Larotrectinib sulfate_H4 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Larotrectinib sulfate perturbation in H4 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Larotrectinib sulfate_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.285722
FNDC3B fibronectin type III domain containing 3B 0.144036
AKAP12 A kinase (PRKA) anchor protein 12 0.133897
VIM vimentin 0.109803
EGFR epidermal growth factor receptor 0.105976
AHNAK AHNAK nucleoprotein 0.104798
TRIO trio Rho guanine nucleotide exchange factor 0.097394
SBF2 SET binding factor 2 0.0801134
FN1 fibronectin 1 0.0767488
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0740963
DGKD diacylglycerol kinase, delta 130kDa 0.0734527
CALD1 caldesmon 1 0.0719213
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0674513
CD44 CD44 molecule (Indian blood group) 0.0638067
MYOF myoferlin 0.0633393
ERRFI1 ERBB receptor feedback inhibitor 1 0.062592
TGFBI transforming growth factor, beta-induced, 68kDa 0.0614512
DST dystonin 0.0606514
ZNF395 zinc finger protein 395 0.060209
MYO10 myosin X 0.0593559
TNS3 tensin 3 0.0580695
ANXA2 annexin A2 0.0561869
CANX calnexin 0.0559034
FAM13A family with sequence similarity 13, member A 0.0552676
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0548279
SMAD3 SMAD family member 3 0.0531301
NDRG1 N-myc downstream regulated 1 0.0513239
GOLGB1 golgin B1 0.0509504
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0490974
CADM1 cell adhesion molecule 1 0.0483166
ANO6 anoctamin 6 0.0481498
LOXL2 lysyl oxidase-like 2 0.0474129
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0472179
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.046721
AKAP9 A kinase (PRKA) anchor protein 9 0.0464098
FNIP1 folliculin interacting protein 1 0.0443185
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0441103
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0440138
LPP LIM domain containing preferred translocation partner in lipoma 0.0433182
PRKCSH protein kinase C substrate 80K-H 0.0426442
TAPBP TAP binding protein (tapasin) 0.0425242
VMP1 vacuole membrane protein 1 0.0416534
LDHA lactate dehydrogenase A 0.0407323
TPM4 tropomyosin 4 0.0388387
FMNL2 formin-like 2 0.0379587
RAI14 retinoic acid induced 14 0.0372182
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0370648
BBS9 Bardet-Biedl syndrome 9 0.0368067
NAV2 neuron navigator 2 0.0362653
SQSTM1 sequestosome 1 0.0357783
FLNB filamin B, beta 0.0352103
TPM1 tropomyosin 1 (alpha) 0.0350635
HIP1 huntingtin interacting protein 1 0.0345187
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0344178
CTSB cathepsin B 0.0336709
TTC3 tetratricopeptide repeat domain 3 0.0334597
GOLGA4 golgin A4 0.0331213
INHBA inhibin, beta A 0.0329108
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog 0.032478
MMP12 matrix metallopeptidase 12 0.0320493
HMGA2 high mobility group AT-hook 2 0.032032
FTH1 ferritin, heavy polypeptide 1 0.0314046
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0309846
COL5A1 collagen, type V, alpha 1 0.0307792
ANKRD12 ankyrin repeat domain 12 0.0299736
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0298957
CD109 CD109 molecule 0.029786
RPS6 ribosomal protein S6 0.0294975
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0292895
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0290163
OSMR oncostatin M receptor 0.0288315
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0287955
MACF1 microtubule-actin crosslinking factor 1 0.0287948
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0286841
JMJD1C jumonji domain containing 1C 0.0285436
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0285358
BHLHE40 basic helix-loop-helix family, member e40 0.0283874
KTN1 kinectin 1 (kinesin receptor) 0.0282268
RPS3 ribosomal protein S3 0.0278398
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.027809
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.027568
RPS4X ribosomal protein S4, X-linked 0.0273798
TGFB1 transforming growth factor, beta 1 0.0273373
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0272274
DOCK5 dedicator of cytokinesis 5 0.0271709
IGFBP3 insulin-like growth factor binding protein 3 0.0269771
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0264571
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0261375
MYLK myosin light chain kinase 0.0260164
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.0260119
CLIP2 CAP-GLY domain containing linker protein 2 0.0255567
ELL2 elongation factor, RNA polymerase II, 2 0.025396
MAP1B microtubule-associated protein 1B 0.0253081
APP amyloid beta (A4) precursor protein 0.0252538
ARHGAP35 Rho GTPase activating protein 35 0.0251248
RNF144A ring finger protein 144A 0.0250817
USP47 ubiquitin specific peptidase 47 0.0249529
NFE2L1 nuclear factor, erythroid 2-like 1 0.0247709
LRRC49 leucine rich repeat containing 49 0.0246635
FRMD6 FERM domain containing 6 0.0244425

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.218917
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.111989
PDE4D phosphodiesterase 4D, cAMP-specific -0.0712098
