| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Larotrectinib sulfate perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Larotrectinib sulfate_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.139818 |
| COL6A3 | collagen, type VI, alpha 3 | 0.124809 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.102669 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0951082 |
| NAV2 | neuron navigator 2 | 0.0793666 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | 0.0712424 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.069208 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0615163 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0595863 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0530208 |
| COL5A1 | collagen, type V, alpha 1 | 0.0500206 |
| CDH13 | cadherin 13 | 0.0447364 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0440053 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0411586 |
| AHNAK | AHNAK nucleoprotein | 0.0407765 |
| FMNL2 | formin-like 2 | 0.0407 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0384048 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0380187 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0380143 |
| PTK2 | protein tyrosine kinase 2 | 0.0379313 |
| ATP13A3 | ATPase type 13A3 | 0.0378038 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 0.0341818 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0336717 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0334215 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0328017 |
| SMAD3 | SMAD family member 3 | 0.0327233 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0321116 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0320142 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0313214 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0304962 |
| COL7A1 | collagen, type VII, alpha 1 | 0.0298599 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0291108 |
| MTSS1 | metastasis suppressor 1 | 0.0290612 |
| RND3 | Rho family GTPase 3 | 0.0289771 |
| PDE10A | phosphodiesterase 10A | 0.0283331 |
| NAV1 | neuron navigator 1 | 0.0279585 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0277336 |
| RASA2 | RAS p21 protein activator 2 | 0.0275774 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.027117 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0270345 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0268727 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0256461 |
| FNIP1 | folliculin interacting protein 1 | 0.0250218 |
| PLEC | plectin | 0.024596 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0242983 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0238668 |
| VCAN | versican | 0.0238284 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0236749 |
| RIGI | RNA sensor RIG-I | 0.023178 |
| FLNA | filamin A, alpha | 0.0231243 |
| DST | dystonin | 0.0230196 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0230138 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | 0.0227095 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | 0.0225408 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0222844 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.02177 |
| APP | amyloid beta (A4) precursor protein | 0.021716 |
| RAI14 | retinoic acid induced 14 | 0.0216381 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0216112 |
| RUNX1 | runt-related transcription factor 1 | 0.0215491 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0212341 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | 0.0210356 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0209453 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0208741 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0208562 |
| PRELID2 | PRELI domain containing 2 | 0.0205923 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0203508 |
| MSI2 | musashi RNA-binding protein 2 | 0.0202329 |
| ATXN1 | ataxin 1 | 0.0198919 |
| HMGA2 | high mobility group AT-hook 2 | 0.0195215 |
| FBXO32 | F-box protein 32 | 0.0194377 |
| COL6A1 | collagen, type VI, alpha 1 | 0.0191787 |
| ADAM19 | ADAM metallopeptidase domain 19 | 0.0189386 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0188518 |
| AMPD3 | adenosine monophosphate deaminase 3 | 0.0187594 |
| JAK1 | Janus kinase 1 | 0.0184801 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0184572 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.01845 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0179727 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0179256 |
| INHBA | inhibin, beta A | 0.0178136 |
| PLSCR1 | phospholipid scramblase 1 | 0.0176751 |
| COL3A1 | collagen, type III, alpha 1 | 0.0176597 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0175023 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | 0.0174508 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.017412 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0173866 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.0173065 |
| ANO6 | anoctamin 6 | 0.0171912 |
| SLC22A23 | solute carrier family 22, member 23 | 0.0171142 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0171091 |
| COL4A2 | collagen, type IV, alpha 2 | 0.0170597 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.0164529 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0164086 |
| HDAC9 | histone deacetylase 9 | 0.0163 |
| COL4A1 | collagen, type IV, alpha 1 | 0.0162723 |
