| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Larotrectinib sulfate perturbation in HEC-1-A cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Larotrectinib sulfate_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MYH9 | myosin, heavy chain 9, non-muscle | 0.154984 |
| LAMB3 | laminin, beta 3 | 0.10159 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0920413 |
| MT2A | metallothionein 2A | 0.0790374 |
| LAMC2 | laminin, gamma 2 | 0.0632107 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0601489 |
| FLNA | filamin A, alpha | 0.050933 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0500835 |
| GOLGA4 | golgin A4 | 0.0498694 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0490741 |
| RPS6 | ribosomal protein S6 | 0.0459122 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0458176 |
| SEPTIN9 | septin 9 | 0.045733 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0445114 |
| FNIP1 | folliculin interacting protein 1 | 0.0431403 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0428545 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.042278 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0416552 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0400041 |
| RPS3 | ribosomal protein S3 | 0.0398482 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0390576 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0389294 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0387976 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0381987 |
| RPL14 | ribosomal protein L14 | 0.0377022 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0376334 |
| FLNB | filamin B, beta | 0.0368105 |
| SET | SET nuclear proto-oncogene | 0.0363335 |
| KRT7 | keratin 7, type II | 0.0360409 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0354011 |
| OPTN | optineurin | 0.0346095 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0338599 |
| AXL | AXL receptor tyrosine kinase | 0.0304901 |
| CREBRF | CREB3 regulatory factor | 0.0304079 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0302886 |
| TMF1 | TATA element modulatory factor 1 | 0.0299486 |
| HSPA8 | heat shock 70kDa protein 8 | 0.029879 |
| PHF3 | PHD finger protein 3 | 0.029777 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0296031 |
| CD47 | CD47 molecule | 0.0289493 |
| PCBP2 | poly(rC) binding protein 2 | 0.0289229 |
| SKAP2 | src kinase associated phosphoprotein 2 | 0.0288262 |
| OGA | O-GlcNAcase | 0.0281141 |
| B2M | beta-2-microglobulin | 0.0276714 |
| RIOK3 | RIO kinase 3 | 0.0275844 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0275785 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.027239 |
| APP | amyloid beta (A4) precursor protein | 0.0271741 |
| CD44 | CD44 molecule (Indian blood group) | 0.0271064 |
| SFTPA2 | surfactant protein A2 | 0.0268809 |
| HDGF | hepatoma-derived growth factor | 0.0267683 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0266029 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0259656 |
| FOXP1 | forkhead box P1 | 0.0259205 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0257672 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.025493 |
| MTR | 5-methyltetrahydrofolate-homocysteine methyltransferase | 0.0250716 |
| SERINC1 | serine incorporator 1 | 0.0250299 |
| DSPP | dentin sialophosphoprotein | 0.0249647 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0246358 |
| CNBP | CCHC-type zinc finger, nucleic acid binding protein | 0.0239681 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0238365 |
| RPL3 | ribosomal protein L3 | 0.023652 |
| TAPBP | TAP binding protein (tapasin) | 0.0235119 |
| TMA7 | translation machinery associated 7 homolog (S. cerevisiae) | 0.0234932 |
| NCKAP1 | NCK-associated protein 1 | 0.0232606 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0229081 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0228143 |
| CDCP1 | CUB domain containing protein 1 | 0.0225878 |
| EZR | ezrin | 0.0222617 |
| PDE10A | phosphodiesterase 10A | 0.0215112 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 0.0213112 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.0212618 |
| DHX40 | DEAH (Asp-Glu-Ala-His) box polypeptide 40 | 0.0212464 |
| PLEKHA2 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 | 0.0212134 |
| CENPF | centromere protein F, 350/400kDa | 0.0211894 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | 0.021111 |
| FN1 | fibronectin 1 | 0.020555 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0204637 |
| RPL13A | ribosomal protein L13a | 0.0202036 |
| YEATS2 | YEATS domain containing 2 | 0.0201029 |
| ECPAS | Ecm29 proteasome adaptor and scaffold | 0.0200046 |
| KRT18 | keratin 18, type I | 0.0199969 |
| GOLGB1 | golgin B1 | 0.0199114 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.019803 |
| PNN | pinin, desmosome associated protein | 0.019772 |
| SCRN1 | secernin 1 | 0.0196518 |
| ANKRD36B | ankyrin repeat domain 36B | 0.0196022 |
| FAM13A | family with sequence similarity 13, member A | 0.0195513 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0194885 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0194588 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0192743 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | 0.0191365 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0190029 |
| GALNT12 | polypeptide N-acetylgalactosaminyltransferase 12 | 0.0189456 |
| DNAJC7 | DnaJ (Hsp40) homolog, subfamily C, member 7 | 0.0187981 |
| VIM | vimentin | 0.0187092 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.018651 |
