| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Larotrectinib sulfate perturbation in AsPC-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Larotrectinib sulfate_AsPC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.370442 |
| FLNB | filamin B, beta | 0.160203 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.12106 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.113847 |
| VCAN | versican | 0.108106 |
| AHNAK | AHNAK nucleoprotein | 0.0857214 |
| EFNA5 | ephrin-A5 | 0.0755447 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0747277 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0722895 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0716446 |
| SMAD3 | SMAD family member 3 | 0.0698073 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0630797 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0562111 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0558358 |
| EGFR | epidermal growth factor receptor | 0.0549526 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0522243 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0518047 |
| MYOF | myoferlin | 0.0515077 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0507927 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0498308 |
| ITGA6 | integrin, alpha 6 | 0.0493159 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0480816 |
| FAM107B | family with sequence similarity 107, member B | 0.0474802 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0459851 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0455296 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0446509 |
| FGD6 | FYVE, RhoGEF and PH domain containing 6 | 0.0435118 |
| CORO1C | coronin, actin binding protein, 1C | 0.0428609 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0428343 |
| CAPRIN2 | caprin family member 2 | 0.0425335 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0417936 |
| HMGA2 | high mobility group AT-hook 2 | 0.0416331 |
| DSPP | dentin sialophosphoprotein | 0.0408388 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.039145 |
| VCL | vinculin | 0.0374273 |
| CDCP1 | CUB domain containing protein 1 | 0.0356065 |
| NDRG1 | N-myc downstream regulated 1 | 0.0355099 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0330597 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0329871 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0320422 |
| KIRREL1 | kirre like nephrin family adhesion molecule 1 | 0.0319046 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0318442 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0305419 |
| ASPH | aspartate beta-hydroxylase | 0.0298556 |
| NEK7 | NIMA-related kinase 7 | 0.0295177 |
| ARHGAP42 | Rho GTPase activating protein 42 | 0.028658 |
| CEACAM1 | carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) | 0.0283182 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0280653 |
| LMO7 | LIM domain 7 | 0.028048 |
| SQSTM1 | sequestosome 1 | 0.027871 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0278327 |
| JMJD1C | jumonji domain containing 1C | 0.0271143 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0269943 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | 0.0268114 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0267521 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0267375 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0263203 |
| PARD3 | par-3 family cell polarity regulator | 0.0262177 |
| BCL2L1 | BCL2-like 1 | 0.0261651 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.026003 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0259976 |
| RESF1 | retroelement silencing factor 1 | 0.025978 |
| RPS2 | ribosomal protein S2 | 0.0259039 |
| STK39 | serine threonine kinase 39 | 0.0255614 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0253376 |
| FAM3C | family with sequence similarity 3, member C | 0.0253189 |
| PLEC | plectin | 0.0249524 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0249009 |
| FMNL2 | formin-like 2 | 0.024717 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 0.0246693 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0246037 |
| CDC42BPB | CDC42 binding protein kinase beta (DMPK-like) | 0.024274 |
| SLTM | SAFB-like, transcription modulator | 0.0239071 |
| ARRDC3 | arrestin domain containing 3 | 0.023745 |
| NCKAP1 | NCK-associated protein 1 | 0.0232129 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.022827 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.022701 |
| PTK2B | protein tyrosine kinase 2 beta | 0.0226661 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | 0.0225848 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0221609 |
| ANO6 | anoctamin 6 | 0.0217174 |
| ADAM19 | ADAM metallopeptidase domain 19 | 0.0216897 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.0213771 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0212659 |
| CCNY | cyclin Y | 0.0211934 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0211328 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0209631 |
| CAB39 | calcium binding protein 39 | 0.0208858 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0208648 |
| FAT1 | FAT atypical cadherin 1 | 0.0208182 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0206402 |
| SEPTIN10 | septin 10 | 0.0205795 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | 0.020433 |
| TUFT1 | tuftelin 1 | 0.0203561 |
| MED13L | mediator complex subunit 13-like | 0.0202282 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0201781 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.020167 |
| DUSP4 | dual specificity phosphatase 4 | 0.0201532 |
| OGA | O-GlcNAcase | 0.0200231 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | 0.0196188 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.173466 |
