Larotrectinib sulfate_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Larotrectinib sulfate perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Larotrectinib sulfate_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERRFI1 ERBB receptor feedback inhibitor 1 0.124124
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0731345
APOB apolipoprotein B 0.067737
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0635472
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0436588
FNDC3B fibronectin type III domain containing 3B 0.0430674
GPAM glycerol-3-phosphate acyltransferase, mitochondrial 0.0429147
SLC38A2 solute carrier family 38, member 2 0.0413626
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) 0.0410502
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0390091
ELL2 elongation factor, RNA polymerase II, 2 0.0389729
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0383997
AFDN afadin, adherens junction formation factor 0.0358751
TRIO trio Rho guanine nucleotide exchange factor 0.0348779
DOCK4 dedicator of cytokinesis 4 0.0328557
MYH9 myosin, heavy chain 9, non-muscle 0.0326351
ARHGAP9 Rho GTPase activating protein 9 0.0318088
AKAP12 A kinase (PRKA) anchor protein 12 0.0310407
NKD1 naked cuticle homolog 1 (Drosophila) 0.0294795
MAML2 mastermind-like 2 (Drosophila) 0.0274457
ACSL4 acyl-CoA synthetase long-chain family member 4 0.0265971
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0241391
DSPP dentin sialophosphoprotein 0.0236024
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0235942
SAMD4A sterile alpha motif domain containing 4A 0.0231309
ABTB3 ankyrin repeat and BTB domain containing 3 0.0230277
KDM3A lysine (K)-specific demethylase 3A 0.0228583
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0228427
RAI14 retinoic acid induced 14 0.0221472
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0221136
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0217394
TNS1 tensin 1 0.0216554
PTPRM protein tyrosine phosphatase, receptor type, M 0.0210924
EML4 echinoderm microtubule associated protein like 4 0.0210312
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0198825
SESTD1 SEC14 and spectrin domains 1 0.0197557
MSI2 musashi RNA-binding protein 2 0.0197163
ENAH enabled homolog (Drosophila) 0.0196904
IGF1R insulin-like growth factor 1 receptor 0.0193496
CTSB cathepsin B 0.0192896
TRIM26 tripartite motif containing 26 0.0189486
RBM39 RNA binding motif protein 39 0.0183803
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0181808
SDC4 syndecan 4 0.0176203
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0175261
LCOR ligand dependent nuclear receptor corepressor 0.0168446
SERINC1 serine incorporator 1 0.016745
PEG3 paternally expressed 3 0.0166584
IQSEC1 IQ motif and Sec7 domain 1 0.0165535
MTUS1 microtubule associated tumor suppressor 1 0.0165472
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0164752
SMAD3 SMAD family member 3 0.0162629
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2 0.0160713
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0157514
PUM2 pumilio RNA-binding family member 2 0.0156045
FMNL2 formin-like 2 0.0155659
TF transferrin 0.0155136
LRRC1 leucine rich repeat containing 1 0.0155091
FRMD5 FERM domain containing 5 0.015352
MALT1 MALT1 paracaspase 0.0151999
MACF1 microtubule-actin crosslinking factor 1 0.0149462
TNS3 tensin 3 0.014888
CNKSR3 CNKSR family member 3 0.0147123
VMP1 vacuole membrane protein 1 0.0146875
PDGFB platelet-derived growth factor beta polypeptide 0.0143211
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.014252
DOCK5 dedicator of cytokinesis 5 0.0139991
ZEB1 zinc finger E-box binding homeobox 1 0.0139286
ANO6 anoctamin 6 0.013674
BHLHE40 basic helix-loop-helix family, member e40 0.0134334
CAMTA1 calmodulin binding transcription activator 1 0.0133424
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0132663
FNIP1 folliculin interacting protein 1 0.0128744
EIF4B eukaryotic translation initiation factor 4B 0.0127847
IGF2R insulin-like growth factor 2 receptor 0.0127402
HLF hepatic leukemia factor 0.0126646
QKI QKI, KH domain containing, RNA binding 0.0125787
WWTR1 WW domain containing transcription regulator 1 0.0120857
PLEC plectin 0.0119749
ASXL1 additional sex combs like transcriptional regulator 1 0.0119324
H1-0 H1.0 linker histone 0.0119292
LRMDA leucine rich melanocyte differentiation associated 0.0119056
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0118459
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0118152
MTSS1 metastasis suppressor 1 0.0116754
TCF12 transcription factor 12 0.01153
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0112861
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0112625
ANKRD10 ankyrin repeat domain 10 0.0112244
CYTH1 cytohesin 1 0.0112113
RPL14 ribosomal protein L14 0.0112055
ZFHX3 zinc finger homeobox 3 0.0111909
