| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Larotrectinib sulfate perturbation in CFPAC-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Larotrectinib sulfate_CFPAC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.16053 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.15156 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.135701 |
| LAMB3 | laminin, beta 3 | 0.118006 |
| SMAD3 | SMAD family member 3 | 0.11111 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0976807 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0932506 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0855261 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0834679 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0818256 |
| APP | amyloid beta (A4) precursor protein | 0.0714364 |
| EZR | ezrin | 0.068664 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0638961 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0590405 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0578039 |
| FLNA | filamin A, alpha | 0.0559923 |
| FLNB | filamin B, beta | 0.0543943 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0539167 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0491111 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0481963 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0480323 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0480306 |
| KLF6 | Kruppel-like factor 6 | 0.0465255 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0463663 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0461551 |
| CCNY | cyclin Y | 0.046043 |
| VEGFA | vascular endothelial growth factor A | 0.0448623 |
| VIM | vimentin | 0.0414536 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0409918 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.040424 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0402924 |
| DSPP | dentin sialophosphoprotein | 0.0396765 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0386794 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0381958 |
| TGM2 | transglutaminase 2 | 0.0376564 |
| FAM13A | family with sequence similarity 13, member A | 0.0368729 |
| OPTN | optineurin | 0.0364951 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0360607 |
| RIOK3 | RIO kinase 3 | 0.0360302 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.035034 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0348535 |
| ANXA11 | annexin A11 | 0.0347868 |
| DIAPH1 | diaphanous-related formin 1 | 0.034328 |
| PADI1 | peptidyl arginine deiminase, type I | 0.0337651 |
| RAB8B | RAB8B, member RAS oncogene family | 0.0321655 |
| MCL1 | myeloid cell leukemia 1 | 0.0320314 |
| PLEC | plectin | 0.031954 |
| OGA | O-GlcNAcase | 0.0316198 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | 0.0316188 |
| ACTN4 | actinin, alpha 4 | 0.0315238 |
| FNBP1L | formin binding protein 1-like | 0.0314521 |
| MYOF | myoferlin | 0.0311747 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.031122 |
| AHNAK | AHNAK nucleoprotein | 0.0308722 |
| ARRDC3 | arrestin domain containing 3 | 0.0307631 |
| NAV2 | neuron navigator 2 | 0.0305979 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0299215 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0296041 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0293048 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0289333 |
| CASC3 | cancer susceptibility candidate 3 | 0.0286506 |
| FOSL1 | FOS-like antigen 1 | 0.027757 |
| CDCP1 | CUB domain containing protein 1 | 0.0276981 |
| HDAC9 | histone deacetylase 9 | 0.0274894 |
| HPCAL1 | hippocalcin-like 1 | 0.0272811 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0272686 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0268508 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0267254 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0265756 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0265282 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0263743 |
| FMNL2 | formin-like 2 | 0.0262925 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | 0.0262258 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0260921 |
| BRD2 | bromodomain containing 2 | 0.0260436 |
| YTHDC1 | YTH domain containing 1 | 0.0259603 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0259191 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0252054 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0251085 |
| MYO5B | myosin VB | 0.0250763 |
| SEPTIN9 | septin 9 | 0.0247196 |
| PCBP2 | poly(rC) binding protein 2 | 0.0245297 |
| CCNL1 | cyclin L1 | 0.024524 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0242914 |
| CIB1 | calcium and integrin binding 1 (calmyrin) | 0.024056 |
| IRF6 | interferon regulatory factor 6 | 0.0239183 |
| CLIP4 | CAP-GLY domain containing linker protein family, member 4 | 0.0238865 |
| CDC42BPB | CDC42 binding protein kinase beta (DMPK-like) | 0.0237953 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0237731 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0237374 |
| RAI14 | retinoic acid induced 14 | 0.0237342 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0236867 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0235372 |
| CEP250 | centrosomal protein 250kDa | 0.0235367 |
| LAMB1 | laminin, beta 1 | 0.023492 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0234128 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.023184 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.022917 |
