| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Larotrectinib sulfate perturbation in BT-474 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Larotrectinib sulfate_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.10743 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0986234 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | 0.0889126 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | 0.084572 |
| VMP1 | vacuole membrane protein 1 | 0.0807036 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0685294 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0667379 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0654037 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0594246 |
| APP | amyloid beta (A4) precursor protein | 0.0582856 |
| CEP250 | centrosomal protein 250kDa | 0.0578814 |
| MLLT6 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 | 0.0559491 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0534419 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0507844 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0503448 |
| SRCIN1 | SRC kinase signaling inhibitor 1 | 0.0494681 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0487278 |
| SMAD3 | SMAD family member 3 | 0.0487036 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.04526 |
| DSPP | dentin sialophosphoprotein | 0.0448942 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0445141 |
| FBXO32 | F-box protein 32 | 0.0442998 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0427471 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.0421064 |
| ANKRD36C | ankyrin repeat domain 36C | 0.0414407 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0407312 |
| SMYD3 | SET and MYND domain containing 3 | 0.0405132 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0402899 |
| NDRG1 | N-myc downstream regulated 1 | 0.0398521 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0392481 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0387651 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0384873 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.038273 |
| PLEC | plectin | 0.0381706 |
| MSI2 | musashi RNA-binding protein 2 | 0.0380429 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.036143 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0357251 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0353676 |
| KIAA1217 | KIAA1217 | 0.0347265 |
| MT2A | metallothionein 2A | 0.0341924 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0339433 |
| VEGFA | vascular endothelial growth factor A | 0.0339032 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0337033 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0330474 |
| MLPH | melanophilin | 0.0328465 |
| ZHX2 | zinc fingers and homeoboxes 2 | 0.0326841 |
| ATXN1 | ataxin 1 | 0.0321477 |
| MYO10 | myosin X | 0.0321334 |
| SEPTIN9 | septin 9 | 0.0317821 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0317684 |
| JAK1 | Janus kinase 1 | 0.0316417 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0307673 |
| TPD52 | tumor protein D52 | 0.0306833 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.0305958 |
| NCOA3 | nuclear receptor coactivator 3 | 0.0304812 |
| YBX3 | Y box binding protein 3 | 0.0304217 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.0303922 |
| ITGB6 | integrin, beta 6 | 0.0298359 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | 0.0296906 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0292612 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.029243 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0290516 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0289682 |
| SAMD12 | sterile alpha motif domain containing 12 | 0.0288173 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0285411 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0284047 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0280299 |
| SBF2 | SET binding factor 2 | 0.0278386 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0277188 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0276194 |
| SET | SET nuclear proto-oncogene | 0.0273328 |
| YPEL2 | yippee-like 2 (Drosophila) | 0.0272555 |
| GRB7 | growth factor receptor-bound protein 7 | 0.027096 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0270664 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0268062 |
| MCL1 | myeloid cell leukemia 1 | 0.0267895 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0266847 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0266182 |
| EGFR | epidermal growth factor receptor | 0.0265732 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0258197 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0255989 |
| KLHL24 | kelch-like family member 24 | 0.0252081 |
| KIF1A | kinesin family member 1A | 0.02507 |
| FOXO3 | forkhead box O3 | 0.0248981 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0247602 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.0247563 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0246883 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.024667 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0246278 |
| MYO6 | myosin VI | 0.0245818 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0245314 |
| SOS2 | son of sevenless homolog 2 (Drosophila) | 0.0244695 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0243904 |
| PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | 0.024299 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0242848 |
| SLC22A23 | solute carrier family 22, member 23 | 0.0242136 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.0241963 |
