| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Larotrectinib sulfate perturbation in HT-29 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Larotrectinib sulfate_HT-29 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LMO7 | LIM domain 7 | 0.113297 |
| EZR | ezrin | 0.109803 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.103181 |
| BCL2L1 | BCL2-like 1 | 0.0954418 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 0.093968 |
| STK24 | serine/threonine kinase 24 | 0.0888862 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0668882 |
| DST | dystonin | 0.0645914 |
| TXNRD1 | thioredoxin reductase 1 | 0.0625512 |
| NECTIN2 | nectin cell adhesion molecule 2 | 0.0606721 |
| GOLGA4 | golgin A4 | 0.0600219 |
| ACTN4 | actinin, alpha 4 | 0.0577862 |
| MSN | moesin | 0.0569379 |
| FOXO1 | forkhead box O1 | 0.0560368 |
| FAT1 | FAT atypical cadherin 1 | 0.05457 |
| AHNAK | AHNAK nucleoprotein | 0.0532547 |
| GOLGB1 | golgin B1 | 0.0525974 |
| LATS2 | large tumor suppressor kinase 2 | 0.0525969 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0520866 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0508673 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0507047 |
| PLK2 | polo-like kinase 2 | 0.0505626 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0502967 |
| RHPN2 | rhophilin, Rho GTPase binding protein 2 | 0.0499643 |
| ZFP36 | ZFP36 ring finger protein | 0.0477888 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0472388 |
| WWC1 | WW and C2 domain containing 1 | 0.0470834 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0460575 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0453283 |
| ANXA11 | annexin A11 | 0.0440978 |
| TNS4 | tensin 4 | 0.0440427 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.043794 |
| SUCO | SUN domain containing ossification factor | 0.0425701 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0417742 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0415843 |
| RTN4 | reticulon 4 | 0.0404273 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0401309 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0400425 |
| LAMB3 | laminin, beta 3 | 0.039747 |
| TMC5 | transmembrane channel-like 5 | 0.0395072 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0394548 |
| AFDN | afadin, adherens junction formation factor | 0.0378021 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0375657 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0372849 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0370295 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0366317 |
| CTTNBP2NL | CTTNBP2 N-terminal like | 0.0361345 |
| NCKAP1 | NCK-associated protein 1 | 0.0359175 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | 0.0356512 |
| MYO6 | myosin VI | 0.0353901 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0350342 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0350321 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0347482 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0347303 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | 0.0346085 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0339589 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0338031 |
| ITGA6 | integrin, alpha 6 | 0.0337542 |
| RAPGEF5 | Rap guanine nucleotide exchange factor (GEF) 5 | 0.0336487 |
| VMP1 | vacuole membrane protein 1 | 0.0330408 |
| FLNB | filamin B, beta | 0.0329737 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0329706 |
| HYOU1 | hypoxia up-regulated 1 | 0.0323713 |
| C6ORF132 | chromosome 6 open reading frame 132 | 0.0322256 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0319641 |
| NEK7 | NIMA-related kinase 7 | 0.0316978 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0316143 |
| EFR3A | EFR3 homolog A (S. cerevisiae) | 0.0315628 |
| FAM91A1 | family with sequence similarity 91, member A1 | 0.0315582 |
| NIBAN2 | niban apoptosis regulator 2 | 0.0310716 |
| PDZD8 | PDZ domain containing 8 | 0.030973 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0308851 |
| CANX | calnexin | 0.030874 |
| TAPBP | TAP binding protein (tapasin) | 0.0307983 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.030784 |
| KIAA0232 | KIAA0232 | 0.0306456 |
| TPM3 | tropomyosin 3 | 0.030275 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | 0.0300941 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0297686 |
| UTRN | utrophin | 0.0296969 |
| WASL | Wiskott-Aldrich syndrome-like | 0.0294797 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0294575 |
| TMF1 | TATA element modulatory factor 1 | 0.0291724 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0289345 |
| CLIC5 | chloride intracellular channel 5 | 0.0289065 |
| SEC63 | SEC63 homolog (S. cerevisiae) | 0.0282689 |
| ITGB4 | integrin, beta 4 | 0.0277634 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0276965 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0276853 |
| BLTP1 | bridge-like lipid transfer protein family member 1 | 0.0274954 |
| LPCAT2 | lysophosphatidylcholine acyltransferase 2 | 0.0272766 |
| PHLPP2 | PH domain and leucine rich repeat protein phosphatase 2 | 0.027162 |
| CNBP | CCHC-type zinc finger, nucleic acid binding protein | 0.0269309 |
| RRAS2 | related RAS viral (r-ras) oncogene homolog 2 | 0.0269003 |
| NSMCE2 | non-SMC element 2, MMS21 homolog (S. cerevisiae) | 0.0268471 |
| ATXN1 | ataxin 1 | 0.0268302 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0267804 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0267345 |
| SMAD3 | SMAD family member 3 | 0.0267191 |