| PROSER2 | proline and serine rich 2 | 0.0225762 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0225642 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.294347 |
| TMSB10 | thymosin beta 10 | -0.195018 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.117477 |
| MMP7 | matrix metallopeptidase 7 | -0.117153 |
| HLA-B | major histocompatibility complex, class I, B | -0.105841 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0959573 |
| PTMA | prothymosin, alpha | -0.0845772 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0787959 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0770569 |
| CP | ceruloplasmin (ferroxidase) | -0.0727577 |
| S100A6 | S100 calcium binding protein A6 | -0.0720871 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0711357 |
| MT1X | metallothionein 1X | -0.0622971 |
| MT2A | metallothionein 2A | -0.0611832 |
| ANXA2 | annexin A2 | -0.0609128 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0604583 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0576246 |
| EFNA5 | ephrin-A5 | -0.0561335 |
| RPLP1 | ribosomal protein, large, P1 | -0.0553239 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0552805 |
| RPL35A | ribosomal protein L35a | -0.0550285 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0535336 |
| FTL | ferritin, light polypeptide | -0.0534511 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0527617 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0520073 |
| B2M | beta-2-microglobulin | -0.048699 |
| S100A10 | S100 calcium binding protein A10 | -0.0468724 |
| IER3 | immediate early response 3 | -0.0453301 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0448879 |
| OSMR | oncostatin M receptor | -0.0435242 |
| ACTG1 | actin gamma 1 | -0.043203 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0409756 |
| HLA-A | major histocompatibility complex, class I, A | -0.0404801 |
| ASPH | aspartate beta-hydroxylase | -0.0396188 |
| EGR1 | early growth response 1 | -0.0392822 |
| LCN2 | lipocalin 2 | -0.0392387 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.0389913 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0387669 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0381484 |
| ENO1 | enolase 1, (alpha) | -0.036904 |
| LMO7 | LIM domain 7 | -0.0368563 |
| RPL34 | ribosomal protein L34 | -0.0368493 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0350909 |
| GNAS | GNAS complex locus | -0.0349015 |
| FBXO11 | F-box protein 11 | -0.0347174 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0341419 |
| RPS24 | ribosomal protein S24 | -0.0333192 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0333107 |
| PKM | pyruvate kinase, muscle | -0.0332407 |
| MYO1E | myosin IE | -0.0326587 |
| CSTB | cystatin B (stefin B) | -0.0324551 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0314136 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0313879 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0311768 |
| ARF1 | ADP-ribosylation factor 1 | -0.030748 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0303547 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0296188 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0294803 |
| SGMS2 | sphingomyelin synthase 2 | -0.0293717 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0283026 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0278284 |
| PLAT | plasminogen activator, tissue | -0.0278227 |
| RPLP0 | ribosomal protein, large, P0 | -0.0275696 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0274797 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0271982 |
| TXNIP | thioredoxin interacting protein | -0.0271825 |
| H1-0 | H1.0 linker histone | -0.0270851 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0270052 |
| TAGLN2 | transgelin 2 | -0.0268443 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0267753 |
| RRBP1 | ribosome binding protein 1 | -0.0267165 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0266908 |
| ITGA6 | integrin, alpha 6 | -0.0266559 |
| RPS29 | ribosomal protein S29 | -0.0265935 |
| RPS8 | ribosomal protein S8 | -0.0265333 |
| RPS21 | ribosomal protein S21 | -0.0264305 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0263704 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0262062 |
| EHBP1 | EH domain binding protein 1 | -0.02596 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0257557 |
| CD2AP | CD2-associated protein | -0.0255349 |
| UGDH | UDP-glucose 6-dehydrogenase | -0.0254204 |
| LAMA4 | laminin, alpha 4 | -0.025314 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0252141 |
| KRT19 | keratin 19, type I | -0.0250556 |
| TMEM123 | transmembrane protein 123 | -0.0250254 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0249759 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.024855 |
| POTEF | POTE ankyrin domain family, member F | -0.0248326 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0247543 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0245798 |
| HMGA1 | high mobility group AT-hook 1 | -0.0245571 |
| NRP1 | neuropilin 1 | -0.0245395 |
| MORF4L2 | mortality factor 4 like 2 | -0.0241307 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0240932 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | -0.0240192 |
| RPL8 | ribosomal protein L8 | -0.0238075 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0238024 |
| RPS19 | ribosomal protein S19 | -0.0237211 |
| RPS6 | ribosomal protein S6 | -0.0236085 |