| ACTN1 | actinin, alpha 1 | 0.0239621 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0239449 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0235331 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.111996 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0817218 |
| ACSS2 | acyl-CoA synthetase short-chain family member 2 | -0.0667106 |
| RPL23 | ribosomal protein L23 | -0.0634138 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0590393 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0564652 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.0508712 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0460346 |
| ASPH | aspartate beta-hydroxylase | -0.0360148 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0351793 |
| FASN | fatty acid synthase | -0.0323996 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0317549 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0298818 |
| RPL35A | ribosomal protein L35a | -0.0290064 |
| CCND1 | cyclin D1 | -0.0287831 |
| RARRES1 | retinoic acid receptor responder (tazarotene induced) 1 | -0.0279219 |
| POTEF | POTE ankyrin domain family, member F | -0.0260128 |
| FADS2 | fatty acid desaturase 2 | -0.0246894 |
| TMSB10 | thymosin beta 10 | -0.0240133 |
| INTS6 | integrator complex subunit 6 | -0.0238287 |
| MSMO1 | methylsterol monooxygenase 1 | -0.0227585 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | -0.0220663 |
| FDPS | farnesyl diphosphate synthase | -0.0210484 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0207083 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.019377 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0188623 |
| INSIG1 | insulin induced gene 1 | -0.0181243 |
| S100A9 | S100 calcium binding protein A9 | -0.0179684 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0179598 |
| RPS24 | ribosomal protein S24 | -0.0178191 |
| TCEA2 | transcription elongation factor A (SII), 2 | -0.017738 |
| ELOVL5 | ELOVL fatty acid elongase 5 | -0.0170472 |
| POLD3 | polymerase (DNA-directed), delta 3, accessory subunit | -0.0169662 |
| TUBA1B | tubulin, alpha 1b | -0.0168716 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0167712 |
| BPTF | bromodomain PHD finger transcription factor | -0.0167689 |
| MUC6 | mucin 6, oligomeric mucus/gel-forming | -0.0156545 |
| HSD17B12 | hydroxysteroid (17-beta) dehydrogenase 12 | -0.0156294 |
| HMGB1 | high mobility group box 1 | -0.0155557 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.015534 |
| TUBB | tubulin, beta class I | -0.0150947 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.015075 |
| S100A8 | S100 calcium binding protein A8 | -0.0147371 |
| RPL34 | ribosomal protein L34 | -0.0142448 |
| ENAH | enabled homolog (Drosophila) | -0.0138322 |
| PLSCR2 | phospholipid scramblase 2 | -0.0136153 |
| RCOR1 | REST corepressor 1 | -0.0132844 |
| RPL30 | ribosomal protein L30 | -0.013277 |
| CD24 | CD24 molecule | -0.0132458 |
| SERPINB4 | serpin peptidase inhibitor, clade B (ovalbumin), member 4 | -0.0130866 |
| RTN3 | reticulon 3 | -0.0129539 |
| GPC5 | glypican 5 | -0.0127974 |
| SQLE | squalene epoxidase | -0.0127581 |
| RAB10 | RAB10, member RAS oncogene family | -0.0126788 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0123946 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0122971 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | -0.0120491 |
| RPS20 | ribosomal protein S20 | -0.0120204 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | -0.0118936 |
| NCAM2 | neural cell adhesion molecule 2 | -0.0117691 |
| TTC6 | tetratricopeptide repeat domain 6 | -0.0116219 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0115264 |
| IDI1 | isopentenyl-diphosphate delta isomerase 1 | -0.0113267 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0112635 |
| RHOB | ras homolog family member B | -0.0111239 |
| TMEM123 | transmembrane protein 123 | -0.0111113 |
| EGR1 | early growth response 1 | -0.0110414 |
| RPL27A | ribosomal protein L27a | -0.0109412 |
| OLA1 | Obg-like ATPase 1 | -0.0108815 |
| TOB1 | transducer of ERBB2, 1 | -0.0108812 |
| KDELR2 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 | -0.0108775 |
| SERPINB3 | serpin peptidase inhibitor, clade B (ovalbumin), member 3 | -0.0107983 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.010782 |
| RPS12 | ribosomal protein S12 | -0.010632 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | -0.0105797 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0104311 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | -0.0103269 |
| FOXP2 | forkhead box P2 | -0.0101966 |
| CDK14 | cyclin-dependent kinase 14 | -0.0101605 |
| RAB22A | RAB22A, member RAS oncogene family | -0.01015 |
| MVD | mevalonate (diphospho) decarboxylase | -0.0101146 |
| TAOK1 | TAO kinase 1 | -0.0101083 |
| LRP1B | low density lipoprotein receptor-related protein 1B | -0.0100908 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0100662 |
| TMEM135 | transmembrane protein 135 | -0.0100411 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0100393 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0100312 |
| HOMER1 | homer scaffolding protein 1 | -0.00998904 |
| COX8A | cytochrome c oxidase subunit VIIIA (ubiquitous) | -0.00997065 |
| FGB | fibrinogen beta chain | -0.00995392 |
| GRHL1 | grainyhead-like 1 (Drosophila) | -0.00988179 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.00977504 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.00974171 |
| RPLP1 | ribosomal protein, large, P1 | -0.0097194 |
| RPL12 | ribosomal protein L12 | -0.0097175 |
| UQCC1 | ubiquinol-cytochrome c reductase complex assembly factor 1 | -0.00970503 |
| DHCR7 | 7-dehydrocholesterol reductase | -0.00969467 |
| MBD4 | methyl-CpG binding domain protein 4 | -0.00966995 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.00958645 |
| VDAC1 | voltage-dependent anion channel 1 | -0.00955813 |