| ZFAND5 | zinc finger, AN1-type domain 5 | 0.0266955 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MYH14 | myosin, heavy chain 14, non-muscle | -0.179852 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.156575 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.150531 |
| FTL | ferritin, light polypeptide | -0.123323 |
| INTS6 | integrator complex subunit 6 | -0.11972 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0992547 |
| KRT20 | keratin 20, type I | -0.0845409 |
| TMSB10 | thymosin beta 10 | -0.0820756 |
| LYZ | lysozyme | -0.0774706 |
| RPLP1 | ribosomal protein, large, P1 | -0.0769015 |
| PKM | pyruvate kinase, muscle | -0.0751484 |
| NDRG1 | N-myc downstream regulated 1 | -0.0723585 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.072174 |
| RPL23 | ribosomal protein L23 | -0.0691738 |
| EGR1 | early growth response 1 | -0.0652186 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0651565 |
| PTMA | prothymosin, alpha | -0.0617654 |
| POF1B | premature ovarian failure, 1B | -0.0615216 |
| TMEM65 | transmembrane protein 65 | -0.0580231 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | -0.05787 |
| FRY | furry homolog (Drosophila) | -0.0562067 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | -0.055441 |
| RPS24 | ribosomal protein S24 | -0.0544918 |
| LAMA4 | laminin, alpha 4 | -0.0544105 |
| RNF213 | ring finger protein 213 | -0.0538312 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0532325 |
| SLC45A4 | solute carrier family 45, member 4 | -0.0527004 |
| RPLP2 | ribosomal protein, large, P2 | -0.0504987 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0499018 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0472436 |
| RPL27A | ribosomal protein L27a | -0.0460828 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0460804 |
| S100A10 | S100 calcium binding protein A10 | -0.0447085 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.0439921 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0438904 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0427681 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0419361 |
| HIVEP1 | human immunodeficiency virus type I enhancer binding protein 1 | -0.0411743 |
| KRT8 | keratin 8, type II | -0.0408781 |
| SLC7A1 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | -0.0408562 |
| EPB41L5 | erythrocyte membrane protein band 4.1 like 5 | -0.0406694 |
| GCNT3 | glucosaminyl (N-acetyl) transferase 3, mucin type | -0.0393812 |
| JUN | jun proto-oncogene | -0.0391936 |
| DIAPH2 | diaphanous-related formin 2 | -0.0390327 |
| RPS5 | ribosomal protein S5 | -0.0384162 |
| RPS19 | ribosomal protein S19 | -0.0384017 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0381828 |
| RPLP0 | ribosomal protein, large, P0 | -0.0379502 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0379013 |
| FOXO3 | forkhead box O3 | -0.0377245 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.0370906 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | -0.0363147 |
| MCL1 | myeloid cell leukemia 1 | -0.0362483 |
| MMP7 | matrix metallopeptidase 7 | -0.0361386 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0361088 |
| MUC5AC | mucin 5AC, oligomeric mucus/gel-forming | -0.0358259 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0354018 |
| GNAS | GNAS complex locus | -0.0348418 |
| RPS8 | ribosomal protein S8 | -0.0347861 |
| RPS11 | ribosomal protein S11 | -0.0345953 |
| RPS16 | ribosomal protein S16 | -0.0342152 |
| RPL35A | ribosomal protein L35a | -0.0338033 |
| TMEM123 | transmembrane protein 123 | -0.033277 |
| RPL9 | ribosomal protein L9 | -0.0332184 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0330276 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.03292 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0326039 |
| HMGA1 | high mobility group AT-hook 1 | -0.0325434 |
| RPS25 | ribosomal protein S25 | -0.0323978 |
| RPL31 | ribosomal protein L31 | -0.0322533 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.0317572 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0317509 |
| TLE4 | transducin-like enhancer of split 4 | -0.0314824 |
| RPL19 | ribosomal protein L19 | -0.0314613 |
| WNT2B | wingless-type MMTV integration site family, member 2B | -0.0313852 |
| PRR5L | proline rich 5 like | -0.0311216 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | -0.0308364 |
| SERTAD2 | SERTA domain containing 2 | -0.0306489 |
| ACTG1 | actin gamma 1 | -0.0306045 |
| GSN | gelsolin | -0.0305819 |
| RPL8 | ribosomal protein L8 | -0.0303236 |
| VEGFA | vascular endothelial growth factor A | -0.0300939 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | -0.0295553 |
| HMGB1 | high mobility group box 1 | -0.0294673 |
| UBAP2 | ubiquitin associated protein 2 | -0.0294032 |
| RPL28 | ribosomal protein L28 | -0.0292682 |
| RPL12 | ribosomal protein L12 | -0.0291384 |
| S100A6 | S100 calcium binding protein A6 | -0.0291187 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0290831 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | -0.0289661 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0289507 |
| RPS13 | ribosomal protein S13 | -0.0289168 |
| SDCBP | syndecan binding protein (syntenin) | -0.0283286 |
| FBXO32 | F-box protein 32 | -0.0282484 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0279491 |
| WDR45B | WD repeat domain 45B | -0.0279317 |
| FBXO11 | F-box protein 11 | -0.0276679 |
| HM13 | histocompatibility (minor) 13 | -0.0275833 |
| RPL7A | ribosomal protein L7a | -0.0274239 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0273362 |
