Larotrectinib sulfate_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Larotrectinib sulfate perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Larotrectinib sulfate_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.125746
MYOF myoferlin 0.0903495
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 0.0762168
RICTOR RPTOR independent companion of MTOR, complex 2 0.0738488
ITGA6 integrin, alpha 6 0.0685514
TRIO trio Rho guanine nucleotide exchange factor 0.0638213
CEMIP cell migration inducing protein, hyaluronan binding 0.0604507
RAI14 retinoic acid induced 14 0.0572639
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0536155
CAPRIN2 caprin family member 2 0.0531461
NEK7 NIMA-related kinase 7 0.0511786
TIMP3 TIMP metallopeptidase inhibitor 3 0.0507989
PDE4D phosphodiesterase 4D, cAMP-specific 0.050402
ARHGAP29 Rho GTPase activating protein 29 0.0501404
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 0.0490664
DOCK9 dedicator of cytokinesis 9 0.0473059
MACF1 microtubule-actin crosslinking factor 1 0.0467362
RIN2 Ras and Rab interactor 2 0.0465983
BCL2L1 BCL2-like 1 0.0461538
UTRN utrophin 0.0461504
PDLIM5 PDZ and LIM domain 5 0.0455883
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0432188
KDM7A lysine (K)-specific demethylase 7A 0.0431774
NRG1 neuregulin 1 0.0425481
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 0.0407584
DOCK5 dedicator of cytokinesis 5 0.0392316
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.038938
FNIP1 folliculin interacting protein 1 0.0383417
OSBPL6 oxysterol binding protein-like 6 0.038082
DOCK4 dedicator of cytokinesis 4 0.0379679
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0370755
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0363064
SLK STE20-like kinase 0.0362334
BLCAP bladder cancer associated protein 0.0353935
APLP2 amyloid beta (A4) precursor-like protein 2 0.034579
UBA6 ubiquitin-like modifier activating enzyme 6 0.0343428
MSN moesin 0.0329668
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0327424
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0324577
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.0316663
FAM3C family with sequence similarity 3, member C 0.0314289
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0312102
MEF2A myocyte enhancer factor 2A 0.0311176
ZEB1 zinc finger E-box binding homeobox 1 0.0309256
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0306555
ADAM10 ADAM metallopeptidase domain 10 0.0306429
TAPBP TAP binding protein (tapasin) 0.0304568
IVNS1ABP influenza virus NS1A binding protein 0.030189
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0296631
PRELID2 PRELI domain containing 2 0.0293088
CDKN2A cyclin-dependent kinase inhibitor 2A 0.0290619
CD47 CD47 molecule 0.0289958
DUSP4 dual specificity phosphatase 4 0.0287782
PICALM phosphatidylinositol binding clathrin assembly protein 0.0287296
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0283296
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0283263
MYO10 myosin X 0.02826
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0281875
RBMS2 RNA binding motif, single stranded interacting protein 2 0.0280226
NAMPT nicotinamide phosphoribosyltransferase 0.0279002
FMNL2 formin-like 2 0.0277276
FOXP1 forkhead box P1 0.0273776
YBX3 Y box binding protein 3 0.0271984
ITCH itchy E3 ubiquitin protein ligase 0.0271235
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0269421
CEP170 centrosomal protein 170kDa 0.0267078
SLTM SAFB-like, transcription modulator 0.0267046
DST dystonin 0.0257518
ARHGAP21 Rho GTPase activating protein 21 0.0257299
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0250388
FRMD6 FERM domain containing 6 0.025016
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) 0.0245907
RB1CC1 RB1-inducible coiled-coil 1 0.0243963
AHNAK AHNAK nucleoprotein 0.0243265
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0242089
PODXL podocalyxin-like 0.0232557
RUNX1 runt-related transcription factor 1 0.0230521
GRIA1 glutamate receptor, ionotropic, AMPA 1 0.0228255
ITSN1 intersectin 1 (SH3 domain protein) 0.0227837
ZNF292 zinc finger protein 292 0.022633
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0225313
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.022234
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.0221135
KDM6A lysine (K)-specific demethylase 6A 0.0216023
IFI44 interferon-induced protein 44 0.0215105
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.02136
ADSS2 adenylosuccinate synthase 2 0.0213471
JMJD1C jumonji domain containing 1C 0.0212014
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0211971
BCAR3 breast cancer anti-estrogen resistance 3 0.02102
NAV2 neuron navigator 2 0.0207835
UBE2H ubiquitin-conjugating enzyme E2H 0.0207253
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0205637
APP amyloid beta (A4) precursor protein 0.0205464
