| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Larotrectinib sulfate perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Larotrectinib sulfate_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.282222 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.254768 |
| GRAMD1B | GRAM domain containing 1B | 0.199403 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0917821 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.08212 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0745655 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0732331 |
| VIM | vimentin | 0.0716559 |
| WWOX | WW domain containing oxidoreductase | 0.069099 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0603764 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0598686 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0583505 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0553352 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0529598 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0525903 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0522047 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0502429 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0489141 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0481904 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0447446 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0443639 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0437131 |
| AHNAK | AHNAK nucleoprotein | 0.0435246 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0430692 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0417558 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 0.0412393 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0399345 |
| NTN4 | netrin 4 | 0.0377924 |
| SMAD3 | SMAD family member 3 | 0.0374731 |
| RPL4 | ribosomal protein L4 | 0.0373087 |
| RPS3 | ribosomal protein S3 | 0.0365078 |
| FAM107B | family with sequence similarity 107, member B | 0.0360734 |
| KIAA0319 | KIAA0319 | 0.0357741 |
| ASPH | aspartate beta-hydroxylase | 0.0353346 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0346058 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0345095 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0341874 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0332476 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0317127 |
| BMP6 | bone morphogenetic protein 6 | 0.0315145 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0309054 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0307003 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.0306841 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0305407 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0305013 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.0298628 |
| RPS2 | ribosomal protein S2 | 0.0287074 |
| RPL19 | ribosomal protein L19 | 0.0285609 |
| ATP11A | ATPase, class VI, type 11A | 0.0285486 |
| PLEC | plectin | 0.0282567 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.028057 |
| FHIT | fragile histidine triad | 0.0277649 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0277288 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0277145 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0270927 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0263357 |
| FMNL2 | formin-like 2 | 0.0262612 |
| LANCL1 | LanC lantibiotic synthetase component C-like 1 (bacterial) | 0.0260406 |
| MCL1 | myeloid cell leukemia 1 | 0.0260194 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0259318 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0258204 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | 0.0253541 |
| MYOF | myoferlin | 0.0253419 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0252775 |
| LAMB1 | laminin, beta 1 | 0.0251585 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0248646 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0243783 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0238756 |
| SERINC1 | serine incorporator 1 | 0.0237036 |
| SET | SET nuclear proto-oncogene | 0.0234966 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0230631 |
| HMOX1 | heme oxygenase 1 | 0.022953 |
| DST | dystonin | 0.0226547 |
| PFKP | phosphofructokinase, platelet | 0.0226104 |
| RPL14 | ribosomal protein L14 | 0.0225669 |
| TPM3 | tropomyosin 3 | 0.0220908 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0217894 |
| PTMA | prothymosin, alpha | 0.0216477 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0215985 |
| H1-2 | H1.2 linker histone, cluster member | 0.0214014 |
| RPL7 | ribosomal protein L7 | 0.0210318 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0209422 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.020642 |
| SEPTIN10 | septin 10 | 0.0206175 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.020506 |
| RPL26 | ribosomal protein L26 | 0.0202153 |
| CANX | calnexin | 0.0200233 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0200177 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0197891 |
| GAN | gigaxonin | 0.0197876 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | 0.0197379 |
| ZFAND6 | zinc finger, AN1-type domain 6 | 0.0194678 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0191926 |
| KLF6 | Kruppel-like factor 6 | 0.0191855 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | 0.0190238 |
| ITGB5 | integrin, beta 5 | 0.0188542 |
| RPS8 | ribosomal protein S8 | 0.0186344 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0185317 |
| H1-4 | H1.4 linker histone, cluster member | 0.0183948 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0182016 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.192379 |
