| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Larotrectinib sulfate perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Larotrectinib sulfate_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.146449 |
| DST | dystonin | 0.0925522 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0698477 |
| CAPRIN2 | caprin family member 2 | 0.064511 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.062117 |
| PODXL | podocalyxin-like | 0.0595764 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0469581 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0460757 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0457567 |
| TXNRD1 | thioredoxin reductase 1 | 0.0433972 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0407069 |
| FMNL2 | formin-like 2 | 0.0377734 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | 0.0362898 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0355617 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0353857 |
| TSC22D1 | TSC22 domain family, member 1 | 0.0348396 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0340321 |
| RAB27B | RAB27B, member RAS oncogene family | 0.0335242 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0323208 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | 0.031591 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0296798 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0289095 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0280319 |
| EMP1 | epithelial membrane protein 1 | 0.0273226 |
| SDCCAG8 | serologically defined colon cancer antigen 8 | 0.0269594 |
| APP | amyloid beta (A4) precursor protein | 0.0266915 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0266776 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0263059 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0261864 |
| FLNB | filamin B, beta | 0.0260173 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0251633 |
| UPP1 | uridine phosphorylase 1 | 0.0251461 |
| PYGL | phosphorylase, glycogen, liver | 0.0248691 |
| EXOC4 | exocyst complex component 4 | 0.023679 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0236361 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0229526 |
| NAV2 | neuron navigator 2 | 0.0224731 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | 0.0224413 |
| FNIP1 | folliculin interacting protein 1 | 0.0221345 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0216655 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | 0.0214597 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.021447 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0214189 |
| PYGB | phosphorylase, glycogen; brain | 0.0208237 |
| LOXL2 | lysyl oxidase-like 2 | 0.0205651 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0204553 |
| CMIP | c-Maf inducing protein | 0.0204223 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0201415 |
| PRELID2 | PRELI domain containing 2 | 0.0188832 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0188362 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0184176 |
| PDE10A | phosphodiesterase 10A | 0.0181291 |
| USP34 | ubiquitin specific peptidase 34 | 0.0179424 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.017899 |
| PPFIA4 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 | 0.017517 |
| RGS4 | regulator of G-protein signaling 4 | 0.0174747 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0171223 |
| ANGPTL4 | angiopoietin-like 4 | 0.0168776 |
| MLPH | melanophilin | 0.0166677 |
| AHNAK | AHNAK nucleoprotein | 0.0165629 |
| CDCP1 | CUB domain containing protein 1 | 0.016183 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0158506 |
| CSMD3 | CUB and Sushi multiple domains 3 | 0.0157385 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0154844 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0153721 |
| YEATS2 | YEATS domain containing 2 | 0.0151798 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0151202 |
| DOCK11 | dedicator of cytokinesis 11 | 0.0146948 |
| FERMT1 | fermitin family member 1 | 0.0145836 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0142405 |
| DNER | delta/notch-like EGF repeat containing | 0.0137474 |
| GYS1 | glycogen synthase 1 (muscle) | 0.0137261 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0137238 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.013618 |
| TBC1D22A | TBC1 domain family, member 22A | 0.01358 |
| SERPINB6 | serpin peptidase inhibitor, clade B (ovalbumin), member 6 | 0.0134767 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.013445 |
| CEP170 | centrosomal protein 170kDa | 0.0134407 |
| EHBP1 | EH domain binding protein 1 | 0.0132607 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0132571 |
| DNTTIP1 | deoxynucleotidyltransferase, terminal, interacting protein 1 | 0.0132312 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0131784 |
| PLEC | plectin | 0.0130708 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0129837 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0128661 |
| MYSM1 | Myb-like, SWIRM and MPN domains 1 | 0.0126898 |
| STX1A | syntaxin 1A (brain) | 0.0126894 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0126165 |
| KLC1 | kinesin light chain 1 | 0.0124705 |
| TAF1 | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa | 0.0122709 |
| BCL2L1 | BCL2-like 1 | 0.0120135 |
| SQSTM1 | sequestosome 1 | 0.0120086 |
| NT5E | 5'-nucleotidase, ecto (CD73) | 0.0118239 |
| DENND1A | DENN/MADD domain containing 1A | 0.0118237 |
| CAPN2 | calpain 2, (m/II) large subunit | 0.0116936 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | 0.0115539 |