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.020338
SBF2 SET binding factor 2 0.0202955
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.02027
BHLHE40 basic helix-loop-helix family, member e40 0.019971
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0199583
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0195426

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.235331
TMSB10 thymosin beta 10 -0.138411
TPT1 tumor protein, translationally-controlled 1 -0.13058
PTMA prothymosin, alpha -0.122513
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.117942
S100A10 S100 calcium binding protein A10 -0.0997588
RPLP1 ribosomal protein, large, P1 -0.0985053
RPLP2 ribosomal protein, large, P2 -0.0973856
RPS8 ribosomal protein S8 -0.0965756
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0932335
HLA-B major histocompatibility complex, class I, B -0.0885366
RPS6 ribosomal protein S6 -0.0879544
MT2A metallothionein 2A -0.0866296
RPS21 ribosomal protein S21 -0.0810013
B2M beta-2-microglobulin -0.0780515
RPS13 ribosomal protein S13 -0.0777841
RPS19 ribosomal protein S19 -0.0760368
HM13 histocompatibility (minor) 13 -0.0757574
LMNA lamin A/C -0.0737567
RPS24 ribosomal protein S24 -0.0723792
MTSS1 metastasis suppressor 1 -0.0719583
IFITM3 interferon induced transmembrane protein 3 -0.0718057
NDRG1 N-myc downstream regulated 1 -0.0696951
LOC112694756 uncharaterized LOC112694756 -0.0684729
RPL11 ribosomal protein L11 -0.0680808
RPS25 ribosomal protein S25 -0.0669923
RPL23 ribosomal protein L23 -0.0664135
STC1 stanniocalcin 1 -0.0652315
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0628561
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0626128
GNAS GNAS complex locus -0.0613413
S100A9 S100 calcium binding protein A9 -0.0611988
RPL37 ribosomal protein L37 -0.05783
TMSB4X thymosin beta 4, X-linked -0.0564019
RPL8 ribosomal protein L8 -0.0559249
RPL35A ribosomal protein L35a -0.0534045
PLEC plectin -0.0519876
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0517271
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0514635
PKM pyruvate kinase, muscle -0.0511213
FTL ferritin, light polypeptide -0.05077
LDHA lactate dehydrogenase A -0.0507318
ANXA2 annexin A2 -0.0505808
ENO1 enolase 1, (alpha) -0.0503069
RPS27 ribosomal protein S27 -0.0485718
RPL37A ribosomal protein L37a -0.0485462
RPL12 ribosomal protein L12 -0.0484907
PALLD palladin, cytoskeletal associated protein -0.0478731
RPL19 ribosomal protein L19 -0.0477233
RPL31 ribosomal protein L31 -0.0474461
S100A6 S100 calcium binding protein A6 -0.047146
RPL35 ribosomal protein L35 -0.0465339
RPL34 ribosomal protein L34 -0.0453267
RPS27A ribosomal protein S27a -0.0452384
CANX calnexin -0.0442973
RPL27A ribosomal protein L27a -0.044118
RPS23 ribosomal protein S23 -0.0437335
ALCAM activated leukocyte cell adhesion molecule -0.0433981
RPS29 ribosomal protein S29 -0.0430491
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0427566
CALR calreticulin -0.0426168
EIF1 eukaryotic translation initiation factor 1 -0.0426132
INTS6 integrator complex subunit 6 -0.0425194
RPL7A ribosomal protein L7a -0.0424533
RPL32 ribosomal protein L32 -0.0406255
IFITM1 interferon induced transmembrane protein 1 -0.0402819
PGK1 phosphoglycerate kinase 1 -0.0401993
RPL26 ribosomal protein L26 -0.0395561
RPS12 ribosomal protein S12 -0.0394592
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0391846
RPS11 ribosomal protein S11 -0.0391829
S100A2 S100 calcium binding protein A2 -0.0389955
RPL36 ribosomal protein L36 -0.0386216
RPL36A ribosomal protein L36a -0.0382168
GUK1 guanylate kinase 1 -0.0378619
RPS16 ribosomal protein S16 -0.0378431
CALU calumenin -0.0378424
RPL30 ribosomal protein L30 -0.0377349
RPLP0 ribosomal protein, large, P0 -0.0375661
ACTG1 actin gamma 1 -0.0374358
VDAC1 voltage-dependent anion channel 1 -0.0371358
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0367947
SLC35F3 solute carrier family 35, member F3 -0.0366909
RPS14 ribosomal protein S14 -0.0366434
RPL28 ribosomal protein L28 -0.035442
RPL5 ribosomal protein L5 -0.0354013
RRBP1 ribosome binding protein 1 -0.0353438
RPS3 ribosomal protein S3 -0.0351993
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0351893
S100A11 S100 calcium binding protein A11 -0.0351893
NAP1L1 nucleosome assembly protein 1-like 1 -0.0347604
RPS4X ribosomal protein S4, X-linked -0.0342933
CAV1 caveolin 1, caveolae protein, 22kDa -0.0342234
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0341586
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0341482
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0338794
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0329997
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0328803
STAU1 staufen double-stranded RNA binding protein 1 -0.0328505
PSD3 pleckstrin and Sec7 domain containing 3 -0.0326225