| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Larotrectinib sulfate perturbation in C32 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Larotrectinib sulfate_C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.255526 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0676359 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0645799 |
| NAV2 | neuron navigator 2 | 0.0618916 |
| TMEM178B | transmembrane protein 178B | 0.0549476 |
| CD109 | CD109 molecule | 0.0486512 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.048373 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0448144 |
| MT2A | metallothionein 2A | 0.0417511 |
| SSBP3 | single stranded DNA binding protein 3 | 0.0415682 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.035613 |
| TPR | translocated promoter region, nuclear basket protein | 0.0346765 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0337386 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0336164 |
| FGF13 | fibroblast growth factor 13 | 0.0333749 |
| ZNF704 | zinc finger protein 704 | 0.0329544 |
| CPEB2 | cytoplasmic polyadenylation element binding protein 2 | 0.0303982 |
| NAV1 | neuron navigator 1 | 0.0303693 |
| RNF145 | ring finger protein 145 | 0.0300736 |
| PTK2 | protein tyrosine kinase 2 | 0.029481 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0293795 |
| FBXO7 | F-box protein 7 | 0.0289656 |
| ZFP36 | ZFP36 ring finger protein | 0.0273816 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0270268 |
| MYO10 | myosin X | 0.0266296 |
| FOSL1 | FOS-like antigen 1 | 0.0263522 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0263057 |
| FRMD6 | FERM domain containing 6 | 0.0248293 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0243911 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0229685 |
| TSC22D1 | TSC22 domain family, member 1 | 0.022924 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.022561 |
| CENPF | centromere protein F, 350/400kDa | 0.0220245 |
| COPA | coatomer protein complex, subunit alpha | 0.0218958 |
| STXBP1 | syntaxin binding protein 1 | 0.0217112 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0216536 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0214927 |
| CDK19 | cyclin-dependent kinase 19 | 0.0211352 |
| SETD5 | SET domain containing 5 | 0.0210317 |
| MIDEAS | mitotic deacetylase associated SANT domain protein | 0.0210121 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.02101 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0208553 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.020254 |
| AFDN | afadin, adherens junction formation factor | 0.0199466 |
| ZNF451 | zinc finger protein 451 | 0.0194525 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0190611 |
| PCBP2 | poly(rC) binding protein 2 | 0.018986 |
| VEGFA | vascular endothelial growth factor A | 0.0189472 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.0187501 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0187488 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0183778 |
| TAPBP | TAP binding protein (tapasin) | 0.0183346 |
| STOM | stomatin | 0.0182176 |
| NOTCH2 | notch 2 | 0.0180395 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0173564 |
| SMAP1 | small ArfGAP 1 | 0.017257 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | 0.0172218 |
| SUCO | SUN domain containing ossification factor | 0.0172165 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | 0.0170932 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.0166841 |
| EFR3B | EFR3 homolog B (S. cerevisiae) | 0.0164093 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0163944 |
| DDX41 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 | 0.016389 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0163068 |
| PCMTD1 | protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 | 0.016279 |
| HDGF | hepatoma-derived growth factor | 0.016021 |
| SPAG9 | sperm associated antigen 9 | 0.0159811 |
| AGPAT5 | 1-acylglycerol-3-phosphate O-acyltransferase 5 | 0.0159092 |
| LNPK | lunapark, ER junction formation factor | 0.0158861 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0157451 |
| SCARB1 | scavenger receptor class B, member 1 | 0.0155129 |
| NT5C3A | 5'-nucleotidase, cytosolic IIIA | 0.0154952 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0154667 |
| CCDC91 | coiled-coil domain containing 91 | 0.0154435 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0153886 |
| GOLGA4 | golgin A4 | 0.0153373 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0153286 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0152916 |
| TANC1 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 | 0.0149532 |
| PTMA | prothymosin, alpha | 0.0148054 |
| TPD52 | tumor protein D52 | 0.0144714 |
| INSIG2 | insulin induced gene 2 | 0.0144663 |
| RYK | receptor-like tyrosine kinase | 0.0142626 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0141985 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.014155 |
| TMF1 | TATA element modulatory factor 1 | 0.0140991 |
| RPS12 | ribosomal protein S12 | 0.0140804 |
| MMP14 | matrix metallopeptidase 14 (membrane-inserted) | 0.0139328 |
| YAP1 | Yes-associated protein 1 | 0.0138886 |
| PLA2G4A | phospholipase A2, group IVA (cytosolic, calcium-dependent) | 0.0138641 |
| CHD1L | chromodomain helicase DNA binding protein 1-like | 0.0138091 |
| SLC4A2 | solute carrier family 4 (anion exchanger), member 2 | 0.0138038 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0137675 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 0.0137662 |
| ANO6 | anoctamin 6 | 0.0136169 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0135383 |
| FBXO32 | F-box protein 32 | 0.0133822 |
| SEPTIN9 | septin 9 | 0.0133172 |