| DENND5A | DENN/MADD domain containing 5A | 0.0159752 |
| EPHB1 | EPH receptor B1 | 0.015791 |
| VCL | vinculin | 0.0157821 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.0157716 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.396521 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.270581 |
| MT2A | metallothionein 2A | -0.213416 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.1753 |
| NDRG1 | N-myc downstream regulated 1 | -0.172418 |
| TMSB10 | thymosin beta 10 | -0.155411 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.151338 |
| COL1A1 | collagen, type I, alpha 1 | -0.147122 |
| VIM | vimentin | -0.125535 |
| FTL | ferritin, light polypeptide | -0.108921 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.103985 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0993456 |
| COL1A2 | collagen, type I, alpha 2 | -0.0946139 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0925256 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0698363 |
| ENO1 | enolase 1, (alpha) | -0.0654579 |
| PTMA | prothymosin, alpha | -0.0591176 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0590864 |
| RPS8 | ribosomal protein S8 | -0.0581805 |
| RPS6 | ribosomal protein S6 | -0.0565278 |
| RPL35A | ribosomal protein L35a | -0.0539125 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.0520857 |
| B2M | beta-2-microglobulin | -0.0515835 |
| LDHA | lactate dehydrogenase A | -0.0515466 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0506248 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0499268 |
| S100A9 | S100 calcium binding protein A9 | -0.0483597 |
| PFN1 | profilin 1 | -0.0480985 |
| RPS19 | ribosomal protein S19 | -0.04608 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0458785 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0450176 |
| PKM | pyruvate kinase, muscle | -0.0448644 |
| IER3 | immediate early response 3 | -0.0429849 |
| MT1X | metallothionein 1X | -0.0424054 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0413427 |
| HLA-B | major histocompatibility complex, class I, B | -0.0411475 |
| LOX | lysyl oxidase | -0.0410108 |
| RPL8 | ribosomal protein L8 | -0.0399786 |
| CALU | calumenin | -0.0382063 |
| TPM4 | tropomyosin 4 | -0.0374052 |
| S100A10 | S100 calcium binding protein A10 | -0.0370991 |
| RPL28 | ribosomal protein L28 | -0.0370679 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0367018 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0364962 |
| CALR | calreticulin | -0.0363213 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0362269 |
| RPLP1 | ribosomal protein, large, P1 | -0.0359254 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0352923 |
| ACTG1 | actin gamma 1 | -0.0352038 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0352017 |
| HLA-A | major histocompatibility complex, class I, A | -0.0347162 |
| LMAN1 | lectin, mannose-binding, 1 | -0.034582 |
| SH3BGRL3 | SH3 domain binding glutamate-rich protein like 3 | -0.0340818 |
| MAP1B | microtubule-associated protein 1B | -0.0333352 |
| TPI1 | triosephosphate isomerase 1 | -0.0327274 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0320389 |
| RPLP2 | ribosomal protein, large, P2 | -0.0314265 |
| RPL12 | ribosomal protein L12 | -0.0311304 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0309554 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0307704 |
| YBX1 | Y box binding protein 1 | -0.0305529 |
| RPLP0 | ribosomal protein, large, P0 | -0.0304612 |
| RPL19 | ribosomal protein L19 | -0.0290468 |
| RPS13 | ribosomal protein S13 | -0.0283723 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0283112 |
| RPS14 | ribosomal protein S14 | -0.028148 |
| RPL36 | ribosomal protein L36 | -0.0280158 |
| EGR1 | early growth response 1 | -0.0279503 |
| POTEF | POTE ankyrin domain family, member F | -0.0279269 |
| RPL23 | ribosomal protein L23 | -0.0275917 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0270509 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.026589 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0263497 |
| RPS11 | ribosomal protein S11 | -0.0262295 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.0260433 |
| UBC | ubiquitin C | -0.025979 |
| RPS5 | ribosomal protein S5 | -0.0259464 |
| S100A6 | S100 calcium binding protein A6 | -0.0252446 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0248114 |
| GNAS | GNAS complex locus | -0.0246047 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0244183 |
| RPL37A | ribosomal protein L37a | -0.024406 |
| BSG | basigin (Ok blood group) | -0.0243178 |
| RPS16 | ribosomal protein S16 | -0.0242824 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0241001 |
| RPL30 | ribosomal protein L30 | -0.0238736 |
| RPL11 | ribosomal protein L11 | -0.0237723 |
| RPS15 | ribosomal protein S15 | -0.0233484 |
| OAZ1 | ornithine decarboxylase antizyme 1 | -0.0230905 |
| RTN4 | reticulon 4 | -0.0228581 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0224344 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0221675 |
| RPL34 | ribosomal protein L34 | -0.0220811 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0219551 |
| HMGA1 | high mobility group AT-hook 1 | -0.0217139 |
| RPS25 | ribosomal protein S25 | -0.0216611 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -0.0215642 |
| RPL31 | ribosomal protein L31 | -0.0214582 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0213158 |
| TAGLN2 | transgelin 2 | -0.0212464 |
