| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Larotrectinib sulfate perturbation in NCI-H1792 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Larotrectinib sulfate_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NAMPT | nicotinamide phosphoribosyltransferase | 0.274639 |
| FNDC3B | fibronectin type III domain containing 3B | 0.121918 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.10787 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.105532 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.104048 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.103036 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0961564 |
| FAM13A | family with sequence similarity 13, member A | 0.0961233 |
| SMAD3 | SMAD family member 3 | 0.0843274 |
| PCBP2 | poly(rC) binding protein 2 | 0.0703881 |
| CD44 | CD44 molecule (Indian blood group) | 0.0662456 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0655067 |
| GOLGA4 | golgin A4 | 0.0615105 |
| ATP13A3 | ATPase type 13A3 | 0.0575291 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0568009 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0511774 |
| ZNF292 | zinc finger protein 292 | 0.0504852 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0485623 |
| RAB27B | RAB27B, member RAS oncogene family | 0.0481274 |
| FLNB | filamin B, beta | 0.0470265 |
| RBM39 | RNA binding motif protein 39 | 0.0468413 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0460791 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0460261 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0454681 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0454237 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0453982 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0442039 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0431696 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0430713 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0425811 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0424308 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0418513 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0416742 |
| OGA | O-GlcNAcase | 0.0409807 |
| ADD3 | adducin 3 (gamma) | 0.0404286 |
| RAD51B | RAD51 paralog B | 0.0404273 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.040395 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0373372 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0372742 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0372498 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0371139 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0366685 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0363059 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | 0.0361509 |
| SBF2 | SET binding factor 2 | 0.0353513 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0344857 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0344514 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0343315 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0343163 |
| OS9 | osteosarcoma amplified 9, endoplasmic reticulum lectin | 0.0342896 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0338805 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0336973 |
| PRRC2C | proline-rich coiled-coil 2C | 0.033657 |
| RIOK3 | RIO kinase 3 | 0.0336458 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0333343 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0331706 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0329311 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | 0.0327032 |
| MYOF | myoferlin | 0.0327004 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.032536 |
| MAP1B | microtubule-associated protein 1B | 0.0324164 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0319711 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0318991 |
| SLTM | SAFB-like, transcription modulator | 0.0313878 |
| NAV2 | neuron navigator 2 | 0.0310888 |
| KLF6 | Kruppel-like factor 6 | 0.0310569 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0310136 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0309591 |
| PARP8 | poly (ADP-ribose) polymerase family, member 8 | 0.0309559 |
| YBX3 | Y box binding protein 3 | 0.0306741 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0305212 |
| PIAS2 | protein inhibitor of activated STAT, 2 | 0.0304892 |
| OPTN | optineurin | 0.0301474 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0301087 |
| FBXL13 | F-box and leucine-rich repeat protein 13 | 0.0297812 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0296828 |
| SYAP1 | synapse associated protein 1 | 0.0296305 |
| ANXA1 | annexin A1 | 0.0294594 |
| EZR | ezrin | 0.0294179 |
| SPAG9 | sperm associated antigen 9 | 0.0292273 |
| RAB8B | RAB8B, member RAS oncogene family | 0.0286391 |
| RUNX1 | runt-related transcription factor 1 | 0.0283559 |
| PRELID2 | PRELI domain containing 2 | 0.0282544 |
| RNF24 | ring finger protein 24 | 0.0281887 |
| C15ORF48 | chromosome 15 open reading frame 48 | 0.0279543 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0278638 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0277539 |
| CD109 | CD109 molecule | 0.0273157 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0271106 |
| RUNX2 | runt-related transcription factor 2 | 0.0270641 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0269021 |
| ARRDC3 | arrestin domain containing 3 | 0.0268034 |
| TPR | translocated promoter region, nuclear basket protein | 0.0267093 |
| YEATS2 | YEATS domain containing 2 | 0.0264629 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0263312 |
| USP3 | ubiquitin specific peptidase 3 | 0.0257865 |
| HAS2 | hyaluronan synthase 2 | 0.0255618 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0253789 |
