| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Larotrectinib sulfate perturbation in LoVo cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Larotrectinib sulfate_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FAT1 | FAT atypical cadherin 1 | 0.185458 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.17969 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.124205 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | 0.119467 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | 0.112264 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.101506 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.100828 |
| GCNT3 | glucosaminyl (N-acetyl) transferase 3, mucin type | 0.0783015 |
| EGFR | epidermal growth factor receptor | 0.0763389 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.072495 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0722548 |
| FLNB | filamin B, beta | 0.0705823 |
| KRT18 | keratin 18, type I | 0.0642402 |
| LOC105378220 | macrophage receptor MARCO-like | 0.0629392 |
| LMO7 | LIM domain 7 | 0.0612637 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0600168 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0599904 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0575322 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | 0.0565002 |
| NOS1AP | nitric oxide synthase 1 (neuronal) adaptor protein | 0.0563207 |
| SMAD3 | SMAD family member 3 | 0.0549141 |
| EZR | ezrin | 0.0536938 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0528737 |
| RAD51B | RAD51 paralog B | 0.0482577 |
| SPON1 | spondin 1, extracellular matrix protein | 0.048225 |
| RPS3 | ribosomal protein S3 | 0.0478188 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0474728 |
| UTRN | utrophin | 0.0466804 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0465929 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0463534 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.0461033 |
| RPL4 | ribosomal protein L4 | 0.0453023 |
| FOXO1 | forkhead box O1 | 0.0436464 |
| LAMB3 | laminin, beta 3 | 0.0436143 |
| ABHD17C | abhydrolase domain containing 17C | 0.0429987 |
| FOXP1 | forkhead box P1 | 0.0429797 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0429286 |
| PRELID2 | PRELI domain containing 2 | 0.0423305 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0416045 |
| PLAC8 | placenta-specific 8 | 0.0411638 |
| RPL7 | ribosomal protein L7 | 0.0411365 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0403646 |
| RPL13A | ribosomal protein L13a | 0.0397716 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0392817 |
| TNRC18 | trinucleotide repeat containing 18 | 0.0382979 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | 0.038012 |
| CALB1 | calbindin 1, 28kDa | 0.0378291 |
| RPL14 | ribosomal protein L14 | 0.0368708 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0352044 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0336496 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0332813 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0319889 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0319463 |
| CSTPP1 | centriolar satellite-associated tubulin polyglutamylase complex regulator 1 | 0.0318403 |
| VPS13C | vacuolar protein sorting 13 homolog C (S. cerevisiae) | 0.0317841 |
| ACTN4 | actinin, alpha 4 | 0.0310362 |
| BCL2L1 | BCL2-like 1 | 0.0309856 |
| GDA | guanine deaminase | 0.0308609 |
| CD9 | CD9 molecule | 0.0308333 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0307587 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 0.0306633 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0304741 |
| DUSP4 | dual specificity phosphatase 4 | 0.0303259 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0301354 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0300031 |
| ITGB4 | integrin, beta 4 | 0.0291056 |
| ITGA6 | integrin, alpha 6 | 0.0291032 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0287499 |
| PCBP2 | poly(rC) binding protein 2 | 0.028663 |
| RPS4X | ribosomal protein S4, X-linked | 0.0286481 |
| EPHA2 | EPH receptor A2 | 0.0279073 |
| KIF16B | kinesin family member 16B | 0.0274457 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0267823 |
| ETV6 | ets variant 6 | 0.0265826 |
| NRDC | nardilysin convertase | 0.0264544 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0260797 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0260105 |
| CLIC5 | chloride intracellular channel 5 | 0.0257195 |
| SLTM | SAFB-like, transcription modulator | 0.0256652 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0255894 |
| ANXA11 | annexin A11 | 0.0252106 |
| DSPP | dentin sialophosphoprotein | 0.0251313 |
| SEPTIN10 | septin 10 | 0.0250911 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0250536 |
| TNS4 | tensin 4 | 0.0249946 |
| SLK | STE20-like kinase | 0.0247843 |
| ABHD2 | abhydrolase domain containing 2 | 0.0246595 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0245037 |
| TINAGL1 | tubulointerstitial nephritis antigen-like 1 | 0.0239643 |
| TLN2 | talin 2 | 0.0231134 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0229843 |
| CDK19 | cyclin-dependent kinase 19 | 0.0228594 |
| DIAPH1 | diaphanous-related formin 1 | 0.0226761 |
| CANX | calnexin | 0.0226165 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0226054 |
| SHROOM3 | shroom family member 3 | 0.0222835 |
| ANTXR2 | anthrax toxin receptor 2 | 0.022185 |
| DST | dystonin | 0.0221132 |
