Larotrectinib sulfate_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Larotrectinib sulfate perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Larotrectinib sulfate_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.185261
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.168769
FAT1 FAT atypical cadherin 1 0.154403
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.143282
NDRG1 N-myc downstream regulated 1 0.121031
FAM13A family with sequence similarity 13, member A 0.118417
PTMA prothymosin, alpha 0.112368
DSPP dentin sialophosphoprotein 0.107361
EZR ezrin 0.105547
TXNIP thioredoxin interacting protein 0.101245
CEMIP cell migration inducing protein, hyaluronan binding 0.0992246
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0978058
KRT18 keratin 18, type I 0.0974508
FLNB filamin B, beta 0.0957308
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0915729
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0852878
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0797459
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.078522
H1-0 H1.0 linker histone 0.0674574
EREG epiregulin 0.0671884
AHNAK AHNAK nucleoprotein 0.0670779
MYH9 myosin, heavy chain 9, non-muscle 0.0659889
TNS4 tensin 4 0.0657755
GOLGA4 golgin A4 0.0634585
CALR calreticulin 0.0628773
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0605886
HSPA8 heat shock 70kDa protein 8 0.0598572
KRT8 keratin 8, type II 0.0571107
ERRFI1 ERBB receptor feedback inhibitor 1 0.0568362
PGK1 phosphoglycerate kinase 1 0.0542471
PDIA4 protein disulfide isomerase family A, member 4 0.0538814
LMO7 LIM domain 7 0.0533011
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0527065
RPS3 ribosomal protein S3 0.0522051
EHF ets homologous factor 0.0514391
ESYT2 extended synaptotagmin-like protein 2 0.0506995
CANX calnexin 0.0495334
RPS6 ribosomal protein S6 0.0483751
CCNY cyclin Y 0.0454704
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0447376
KDM3A lysine (K)-specific demethylase 3A 0.0435267
MXI1 MAX interactor 1, dimerization protein 0.0429881
DSCAM Down syndrome cell adhesion molecule 0.0429242
ZNF292 zinc finger protein 292 0.0427696
PRELID2 PRELI domain containing 2 0.0426954
ANXA2 annexin A2 0.0425207
MED13L mediator complex subunit 13-like 0.042383
PTPRR protein tyrosine phosphatase, receptor type, R 0.0419664
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0419341
ITPRID2 ITPR interacting domain containing 2 0.0419079
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0417351
SRRM2 serine/arginine repetitive matrix 2 0.0412552
DSG2 desmoglein 2 0.0403307
KTN1 kinectin 1 (kinesin receptor) 0.0395457
GOLGB1 golgin B1 0.0392205
PRRC2C proline-rich coiled-coil 2C 0.0375759
TMSB4X thymosin beta 4, X-linked 0.0371247
RREB1 ras responsive element binding protein 1 0.0369601
VEGFA vascular endothelial growth factor A 0.0367226
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0367175
IQGAP1 IQ motif containing GTPase activating protein 1 0.0358446
LDHA lactate dehydrogenase A 0.0356857
TMF1 TATA element modulatory factor 1 0.0355718
ABHD2 abhydrolase domain containing 2 0.0354037
TPD52 tumor protein D52 0.0348395
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0346522
APLP2 amyloid beta (A4) precursor-like protein 2 0.0345398
TPM4 tropomyosin 4 0.0343798
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0342707
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0339832
RPL14 ribosomal protein L14 0.0333854
EIF4A2 eukaryotic translation initiation factor 4A2 0.0331187
NAP1L1 nucleosome assembly protein 1-like 1 0.0327799
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) 0.0324071
RAB1A RAB1A, member RAS oncogene family 0.0321844
PDIA6 protein disulfide isomerase family A, member 6 0.0319977
NCKAP1 NCK-associated protein 1 0.0316323
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0315819
FNBP1L formin binding protein 1-like 0.0311373
TPM3 tropomyosin 3 0.0310833
MYOF myoferlin 0.0310462
DDIT4 DNA-damage-inducible transcript 4 0.0309277
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.0308151
MBNL2 muscleblind-like splicing regulator 2 0.0305672
MACF1 microtubule-actin crosslinking factor 1 0.0305483
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0304196
RNF43 ring finger protein 43 0.0300272
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0298465
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0298271
ADD3 adducin 3 (gamma) 0.0297926
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0297357
ITGB4 integrin, beta 4 0.0293906
PLAUR plasminogen activator, urokinase receptor 0.0292566
CDCP1 CUB domain containing protein 1 0.0287119
UBA6 ubiquitin-like modifier activating enzyme 6 0.0286491
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0286363
CENPF centromere protein F, 350/400kDa 0.0285277
H1-4 H1.4 linker histone, cluster member 0.0284874
SLK STE20-like kinase 0.0283945
BAZ2B bromodomain adjacent to zinc finger domain, 2B 0.0282926

decreased expression

Symbol Name Standardized Value
GMDS GDP-mannose 4,6-dehydratase -0.0966646