| DHRS9 | dehydrogenase/reductase (SDR family) member 9 | -0.125922 |
| ARPC1A | actin related protein 2/3 complex, subunit 1A, 41kDa | -0.116347 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.109763 |
| HMGA1 | high mobility group AT-hook 1 | -0.100567 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0963587 |
| MUC17 | mucin 17, cell surface associated | -0.0931673 |
| ARPC1B | actin related protein 2/3 complex, subunit 1B, 41kDa | -0.0888005 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0810856 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0790739 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.077093 |
| PTMA | prothymosin, alpha | -0.0752975 |
| KLK10 | kallikrein-related peptidase 10 | -0.0675177 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0665239 |
| TMBIM1 | transmembrane BAX inhibitor motif containing 1 | -0.0622104 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0606685 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0583813 |
| PDXDC1 | pyridoxal-dependent decarboxylase domain containing 1 | -0.0578475 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0577104 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0572903 |
| EGR1 | early growth response 1 | -0.057228 |
| MXD1 | MAX dimerization protein 1 | -0.0536207 |
| VIM | vimentin | -0.052716 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0515043 |
| PERP | PERP, TP53 apoptosis effector | -0.0503058 |
| MORF4L2 | mortality factor 4 like 2 | -0.0482452 |
| S100A6 | S100 calcium binding protein A6 | -0.047459 |
| LAMB3 | laminin, beta 3 | -0.0456442 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0452871 |
| TXNIP | thioredoxin interacting protein | -0.0452182 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0441202 |
| CALU | calumenin | -0.0439618 |
| ARF4 | ADP-ribosylation factor 4 | -0.0437605 |
| TRRAP | transformation/transcription domain-associated protein | -0.0432374 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0418619 |
| GOLGA4 | golgin A4 | -0.0413435 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0410802 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0407659 |
| S100A10 | S100 calcium binding protein A10 | -0.0405653 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0405362 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0404428 |
| SACK1A | scaffolding CK1 anchoring protein A | -0.0399543 |
| FTL | ferritin, light polypeptide | -0.0382825 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0377975 |
| S100A11 | S100 calcium binding protein A11 | -0.0377616 |
| COG5 | component of oligomeric golgi complex 5 | -0.0369073 |
| S100A4 | S100 calcium binding protein A4 | -0.0366178 |
| GNAS | GNAS complex locus | -0.0365739 |
| SPAG9 | sperm associated antigen 9 | -0.0351987 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0351 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.034654 |
| PGK1 | phosphoglycerate kinase 1 | -0.0344681 |
| LOC112694756 | uncharaterized LOC112694756 | -0.034443 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0343641 |
| SRP54 | signal recognition particle 54kDa | -0.0341885 |
| COPA | coatomer protein complex, subunit alpha | -0.0331767 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.032978 |
| HM13 | histocompatibility (minor) 13 | -0.0327855 |
| EXT1 | exostosin glycosyltransferase 1 | -0.032643 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0324204 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0318488 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0315264 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.031462 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0303024 |
| SEC24A | SEC24 family member A | -0.0299624 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0299425 |
| HDLBP | high density lipoprotein binding protein | -0.0297205 |
| B2M | beta-2-microglobulin | -0.0295357 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0294154 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0287258 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0282887 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0282474 |
| JUP | junction plakoglobin | -0.0279681 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.027836 |
| PMM2 | phosphomannomutase 2 | -0.0278047 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0277949 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0277646 |
| UBC | ubiquitin C | -0.027522 |
| CDK13 | cyclin-dependent kinase 13 | -0.0274878 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0274445 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0273569 |
| FBXO11 | F-box protein 11 | -0.0270372 |
| RRBP1 | ribosome binding protein 1 | -0.0270002 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0269809 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | -0.0269573 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0269433 |
| LAMA4 | laminin, alpha 4 | -0.0268793 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0268489 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0267776 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0266286 |
| EMP1 | epithelial membrane protein 1 | -0.0265216 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0264655 |
| PKM | pyruvate kinase, muscle | -0.0264539 |
| ANXA2 | annexin A2 | -0.0263648 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.026067 |
| CD9 | CD9 molecule | -0.0259474 |
| USP15 | ubiquitin specific peptidase 15 | -0.0259452 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0258183 |
| CCNK | cyclin K | -0.0257814 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.025684 |