| MYEOV | myeloma overexpressed | 0.0183179 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0179031 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.183803 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.119535 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.114635 |
| ASPH | aspartate beta-hydroxylase | -0.110472 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.106595 |
| TMSB10 | thymosin beta 10 | -0.105611 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0846452 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0743667 |
| RHEX | regulator of hemoglobinization and erythroid cell expansion | -0.0704226 |
| WWC1 | WW and C2 domain containing 1 | -0.0641607 |
| ANXA2 | annexin A2 | -0.0607585 |
| PCSK5 | proprotein convertase subtilisin/kexin type 5 | -0.0606145 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.056981 |
| FTL | ferritin, light polypeptide | -0.0555775 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0555029 |
| CCDC138 | coiled-coil domain containing 138 | -0.0535772 |
| NF1 | neurofibromin 1 | -0.0534397 |
| CCND1 | cyclin D1 | -0.053357 |
| RFC3 | replication factor C (activator 1) 3, 38kDa | -0.0520967 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0510936 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0498087 |
| ITGB8 | integrin, beta 8 | -0.0495187 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0493609 |
| ECT2 | epithelial cell transforming 2 | -0.0491189 |
| TJP1 | tight junction protein 1 | -0.0488789 |
| INTS6 | integrator complex subunit 6 | -0.0487853 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0485773 |
| RPL35A | ribosomal protein L35a | -0.0481628 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.046252 |
| PLCB4 | phospholipase C, beta 4 | -0.0454999 |
| SVIL | supervillin | -0.0437281 |
| PKM | pyruvate kinase, muscle | -0.0436828 |
| FUS | FUS RNA binding protein | -0.0435756 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0434315 |
| ATG7 | autophagy related 7 | -0.0433696 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0415713 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0414493 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.04142 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0413295 |
| MAP4 | microtubule-associated protein 4 | -0.0405528 |
| PAX8 | paired box 8 | -0.0405112 |
| TXNRD1 | thioredoxin reductase 1 | -0.0401044 |
| HELLS | helicase, lymphoid-specific | -0.0398657 |
| RPS24 | ribosomal protein S24 | -0.0397529 |
| RPLP1 | ribosomal protein, large, P1 | -0.0396201 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0391857 |
| DIAPH3 | diaphanous-related formin 3 | -0.0391634 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0391386 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0388979 |
| DPP4 | dipeptidyl-peptidase 4 | -0.0388515 |
| ZNF644 | zinc finger protein 644 | -0.0382574 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0374947 |
| ACTN4 | actinin, alpha 4 | -0.0374856 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0372123 |
| G3BP1 | GTPase activating protein (SH3 domain) binding protein 1 | -0.0370822 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.0368824 |
| ZNF207 | zinc finger protein 207 | -0.03671 |
| EREG | epiregulin | -0.0365999 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0364535 |
| RTN3 | reticulon 3 | -0.0363949 |
| ACTG1 | actin gamma 1 | -0.0359319 |
| HMGB1 | high mobility group box 1 | -0.0348821 |
| S100A10 | S100 calcium binding protein A10 | -0.0346208 |
| TUBB4B | tubulin, beta 4B class IVb | -0.034476 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | -0.0339235 |
| DSCAML1 | Down syndrome cell adhesion molecule like 1 | -0.0338203 |
| EPB41L5 | erythrocyte membrane protein band 4.1 like 5 | -0.0337161 |
| LARP1 | La ribonucleoprotein domain family, member 1 | -0.0336581 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0331807 |
| ITGA6 | integrin, alpha 6 | -0.0330385 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0330032 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.0327574 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0325631 |
| RAD51B | RAD51 paralog B | -0.0323453 |
| UBAP2 | ubiquitin associated protein 2 | -0.0320862 |
| ATAD2 | ATPase family, AAA domain containing 2 | -0.0318485 |
| FBXO11 | F-box protein 11 | -0.031771 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0315121 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0314407 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0314097 |
| MYO1E | myosin IE | -0.0313872 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0313311 |
| GPATCH8 | G patch domain containing 8 | -0.030916 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.03058 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0301676 |
| PPP2CA | protein phosphatase 2, catalytic subunit, alpha isozyme | -0.0296841 |
| OSBPL10 | oxysterol binding protein-like 10 | -0.0296113 |
| MICAL3 | microtubule associated monooxygenase, calponin and LIM domain containing 3 | -0.0290686 |
| LOC112694756 | uncharaterized LOC112694756 | -0.029017 |
| OLA1 | Obg-like ATPase 1 | -0.0288992 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0288526 |
| HM13 | histocompatibility (minor) 13 | -0.0288381 |
| BPTF | bromodomain PHD finger transcription factor | -0.0288011 |
| TFRC | transferrin receptor | -0.028771 |
| ARF1 | ADP-ribosylation factor 1 | -0.0286603 |
| SSH2 | slingshot protein phosphatase 2 | -0.0284119 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0283864 |
| TCF12 | transcription factor 12 | -0.0283547 |
| DHX9 | DEAH (Asp-Glu-Ala-His) box helicase 9 | -0.0283258 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0281575 |