| TJP2 | tight junction protein 2 | 0.0220777 |
| MYO6 | myosin VI | 0.0218083 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.200018 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.136907 |
| RPLP1 | ribosomal protein, large, P1 | -0.120418 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0972514 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0784592 |
| TMSB10 | thymosin beta 10 | -0.0774335 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.069142 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.06596 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0631981 |
| COG5 | component of oligomeric golgi complex 5 | -0.0627565 |
| ANXA2 | annexin A2 | -0.0617624 |
| TXNRD1 | thioredoxin reductase 1 | -0.0602709 |
| ACTG1 | actin gamma 1 | -0.0594647 |
| PKM | pyruvate kinase, muscle | -0.0566243 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0558004 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0553204 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0549046 |
| RPL35A | ribosomal protein L35a | -0.0546512 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.0505475 |
| RPS24 | ribosomal protein S24 | -0.0497303 |
| CALU | calumenin | -0.0491363 |
| RPLP0 | ribosomal protein, large, P0 | -0.0489922 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.048717 |
| CCND2 | cyclin D2 | -0.0482145 |
| LOC112694756 | uncharaterized LOC112694756 | -0.046933 |
| RPL34 | ribosomal protein L34 | -0.0463103 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0458606 |
| MYO1E | myosin IE | -0.0454185 |
| TC2N | tandem C2 domains, nuclear | -0.043921 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | -0.0429635 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0418481 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0411459 |
| FBXO11 | F-box protein 11 | -0.0402636 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0401551 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0400981 |
| FUS | FUS RNA binding protein | -0.0399145 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0398597 |
| RIGI | RNA sensor RIG-I | -0.0397734 |
| RPS21 | ribosomal protein S21 | -0.0384563 |
| RPLP2 | ribosomal protein, large, P2 | -0.038034 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0377605 |
| RRBP1 | ribosome binding protein 1 | -0.0368425 |
| EREG | epiregulin | -0.0363815 |
| NLRP1 | NLR family, pyrin domain containing 1 | -0.0356352 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0356033 |
| OXSR1 | oxidative stress responsive 1 | -0.0355342 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0353075 |
| GOLGA4 | golgin A4 | -0.0352298 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0351419 |
| PCDHB16 | protocadherin beta 16 | -0.0349296 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0346409 |
| UBAP2 | ubiquitin associated protein 2 | -0.0342147 |
| INTS6 | integrator complex subunit 6 | -0.0341791 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0341053 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0338987 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | -0.0336469 |
| MX1 | MX dynamin-like GTPase 1 | -0.0334852 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0333266 |
| RPS6 | ribosomal protein S6 | -0.0328817 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.032725 |
| RPS2 | ribosomal protein S2 | -0.0325675 |
| RPS5 | ribosomal protein S5 | -0.0325571 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0323916 |
| GPHN | gephyrin | -0.0320657 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0319294 |
| TJP1 | tight junction protein 1 | -0.0316983 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0316693 |
| TBCA | tubulin folding cofactor A | -0.031631 |
| RPS13 | ribosomal protein S13 | -0.031627 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.0313692 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0312783 |
| USP15 | ubiquitin specific peptidase 15 | -0.0312307 |
| HLA-B | major histocompatibility complex, class I, B | -0.0312297 |
| RPS25 | ribosomal protein S25 | -0.0304322 |
| IRF1 | interferon regulatory factor 1 | -0.0300122 |
| HM13 | histocompatibility (minor) 13 | -0.0299972 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0298458 |
| RBM39 | RNA binding motif protein 39 | -0.0296646 |
| ZNF207 | zinc finger protein 207 | -0.0291953 |
| RPL38 | ribosomal protein L38 | -0.0290621 |
| GLG1 | golgi glycoprotein 1 | -0.0288484 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0288324 |
| PPP1CC | protein phosphatase 1, catalytic subunit, gamma isozyme | -0.0283511 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0281572 |
| RPS15 | ribosomal protein S15 | -0.0280304 |
| ARF4 | ADP-ribosylation factor 4 | -0.0277352 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0276834 |
| HDLBP | high density lipoprotein binding protein | -0.0274086 |
| RPL28 | ribosomal protein L28 | -0.0272486 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0271917 |
| RPS23 | ribosomal protein S23 | -0.0271398 |
| RPS19 | ribosomal protein S19 | -0.0270457 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0270369 |
| AHCYL2 | adenosylhomocysteinase-like 2 | -0.0269631 |
| EGR1 | early growth response 1 | -0.0269552 |
| RPL30 | ribosomal protein L30 | -0.0269171 |
| FRMD5 | FERM domain containing 5 | -0.0267906 |
| RPS8 | ribosomal protein S8 | -0.026764 |
| PDXDC1 | pyridoxal-dependent decarboxylase domain containing 1 | -0.0267538 |
| DSG3 | desmoglein 3 | -0.0264673 |
