| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Larotrectinib sulfate perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Larotrectinib sulfate_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EGFR | epidermal growth factor receptor | 0.225519 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0894527 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0848718 |
| FAM13A | family with sequence similarity 13, member A | 0.0746545 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0649313 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0628576 |
| LAMC2 | laminin, gamma 2 | 0.0601169 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0592662 |
| RPS3 | ribosomal protein S3 | 0.0566136 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0526451 |
| SMAD3 | SMAD family member 3 | 0.0497966 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0495776 |
| FNIP1 | folliculin interacting protein 1 | 0.0495287 |
| LAMB3 | laminin, beta 3 | 0.0492829 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0468688 |
| SQSTM1 | sequestosome 1 | 0.0455387 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0439214 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0409693 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0395526 |
| PTMA | prothymosin, alpha | 0.039412 |
| NGLY1 | N-glycanase 1 | 0.0394102 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0392252 |
| CD163L1 | CD163 molecule-like 1 | 0.0392244 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0384874 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0371454 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.03692 |
| SPIRE1 | spire-type actin nucleation factor 1 | 0.0368126 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0365584 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0347105 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0345873 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0345463 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | 0.0339486 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0337262 |
| UVRAG | UV radiation resistance associated | 0.0336885 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0331811 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0327459 |
| NDRG1 | N-myc downstream regulated 1 | 0.0326574 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0313083 |
| CANX | calnexin | 0.0312171 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0307058 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0294049 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0291857 |
| MT2A | metallothionein 2A | 0.0288079 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0286801 |
| TPD52 | tumor protein D52 | 0.0283736 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0282507 |
| ITSN2 | intersectin 2 | 0.027659 |
| PRRC2C | proline-rich coiled-coil 2C | 0.027399 |
| CDCP1 | CUB domain containing protein 1 | 0.0272291 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | 0.0269684 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0265027 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0259617 |
| TRPM7 | transient receptor potential cation channel, subfamily M, member 7 | 0.0255061 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0254326 |
| HECTD1 | HECT domain containing E3 ubiquitin protein ligase 1 | 0.0250245 |
| CTTN | cortactin | 0.0248923 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0248658 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0246885 |
| GOLGB1 | golgin B1 | 0.0246006 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0245776 |
| ARRDC3 | arrestin domain containing 3 | 0.0245197 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0244941 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0243382 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0241253 |
| ZNF292 | zinc finger protein 292 | 0.0241149 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0239862 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0235095 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0233294 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0229678 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0228624 |
| SEC61G | Sec61 gamma subunit | 0.0227983 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0225944 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0225734 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0224998 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0224638 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.02239 |
| RPS6 | ribosomal protein S6 | 0.0222596 |
| HYOU1 | hypoxia up-regulated 1 | 0.0221172 |
| UBC | ubiquitin C | 0.0218299 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0217348 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | 0.0214691 |
| SDC4 | syndecan 4 | 0.0213558 |
| ASPH | aspartate beta-hydroxylase | 0.0212447 |
| RAD51B | RAD51 paralog B | 0.0210167 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0209547 |
| STAG2 | stromal antigen 2 | 0.0209529 |
| B2M | beta-2-microglobulin | 0.0209089 |
| LANCL2 | LanC lantibiotic synthetase component C-like 2 (bacterial) | 0.0207937 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0207419 |
| GOLGA4 | golgin A4 | 0.0206642 |
| SFTPA2 | surfactant protein A2 | 0.0205374 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0204275 |
| RPL4 | ribosomal protein L4 | 0.0203293 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0202968 |
| RPL11 | ribosomal protein L11 | 0.0201723 |
| RSL1D1 | ribosomal L1 domain containing 1 | 0.0201056 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0200835 |
| ENO1 | enolase 1, (alpha) | 0.0198729 |