GRB10 growth factor receptor-bound protein 10 -0.0630143
ASPH aspartate beta-hydroxylase -0.0593836
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0495112
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0444336
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0440169
NLGN1 neuroligin 1 -0.0439537
PKM pyruvate kinase, muscle -0.04095
DTNA dystrobrevin, alpha -0.0389432
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0370077
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0352762
PLEC plectin -0.0349481
FTL ferritin, light polypeptide -0.0335959
VEGFA vascular endothelial growth factor A -0.0324349
SDK1 sidekick cell adhesion molecule 1 -0.0324155
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0322775
LOC112694756 uncharaterized LOC112694756 -0.0319201
HLA-B major histocompatibility complex, class I, B -0.0311752
TENT5A terminal nucleotidyltransferase 5A -0.0299572
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0299555
INTS6 integrator complex subunit 6 -0.0295277
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0285569
CDK13 cyclin-dependent kinase 13 -0.0283586
STK17A serine/threonine kinase 17a -0.0283464
RPLP1 ribosomal protein, large, P1 -0.0270039
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 -0.0269928
NALF1 NALCN channel auxiliary factor 1 -0.0266109
KCTD16 potassium channel tetramerization domain containing 16 -0.026172
GLCCI1 glucocorticoid induced 1 -0.0258988
ZNF207 zinc finger protein 207 -0.0255242
WNK1 WNK lysine deficient protein kinase 1 -0.0253628
FBXL7 F-box and leucine-rich repeat protein 7 -0.0241601
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0240522
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0239252
NAMPT nicotinamide phosphoribosyltransferase -0.0235558
CEP128 centrosomal protein 128kDa -0.0232673
TMSB10 thymosin beta 10 -0.0230149
ALCAM activated leukocyte cell adhesion molecule -0.022751
VDAC1 voltage-dependent anion channel 1 -0.0226735
CSNK1A1 casein kinase 1, alpha 1 -0.0219847
NUP98 nucleoporin 98kDa -0.0219221
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0212799
RPL3 ribosomal protein L3 -0.0210119
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0209739
HYOU1 hypoxia up-regulated 1 -0.0207018
TXNIP thioredoxin interacting protein -0.0205441
WARS1 tryptophanyl-tRNA synthetase 1 -0.0201258
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0201239
TXNRD1 thioredoxin reductase 1 -0.0199865
WWOX WW domain containing oxidoreductase -0.0197196
SETX senataxin -0.0195163
RPLP2 ribosomal protein, large, P2 -0.0194644
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 -0.01926
MT2A metallothionein 2A -0.0186869
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0186534
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 -0.0185708
KIF4A kinesin family member 4A -0.0185147
FAF1 Fas (TNFRSF6) associated factor 1 -0.0182688
MAP2K1 mitogen-activated protein kinase kinase 1 -0.0182632
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0182251
EPHA4 EPH receptor A4 -0.0181362
RPS11 ribosomal protein S11 -0.0180523
IARS1 isoleucyl-tRNA synthetase 1 -0.0180269
RPL35 ribosomal protein L35 -0.0180042
SMC4 structural maintenance of chromosomes 4 -0.017963
USP34 ubiquitin specific peptidase 34 -0.0176528
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0176457
RIGI RNA sensor RIG-I -0.0176301
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.017541
UBAP2 ubiquitin associated protein 2 -0.0175014
TUSC3 tumor suppressor candidate 3 -0.0174628
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0173457
RFX8 RFX family member 8, lacking RFX DNA binding domain -0.0172775
SYT1 synaptotagmin I -0.0172749
TPT1 tumor protein, translationally-controlled 1 -0.0171103
CKAP4 cytoskeleton-associated protein 4 -0.0170049
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 -0.0168868
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0167854
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0167622
ZEB1 zinc finger E-box binding homeobox 1 -0.0164786
KDM4C lysine (K)-specific demethylase 4C -0.0164752
CDH12 cadherin 12, type 2 (N-cadherin 2) -0.0164374
LRP1B low density lipoprotein receptor-related protein 1B -0.0163982
RPS5 ribosomal protein S5 -0.0163979
WDPCP WD repeat containing planar cell polarity effector -0.016388
DGKI diacylglycerol kinase, iota -0.0163206
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0161663
LRRC23 leucine rich repeat containing 23 -0.0160545
MAP3K13 mitogen-activated protein kinase kinase kinase 13 -0.015981
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -0.0156427
HS6ST3 heparan sulfate 6-O-sulfotransferase 3 -0.01554
GLYATL2 glycine-N-acyltransferase-like 2 -0.0154717
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) -0.0153648
PTPRD protein tyrosine phosphatase, receptor type, D -0.015331
HM13 histocompatibility (minor) 13 -0.0152858
MPRIP myosin phosphatase Rho interacting protein -0.0151815
MBNL1 muscleblind-like splicing regulator 1 -0.0151271
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa -0.0150465