| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Larotrectinib sulfate perturbation in J82 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Larotrectinib sulfate_J82 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0761149 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0696408 |
| ATP13A3 | ATPase type 13A3 | 0.068053 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0650593 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0616707 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0599716 |
| ZNF841 | zinc finger protein 841 | 0.0546124 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.048786 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0479378 |
| COL5A1 | collagen, type V, alpha 1 | 0.0475254 |
| SLC12A8 | solute carrier family 12, member 8 | 0.0474601 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0466451 |
| SEC61A1 | Sec61 alpha 1 subunit (S. cerevisiae) | 0.0450299 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0421398 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0374839 |
| ARF4 | ADP-ribosylation factor 4 | 0.0365601 |
| FLNB | filamin B, beta | 0.0352063 |
| CD44 | CD44 molecule (Indian blood group) | 0.034405 |
| NEK7 | NIMA-related kinase 7 | 0.0343903 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0337003 |
| B2M | beta-2-microglobulin | 0.0336602 |
| PODXL | podocalyxin-like | 0.0324512 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.031164 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0309589 |
| TPM1 | tropomyosin 1 (alpha) | 0.0298267 |
| GOLGA4 | golgin A4 | 0.0293954 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0269435 |
| COL4A2 | collagen, type IV, alpha 2 | 0.0263579 |
| TMEM41B | transmembrane protein 41B | 0.0256305 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | 0.0252555 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0239247 |
| VGLL3 | vestigial-like family member 3 | 0.0236579 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0228191 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0225148 |
| TPD52 | tumor protein D52 | 0.0221671 |
| FOXP1 | forkhead box P1 | 0.0214144 |
| MT1X | metallothionein 1X | 0.0205189 |
| TGFB2 | transforming growth factor, beta 2 | 0.0204157 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0202738 |
| BCL2L1 | BCL2-like 1 | 0.0200013 |
| SUCO | SUN domain containing ossification factor | 0.0194728 |
| MKI67 | marker of proliferation Ki-67 | 0.0192695 |
| PPME1 | protein phosphatase methylesterase 1 | 0.019245 |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | 0.0191928 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.018769 |
| CCNL1 | cyclin L1 | 0.0186258 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0184216 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0182711 |
| COL7A1 | collagen, type VII, alpha 1 | 0.0182333 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | 0.0180989 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.017995 |
| AFAP1 | actin filament associated protein 1 | 0.0177903 |
| IL6ST | interleukin 6 signal transducer | 0.0176781 |
| GOLPH3 | golgi phosphoprotein 3 (coat-protein) | 0.0174691 |
| NCKAP1 | NCK-associated protein 1 | 0.0174088 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0173867 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.0173231 |
| TMF1 | TATA element modulatory factor 1 | 0.017239 |
| SMAP1 | small ArfGAP 1 | 0.0170778 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | 0.0169678 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.016376 |
| VMP1 | vacuole membrane protein 1 | 0.0162122 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0160929 |
| OSMR | oncostatin M receptor | 0.0160512 |
| CENPF | centromere protein F, 350/400kDa | 0.0159331 |
| TAPBP | TAP binding protein (tapasin) | 0.0159142 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0157719 |
| VPS53 | vacuolar protein sorting 53 homolog (S. cerevisiae) | 0.0154442 |
| H1-4 | H1.4 linker histone, cluster member | 0.0153957 |
| TM9SF2 | transmembrane 9 superfamily member 2 | 0.0152658 |
| HEG1 | heart development protein with EGF-like domains 1 | 0.0152316 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0151122 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0150901 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0148786 |
| SKIL | SKI-like proto-oncogene | 0.0147803 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0146851 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0146162 |
| SRP54 | signal recognition particle 54kDa | 0.0145967 |
| COPB1 | coatomer protein complex, subunit beta 1 | 0.0144564 |
| TXNRD1 | thioredoxin reductase 1 | 0.0144253 |
| SCAF11 | SR-related CTD-associated factor 11 | 0.0143442 |
| ANXA5 | annexin A5 | 0.0142452 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0141468 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0140457 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0139951 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0139528 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0138672 |
| SEC22B | SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene) | 0.0138581 |
| ANO6 | anoctamin 6 | 0.0137618 |
| RASA2 | RAS p21 protein activator 2 | 0.0137104 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.0136756 |
| AGFG1 | ArfGAP with FG repeats 1 | 0.0136404 |
| OLR1 | oxidized low density lipoprotein (lectin-like) receptor 1 | 0.013494 |
| ECPAS | Ecm29 proteasome adaptor and scaffold | 0.0134487 |
| ZFR | zinc finger RNA binding protein | 0.0133318 |
| TPM3 | tropomyosin 3 | 0.0133244 |
| TMEM39A | transmembrane protein 39A | 0.0132257 |
| ZFAND5 | zinc finger, AN1-type domain 5 | 0.0132059 |
| LOXL2 | lysyl oxidase-like 2 | 0.0131807 |
