| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Larotrectinib sulfate perturbation in COLO 205 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Larotrectinib sulfate_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MLPH | melanophilin | 0.0560474 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0406425 |
| PHF3 | PHD finger protein 3 | 0.040161 |
| FNIP1 | folliculin interacting protein 1 | 0.0341994 |
| ASPH | aspartate beta-hydroxylase | 0.0332156 |
| RNF149 | ring finger protein 149 | 0.0325366 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0323563 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0321841 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.03218 |
| ARRDC3 | arrestin domain containing 3 | 0.0306271 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.029943 |
| RAD51B | RAD51 paralog B | 0.0297744 |
| ARGLU1 | arginine and glutamate rich 1 | 0.0296805 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0286726 |
| PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | 0.0283668 |
| ZNF395 | zinc finger protein 395 | 0.0280982 |
| VEGFA | vascular endothelial growth factor A | 0.0278196 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0277267 |
| NDRG1 | N-myc downstream regulated 1 | 0.0275409 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | 0.0267123 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0264071 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0263343 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0258428 |
| DNAJC15 | DnaJ (Hsp40) homolog, subfamily C, member 15 | 0.025717 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0251546 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0246221 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.024619 |
| CANX | calnexin | 0.0243739 |
| KIF16B | kinesin family member 16B | 0.0243317 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0240225 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.023819 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0237772 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0237741 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0236858 |
| VPS13C | vacuolar protein sorting 13 homolog C (S. cerevisiae) | 0.0234608 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0233074 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | 0.0232629 |
| ZNF638 | zinc finger protein 638 | 0.0227668 |
| PCBP2 | poly(rC) binding protein 2 | 0.0222831 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0222256 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0220711 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0219682 |
| ARHGEF10L | Rho guanine nucleotide exchange factor (GEF) 10-like | 0.021498 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.021486 |
| TMC5 | transmembrane channel-like 5 | 0.0209642 |
| DST | dystonin | 0.0207962 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0207367 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | 0.0197466 |
| UTY | ubiquitously transcribed tetratricopeptide repeat containing, Y-linked | 0.0196695 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0195577 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0193402 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.0193114 |
| DSPP | dentin sialophosphoprotein | 0.0191319 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0190989 |
| ALPK1 | alpha-kinase 1 | 0.0190749 |
| UBR2 | ubiquitin protein ligase E3 component n-recognin 2 | 0.0187926 |
| OARD1 | O-acyl-ADP-ribose deacylase 1 | 0.018609 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.0185853 |
| MYO10 | myosin X | 0.0184851 |
| RPL7 | ribosomal protein L7 | 0.0183376 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0181611 |
| TSC22D1 | TSC22 domain family, member 1 | 0.0180763 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0179923 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.0176958 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0173729 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0173325 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0172069 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0171796 |
| MXI1 | MAX interactor 1, dimerization protein | 0.017109 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0169797 |
| KLHL24 | kelch-like family member 24 | 0.0169226 |
| SCAPER | S-phase cyclin A-associated protein in the ER | 0.0168199 |
| DENND4C | DENN/MADD domain containing 4C | 0.0167836 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.016632 |
| PDZD8 | PDZ domain containing 8 | 0.0165599 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.016177 |
| IFNGR1 | interferon gamma receptor 1 | 0.0161493 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0161309 |
| FOSL2 | FOS-like antigen 2 | 0.016063 |
| MTUS1 | microtubule associated tumor suppressor 1 | 0.0159946 |
| PGK1 | phosphoglycerate kinase 1 | 0.0159049 |
| SKAP2 | src kinase associated phosphoprotein 2 | 0.0158638 |
| GALK2 | galactokinase 2 | 0.0158264 |
| PADI1 | peptidyl arginine deiminase, type I | 0.015742 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.015538 |
| PFKP | phosphofructokinase, platelet | 0.0154903 |
| RPS3 | ribosomal protein S3 | 0.0154178 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0152368 |
| SKIC3 | SKI3 subunit of superkiller complex | 0.0151244 |
| TAPBP | TAP binding protein (tapasin) | 0.0151238 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0148744 |
| SCARB1 | scavenger receptor class B, member 1 | 0.0147724 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0145777 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0144887 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0144658 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0144286 |
