| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Larotrectinib sulfate perturbation in LOX-IMVI cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Larotrectinib sulfate_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CD109 | CD109 molecule | 0.0954908 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0929989 |
| FMNL2 | formin-like 2 | 0.087475 |
| MMP12 | matrix metallopeptidase 12 | 0.0767321 |
| LSAMP | limbic system-associated membrane protein | 0.0686608 |
| FOXP1 | forkhead box P1 | 0.0638716 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0620357 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0597057 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.0568545 |
| DST | dystonin | 0.0566348 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0560468 |
| SPAG9 | sperm associated antigen 9 | 0.0526867 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0520304 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0520018 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0511746 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0501974 |
| MYO10 | myosin X | 0.0490076 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0463405 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0458199 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0445342 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0439124 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0430222 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0429293 |
| PTK2 | protein tyrosine kinase 2 | 0.0423576 |
| FNIP1 | folliculin interacting protein 1 | 0.0412914 |
| RUNX1 | runt-related transcription factor 1 | 0.0405441 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0404288 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0372593 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0369899 |
| FNDC3B | fibronectin type III domain containing 3B | 0.036896 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0366871 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0352814 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0324531 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0324081 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0316013 |
| MED13L | mediator complex subunit 13-like | 0.0313855 |
| ANO6 | anoctamin 6 | 0.0309541 |
| ZNF292 | zinc finger protein 292 | 0.0308282 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0307948 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0300419 |
| NCKAP1 | NCK-associated protein 1 | 0.0300106 |
| GNAQ | guanine nucleotide binding protein (G protein), q polypeptide | 0.0296722 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0294929 |
| ENKUR | enkurin, TRPC channel interacting protein | 0.0284018 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0280804 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0277622 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0276941 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0274662 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0270249 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.0268344 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0266724 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0263588 |
| NDRG1 | N-myc downstream regulated 1 | 0.025923 |
| ADAM19 | ADAM metallopeptidase domain 19 | 0.0254037 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0252421 |
| FLNA | filamin A, alpha | 0.0248503 |
| ATXN1 | ataxin 1 | 0.0242667 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0239897 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0238848 |
| CASC3 | cancer susceptibility candidate 3 | 0.0238829 |
| OGA | O-GlcNAcase | 0.0235923 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0235054 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0233962 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0226918 |
| HDAC9 | histone deacetylase 9 | 0.0226161 |
| EFR3A | EFR3 homolog A (S. cerevisiae) | 0.0224892 |
| SKIL | SKI-like proto-oncogene | 0.0224577 |
| FRMD6 | FERM domain containing 6 | 0.0221441 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0220925 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.021952 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0216597 |
| SMAP1 | small ArfGAP 1 | 0.0212795 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0209205 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.020873 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0207529 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.020704 |
| NEK7 | NIMA-related kinase 7 | 0.0206182 |
| CDK19 | cyclin-dependent kinase 19 | 0.0205698 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.0204365 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | 0.0203516 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | 0.020201 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0200847 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.0199518 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0197339 |
| RND3 | Rho family GTPase 3 | 0.019508 |
| NKTR | natural killer cell triggering receptor | 0.0193859 |
| NRP2 | neuropilin 2 | 0.0192431 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0189274 |
| INHBA | inhibin, beta A | 0.018893 |
| TM4SF19 | transmembrane 4 L six family member 19 | 0.0188537 |
| CORO1C | coronin, actin binding protein, 1C | 0.0187728 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0186498 |
| LAMB1 | laminin, beta 1 | 0.0185597 |
| CCNY | cyclin Y | 0.0184456 |
| AFDN | afadin, adherens junction formation factor | 0.0182846 |
| SERINC1 | serine incorporator 1 | 0.0177516 |