GPHN gephyrin -0.0898552
MYO1E myosin IE -0.0884554
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0793832
VCL vinculin -0.0754359
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0673835
TMSB10 thymosin beta 10 -0.0671854
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0642598
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.053305
TPT1 tumor protein, translationally-controlled 1 -0.0512545
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0492406
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0428736
LOC102724023 ES1 protein homolog, mitochondrial -0.0384119
RPLP1 ribosomal protein, large, P1 -0.037644
FTH1 ferritin, heavy polypeptide 1 -0.0372841
EXT1 exostosin glycosyltransferase 1 -0.0371961
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0371852
EGR1 early growth response 1 -0.0356932
PTPRK protein tyrosine phosphatase, receptor type, K -0.0339662
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0331789
MBNL1 muscleblind-like splicing regulator 1 -0.0315376
MED13 mediator complex subunit 13 -0.0312499
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.0310995
INSIG1 insulin induced gene 1 -0.0297594
HMGA1 high mobility group AT-hook 1 -0.0296068
POF1B premature ovarian failure, 1B -0.0292294
NPSR1 neuropeptide S receptor 1 -0.0289387
PDLIM5 PDZ and LIM domain 5 -0.0287714
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0280494
ADIPOR2 adiponectin receptor 2 -0.027421
RPS24 ribosomal protein S24 -0.0268118
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0261307
PCDHB16 protocadherin beta 16 -0.0260267
TJP1 tight junction protein 1 -0.0256801
RPL35A ribosomal protein L35a -0.0251755
RAB10 RAB10, member RAS oncogene family -0.0243411
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.024327
IER3 immediate early response 3 -0.024282
MGST1 microsomal glutathione S-transferase 1 -0.024021
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0233039
POTEF POTE ankyrin domain family, member F -0.0232565
B4GALNT3 beta-1,4-N-acetyl-galactosaminyl transferase 3 -0.0232062
PALLD palladin, cytoskeletal associated protein -0.0223137
MUC5B mucin 5B, oligomeric mucus/gel-forming -0.0221976
ACTG1 actin gamma 1 -0.0221666
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0219049
MACC1 metastasis associated in colon cancer 1 -0.021456
CATSPERB catsper channel auxiliary subunit beta -0.0213992
LAMA4 laminin, alpha 4 -0.0210341
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0208461
LURAP1L leucine rich adaptor protein 1-like -0.0208323
FTL ferritin, light polypeptide -0.0206531
ABR active BCR-related -0.020495
PKP2 plakophilin 2 -0.0202425
GCLC glutamate-cysteine ligase, catalytic subunit -0.0202207
AHCYL2 adenosylhomocysteinase-like 2 -0.0202189
SLC38A2 solute carrier family 38, member 2 -0.0201884
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.0201409
FBXO11 F-box protein 11 -0.0196622
NCEH1 neutral cholesterol ester hydrolase 1 -0.0193128
CLDN4 claudin 4 -0.0192522
GATAD2A GATA zinc finger domain containing 2A -0.019113
ZNF207 zinc finger protein 207 -0.0190476
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0187879
MARCHF3 membrane associated ring-CH-type finger 3 -0.0187716
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.018514
ANKRD17 ankyrin repeat domain 17 -0.018413
TFF1 trefoil factor 1 -0.0182547
TRIM2 tripartite motif containing 2 -0.0181831
CLOCK clock circadian regulator -0.0176624
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa -0.0176393
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.0174672
TRIB1 tribbles pseudokinase 1 -0.0173774
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0171089
CADPS Ca++-dependent secretion activator -0.0170055
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.016786
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0167276
AHI1 Abelson helper integration site 1 -0.0166888
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0165827
VDAC1 voltage-dependent anion channel 1 -0.0165313
LLGL2 lethal giant larvae homolog 2 (Drosophila) -0.0164621
LOC112694756 uncharaterized LOC112694756 -0.0164565
TUBA1B tubulin, alpha 1b -0.0160843
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -0.0160287
LSAMP limbic system-associated membrane protein -0.0159086
FDPS farnesyl diphosphate synthase -0.0159063
PTPRB protein tyrosine phosphatase, receptor type, B -0.015805
ATP5F1B ATP synthase F1 subunit beta -0.0156876
EPHB2 EPH receptor B2 -0.0156159
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0155843
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 -0.0155285
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -0.0155261
IARS1 isoleucyl-tRNA synthetase 1 -0.0152324
RAB7A RAB7A, member RAS oncogene family -0.0152115
CCDC138 coiled-coil domain containing 138 -0.0151628
ALCAM activated leukocyte cell adhesion molecule -0.0151329
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0149201
LIPG lipase, endothelial -0.0148875
TUBB4B tubulin, beta 4B class IVb -0.0148849
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0148715