| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Larotrectinib sulfate perturbation in HCT15 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Larotrectinib sulfate_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.175312 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.124688 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0997355 |
| FHIT | fragile histidine triad | 0.0843241 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0773423 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0752483 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0709066 |
| WWOX | WW domain containing oxidoreductase | 0.057859 |
| RPS3 | ribosomal protein S3 | 0.0562991 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0540272 |
| PRELID2 | PRELI domain containing 2 | 0.0539591 |
| RAD51B | RAD51 paralog B | 0.0537064 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0532783 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0521435 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0513426 |
| RPS6 | ribosomal protein S6 | 0.0482712 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0470253 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0450021 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0442765 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0439496 |
| RPS8 | ribosomal protein S8 | 0.0430106 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0415787 |
| RBM39 | RNA binding motif protein 39 | 0.0412298 |
| AHNAK | AHNAK nucleoprotein | 0.0411526 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0408718 |
| ATXN1 | ataxin 1 | 0.039408 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0392913 |
| RUNX1 | runt-related transcription factor 1 | 0.0384935 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0378536 |
| NEBL | nebulette | 0.0378426 |
| MED13L | mediator complex subunit 13-like | 0.0377659 |
| ASPH | aspartate beta-hydroxylase | 0.0377607 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0369945 |
| EZR | ezrin | 0.0364937 |
| YEATS2 | YEATS domain containing 2 | 0.0363699 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0363208 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0360404 |
| SMYD3 | SET and MYND domain containing 3 | 0.0357093 |
| ZNF292 | zinc finger protein 292 | 0.0354099 |
| RPS2 | ribosomal protein S2 | 0.0352335 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0337207 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0337163 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0326805 |
| RPS12 | ribosomal protein S12 | 0.0325925 |
| RPL26 | ribosomal protein L26 | 0.032238 |
| TJP1 | tight junction protein 1 | 0.0318222 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0316196 |
| HELZ | helicase with zinc finger | 0.0315618 |
| RPL14 | ribosomal protein L14 | 0.0314221 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0313687 |
| PCBP2 | poly(rC) binding protein 2 | 0.0312249 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0311797 |
| SERINC1 | serine incorporator 1 | 0.0309294 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0309195 |
| BBX | bobby sox homolog (Drosophila) | 0.0306901 |
| GOLGB1 | golgin B1 | 0.0306406 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0305433 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0301666 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0300809 |
| H1-4 | H1.4 linker histone, cluster member | 0.0296002 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0291508 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0288835 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0288511 |
| SBF2 | SET binding factor 2 | 0.0283762 |
| SET | SET nuclear proto-oncogene | 0.0278857 |
| RPL3 | ribosomal protein L3 | 0.0275872 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0275711 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0270532 |
| OGA | O-GlcNAcase | 0.0269819 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0265043 |
| KIAA1217 | KIAA1217 | 0.0263731 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0259527 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0256695 |
| BRD2 | bromodomain containing 2 | 0.0256174 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.02554 |
| PLEC | plectin | 0.0248477 |
| KDM4B | lysine (K)-specific demethylase 4B | 0.0247617 |
| VPS13C | vacuolar protein sorting 13 homolog C (S. cerevisiae) | 0.0247537 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0246997 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0243855 |
| CCNG2 | cyclin G2 | 0.024349 |
| FNIP1 | folliculin interacting protein 1 | 0.0243068 |
| CHD8 | chromodomain helicase DNA binding protein 8 | 0.0242564 |
| NCKAP1 | NCK-associated protein 1 | 0.0230203 |
| UTRN | utrophin | 0.0229955 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0223991 |
| RPL13A | ribosomal protein L13a | 0.0222024 |
| RPL4 | ribosomal protein L4 | 0.0221342 |
| TPR | translocated promoter region, nuclear basket protein | 0.0218191 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0217721 |
| ANKRD36 | ankyrin repeat domain 36 | 0.021762 |
| DIAPH1 | diaphanous-related formin 1 | 0.0217171 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0216606 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0216449 |
| WDFY3 | WD repeat and FYVE domain containing 3 | 0.0215725 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0215184 |
| AFDN | afadin, adherens junction formation factor | 0.0214978 |
| EXOC6B | exocyst complex component 6B | 0.0214962 |
| PNN | pinin, desmosome associated protein | 0.0214811 |
| RPL37A | ribosomal protein L37a | 0.0213967 |
