| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Larotrectinib sulfate perturbation in KATO III cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Larotrectinib sulfate_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FGFR2 | fibroblast growth factor receptor 2 | 0.489772 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.157463 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.12765 |
| HYOU1 | hypoxia up-regulated 1 | 0.111015 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.101702 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0948995 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0734951 |
| KRT18 | keratin 18, type I | 0.0713966 |
| LMO7 | LIM domain 7 | 0.0643296 |
| PLEC | plectin | 0.0611738 |
| GOLGA4 | golgin A4 | 0.0590653 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0572178 |
| GOLGB1 | golgin B1 | 0.0552153 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0522812 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0517224 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0515214 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0505165 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0491401 |
| DSPP | dentin sialophosphoprotein | 0.0471019 |
| EZR | ezrin | 0.0444692 |
| SEL1L | sel-1 suppressor of lin-12-like (C. elegans) | 0.0415261 |
| PHF3 | PHD finger protein 3 | 0.040555 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0402731 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0402214 |
| TMC5 | transmembrane channel-like 5 | 0.0381644 |
| LAMB3 | laminin, beta 3 | 0.0372915 |
| CANX | calnexin | 0.0359603 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0359102 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0356146 |
| TMF1 | TATA element modulatory factor 1 | 0.0348024 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0346435 |
| DST | dystonin | 0.0340865 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0334329 |
| TMSB4X | thymosin beta 4, X-linked | 0.0332268 |
| AHNAK | AHNAK nucleoprotein | 0.0331853 |
| FNIP1 | folliculin interacting protein 1 | 0.0314456 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0287978 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0284036 |
| HDLBP | high density lipoprotein binding protein | 0.0281813 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0280625 |
| SERINC1 | serine incorporator 1 | 0.0279207 |
| FAM13A | family with sequence similarity 13, member A | 0.0276819 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0276018 |
| RAB1A | RAB1A, member RAS oncogene family | 0.027491 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0274158 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0273731 |
| KIF16B | kinesin family member 16B | 0.0273221 |
| MYOF | myoferlin | 0.0267518 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0265762 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0264818 |
| ZNF292 | zinc finger protein 292 | 0.026261 |
| KRT17 | keratin 17, type I | 0.0261372 |
| OGA | O-GlcNAcase | 0.0258014 |
| CALCOCO2 | calcium binding and coiled-coil domain 2 | 0.0257142 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0255289 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0254523 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.025421 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0247502 |
| H1-0 | H1.0 linker histone | 0.0247403 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0245593 |
| KLHL24 | kelch-like family member 24 | 0.024537 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0244398 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.0242857 |
| UMAD1 | UBAP1-MVB12-associated (UMA) domain containing 1 | 0.0241463 |
| HKDC1 | hexokinase domain containing 1 | 0.0240734 |
| ARGLU1 | arginine and glutamate rich 1 | 0.0239976 |
| OXR1 | oxidation resistance 1 | 0.023754 |
| NDRG1 | N-myc downstream regulated 1 | 0.0237014 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0234625 |
| TXNIP | thioredoxin interacting protein | 0.0234171 |
| TNRC6B | trinucleotide repeat containing 6B | 0.0233465 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0233 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0229679 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0227643 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0226217 |
| ANLN | anillin, actin binding protein | 0.022594 |
| CTTN | cortactin | 0.0225527 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.0223404 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0223188 |
| NONO | non-POU domain containing, octamer-binding | 0.0222454 |
| CAPN8 | calpain 8 | 0.0222055 |
| SPAG9 | sperm associated antigen 9 | 0.0221557 |
| SFTPA2 | surfactant protein A2 | 0.022106 |
| PPL | periplakin | 0.0220286 |
| ATXN1 | ataxin 1 | 0.0218019 |
| CDK19 | cyclin-dependent kinase 19 | 0.0217792 |
| ATM | ATM serine/threonine kinase | 0.0217033 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0216668 |
| VPS41 | vacuolar protein sorting 41 homolog (S. cerevisiae) | 0.0214308 |
| MORF4L2 | mortality factor 4 like 2 | 0.0214042 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | 0.0213046 |
| CPNE1 | copine I | 0.0212785 |
| MUC17 | mucin 17, cell surface associated | 0.021093 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0210224 |
| CALR | calreticulin | 0.0209815 |
| HLA-E | major histocompatibility complex, class I, E | 0.0207595 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0207138 |
| SSR1 | signal sequence receptor, alpha | 0.02068 |
| KMT2A | lysine (K)-specific methyltransferase 2A | 0.0205622 |
| PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | 0.0205073 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NPSR1 | neuropeptide S receptor 1 | -0.166991 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.158363 |
| TMSB10 | thymosin beta 10 | -0.134108 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.112908 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.10884 |
| HSD17B12 | hydroxysteroid (17-beta) dehydrogenase 12 | -0.0950113 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0869087 |
| POTEF | POTE ankyrin domain family, member F | -0.0754813 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0698034 |
| RPL35A | ribosomal protein L35a | -0.0596664 |
| S100A10 | S100 calcium binding protein A10 | -0.0547827 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0517238 |
| ANXA2 | annexin A2 | -0.049825 |
| LCN2 | lipocalin 2 | -0.0493264 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0478165 |
| S100A6 | S100 calcium binding protein A6 | -0.0475329 |
| INSIG1 | insulin induced gene 1 | -0.0470387 |
| PKM | pyruvate kinase, muscle | -0.0470199 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0464583 |
| GPX2 | glutathione peroxidase 2 | -0.0422854 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0411675 |
| ATF5 | activating transcription factor 5 | -0.0394921 |
| ITGA6 | integrin, alpha 6 | -0.038374 |
| S100A9 | S100 calcium binding protein A9 | -0.0377435 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0360036 |
| S100A11 | S100 calcium binding protein A11 | -0.0358526 |
| HMGA1 | high mobility group AT-hook 1 | -0.0357739 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0356497 |
| RPL23 | ribosomal protein L23 | -0.0351246 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0348633 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0340814 |
| TMEM123 | transmembrane protein 123 | -0.0324515 |
| FASN | fatty acid synthase | -0.0321848 |
| PRSS3 | protease, serine, 3 | -0.0321039 |
| PFN1 | profilin 1 | -0.0320218 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | -0.0317788 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0305509 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0300911 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0297505 |
| TNIK | TRAF2 and NCK interacting kinase | -0.0296011 |
| LLGL2 | lethal giant larvae homolog 2 (Drosophila) | -0.0293044 |
| RPS6 | ribosomal protein S6 | -0.0291437 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | -0.0291286 |
| RPLP1 | ribosomal protein, large, P1 | -0.0283668 |
| CLDN7 | claudin 7 | -0.028233 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0273855 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.02687 |
| C6ORF132 | chromosome 6 open reading frame 132 | -0.0268299 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0266063 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0265898 |
| RPS19 | ribosomal protein S19 | -0.026562 |
| PHF14 | PHD finger protein 14 | -0.0263954 |
| PTMA | prothymosin, alpha | -0.0261297 |
| ACSS2 | acyl-CoA synthetase short-chain family member 2 | -0.0260311 |
| SULF2 | sulfatase 2 | -0.0256441 |
| NHSL1 | NHS-like 1 | -0.0255511 |
| DEK | DEK proto-oncogene | -0.02547 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0254443 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0252869 |
| TTYH3 | tweety family member 3 | -0.025206 |
| HMGB1 | high mobility group box 1 | -0.0250622 |
| CBX3 | chromobox homolog 3 | -0.0250076 |
| PRKCA | protein kinase C, alpha | -0.0249546 |
| CLDN4 | claudin 4 | -0.0247495 |
| ENO1 | enolase 1, (alpha) | -0.0246378 |
| RPS24 | ribosomal protein S24 | -0.0246341 |
| DIAPH2 | diaphanous-related formin 2 | -0.024608 |
| COBL | cordon-bleu WH2 repeat protein | -0.023999 |
| MCU | mitochondrial calcium uniporter | -0.0235257 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0234178 |
| ZFP36L2 | ZFP36 ring finger protein-like 2 | -0.023276 |
| SPINT2 | serine peptidase inhibitor, Kunitz type, 2 | -0.0231208 |
| MUC1 | mucin 1, cell surface associated | -0.0227992 |
| CCT6A | chaperonin containing TCP1, subunit 6A (zeta 1) | -0.02278 |
| RPS25 | ribosomal protein S25 | -0.0227347 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0226315 |
| SLC7A1 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | -0.0222259 |
| LGALS3BP | lectin, galactoside-binding, soluble, 3 binding protein | -0.022103 |
| JUP | junction plakoglobin | -0.0218305 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0217046 |
| CAMKMT | calmodulin-lysine N-methyltransferase | -0.0217022 |
| RPS21 | ribosomal protein S21 | -0.0209734 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0209535 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | -0.020938 |
| AHR | aryl hydrocarbon receptor | -0.0208136 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0205431 |
| PKP4 | plakophilin 4 | -0.0204578 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0201648 |
| LAMA5 | laminin, alpha 5 | -0.0201557 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0198849 |
| FBXO11 | F-box protein 11 | -0.0197903 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0196892 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0196805 |
| SIK3 | SIK family kinase 3 | -0.0192673 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.019267 |
| S100P | S100 calcium binding protein P | -0.0191767 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0191191 |
| CST3 | cystatin C | -0.0188511 |
| TUBB4B | tubulin, beta 4B class IVb | -0.018811 |
| HLA-A | major histocompatibility complex, class I, A | -0.0187112 |
