| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Larotrectinib sulfate perturbation in HOP62 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Larotrectinib sulfate_HOP62 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.105339 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0948867 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0767945 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0721584 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.070658 |
| CD44 | CD44 molecule (Indian blood group) | 0.0590122 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0498174 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0489321 |
| FN1 | fibronectin 1 | 0.046494 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0409112 |
| PLEC | plectin | 0.0406211 |
| HMGA2 | high mobility group AT-hook 2 | 0.040182 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0399005 |
| DST | dystonin | 0.0385286 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0381031 |
| CAPRIN2 | caprin family member 2 | 0.0336547 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0335813 |
| AHNAK | AHNAK nucleoprotein | 0.0288323 |
| SEPTIN9 | septin 9 | 0.0276371 |
| CD109 | CD109 molecule | 0.0271974 |
| SMAD3 | SMAD family member 3 | 0.0268074 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0262411 |
| SPAG9 | sperm associated antigen 9 | 0.025456 |
| CDCP1 | CUB domain containing protein 1 | 0.0252414 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0242193 |
| DNMBP | dynamin binding protein | 0.0235235 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0225255 |
| PRELID2 | PRELI domain containing 2 | 0.0221066 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0208089 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0197223 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0196573 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0195309 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0184325 |
| SBF2 | SET binding factor 2 | 0.0183792 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0180549 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0178673 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.017606 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0175638 |
| RTN4 | reticulon 4 | 0.0174106 |
| MYOF | myoferlin | 0.0171426 |
| SFTPA2 | surfactant protein A2 | 0.0169639 |
| LOXL2 | lysyl oxidase-like 2 | 0.0168628 |
| TXNIP | thioredoxin interacting protein | 0.0164257 |
| NGLY1 | N-glycanase 1 | 0.0161832 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0161473 |
| APP | amyloid beta (A4) precursor protein | 0.0161167 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0160844 |
| SEPTIN10 | septin 10 | 0.0160211 |
| FAM13A | family with sequence similarity 13, member A | 0.0160097 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0159767 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.015904 |
| PHF3 | PHD finger protein 3 | 0.0159038 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0157622 |
| MSN | moesin | 0.0156947 |
| KLF6 | Kruppel-like factor 6 | 0.0155935 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0152219 |
| FLNB | filamin B, beta | 0.0150787 |
| IGF1R | insulin-like growth factor 1 receptor | 0.014861 |
| VCL | vinculin | 0.0145574 |
| NECTIN2 | nectin cell adhesion molecule 2 | 0.014485 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0142526 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0141211 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0141177 |
| ANTXR1 | anthrax toxin receptor 1 | 0.0140444 |
| FNIP1 | folliculin interacting protein 1 | 0.0138851 |
| DUSP6 | dual specificity phosphatase 6 | 0.0138188 |
| SERINC1 | serine incorporator 1 | 0.0137816 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | 0.0135126 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0133061 |
| H1-4 | H1.4 linker histone, cluster member | 0.0132346 |
| VMP1 | vacuole membrane protein 1 | 0.0132304 |
| CLIC4 | chloride intracellular channel 4 | 0.0130882 |
| NAV2 | neuron navigator 2 | 0.0130562 |
| NONO | non-POU domain containing, octamer-binding | 0.0127295 |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | 0.0126085 |
| NCKAP1 | NCK-associated protein 1 | 0.0125437 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.0125153 |
| MLPH | melanophilin | 0.0121878 |
| KLC1 | kinesin light chain 1 | 0.0121631 |
| WDR26 | WD repeat domain 26 | 0.0121523 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0121306 |
| PDE10A | phosphodiesterase 10A | 0.0119818 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0119791 |
| PRKCSH | protein kinase C substrate 80K-H | 0.0119729 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0119575 |
| PCBP3 | poly(rC) binding protein 3 | 0.0117966 |
| CTTN | cortactin | 0.0117312 |
| F2RL1 | coagulation factor II (thrombin) receptor-like 1 | 0.0116112 |
| GPC6 | glypican 6 | 0.011549 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0113591 |
| ANLN | anillin, actin binding protein | 0.0113456 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0111197 |
| RND3 | Rho family GTPase 3 | 0.0110833 |
| RASA2 | RAS p21 protein activator 2 | 0.011045 |
| OGA | O-GlcNAcase | 0.0110137 |
| DOT1L | DOT1-like histone H3K79 methyltransferase | 0.0108938 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0108668 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0108196 |