| PCBP2 | poly(rC) binding protein 2 | 0.0177282 |
| RPL7 | ribosomal protein L7 | 0.017716 |
| JMJD1C | jumonji domain containing 1C | 0.017622 |
| YTHDC1 | YTH domain containing 1 | 0.0175813 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.492765 |
| TMSB10 | thymosin beta 10 | -0.114203 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0866483 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0775131 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0747501 |
| ACTG1 | actin gamma 1 | -0.0669576 |
| EGR1 | early growth response 1 | -0.0589777 |
| SLC8A1 | solute carrier family 8 (sodium/calcium exchanger), member 1 | -0.0583567 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0571405 |
| NABP1 | nucleic acid binding protein 1 | -0.0525277 |
| VIM | vimentin | -0.0513605 |
| SAMD3 | sterile alpha motif domain containing 3 | -0.0508233 |
| VCL | vinculin | -0.0500045 |
| RPS6 | ribosomal protein S6 | -0.0491226 |
| PHACTR1 | phosphatase and actin regulator 1 | -0.0477627 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0463952 |
| RPLP1 | ribosomal protein, large, P1 | -0.0461115 |
| ASPH | aspartate beta-hydroxylase | -0.045803 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0438069 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0428139 |
| MT2A | metallothionein 2A | -0.042421 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0413179 |
| RPL35A | ribosomal protein L35a | -0.0367269 |
| INTS6 | integrator complex subunit 6 | -0.0365342 |
| PTCHD4 | patched domain containing 4 | -0.0359168 |
| KIAA1217 | KIAA1217 | -0.0345774 |
| FTL | ferritin, light polypeptide | -0.0339915 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0339746 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0335994 |
| HMGA1 | high mobility group AT-hook 1 | -0.0330927 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | -0.0324214 |
| STC1 | stanniocalcin 1 | -0.0309231 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0294585 |
| CDH13 | cadherin 13 | -0.0289844 |
| KYNU | kynureninase | -0.0288735 |
| RPLP0 | ribosomal protein, large, P0 | -0.0286301 |
| PTMA | prothymosin, alpha | -0.0282595 |
| RPS24 | ribosomal protein S24 | -0.027739 |
| PKM | pyruvate kinase, muscle | -0.0275973 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.026912 |
| CDK6 | cyclin-dependent kinase 6 | -0.0260929 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0260078 |
| RPL8 | ribosomal protein L8 | -0.0254128 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0249688 |
| RPS19 | ribosomal protein S19 | -0.024895 |
| RPS13 | ribosomal protein S13 | -0.0244276 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0243963 |
| CFAP251 | cilia and flagella associated protein 251 | -0.0242509 |
| RPS8 | ribosomal protein S8 | -0.0239307 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0233403 |
| ZNF804A | zinc finger protein 804A | -0.0233251 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.0230231 |
| POTEF | POTE ankyrin domain family, member F | -0.0229091 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.022205 |
| LDHA | lactate dehydrogenase A | -0.0219263 |
| RPS20 | ribosomal protein S20 | -0.0212924 |
| RPS25 | ribosomal protein S25 | -0.0212326 |
| ERBIN | erbb2 interacting protein | -0.0210771 |
| WNT2B | wingless-type MMTV integration site family, member 2B | -0.0210706 |
| RPL23 | ribosomal protein L23 | -0.0209545 |
| BPTF | bromodomain PHD finger transcription factor | -0.0207553 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0206985 |
| ENO1 | enolase 1, (alpha) | -0.0205089 |
| RPLP2 | ribosomal protein, large, P2 | -0.0204419 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0203695 |
| ARHGAP18 | Rho GTPase activating protein 18 | -0.0202865 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0200781 |
| WWC1 | WW and C2 domain containing 1 | -0.0199413 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | -0.0198656 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0191994 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0191768 |
| PFN1 | profilin 1 | -0.019044 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0190217 |
| YBX1 | Y box binding protein 1 | -0.0186163 |
| TMPRSS15 | transmembrane protease, serine 15 | -0.0185192 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0183597 |
| NTM | neurotrimin | -0.0183132 |
| SASH1 | SAM and SH3 domain containing 1 | -0.018128 |
| TLE4 | transducin-like enhancer of split 4 | -0.018112 |
| TPI1 | triosephosphate isomerase 1 | -0.0177127 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0167648 |
| ASTN2 | astrotactin 2 | -0.0167479 |
| RPS15 | ribosomal protein S15 | -0.0165791 |
| KCNQ3 | potassium channel, voltage gated KQT-like subfamily Q, member 3 | -0.0164842 |
| MSR1 | macrophage scavenger receptor 1 | -0.0164761 |
| CAVIN1 | caveolae associated protein 1 | -0.0164417 |
| RPS23 | ribosomal protein S23 | -0.0164404 |
| RFX8 | RFX family member 8, lacking RFX DNA binding domain | -0.0163233 |
| PPP1R10 | protein phosphatase 1, regulatory subunit 10 | -0.0161927 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.016125 |
| RPL34 | ribosomal protein L34 | -0.0161192 |
| RPS5 | ribosomal protein S5 | -0.0160901 |
| C2CD2 | C2 calcium-dependent domain containing 2 | -0.0159964 |
| CSMD3 | CUB and Sushi multiple domains 3 | -0.0158927 |
| RPS27A | ribosomal protein S27a | -0.0157657 |
| DIAPH2 | diaphanous-related formin 2 | -0.0157257 |
| AHNAK | AHNAK nucleoprotein | -0.0156438 |
| TXNRD1 | thioredoxin reductase 1 | -0.0155455 |
| RPL27A | ribosomal protein L27a | -0.0155185 |
| RPL30 | ribosomal protein L30 | -0.0153585 |
