| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Larotrectinib sulfate perturbation in CHP-212 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Larotrectinib sulfate_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FAM13A | family with sequence similarity 13, member A | 0.109634 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.104585 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | 0.072304 |
| MEIS2 | Meis homeobox 2 | 0.0656755 |
| LSAMP | limbic system-associated membrane protein | 0.0595134 |
| HELZ | helicase with zinc finger | 0.0582577 |
| VMP1 | vacuole membrane protein 1 | 0.0577055 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0500218 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0495077 |
| FNBP1 | formin binding protein 1 | 0.0486906 |
| GOLGA4 | golgin A4 | 0.0469651 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0468739 |
| RUNX1 | runt-related transcription factor 1 | 0.0428106 |
| PCBP2 | poly(rC) binding protein 2 | 0.0417372 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0416383 |
| MEF2A | myocyte enhancer factor 2A | 0.0381738 |
| NDRG1 | N-myc downstream regulated 1 | 0.0367814 |
| CD36 | CD36 molecule (thrombospondin receptor) | 0.0366638 |
| ZNF148 | zinc finger protein 148 | 0.0357428 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0337127 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0335808 |
| ZNF292 | zinc finger protein 292 | 0.031322 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | 0.029948 |
| DNMBP | dynamin binding protein | 0.0295695 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0292498 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0289012 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.02885 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0286242 |
| RNF145 | ring finger protein 145 | 0.0285885 |
| SNX13 | sorting nexin 13 | 0.0280527 |
| SCAF11 | SR-related CTD-associated factor 11 | 0.0271411 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0270533 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0268952 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0268652 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0261077 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0253942 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0253097 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0252731 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0251995 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0239789 |
| SMAD4 | SMAD family member 4 | 0.0233277 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0223377 |
| WDR45B | WD repeat domain 45B | 0.0223271 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0223237 |
| TAPBP | TAP binding protein (tapasin) | 0.022079 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0217753 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0217401 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0217035 |
| PHIP | pleckstrin homology domain interacting protein | 0.0208517 |
| CD46 | CD46 molecule, complement regulatory protein | 0.0208434 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0206599 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0204225 |
| SNAPC3 | small nuclear RNA activating complex, polypeptide 3, 50kDa | 0.0203278 |
| ZFP36 | ZFP36 ring finger protein | 0.0202801 |
| FAM219A | family with sequence similarity 219, member A | 0.0202666 |
| SSBP3 | single stranded DNA binding protein 3 | 0.0201552 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0201494 |
| TMEM263 | transmembrane protein 263 | 0.0201494 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.020138 |
| SUCO | SUN domain containing ossification factor | 0.0201068 |
| FLNB | filamin B, beta | 0.0200711 |
| ANKRD50 | ankyrin repeat domain 50 | 0.0197936 |
| GCC2 | GRIP and coiled-coil domain containing 2 | 0.0197895 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0197154 |
| FER | fer (fps/fes related) tyrosine kinase | 0.019454 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0193542 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0192895 |
| NSD3 | nuclear receptor binding SET domain protein 3 | 0.0192706 |
| ANO6 | anoctamin 6 | 0.0191164 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0191126 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0189398 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0188065 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0188019 |
| U2SURP | U2 snRNP-associated SURP domain containing | 0.0187625 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0186382 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0185658 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0185249 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.0184665 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | 0.0184252 |
| KLHL13 | kelch-like family member 13 | 0.0183587 |
| JMJD1C | jumonji domain containing 1C | 0.0182261 |
| TPR | translocated promoter region, nuclear basket protein | 0.0181806 |
| PMP22 | peripheral myelin protein 22 | 0.0181163 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.018078 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 0.0180026 |
| TMF1 | TATA element modulatory factor 1 | 0.0177595 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0174426 |
| GYS1 | glycogen synthase 1 (muscle) | 0.0172692 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0172642 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0172144 |
| RBM5 | RNA binding motif protein 5 | 0.0172047 |
| DTNA | dystrobrevin, alpha | 0.0171817 |
| B2M | beta-2-microglobulin | 0.0170016 |
| C6ORF62 | chromosome 6 open reading frame 62 | 0.016755 |
| CEP290 | centrosomal protein 290kDa | 0.0167217 |
