| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Larotrectinib sulfate perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Larotrectinib sulfate_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.153269 |
| PDE10A | phosphodiesterase 10A | 0.0955466 |
| FAM13A | family with sequence similarity 13, member A | 0.0834932 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0769034 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0732802 |
| FLNB | filamin B, beta | 0.0732708 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0647988 |
| NDRG1 | N-myc downstream regulated 1 | 0.0645974 |
| PTK2 | protein tyrosine kinase 2 | 0.0609545 |
| FLNA | filamin A, alpha | 0.0599414 |
| IRS2 | insulin receptor substrate 2 | 0.0597047 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | 0.0577655 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0564916 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | 0.0558029 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0552579 |
| SBF2 | SET binding factor 2 | 0.0546206 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0543407 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0540551 |
| CNOT8 | CCR4-NOT transcription complex, subunit 8 | 0.0532476 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0522177 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0508915 |
| QKI | QKI, KH domain containing, RNA binding | 0.0508813 |
| AP3S1 | adaptor-related protein complex 3, sigma 1 subunit | 0.0506497 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0505765 |
| MATR3 | matrin 3 | 0.0495593 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0473667 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | 0.0465753 |
| NEMF | nuclear export mediator factor | 0.0459179 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | 0.0458835 |
| COG5 | component of oligomeric golgi complex 5 | 0.0456601 |
| FNIP1 | folliculin interacting protein 1 | 0.0454979 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | 0.0454911 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0450517 |
| YEATS2 | YEATS domain containing 2 | 0.0449719 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0446491 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0442991 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | 0.0437458 |
| RAP1B | RAP1B, member of RAS oncogene family | 0.0436431 |
| YY1AP1 | YY1 associated protein 1 | 0.0428382 |
| EML4 | echinoderm microtubule associated protein like 4 | 0.0428106 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.0423361 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0421586 |
| RSF1 | remodeling and spacing factor 1 | 0.0421182 |
| POU2F1 | POU class 2 homeobox 1 | 0.0419328 |
| RORA | RAR-related orphan receptor A | 0.0416872 |
| SEPTIN7 | septin 7 | 0.0416163 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0411902 |
| PPIG | peptidylprolyl isomerase G (cyclophilin G) | 0.0404875 |
| CANX | calnexin | 0.0401507 |
| FAM162A | family with sequence similarity 162, member A | 0.0400136 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.039989 |
| RAD51B | RAD51 paralog B | 0.0398151 |
| RASA2 | RAS p21 protein activator 2 | 0.0398107 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0390465 |
| PTBP2 | polypyrimidine tract binding protein 2 | 0.0388222 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0387127 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | 0.0382825 |
| OGA | O-GlcNAcase | 0.0380431 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0378453 |
| ARHGEF7 | Rho guanine nucleotide exchange factor (GEF) 7 | 0.0376864 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0370845 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0370689 |
| HELZ | helicase with zinc finger | 0.0370426 |
| DTNA | dystrobrevin, alpha | 0.0367734 |
| RBM27 | RNA binding motif protein 27 | 0.036651 |
| HLA-E | major histocompatibility complex, class I, E | 0.0364224 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0360366 |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | 0.0356861 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0350491 |
| CDC73 | cell division cycle 73 | 0.0346242 |
| SCAF8 | SR-related CTD-associated factor 8 | 0.0342976 |
| MORF4L2 | mortality factor 4 like 2 | 0.0342496 |
| KLF6 | Kruppel-like factor 6 | 0.0340615 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0339793 |
| DENND4A | DENN/MADD domain containing 4A | 0.033769 |
| PHF3 | PHD finger protein 3 | 0.0334082 |
| JMJD1C | jumonji domain containing 1C | 0.0333672 |
| RUNX1 | runt-related transcription factor 1 | 0.0333508 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0331661 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0327745 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0325951 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0323391 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0319734 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0318333 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0315858 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.0315685 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0314822 |
| SNX14 | sorting nexin 14 | 0.0314562 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0313956 |
| XRN2 | 5'-3' exoribonuclease 2 | 0.0313552 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0313224 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.0312479 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0303581 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0303154 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | 0.0302364 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | 0.0301923 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0298917 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0297817 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.0297646 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.029407 |
