| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Larotrectinib sulfate perturbation in C-33 A cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Larotrectinib sulfate_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NEBL | nebulette | 0.140512 |
| TENM3 | teneurin transmembrane protein 3 | 0.112014 |
| ZNF608 | zinc finger protein 608 | 0.0833036 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0810926 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0793143 |
| DST | dystonin | 0.072983 |
| ARHGAP32 | Rho GTPase activating protein 32 | 0.0680563 |
| SMAD6 | SMAD family member 6 | 0.0651739 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0595008 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0532839 |
| EPC1 | enhancer of polycomb homolog 1 (Drosophila) | 0.0516837 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0513824 |
| FAT1 | FAT atypical cadherin 1 | 0.0508741 |
| MAP3K14 | mitogen-activated protein kinase kinase kinase 14 | 0.0508043 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | 0.0483042 |
| JMJD1C | jumonji domain containing 1C | 0.0474794 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | 0.0473189 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0453573 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | 0.0452473 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0452174 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0432499 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0431951 |
| SKIL | SKI-like proto-oncogene | 0.0415081 |
| NGLY1 | N-glycanase 1 | 0.0414681 |
| RPL4 | ribosomal protein L4 | 0.0411953 |
| RPS4X | ribosomal protein S4, X-linked | 0.0401544 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.0400656 |
| GYS1 | glycogen synthase 1 (muscle) | 0.040022 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0392458 |
| COL5A2 | collagen, type V, alpha 2 | 0.039184 |
| NFIA | nuclear factor I/A | 0.0390583 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0389883 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0387609 |
| TOX | thymocyte selection-associated high mobility group box | 0.0360418 |
| CHD7 | chromodomain helicase DNA binding protein 7 | 0.0358565 |
| ATP11A | ATPase, class VI, type 11A | 0.035376 |
| ZNF292 | zinc finger protein 292 | 0.0353167 |
| ZC3H12B | zinc finger CCCH-type containing 12B | 0.0348421 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.034703 |
| TMEM41B | transmembrane protein 41B | 0.0345826 |
| YEATS2 | YEATS domain containing 2 | 0.034515 |
| PRELID2 | PRELI domain containing 2 | 0.0318541 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0312558 |
| TPD52 | tumor protein D52 | 0.0310403 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0307794 |
| PARD3 | par-3 family cell polarity regulator | 0.0300509 |
| RPL13A | ribosomal protein L13a | 0.0295468 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.0294359 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0289849 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0288137 |
| IPO7 | importin 7 | 0.0287867 |
| ID4 | inhibitor of DNA binding 4, dominant negative helix-loop-helix protein | 0.0287584 |
| SMAP1 | small ArfGAP 1 | 0.0284341 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0282787 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0281889 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0280027 |
| GOLIM4 | golgi integral membrane protein 4 | 0.0278852 |
| RPL3 | ribosomal protein L3 | 0.027847 |
| DENND5A | DENN/MADD domain containing 5A | 0.0274536 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.027265 |
| RBM33 | RNA binding motif protein 33 | 0.0265531 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0265245 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0263831 |
| CUX1 | cut-like homeobox 1 | 0.0261785 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0260988 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0260743 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0256798 |
| DNAJC6 | DnaJ (Hsp40) homolog, subfamily C, member 6 | 0.0254772 |
| GSE1 | Gse1 coiled-coil protein | 0.0248418 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0248316 |
| AUTS2 | autism susceptibility candidate 2 | 0.0247356 |
| BMPR1A | bone morphogenetic protein receptor, type IA | 0.0247344 |
| SP3 | Sp3 transcription factor | 0.0243206 |
| RPS3 | ribosomal protein S3 | 0.024052 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0239557 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0238722 |
| KIAA1328 | KIAA1328 | 0.0233265 |
| KIAA1958 | KIAA1958 | 0.0230625 |
| CEP250 | centrosomal protein 250kDa | 0.0228929 |
| ATXN7 | ataxin 7 | 0.0228277 |
| OGA | O-GlcNAcase | 0.0226282 |
| QKI | QKI, KH domain containing, RNA binding | 0.0224199 |
| SBF2 | SET binding factor 2 | 0.0220219 |
| PHF3 | PHD finger protein 3 | 0.0219816 |
| CCNY | cyclin Y | 0.0218265 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.021633 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0213675 |
| SET | SET nuclear proto-oncogene | 0.0213661 |
| AFDN | afadin, adherens junction formation factor | 0.0211443 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0210641 |
| CDK19 | cyclin-dependent kinase 19 | 0.020922 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0208914 |
| PIAS2 | protein inhibitor of activated STAT, 2 | 0.0208094 |
| DIDO1 | death inducer-obliterator 1 | 0.0207993 |
| LARGE1 | LARGE xylosyl- and glucuronyltransferase 1 | 0.0206971 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.020685 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0206726 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0206047 |
| USP34 | ubiquitin specific peptidase 34 | 0.0202252 |