| NGLY1 | N-glycanase 1 | 0.0114639 |
| FER | fer (fps/fes related) tyrosine kinase | 0.0113975 |
| MYO10 | myosin X | 0.0112468 |
| CTTN | cortactin | 0.0111884 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.511975 |
| VIM | vimentin | -0.172716 |
| TMSB10 | thymosin beta 10 | -0.153421 |
| MT2A | metallothionein 2A | -0.144376 |
| PTMA | prothymosin, alpha | -0.135312 |
| FTL | ferritin, light polypeptide | -0.0926647 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0896766 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.08373 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0824451 |
| POTEF | POTE ankyrin domain family, member F | -0.0758879 |
| HMGA1 | high mobility group AT-hook 1 | -0.060345 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0562411 |
| RPS19 | ribosomal protein S19 | -0.0553578 |
| TXNIP | thioredoxin interacting protein | -0.0553267 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.051088 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0486297 |
| MT1E | metallothionein 1E | -0.0464267 |
| LOC112694756 | uncharaterized LOC112694756 | -0.046076 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0457988 |
| TNFRSF6B | tumor necrosis factor receptor superfamily, member 6b, decoy | -0.0406867 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.040435 |
| PKM | pyruvate kinase, muscle | -0.0396388 |
| HLA-B | major histocompatibility complex, class I, B | -0.039427 |
| RPS8 | ribosomal protein S8 | -0.0394092 |
| YBX1 | Y box binding protein 1 | -0.039137 |
| TP63 | tumor protein p63 | -0.0390218 |
| ACTG1 | actin gamma 1 | -0.0380959 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0379802 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0374224 |
| RPS6 | ribosomal protein S6 | -0.0363205 |
| PFN1 | profilin 1 | -0.0357534 |
| RPL35A | ribosomal protein L35a | -0.035446 |
| RPL23 | ribosomal protein L23 | -0.0353065 |
| RPL12 | ribosomal protein L12 | -0.0352677 |
| ZNF292 | zinc finger protein 292 | -0.0352067 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0347459 |
| RPL36 | ribosomal protein L36 | -0.0345856 |
| S100A9 | S100 calcium binding protein A9 | -0.0344603 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0342487 |
| RPL28 | ribosomal protein L28 | -0.0339683 |
| RPL8 | ribosomal protein L8 | -0.0336737 |
| TPI1 | triosephosphate isomerase 1 | -0.032731 |
| MT1X | metallothionein 1X | -0.0327086 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0325719 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0324522 |
| ENO1 | enolase 1, (alpha) | -0.0322647 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0318417 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0318167 |
| LDHA | lactate dehydrogenase A | -0.0317621 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0315789 |
| HLA-A | major histocompatibility complex, class I, A | -0.0315025 |
| B2M | beta-2-microglobulin | -0.0313727 |
| RPLP1 | ribosomal protein, large, P1 | -0.0311745 |
| SEPTIN7 | septin 7 | -0.0310215 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0307154 |
| TMSB4X | thymosin beta 4, X-linked | -0.0299537 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0298297 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.029823 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0294406 |
| WDR45B | WD repeat domain 45B | -0.0288821 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0286133 |
| RPLP2 | ribosomal protein, large, P2 | -0.0283198 |
| BSG | basigin (Ok blood group) | -0.0279487 |
| TMEM123 | transmembrane protein 123 | -0.0279343 |
| SPAG9 | sperm associated antigen 9 | -0.0277175 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0276299 |
| EGR1 | early growth response 1 | -0.0275708 |
| WASF2 | WAS protein family, member 2 | -0.0275018 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.0273369 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.0271726 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0265013 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0263919 |
| SRGN | serglycin | -0.0262844 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0262141 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0258607 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.0256334 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0254321 |
| PGK1 | phosphoglycerate kinase 1 | -0.0253976 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0253628 |
| GNAS | GNAS complex locus | -0.025235 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0252301 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.0252282 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0248512 |
| NUP58 | nucleoporin 58 | -0.0245033 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0244009 |
| RACK1 | receptor for activated C kinase 1 | -0.0237667 |
| PCBP2 | poly(rC) binding protein 2 | -0.0237483 |
| CCNL1 | cyclin L1 | -0.0235977 |
| RLF | rearranged L-myc fusion | -0.023245 |
| FOSL1 | FOS-like antigen 1 | -0.0232294 |
| ZNF207 | zinc finger protein 207 | -0.0231688 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0230034 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0229281 |
| DEK | DEK proto-oncogene | -0.0227383 |
| ASTN2 | astrotactin 2 | -0.022611 |
| RPL35 | ribosomal protein L35 | -0.0225524 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0224702 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0224689 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.02191 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0218966 |
