain containing oxidoreductase | 0.0257776 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | 0.025734 |
| VPS41 | vacuolar protein sorting 41 homolog (S. cerevisiae) | 0.0257064 |
| CENPF | centromere protein F, 350/400kDa | 0.0255848 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0253705 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.025086 |
| IGF2R | insulin-like growth factor 2 receptor | 0.0250838 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0249688 |
| CAPRIN1 | cell cycle associated protein 1 | 0.0247988 |
| ZNF292 | zinc finger protein 292 | 0.024776 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0246251 |
| SMAD6 | SMAD family member 6 | 0.0245118 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0243017 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0242756 |
| HSPA4 | heat shock 70kDa protein 4 | 0.0241193 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0239849 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.0237527 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.0236876 |
| H1-2 | H1.2 linker histone, cluster member | 0.0235531 |
| PRKD1 | protein kinase D1 | 0.0235153 |
| CDK19 | cyclin-dependent kinase 19 | 0.0233719 |
| DBN1 | drebrin 1 | 0.0232437 |
| PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | 0.0231482 |
| KLHL24 | kelch-like family member 24 | 0.0228663 |
| SERINC1 | serine incorporator 1 | 0.022707 |
| WWC2 | WW and C2 domain containing 2 | 0.0227005 |
| DNAH14 | dynein, axonemal, heavy chain 14 | 0.0225091 |
| XRN2 | 5'-3' exoribonuclease 2 | 0.0224643 |
| FOXC1 | forkhead box C1 | 0.0224605 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.022459 |
| DNAAF9 | dynein axonemal assembly factor 9 | 0.0224173 |
| MKRN1 | makorin ring finger protein 1 | 0.0224023 |
| FOXP1 | forkhead box P1 | 0.0222541 |
| SLC3A2 | solute carrier family 3 (amino acid transporter heavy chain), member 2 | 0.0222254 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0221838 |
| ATM | ATM serine/threonine kinase | 0.0219622 |
| SMAP1 | small ArfGAP 1 | 0.0217824 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0217031 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | 0.0216295 |
| SKIL | SKI-like proto-oncogene | 0.0213216 |
| AHNAK | AHNAK nucleoprotein | 0.0212466 |
| TIAL1 | TIA1 cytotoxic granule-associated RNA binding protein-like 1 | 0.0211052 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0209671 |
| ZNF532 | zinc finger protein 532 | 0.0209647 |
| SMC1A | structural maintenance of chromosomes 1A | 0.0207534 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PEG10 | paternally expressed 10 | -0.258897 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.191115 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.114419 |
| B3GALT1 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 | -0.109241 |
| CADM2 | cell adhesion molecule 2 | -0.109151 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.101648 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0795247 |
| TPK1 | thiamin pyrophosphokinase 1 | -0.0723895 |
| HMGA1 | high mobility group AT-hook 1 | -0.0722037 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0629688 |
| VIM | vimentin | -0.0615327 |
| PKM | pyruvate kinase, muscle | -0.0584136 |
| NDRG1 | N-myc downstream regulated 1 | -0.0580666 |
| EGR1 | early growth response 1 | -0.0560598 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0525203 |
| ERBIN | erbb2 interacting protein | -0.0522579 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0510862 |
| FBXO11 | F-box protein 11 | -0.0501034 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0500094 |
| ELOVL5 | ELOVL fatty acid elongase 5 | -0.049953 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0498066 |
| CTBP2 | C-terminal binding protein 2 | -0.0493552 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0481991 |
| ENO1 | enolase 1, (alpha) | -0.0473614 |
| TSHZ2 | teashirt zinc finger homeobox 2 | -0.0462505 |
| TMSB10 | thymosin beta 10 | -0.046143 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0460551 |
| FTL | ferritin, light polypeptide | -0.045662 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0440409 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.0438278 |
| RCOR1 | REST corepressor 1 | -0.0419847 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | -0.0417197 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.041136 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0404156 |
| MTDH | metadherin | -0.0403123 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0400773 |
| TOP1 | topoisomerase (DNA) I | -0.0396764 |
| ANKRD17 | ankyrin repeat domain 17 | -0.039366 |
| RPLP1 | ribosomal protein, large, P1 | -0.0393299 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | -0.0393295 |
| RPS6 | ribosomal protein S6 | -0.039149 |
| POTEF | POTE ankyrin domain family, member F | -0.038953 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.0383493 |
| LDHA | lactate dehydrogenase A | -0.0382928 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0378077 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0370057 |
| RPL35A | ribosomal protein L35a | -0.0369559 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0365557 |
| HMGB1 | high mobility group box 1 | -0.0361074 |
| ACTG1 | actin gamma 1 | -0.0357531 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.035498 |
| NFIB | nuclear factor I/B | -0.0354846 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0352837 |
| GOLGA4 | golgin A4 | -0.035181 |
| ADIPOR2 | adiponectin receptor 2 | -0.0346389 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | -0.0336138 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0332047 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0331191 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0326851 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0323999 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.0323447 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0321487 |
| MAP1B | microtubule-associated protein 1B | -0.0321204 |
| DDX56 | DEAD (Asp-Glu-Ala-Asp) box helicase 56 | -0.0320195 |
| TXNRD1 | thioredoxin reductase 1 | -0.0319296 |
| MT2A | metallothionein 2A | -0.0319191 |
| SIK3 | SIK family kinase 3 | -0.0319172 |
| GPC6 | glypican 6 | -0.0317136 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0317076 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0314742 |
| RPS23 | ribosomal protein S23 | -0.0314469 |
| CDK13 | cyclin-dependent kinase 13 | -0.0313109 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0309596 |
| RPS8 | ribosomal protein S8 | -0.030898 |
| DHX36 | DEAH (Asp-Glu-Ala-His) box polypeptide 36 | -0.0308802 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0305457 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0303191 |
| JMJD1C | jumonji domain containing 1C | -0.0302338 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0302149 |
| TPM4 | tropomyosin 4 | -0.030204 |
| RPS25 | ribosomal protein S25 | -0.0300687 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0299977 |
| AGO3 | argonaute RISC catalytic component 3 | -0.0299555 |
| RBM25 | RNA binding motif protein 25 | -0.0298534 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0297637 |
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 | -0.0293508 |
| KDM6A | lysine (K)-specific demethylase 6A | -0.0291509 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0288145 |
| UBE2R2 | ubiquitin-conjugating enzyme E2R 2 | -0.0288116 |
| UBR3 | ubiquitin protein ligase E3 component n-recognin 3 (putative) | -0.0281787 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | -0.0278654 |
| RPL8 | ribosomal protein L8 | -0.0277594 |
| SMC5 | structural maintenance of chromosomes 5 | -0.0277486 |
| NOP58 | NOP58 ribonucleoprotein | -0.0276891 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0276326 |
| CHD1 | chromodomain helicase DNA binding protein 1 | -0.0275684 |
| WASL | Wiskott-Aldrich syndrome-like | -0.0273604 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.027098 |
| RPL28 | ribosomal protein L28 | -0.0269801 |
| BSG | basigin (Ok blood group) | -0.0269083 |