| PRKCSH | protein kinase C substrate 80K-H | 0.0253766 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0252866 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CDH13 | cadherin 13 | -0.15431 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.140011 |
| NRG1 | neuregulin 1 | -0.125313 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | -0.111217 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.110653 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.100575 |
| MTSS1 | metastasis suppressor 1 | -0.0989063 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0977485 |
| HMGA2 | high mobility group AT-hook 2 | -0.0928346 |
| FAM20C | family with sequence similarity 20, member C | -0.0921633 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0903884 |
| FN1 | fibronectin 1 | -0.079749 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0773618 |
| GLCCI1 | glucocorticoid induced 1 | -0.0755511 |
| LOX | lysyl oxidase | -0.071068 |
| STC1 | stanniocalcin 1 | -0.0703553 |
| TMSB10 | thymosin beta 10 | -0.0632161 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0629888 |
| AADAC | arylacetamide deacetylase | -0.0626212 |
| INTS6 | integrator complex subunit 6 | -0.0562447 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0529922 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0508092 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.0505882 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0502046 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0495827 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0489439 |
| FBN1 | fibrillin 1 | -0.0482927 |
| CDK14 | cyclin-dependent kinase 14 | -0.0480025 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0471594 |
| GLIS3 | GLIS family zinc finger 3 | -0.0470263 |
| EFNA5 | ephrin-A5 | -0.0458903 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0456576 |
| NLK | nemo-like kinase | -0.0453567 |
| EFCAB13 | EF-hand calcium binding domain 13 | -0.0440003 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.0430007 |
| ATG7 | autophagy related 7 | -0.0412399 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0409422 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | -0.0389039 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | -0.0384635 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0373796 |
| IL1B | interleukin 1, beta | -0.0366257 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0365159 |
| ZNF804A | zinc finger protein 804A | -0.0342509 |
| TMTC1 | transmembrane and tetratricopeptide repeat containing 1 | -0.0341442 |
| CUX1 | cut-like homeobox 1 | -0.0336702 |
| GALNT18 | polypeptide N-acetylgalactosaminyltransferase 18 | -0.0326257 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0324453 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0320857 |
| NUMB | numb homolog (Drosophila) | -0.0316463 |
| SP100 | SP100 nuclear antigen | -0.0316193 |
| DTNA | dystrobrevin, alpha | -0.0306294 |
| NHSL1 | NHS-like 1 | -0.0305252 |
| FRMD4A | FERM domain containing 4A | -0.0304841 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0304 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0302009 |
| PTPRB | protein tyrosine phosphatase, receptor type, B | -0.0301802 |
| DNER | delta/notch-like EGF repeat containing | -0.0298297 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.029776 |
| HM13 | histocompatibility (minor) 13 | -0.0297146 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0296725 |
| PRRX1 | paired related homeobox 1 | -0.0293379 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0291849 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | -0.0291116 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0287226 |
| SEPTIN9 | septin 9 | -0.0283733 |
| RSU1 | Ras suppressor protein 1 | -0.028208 |
| CLIC4 | chloride intracellular channel 4 | -0.0281881 |
| RPL31 | ribosomal protein L31 | -0.0281811 |
| IFI44L | interferon-induced protein 44-like | -0.0277621 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | -0.0277139 |
| AVIL | advillin | -0.0276409 |
| CLMP | CXADR-like membrane protein | -0.027614 |
| SH3RF3 | SH3 domain containing ring finger 3 | -0.0272973 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.0272126 |
| GREB1L | growth regulation by estrogen in breast cancer-like | -0.0271297 |
| BMERB1 | bMERB domain containing 1 | -0.0270521 |
| TGFB1 | transforming growth factor, beta 1 | -0.0267486 |
| DIAPH2 | diaphanous-related formin 2 | -0.0266542 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0266258 |
| MEF2A | myocyte enhancer factor 2A | -0.0261681 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0258361 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0256904 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0256405 |
| NAV3 | neuron navigator 3 | -0.0253781 |
| ANXA10 | annexin A10 | -0.0253422 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0251551 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0248468 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0248353 |
| RPL35A | ribosomal protein L35a | -0.0246257 |
| TNS3 | tensin 3 | -0.0246127 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0242238 |
| WLS | wntless Wnt ligand secretion mediator | -0.0236358 |
| HPCAL1 | hippocalcin-like 1 | -0.0235165 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0234925 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0231762 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0231537 |
| HDAC4 | histone deacetylase 4 | -0.0230122 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0226034 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0226011 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | -0.0224506 |