| Symbol | Name | Standardized Value |
|---|---|---|
| LMO7 | LIM domain 7 | -0.16346 |
| MUC16 | mucin 16, cell surface associated | -0.105157 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0999658 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0966846 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.093738 |
| MYO1E | myosin IE | -0.084042 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0789852 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0750868 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0702589 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0678392 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | -0.0648944 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0633865 |
| FBXO11 | F-box protein 11 | -0.0579032 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0548286 |
| SVIL | supervillin | -0.0534139 |
| IGF1R | insulin-like growth factor 1 receptor | -0.052578 |
| HLA-B | major histocompatibility complex, class I, B | -0.051419 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0495873 |
| ANXA2 | annexin A2 | -0.048441 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | -0.0482217 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.047758 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0476424 |
| MMP1 | matrix metallopeptidase 1 | -0.0470031 |
| ACTG1 | actin gamma 1 | -0.0461729 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0459519 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0446921 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0444686 |
| C6ORF132 | chromosome 6 open reading frame 132 | -0.0439504 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0439208 |
| OSMR | oncostatin M receptor | -0.0435012 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0431566 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0430745 |
| ERBIN | erbb2 interacting protein | -0.0428738 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.0428385 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0424237 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0424028 |
| MUC13 | mucin 13, cell surface associated | -0.0415024 |
| MYO5B | myosin VB | -0.0404367 |
| VIM | vimentin | -0.0403238 |
| BPTF | bromodomain PHD finger transcription factor | -0.0402766 |
| ADAMTS12 | ADAM metallopeptidase with thrombospondin type 1 motif, 12 | -0.0402476 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0400001 |
| JUP | junction plakoglobin | -0.0395121 |
| AK1 | adenylate kinase 1 | -0.039304 |
| FOXP1 | forkhead box P1 | -0.03917 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | -0.038724 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.03861 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0374209 |
| PERP | PERP, TP53 apoptosis effector | -0.036991 |
| CDK14 | cyclin-dependent kinase 14 | -0.0369449 |
| S100A10 | S100 calcium binding protein A10 | -0.0362374 |
| MSI2 | musashi RNA-binding protein 2 | -0.0360787 |
| TSC22D1 | TSC22 domain family, member 1 | -0.0360001 |
| EGFR | epidermal growth factor receptor | -0.0359524 |
| TMOD3 | tropomodulin 3 (ubiquitous) | -0.0358678 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0346861 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0340165 |
| MT2A | metallothionein 2A | -0.0335411 |
| IGF2 | insulin-like growth factor 2 | -0.0334957 |
| HIPK2 | homeodomain interacting protein kinase 2 | -0.0333118 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | -0.0333106 |
| TNIK | TRAF2 and NCK interacting kinase | -0.0331499 |
| FHIT | fragile histidine triad | -0.0323712 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0320156 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0318437 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0317657 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0313886 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0312737 |
| RIGI | RNA sensor RIG-I | -0.0312068 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0312031 |
| FMN1 | formin 1 | -0.0309194 |
| BLTP1 | bridge-like lipid transfer protein family member 1 | -0.0304875 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0302409 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0302342 |
| NHSL1 | NHS-like 1 | -0.0301925 |
| PTMA | prothymosin, alpha | -0.0299729 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.029937 |
| RPS6 | ribosomal protein S6 | -0.0297859 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0295318 |
| CUX1 | cut-like homeobox 1 | -0.0294453 |
| ACTN4 | actinin, alpha 4 | -0.0293198 |
| ATXN1 | ataxin 1 | -0.0291907 |
| AHNAK | AHNAK nucleoprotein | -0.0291519 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0288497 |
| CDK6 | cyclin-dependent kinase 6 | -0.0287091 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.028704 |
| LDHA | lactate dehydrogenase A | -0.0287036 |
| NCOR2 | nuclear receptor corepressor 2 | -0.0285125 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0285022 |
| B2M | beta-2-microglobulin | -0.0284687 |
| SRPK2 | SRSF protein kinase 2 | -0.0284252 |
| MED13L | mediator complex subunit 13-like | -0.0279827 |
| HMGA2 | high mobility group AT-hook 2 | -0.0278888 |
| MAP7 | microtubule-associated protein 7 | -0.0276104 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0273448 |
| EIF2S3 | eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa | -0.0273076 |
| RPS8 | ribosomal protein S8 | -0.0272935 |
| WASF2 | WAS protein family, member 2 | -0.0271835 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0271498 |
| NUP98 | nucleoporin 98kDa | -0.0270827 |