| BLTP1 | bridge-like lipid transfer protein family member 1 | 0.0200792 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.288431 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.181205 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.148339 |
| NPAS3 | neuronal PAS domain protein 3 | -0.113678 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.10766 |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | -0.100457 |
| SEMA3D | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D | -0.0902951 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0889915 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.076012 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0753224 |
| CDH18 | cadherin 18, type 2 | -0.0737308 |
| TMSB10 | thymosin beta 10 | -0.066112 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0610106 |
| RAD51B | RAD51 paralog B | -0.0567894 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.0549563 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0528058 |
| ACTG1 | actin gamma 1 | -0.0525744 |
| HMGA1 | high mobility group AT-hook 1 | -0.0480264 |
| PFN1 | profilin 1 | -0.0454483 |
| RPLP1 | ribosomal protein, large, P1 | -0.0434098 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0407957 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0401225 |
| CADM2 | cell adhesion molecule 2 | -0.0396452 |
| LDHA | lactate dehydrogenase A | -0.0385603 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0385264 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.038125 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | -0.0377781 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0366898 |
| HMGB1 | high mobility group box 1 | -0.0365487 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0357987 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0347823 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0342513 |
| WDR45B | WD repeat domain 45B | -0.033852 |
| ENO1 | enolase 1, (alpha) | -0.0329998 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0325757 |
| EGR1 | early growth response 1 | -0.0320902 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0314353 |
| PRICKLE1 | prickle homolog 1 (Drosophila) | -0.0313876 |
| SYAP1 | synapse associated protein 1 | -0.0313373 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0305989 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0299004 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0297282 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0291314 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0290479 |
| ANK2 | ankyrin 2, neuronal | -0.0289906 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0286279 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0285092 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0282224 |
| PTMA | prothymosin, alpha | -0.028149 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.0281404 |
| RPL8 | ribosomal protein L8 | -0.0279694 |
| CALU | calumenin | -0.0275953 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0273765 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.0270517 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0266026 |
| POTEF | POTE ankyrin domain family, member F | -0.026453 |
| RAB7A | RAB7A, member RAS oncogene family | -0.026037 |
| PCNX4 | pecanex 4 | -0.0259538 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0258722 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0256354 |
| EIF2S3 | eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa | -0.0254173 |
| YBX1 | Y box binding protein 1 | -0.0253107 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0249198 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0248729 |
| GRID2 | glutamate receptor, ionotropic, delta 2 | -0.02436 |
| NAA15 | N(alpha)-acetyltransferase 15, NatA auxiliary subunit | -0.0243579 |
| MLIP | muscular LMNA-interacting protein | -0.0242942 |
| GAB2 | GRB2-associated binding protein 2 | -0.0241271 |
| TUBA1B | tubulin, alpha 1b | -0.0239036 |
| RPS21 | ribosomal protein S21 | -0.0238137 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0236477 |
| FBXO11 | F-box protein 11 | -0.0236086 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0233228 |
| FBL | fibrillarin | -0.0232765 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0230309 |
| TPI1 | triosephosphate isomerase 1 | -0.0230085 |
| RPL28 | ribosomal protein L28 | -0.0226672 |
| CCDC138 | coiled-coil domain containing 138 | -0.0225717 |
| CAMKMT | calmodulin-lysine N-methyltransferase | -0.0224834 |
| TPM4 | tropomyosin 4 | -0.0223965 |
| RPS15 | ribosomal protein S15 | -0.0223619 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0222847 |
| BSG | basigin (Ok blood group) | -0.022258 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | -0.0221991 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0220658 |
| HOMER1 | homer scaffolding protein 1 | -0.0219685 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -0.0216227 |
| AKAP6 | A kinase (PRKA) anchor protein 6 | -0.0216138 |
| PEG10 | paternally expressed 10 | -0.0215139 |
| SALL4 | spalt-like transcription factor 4 | -0.0214735 |
| NOP58 | NOP58 ribonucleoprotein | -0.0209757 |
| DDX46 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 | -0.0209074 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0206871 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | -0.0204361 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0202884 |
| SHROOM3 | shroom family member 3 | -0.0202122 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.0200513 |
| ATP9A | ATPase, class II, type 9A | -0.0199494 |
| MAP1B | microtubule-associated protein 1B | -0.0199423 |
| TUBB | tubulin, beta class I | -0.0198899 |