PRKCA protein kinase C, alpha 0.0111549
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0111452
NIPBL Nipped-B homolog (Drosophila) 0.0108758
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0108352
HSPA8 heat shock 70kDa protein 8 0.0108092
PKP4 plakophilin 4 0.0107797
CCNY cyclin Y 0.0107309
VCAN versican 0.010728

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.724
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.394194
MT2A metallothionein 2A -0.138144
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.124295
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.108883
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0890906
C3 complement component 3 -0.0827681
FTL ferritin, light polypeptide -0.0628361
APOA2 apolipoprotein A-II -0.0544758
TMSB10 thymosin beta 10 -0.0543311
IGFBP1 insulin-like growth factor binding protein 1 -0.0527909
RPS6 ribosomal protein S6 -0.0397758
RPLP1 ribosomal protein, large, P1 -0.0394865
RPS19 ribosomal protein S19 -0.0383605
AHSG alpha-2-HS-glycoprotein -0.0381458
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.036732
ENO1 enolase 1, (alpha) -0.0366303
RPL37A ribosomal protein L37a -0.0358136
RPL35A ribosomal protein L35a -0.034556
HMGA1 high mobility group AT-hook 1 -0.0333335
NDRG1 N-myc downstream regulated 1 -0.0319338
RPS8 ribosomal protein S8 -0.030577
RPS12 ribosomal protein S12 -0.0290877
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0269949
APOA1 apolipoprotein A-I -0.0261967
RPLP2 ribosomal protein, large, P2 -0.0261714
PLIN2 perilipin 2 -0.0260232
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0251188
RPL23 ribosomal protein L23 -0.0249202
RPL36 ribosomal protein L36 -0.0247421
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0244226
RPL31 ribosomal protein L31 -0.0243387
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0240925
PDIA3 protein disulfide isomerase family A, member 3 -0.0234743
LOC112694756 uncharaterized LOC112694756 -0.0229931
SVIL supervillin -0.0227427
POTEF POTE ankyrin domain family, member F -0.0225923
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0212732
B2M beta-2-microglobulin -0.0210544
PKM pyruvate kinase, muscle -0.0210401
RPS5 ribosomal protein S5 -0.0209797
RPLP0 ribosomal protein, large, P0 -0.0209287
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 -0.020577
EGR1 early growth response 1 -0.0203834
RPL28 ribosomal protein L28 -0.0202289
RPL9 ribosomal protein L9 -0.0200533
RPS13 ribosomal protein S13 -0.018963
RPS25 ribosomal protein S25 -0.0188908
GMDS GDP-mannose 4,6-dehydratase -0.0187508
APOE apolipoprotein E -0.0185939
RPS29 ribosomal protein S29 -0.0182659
RPL34 ribosomal protein L34 -0.0180916
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0177191
AMBP alpha-1-microglobulin/bikunin precursor -0.01768
RPS23 ribosomal protein S23 -0.0176242
RPL11 ribosomal protein L11 -0.0174545
RPL5 ribosomal protein L5 -0.0173871
S100A9 S100 calcium binding protein A9 -0.0171293
CST3 cystatin C -0.0169479
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0168747
RPS21 ribosomal protein S21 -0.0164947
CPE carboxypeptidase E -0.016152
RPL12 ribosomal protein L12 -0.0160347
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0160126
ATP5F1E ATP synthase F1 subunit epsilon -0.0154967
LDHA lactate dehydrogenase A -0.0154609
PDLIM5 PDZ and LIM domain 5 -0.0153611
LCN2 lipocalin 2 -0.0150347
RPL37 ribosomal protein L37 -0.0148646
PTCHD4 patched domain containing 4 -0.0146798
IFITM1 interferon induced transmembrane protein 1 -0.0143871
RPL19 ribosomal protein L19 -0.0143546
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0143148
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0142386
EIF1 eukaryotic translation initiation factor 1 -0.0141151
CYB5R3 cytochrome b5 reductase 3 -0.013843
RPL8 ribosomal protein L8 -0.013841
EEF2 eukaryotic translation elongation factor 2 -0.0138335
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0138327
ICAM1 intercellular adhesion molecule 1 -0.0138247
TPM4 tropomyosin 4 -0.0136202
RPL38 ribosomal protein L38 -0.0136053
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0133633
RPS15 ribosomal protein S15 -0.0131248
PFN1 profilin 1 -0.0129803
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0127888
ZBTB20 zinc finger and BTB domain containing 20 -0.0127313
ISG15 ISG15 ubiquitin-like modifier -0.0126643
RPS24 ribosomal protein S24 -0.0126088
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.012578
RPL36A ribosomal protein L36a -0.0125658
RPL32 ribosomal protein L32 -0.012554
NPAS2 neuronal PAS domain protein 2 -0.0125033
HLA-A major histocompatibility complex, class I, A -0.012493
CCDC88A coiled-coil domain containing 88A -0.0119932
PPIG peptidylprolyl isomerase G (cyclophilin G) -0.0118405
RPS10 ribosomal protein S10 -0.0118306
RPL30 ribosomal protein L30 -0.0117884
RPL27 ribosomal protein L27 -0.0117752
GNAS GNAS complex locus -0.0116494