| SMAD3 | SMAD family member 3 | 0.01431 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0142056 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0141653 |
| ABCA5 | ATP-binding cassette, sub-family A (ABC1), member 5 | 0.0139902 |
| Symbol | Name | Standardized Value |
|---|---|---|
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.122158 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.104298 |
| LCN2 | lipocalin 2 | -0.102048 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0984527 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0900344 |
| ANXA2 | annexin A2 | -0.0874677 |
| HLA-B | major histocompatibility complex, class I, B | -0.0825131 |
| RIGI | RNA sensor RIG-I | -0.0776415 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0770356 |
| EPSTI1 | epithelial stromal interaction 1 (breast) | -0.0762009 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0742448 |
| LMO7 | LIM domain 7 | -0.0718671 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0697596 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0689784 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0657351 |
| MX1 | MX dynamin-like GTPase 1 | -0.0629273 |
| SQSTM1 | sequestosome 1 | -0.0616373 |
| SP100 | SP100 nuclear antigen | -0.0597689 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | -0.0587326 |
| RRBP1 | ribosome binding protein 1 | -0.0580022 |
| LYZ | lysozyme | -0.0563331 |
| INTS6 | integrator complex subunit 6 | -0.0541965 |
| EGR1 | early growth response 1 | -0.054156 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0511682 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0506727 |
| NPSR1 | neuropeptide S receptor 1 | -0.0501713 |
| RNF213 | ring finger protein 213 | -0.0495056 |
| IRF1 | interferon regulatory factor 1 | -0.0473522 |
| EPHB2 | EPH receptor B2 | -0.0472783 |
| MACC1 | metastasis associated in colon cancer 1 | -0.0452432 |
| XAF1 | XIAP associated factor 1 | -0.0448097 |
| ITGA6 | integrin, alpha 6 | -0.0426863 |
| MX2 | MX dynamin-like GTPase 2 | -0.0425554 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0424981 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | -0.042024 |
| HLA-C | major histocompatibility complex, class I, C | -0.0406658 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0397162 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.03922 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0387789 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0372533 |
| C6ORF132 | chromosome 6 open reading frame 132 | -0.0370633 |
| PLSCR1 | phospholipid scramblase 1 | -0.0363996 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | -0.0361334 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0359631 |
| NCOA7 | nuclear receptor coactivator 7 | -0.035698 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | -0.0356326 |
| TJP1 | tight junction protein 1 | -0.0355585 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0355557 |
| MYO1E | myosin IE | -0.0345476 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0341944 |
| PMP22 | peripheral myelin protein 22 | -0.0337124 |
| PERP | PERP, TP53 apoptosis effector | -0.0334942 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0334724 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | -0.0331881 |
| VCL | vinculin | -0.0326594 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | -0.0325269 |
| ACTG1 | actin gamma 1 | -0.0323029 |
| PTMA | prothymosin, alpha | -0.0319831 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | -0.0316712 |
| HM13 | histocompatibility (minor) 13 | -0.0316405 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0314715 |
| TMSB10 | thymosin beta 10 | -0.0309156 |
| NF1 | neurofibromin 1 | -0.0306247 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.030275 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.029873 |
| MAP7 | microtubule-associated protein 7 | -0.0297238 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0296591 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0295366 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0294628 |
| MUC13 | mucin 13, cell surface associated | -0.0281216 |
| ARF1 | ADP-ribosylation factor 1 | -0.0280522 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0279812 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0278375 |
| ERBIN | erbb2 interacting protein | -0.027732 |
| LAP3 | leucine aminopeptidase 3 | -0.0277256 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0277226 |
| BTBD9 | BTB (POZ) domain containing 9 | -0.0274485 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0271984 |
| ELOF1 | elongation factor 1 homolog (S. cerevisiae) | -0.0267222 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0265056 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0259092 |
| HMGB1 | high mobility group box 1 | -0.025809 |
| ABLIM1 | actin binding LIM protein 1 | -0.0256936 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0256341 |
| PRKCA | protein kinase C, alpha | -0.0252387 |
| TRERF1 | transcriptional regulating factor 1 | -0.0252286 |
| SLC7A1 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | -0.0251074 |
| TFRC | transferrin receptor | -0.0249017 |
| SDC4 | syndecan 4 | -0.0247825 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.024589 |
| S100A10 | S100 calcium binding protein A10 | -0.0242478 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0240387 |
| MECOM | MDS1 and EVI1 complex locus | -0.0238203 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0237814 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0237048 |
| EFNB2 | ephrin-B2 | -0.0236147 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0233303 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.023037 |
| RUNX1 | runt-related transcription factor 1 | -0.0228263 |
| S100A6 | S100 calcium binding protein A6 | -0.0227837 |