| CUL4B | cullin 4B | 0.0107893 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0107707 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.189027 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.13097 |
| IGF2 | insulin-like growth factor 2 | -0.0982385 |
| TMSB10 | thymosin beta 10 | -0.0966145 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0846746 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0680358 |
| CDH13 | cadherin 13 | -0.0635413 |
| MT2A | metallothionein 2A | -0.0571558 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.050904 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0493134 |
| COL6A1 | collagen, type VI, alpha 1 | -0.049267 |
| RPS6 | ribosomal protein S6 | -0.0464118 |
| DTNA | dystrobrevin, alpha | -0.0453338 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0450685 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0447427 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0438732 |
| RPLP1 | ribosomal protein, large, P1 | -0.0407109 |
| MYO10 | myosin X | -0.0398463 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0397297 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0379608 |
| CLMP | CXADR-like membrane protein | -0.0363493 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.033349 |
| RPL35A | ribosomal protein L35a | -0.0330764 |
| HMGA1 | high mobility group AT-hook 1 | -0.0299525 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0291514 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0281537 |
| ENO1 | enolase 1, (alpha) | -0.0280458 |
| ACTG1 | actin gamma 1 | -0.0276741 |
| DIAPH2 | diaphanous-related formin 2 | -0.0267858 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0267761 |
| COL5A1 | collagen, type V, alpha 1 | -0.0267345 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0266495 |
| RPL12 | ribosomal protein L12 | -0.0258487 |
| NAV1 | neuron navigator 1 | -0.0251626 |
| GNAS | GNAS complex locus | -0.0251225 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0245654 |
| ADM | adrenomedullin | -0.0242384 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.0240161 |
| FRMD4A | FERM domain containing 4A | -0.0235593 |
| LAMB3 | laminin, beta 3 | -0.0221801 |
| TMEM165 | transmembrane protein 165 | -0.0219408 |
| RPS19 | ribosomal protein S19 | -0.0214632 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0213473 |
| SEC24A | SEC24 family member A | -0.0209982 |
| MT1E | metallothionein 1E | -0.0209742 |
| RPL9 | ribosomal protein L9 | -0.0209269 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0205606 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0205524 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0203884 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | -0.0202112 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0202032 |
| HM13 | histocompatibility (minor) 13 | -0.0199184 |
| RPS8 | ribosomal protein S8 | -0.0198513 |
| ERGIC1 | endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 | -0.0195411 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0193226 |
| NDRG1 | N-myc downstream regulated 1 | -0.0188518 |
| RPL23 | ribosomal protein L23 | -0.0188387 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0187069 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0186099 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0185655 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0184546 |
| GLIS3 | GLIS family zinc finger 3 | -0.0181955 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0180169 |
| HLA-B | major histocompatibility complex, class I, B | -0.0174371 |
| RPL31 | ribosomal protein L31 | -0.0174113 |
| RPS24 | ribosomal protein S24 | -0.0171301 |
| HLA-A | major histocompatibility complex, class I, A | -0.0169343 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0166154 |
| MMP12 | matrix metallopeptidase 12 | -0.0165065 |
| FTL | ferritin, light polypeptide | -0.0164965 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0164806 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.01639 |
| S100A10 | S100 calcium binding protein A10 | -0.0162957 |
| MMP14 | matrix metallopeptidase 14 (membrane-inserted) | -0.0162285 |
| C2CD2 | C2 calcium-dependent domain containing 2 | -0.0160991 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.016096 |
| RPLP0 | ribosomal protein, large, P0 | -0.0160823 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0160093 |
| RPS20 | ribosomal protein S20 | -0.0158897 |
| CCND1 | cyclin D1 | -0.0158721 |
| PTK2 | protein tyrosine kinase 2 | -0.0157839 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0156291 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0156086 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.0156024 |
| ARHGAP22 | Rho GTPase activating protein 22 | -0.0154818 |
| RPLP2 | ribosomal protein, large, P2 | -0.0153449 |
| RPS14 | ribosomal protein S14 | -0.0152568 |
| TPM4 | tropomyosin 4 | -0.0152068 |
| IL11 | interleukin 11 | -0.0151991 |
| ASPH | aspartate beta-hydroxylase | -0.0151654 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0151366 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0151326 |
| TPI1 | triosephosphate isomerase 1 | -0.0151077 |
| CCDC88A | coiled-coil domain containing 88A | -0.0146217 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0144572 |
| RPL8 | ribosomal protein L8 | -0.0143449 |
| RPL37 | ribosomal protein L37 | -0.0143246 |
| RPS13 | ribosomal protein S13 | -0.0142813 |
| RPS16 | ribosomal protein S16 | -0.014082 |
| NAV3 | neuron navigator 3 | -0.0140814 |