| FNIP1 | folliculin interacting protein 1 | 0.0131612 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0131075 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.247315 |
| GPC6 | glypican 6 | -0.213794 |
| VGF | VGF nerve growth factor inducible | -0.189911 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.155586 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.131347 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.130244 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | -0.122877 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0912324 |
| ASPH | aspartate beta-hydroxylase | -0.0873261 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0830239 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0766151 |
| TMSB10 | thymosin beta 10 | -0.0729452 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | -0.0722589 |
| TNNC1 | troponin C type 1 (slow) | -0.0714407 |
| OXR1 | oxidation resistance 1 | -0.0706336 |
| TNFRSF19 | tumor necrosis factor receptor superfamily, member 19 | -0.0703358 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0699989 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0597098 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0587719 |
| NLGN1 | neuroligin 1 | -0.0586081 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0567258 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0559556 |
| IER3 | immediate early response 3 | -0.0532581 |
| MACROD2 | MACRO domain containing 2 | -0.051827 |
| COG5 | component of oligomeric golgi complex 5 | -0.0515694 |
| S100A6 | S100 calcium binding protein A6 | -0.0490423 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0487562 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0467548 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0466854 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.0462737 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0454762 |
| FRMD4A | FERM domain containing 4A | -0.045223 |
| SCFD2 | sec1 family domain containing 2 | -0.0446924 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0443372 |
| RPLP1 | ribosomal protein, large, P1 | -0.043087 |
| CALU | calumenin | -0.0430217 |
| OSMR | oncostatin M receptor | -0.042954 |
| TAGLN2 | transgelin 2 | -0.041477 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0414487 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0409933 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0399994 |
| RHEB | Ras homolog enriched in brain | -0.0395386 |
| PCDH7 | protocadherin 7 | -0.0388988 |
| EYA1 | EYA transcriptional coactivator and phosphatase 1 | -0.038056 |
| HLA-B | major histocompatibility complex, class I, B | -0.0379686 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0376888 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0373749 |
| FMN1 | formin 1 | -0.0369505 |
| CALD1 | caldesmon 1 | -0.0364655 |
| ACTG1 | actin gamma 1 | -0.0362855 |
| HMCN1 | hemicentin 1 | -0.0359127 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.0357363 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0355597 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0353951 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0351007 |
| CPED1 | cadherin-like and PC-esterase domain containing 1 | -0.0346666 |
| DCT | dopachrome tautomerase | -0.0343455 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.033957 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0339432 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.033919 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0338097 |
| NPR2 | natriuretic peptide receptor 2 | -0.033795 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0331021 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0325273 |
| PKM | pyruvate kinase, muscle | -0.0324875 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0322145 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0320515 |
| ADNP | activity-dependent neuroprotector homeobox | -0.0320347 |
| FUS | FUS RNA binding protein | -0.0316674 |
| RTN4 | reticulon 4 | -0.0311274 |
| VCL | vinculin | -0.0309277 |
| PAX3 | paired box 3 | -0.0307278 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0305563 |
| INPP5F | inositol polyphosphate-5-phosphatase F | -0.0304462 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0302583 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0302084 |
| KIRREL1 | kirre like nephrin family adhesion molecule 1 | -0.0300533 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | -0.029924 |
| GNAS | GNAS complex locus | -0.0296687 |
| CD63 | CD63 molecule | -0.0291131 |
| CHSY1 | chondroitin sulfate synthase 1 | -0.0284596 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.028372 |
| CDK14 | cyclin-dependent kinase 14 | -0.0283096 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | -0.0282761 |
| ANKRD28 | ankyrin repeat domain 28 | -0.028275 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0279356 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0279142 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0277249 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0270878 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0269087 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0268356 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.026834 |
| PGK1 | phosphoglycerate kinase 1 | -0.026725 |
| RRBP1 | ribosome binding protein 1 | -0.0265477 |
| EHBP1 | EH domain binding protein 1 | -0.0262447 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0256549 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0256486 |
| ANXA2 | annexin A2 | -0.0254131 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0254008 |
| COL1A2 | collagen, type I, alpha 2 | -0.0252277 |