| HDLBP | high density lipoprotein binding protein | 0.0197818 |
| TMF1 | TATA element modulatory factor 1 | 0.0197354 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.186881 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.103696 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0999163 |
| TXNRD1 | thioredoxin reductase 1 | -0.0721278 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.067878 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0580366 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.053187 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0525111 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0500516 |
| PKM | pyruvate kinase, muscle | -0.0489067 |
| NABP1 | nucleic acid binding protein 1 | -0.0465819 |
| EGR1 | early growth response 1 | -0.0465719 |
| VCL | vinculin | -0.0450178 |
| OSMR | oncostatin M receptor | -0.0449771 |
| CES1 | carboxylesterase 1 | -0.0443969 |
| ANXA2 | annexin A2 | -0.0419961 |
| LRP1B | low density lipoprotein receptor-related protein 1B | -0.0385249 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0384993 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0384084 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0370505 |
| SCEL | sciellin | -0.0358875 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0345446 |
| TES | testin LIM domain protein | -0.0340269 |
| LAMA4 | laminin, alpha 4 | -0.0338479 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0336019 |
| TMSB10 | thymosin beta 10 | -0.0314842 |
| PM20D1 | peptidase M20 domain containing 1 | -0.0314033 |
| FZR1 | fizzy/cell division cycle 20 related 1 (Drosophila) | -0.0313197 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | -0.0304758 |
| INTS6 | integrator complex subunit 6 | -0.0296184 |
| TJP1 | tight junction protein 1 | -0.0291543 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0289481 |
| MYO1E | myosin IE | -0.0287148 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0281728 |
| GSK3B | glycogen synthase kinase 3 beta | -0.028124 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.025845 |
| ST14 | suppression of tumorigenicity 14 (colon carcinoma) | -0.0254317 |
| RAB10 | RAB10, member RAS oncogene family | -0.0237445 |
| NSUN6 | NOP2/Sun domain family, member 6 | -0.0231569 |
| VMP1 | vacuole membrane protein 1 | -0.0226739 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0219488 |
| RAB27B | RAB27B, member RAS oncogene family | -0.0219305 |
| NBEAL1 | neurobeachin-like 1 | -0.021856 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0218189 |
| OCLN | occludin | -0.0210621 |
| MACC1 | metastasis associated in colon cancer 1 | -0.0204022 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0202337 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | -0.0199874 |
| ARL5B | ADP-ribosylation factor-like 5B | -0.0197789 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.019726 |
| AP1G1 | adaptor-related protein complex 1, gamma 1 subunit | -0.0192142 |
| PATJ | PATJ crumbs cell polarity complex component | -0.01916 |
| MCU | mitochondrial calcium uniporter | -0.0191002 |
| MGAT4C | MGAT4 family, member C | -0.0188408 |
| MAP7 | microtubule-associated protein 7 | -0.0188149 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0185641 |
| NTN4 | netrin 4 | -0.018446 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0180863 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | -0.0179806 |
| KRT8 | keratin 8, type II | -0.0178047 |
| PRKCA | protein kinase C, alpha | -0.0175766 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0174888 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.017452 |
| MTHFD2L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like | -0.0173312 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.0172955 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.0172404 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.016824 |
| EZR | ezrin | -0.016763 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.0167188 |
| RCOR1 | REST corepressor 1 | -0.0165236 |
| SIK3 | SIK family kinase 3 | -0.0163321 |
| ABLIM1 | actin binding LIM protein 1 | -0.0162154 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.016031 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0158631 |
| RAP2B | RAP2B, member of RAS oncogene family | -0.0157765 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.0156429 |
| CCNL1 | cyclin L1 | -0.0155625 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0154909 |
| PTEN | phosphatase and tensin homolog | -0.0154626 |
| AP1S3 | adaptor-related protein complex 1, sigma 3 subunit | -0.0154209 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | -0.0152787 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0152198 |
| FRMD4B | FERM domain containing 4B | -0.0150782 |
| SYAP1 | synapse associated protein 1 | -0.0150631 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0149235 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0148735 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0147834 |
| ATP11A | ATPase, class VI, type 11A | -0.0146319 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0145489 |
| MGST1 | microsomal glutathione S-transferase 1 | -0.0143719 |
| CNTN1 | contactin 1 | -0.0143711 |
| OXSR1 | oxidative stress responsive 1 | -0.0143628 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | -0.0143568 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0142773 |
| TRAPPC9 | trafficking protein particle complex 9 | -0.0141521 |
| CST3 | cystatin C | -0.0141303 |
| NF1 | neurofibromin 1 | -0.014069 |
| USP34 | ubiquitin specific peptidase 34 | -0.0138098 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0138054 |
| CCND1 | cyclin D1 | -0.0137529 |