| TPX2 | TPX2, microtubule-associated | 0.0130848 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NALF1 | NALCN channel auxiliary factor 1 | -0.164078 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.111087 |
| PHACTR1 | phosphatase and actin regulator 1 | -0.10575 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.100988 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0753147 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0744433 |
| INTS6 | integrator complex subunit 6 | -0.0724333 |
| NDRG1 | N-myc downstream regulated 1 | -0.0717258 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.066866 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.0539007 |
| DTNA | dystrobrevin, alpha | -0.0524599 |
| FTL | ferritin, light polypeptide | -0.0497437 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0496784 |
| TLE4 | transducin-like enhancer of split 4 | -0.0481726 |
| ASPH | aspartate beta-hydroxylase | -0.0429376 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.042664 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0412389 |
| TMSB10 | thymosin beta 10 | -0.040525 |
| PKM | pyruvate kinase, muscle | -0.0394748 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0394673 |
| ACTG1 | actin gamma 1 | -0.0386995 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0361123 |
| GLIS3 | GLIS family zinc finger 3 | -0.0345258 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0335625 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.033249 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0324331 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0319095 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0308757 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0303217 |
| ZNF804A | zinc finger protein 804A | -0.0301326 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0294597 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.0288082 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0286481 |
| RPL35A | ribosomal protein L35a | -0.0281925 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0275714 |
| DEK | DEK proto-oncogene | -0.0273313 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0269275 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0267288 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0259949 |
| PRELID2 | PRELI domain containing 2 | -0.025273 |
| VIM | vimentin | -0.0248954 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0245729 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0245383 |
| ANXA2 | annexin A2 | -0.024242 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0241969 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0241771 |
| NABP1 | nucleic acid binding protein 1 | -0.0241112 |
| DIPK2A | divergent protein kinase domain 2A | -0.0240532 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0240171 |
| E2F3 | E2F transcription factor 3 | -0.0230096 |
| ADAM32 | ADAM metallopeptidase domain 32 | -0.0228406 |
| GALNT18 | polypeptide N-acetylgalactosaminyltransferase 18 | -0.0224763 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0221836 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0220092 |
| POTEF | POTE ankyrin domain family, member F | -0.0213409 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0211523 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0211059 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.02085 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0207248 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0206359 |
| DENND1A | DENN/MADD domain containing 1A | -0.0205568 |
| ADM | adrenomedullin | -0.0202222 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0202145 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | -0.0201175 |
| CAST | calpastatin | -0.0200893 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0199966 |
| MAP1B | microtubule-associated protein 1B | -0.0196605 |
| PLCB4 | phospholipase C, beta 4 | -0.0196449 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0191419 |
| VCL | vinculin | -0.0185055 |
| PPP1R10 | protein phosphatase 1, regulatory subunit 10 | -0.0184904 |
| AEBP2 | AE binding protein 2 | -0.0182313 |
| RPLP2 | ribosomal protein, large, P2 | -0.0182213 |
| HLA-B | major histocompatibility complex, class I, B | -0.0179963 |
| HMGA1 | high mobility group AT-hook 1 | -0.0179121 |
| CAVIN1 | caveolae associated protein 1 | -0.0179075 |
| RIGI | RNA sensor RIG-I | -0.0176331 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0174457 |
| RPS6 | ribosomal protein S6 | -0.0173754 |
| SMYD3 | SET and MYND domain containing 3 | -0.0173749 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0172859 |
| AHNAK | AHNAK nucleoprotein | -0.0169328 |
| RPLP1 | ribosomal protein, large, P1 | -0.0168897 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0165733 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0162273 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | -0.0162253 |
| ENO1 | enolase 1, (alpha) | -0.0161813 |
| MYO1E | myosin IE | -0.0160476 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0158093 |
| CCDC80 | coiled-coil domain containing 80 | -0.0156718 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.0156367 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0154712 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.01542 |
| UBAP2 | ubiquitin associated protein 2 | -0.0153964 |
| HDAC9 | histone deacetylase 9 | -0.0153785 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0153315 |
| NSD2 | nuclear receptor binding SET domain protein 2 | -0.0151979 |
| ANO4 | anoctamin 4 | -0.0151979 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0150363 |
| PRKCA | protein kinase C, alpha | -0.0149257 |