| Symbol | Name | Standardized Value |
|---|---|---|
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.127202 |
| NDRG1 | N-myc downstream regulated 1 | -0.119124 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.109925 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.105614 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0784521 |
| TMSB10 | thymosin beta 10 | -0.0732367 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0556883 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0548317 |
| PKM | pyruvate kinase, muscle | -0.0546777 |
| PTMA | prothymosin, alpha | -0.0536105 |
| SERINC5 | serine incorporator 5 | -0.0505613 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0476002 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0463299 |
| SCFD2 | sec1 family domain containing 2 | -0.0429957 |
| ARF4 | ADP-ribosylation factor 4 | -0.0424765 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0418828 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0406033 |
| FDPS | farnesyl diphosphate synthase | -0.0395473 |
| ENO1 | enolase 1, (alpha) | -0.036384 |
| HMGA1 | high mobility group AT-hook 1 | -0.036347 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0352723 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0336638 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0336314 |
| WASF2 | WAS protein family, member 2 | -0.0335967 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0335508 |
| ARF1 | ADP-ribosylation factor 1 | -0.0328929 |
| MKI67 | marker of proliferation Ki-67 | -0.0328292 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0324196 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0321787 |
| NF1 | neurofibromin 1 | -0.0302186 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0299574 |
| RBM47 | RNA binding motif protein 47 | -0.0299501 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0293935 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0291712 |
| TUBA1B | tubulin, alpha 1b | -0.0286367 |
| FTL | ferritin, light polypeptide | -0.0284027 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0281085 |
| S100A6 | S100 calcium binding protein A6 | -0.0277043 |
| UFM1 | ubiquitin-fold modifier 1 | -0.0276111 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0273088 |
| EHBP1 | EH domain binding protein 1 | -0.026924 |
| ANKRD17 | ankyrin repeat domain 17 | -0.026495 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.026494 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0257557 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0257546 |
| PDXDC1 | pyridoxal-dependent decarboxylase domain containing 1 | -0.0255833 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0254401 |
| INSIG1 | insulin induced gene 1 | -0.0251645 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0249278 |
| TMEM123 | transmembrane protein 123 | -0.0248927 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0248709 |
| SRP54 | signal recognition particle 54kDa | -0.0248546 |
| CLOCK | clock circadian regulator | -0.0247771 |
| GLG1 | golgi glycoprotein 1 | -0.0247676 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0245974 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.0242377 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.024215 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0239935 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0234543 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0232992 |
| BPTF | bromodomain PHD finger transcription factor | -0.0232446 |
| SEC24A | SEC24 family member A | -0.0229997 |
| TUBB | tubulin, beta class I | -0.022552 |
| EREG | epiregulin | -0.0222103 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0217818 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0216617 |
| KRT19 | keratin 19, type I | -0.0213135 |
| HDLBP | high density lipoprotein binding protein | -0.0212272 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0211079 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | -0.0208971 |
| ZNF207 | zinc finger protein 207 | -0.0204212 |
| CCNI | cyclin I | -0.0200384 |
| NFIA | nuclear factor I/A | -0.0196702 |
| SBNO1 | strawberry notch homolog 1 (Drosophila) | -0.0196018 |
| OSBP | oxysterol binding protein | -0.0194808 |
| ABLIM1 | actin binding LIM protein 1 | -0.0194517 |
| CCND1 | cyclin D1 | -0.0194351 |
| R3HDM1 | R3H domain containing 1 | -0.01936 |
| DOCK6 | dedicator of cytokinesis 6 | -0.0193538 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0193176 |
| PIBF1 | progesterone immunomodulatory binding factor 1 | -0.0192725 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.01918 |
| RPS24 | ribosomal protein S24 | -0.0190778 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | -0.0190212 |
| ITGB4 | integrin, beta 4 | -0.0189426 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.0189401 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0188938 |
| NOP58 | NOP58 ribonucleoprotein | -0.0188914 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0188811 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0188343 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0187958 |
| DCAF7 | DDB1 and CUL4 associated factor 7 | -0.0185866 |
| ADGRE5 | adhesion G protein-coupled receptor E5 | -0.0184749 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.0183953 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0183723 |
| TKT | transketolase | -0.0181316 |
| UBAP2 | ubiquitin associated protein 2 | -0.0181268 |
| RBM25 | RNA binding motif protein 25 | -0.0180765 |
| LTN1 | listerin E3 ubiquitin protein ligase 1 | -0.0180368 |
| TFRC | transferrin receptor | -0.0179765 |