| PTAR1 | protein prenyltransferase alpha subunit repeat containing 1 | 0.0166546 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0166303 |
| EEA1 | early endosome antigen 1 | 0.016615 |
| OPTN | optineurin | 0.0164927 |
| ARPP19 | cAMP-regulated phosphoprotein, 19kDa | 0.016333 |
| Symbol | Name | Standardized Value |
|---|---|---|
| DDX1 | DEAD (Asp-Glu-Ala-Asp) box helicase 1 | -0.346532 |
| NRG1 | neuregulin 1 | -0.197809 |
| IGF2 | insulin-like growth factor 2 | -0.190151 |
| VIM | vimentin | -0.150447 |
| PTMA | prothymosin, alpha | -0.117312 |
| EXT1 | exostosin glycosyltransferase 1 | -0.110849 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0991112 |
| LRFN5 | leucine rich repeat and fibronectin type III domain containing 5 | -0.0781517 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0681671 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0680354 |
| SYT1 | synaptotagmin I | -0.0676811 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0675998 |
| COL1A1 | collagen, type I, alpha 1 | -0.0638573 |
| PRKCA | protein kinase C, alpha | -0.0615562 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0586991 |
| RPL23 | ribosomal protein L23 | -0.0584775 |
| TRIB2 | tribbles pseudokinase 2 | -0.0573714 |
| COL3A1 | collagen, type III, alpha 1 | -0.0573487 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0554444 |
| ACTG1 | actin gamma 1 | -0.0541322 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0506412 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0504098 |
| CADM2 | cell adhesion molecule 2 | -0.0501252 |
| RPS24 | ribosomal protein S24 | -0.0499948 |
| VCL | vinculin | -0.0478652 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0470003 |
| CUX1 | cut-like homeobox 1 | -0.0465938 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.0459811 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0450921 |
| TCF12 | transcription factor 12 | -0.0442446 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0438141 |
| MSI2 | musashi RNA-binding protein 2 | -0.0423546 |
| PLCB4 | phospholipase C, beta 4 | -0.0419435 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0409295 |
| ENAH | enabled homolog (Drosophila) | -0.0408071 |
| ZNF804A | zinc finger protein 804A | -0.0391774 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | -0.0388397 |
| COL4A5 | collagen, type IV, alpha 5 | -0.0388395 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0385056 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0383085 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.0382296 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | -0.038005 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0378194 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.037666 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0373934 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0367501 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0366905 |
| CRH | corticotropin releasing hormone | -0.0364972 |
| NREP | neuronal regeneration related protein | -0.0356516 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0339965 |
| KCNIP4 | Kv channel interacting protein 4 | -0.0330778 |
| B3GALT1 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 | -0.0330258 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0326988 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.032529 |
| FOXK2 | forkhead box K2 | -0.0323392 |
| FKBP10 | FK506 binding protein 10, 65 kDa | -0.0323256 |
| RPL19 | ribosomal protein L19 | -0.0320804 |
| CPED1 | cadherin-like and PC-esterase domain containing 1 | -0.0317952 |
| DHX9 | DEAH (Asp-Glu-Ala-His) box helicase 9 | -0.0314597 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0312612 |
| COL4A2 | collagen, type IV, alpha 2 | -0.0312259 |
| GREM2 | gremlin 2, DAN family BMP antagonist | -0.0302078 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0298133 |
| DKK2 | dickkopf WNT signaling pathway inhibitor 2 | -0.029694 |
| ATRNL1 | attractin-like 1 | -0.0294924 |
| TPM4 | tropomyosin 4 | -0.0294803 |
| RPLP1 | ribosomal protein, large, P1 | -0.0290708 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0286175 |
| RGS5 | regulator of G-protein signaling 5 | -0.0284626 |
| UNC5C | unc-5 homolog C (C. elegans) | -0.0282931 |
| PEAK1 | pseudopodium-enriched atypical kinase 1 | -0.0280519 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0279943 |
| ITGA1 | integrin, alpha 1 | -0.0277191 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0276745 |
| PCDH9 | protocadherin 9 | -0.0272906 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0272084 |
| LMNA | lamin A/C | -0.0271408 |
| NRP1 | neuropilin 1 | -0.0270212 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0270192 |
| PKM | pyruvate kinase, muscle | -0.0267679 |
| MCL1 | myeloid cell leukemia 1 | -0.026507 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0262555 |
| PRKCE | protein kinase C, epsilon | -0.0258083 |
| CADM1 | cell adhesion molecule 1 | -0.0257696 |
| PBX1 | pre-B-cell leukemia homeobox 1 | -0.0253646 |
| RPS23 | ribosomal protein S23 | -0.0252931 |
| RPL38 | ribosomal protein L38 | -0.0252705 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | -0.0252618 |
| RPS4X | ribosomal protein S4, X-linked | -0.0252546 |
| CANX | calnexin | -0.0251352 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0250924 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | -0.0250126 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0246836 |
| RPL37 | ribosomal protein L37 | -0.024661 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0246159 |
| HMGA2 | high mobility group AT-hook 2 | -0.0245388 |
| PRRC2B | proline-rich coiled-coil 2B | -0.0245139 |
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | -0.0242455 |
| LARP1 | La ribonucleoprotein domain family, member 1 | -0.0242114 |
| GLCCI1 | glucocorticoid induced 1 | -0.0240554 |