| IGF2 | insulin-like growth factor 2 | -0.157737 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.13167 |
| TMSB10 | thymosin beta 10 | -0.102052 |
| POTEF | POTE ankyrin domain family, member F | -0.0967924 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0860238 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0845958 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0629012 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -0.0583795 |
| PTK2 | protein tyrosine kinase 2 | -0.0580287 |
| FTL | ferritin, light polypeptide | -0.0570727 |
| ZNF207 | zinc finger protein 207 | -0.0549528 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0545494 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0543103 |
| S100A6 | S100 calcium binding protein A6 | -0.0516177 |
| PKM | pyruvate kinase, muscle | -0.0486584 |
| DENND4A | DENN/MADD domain containing 4A | -0.0483771 |
| NOP58 | NOP58 ribonucleoprotein | -0.0482862 |
| PFN1 | profilin 1 | -0.0481811 |
| FGB | fibrinogen beta chain | -0.0475237 |
| GLG1 | golgi glycoprotein 1 | -0.0472117 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.0471787 |
| HDAC9 | histone deacetylase 9 | -0.0462288 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0455488 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0442311 |
| ERBIN | erbb2 interacting protein | -0.0428198 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0418651 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0398042 |
| COPA | coatomer protein complex, subunit alpha | -0.0392358 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0389648 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -0.0388279 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0387101 |
| INO80 | INO80 complex subunit | -0.0385583 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0381532 |
| HMGA1 | high mobility group AT-hook 1 | -0.0376109 |
| SIK3 | SIK family kinase 3 | -0.0365858 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0359435 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0352226 |
| KHDC4 | KH domain containing 4, pre-mRNA splicing factor | -0.0351678 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0341606 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0336021 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.033389 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0329602 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0325406 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0324155 |
| SRP54 | signal recognition particle 54kDa | -0.0323871 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0321589 |
| FBXO11 | F-box protein 11 | -0.0317782 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0315247 |
| COG5 | component of oligomeric golgi complex 5 | -0.0314005 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0312044 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0311222 |
| USP34 | ubiquitin specific peptidase 34 | -0.0308625 |
| RHOA | ras homolog family member A | -0.0300846 |
| AP1G1 | adaptor-related protein complex 1, gamma 1 subunit | -0.0300219 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.029784 |
| WIPF2 | WAS/WASL interacting protein family, member 2 | -0.0294888 |
| ACTG1 | actin gamma 1 | -0.0294642 |
| RBM25 | RNA binding motif protein 25 | -0.0293318 |
| HLA-B | major histocompatibility complex, class I, B | -0.0286821 |
| RAB7A | RAB7A, member RAS oncogene family | -0.028551 |
| LDHA | lactate dehydrogenase A | -0.0285485 |
| PARD3 | par-3 family cell polarity regulator | -0.0275792 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0275416 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | -0.027422 |
| AK1 | adenylate kinase 1 | -0.0270433 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0269691 |
| UTRN | utrophin | -0.0269535 |
| NF1 | neurofibromin 1 | -0.0264379 |
| HLA-A | major histocompatibility complex, class I, A | -0.026208 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0260561 |
| TAGLN2 | transgelin 2 | -0.0258373 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | -0.0256032 |
| ARF4 | ADP-ribosylation factor 4 | -0.0252593 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | -0.0251359 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | -0.0250768 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0250583 |
| RBM39 | RNA binding motif protein 39 | -0.0248036 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0247686 |
| PTGES2 | prostaglandin E synthase 2 | -0.0247577 |
| PUM1 | pumilio RNA-binding family member 1 | -0.0245932 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0236178 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0236015 |
| TMEM87A | transmembrane protein 87A | -0.0235106 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0234051 |
| NAA15 | N(alpha)-acetyltransferase 15, NatA auxiliary subunit | -0.0233296 |
| NUP58 | nucleoporin 58 | -0.0231945 |
| BTBD7 | BTB (POZ) domain containing 7 | -0.0230654 |
| IST1 | increased sodium tolerance 1 homolog (yeast) | -0.0227384 |
| MTF2 | metal response element binding transcription factor 2 | -0.0225375 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.022458 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | -0.0223578 |
| FOCAD | focadhesin | -0.0222737 |
| BZW2 | basic leucine zipper and W2 domains 2 | -0.0222332 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | -0.0220186 |
| SBNO1 | strawberry notch homolog 1 (Drosophila) | -0.0219378 |
| CHD9 | chromodomain helicase DNA binding protein 9 | -0.021935 |
| MYADM | myeloid-associated differentiation marker | -0.0218591 |
| ENO1 | enolase 1, (alpha) | -0.0218095 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | -0.0217431 |
