| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Larotrectinib sulfate perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Larotrectinib sulfate_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | 0.166805 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.145097 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.118238 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.116722 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.105025 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0989261 |
| RTN4 | reticulon 4 | 0.0790874 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0748787 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0688162 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0685827 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.062582 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0599403 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0571874 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0560536 |
| PHIP | pleckstrin homology domain interacting protein | 0.0543377 |
| MKI67 | marker of proliferation Ki-67 | 0.0528598 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0510865 |
| RPS3 | ribosomal protein S3 | 0.0483734 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0463834 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0459365 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0458334 |
| NCKAP1 | NCK-associated protein 1 | 0.0457704 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0455744 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0448939 |
| TPM3 | tropomyosin 3 | 0.0434998 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | 0.0419422 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.041388 |
| ANXA5 | annexin A5 | 0.0413222 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0409358 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0395803 |
| RASAL2 | RAS protein activator like 2 | 0.0394001 |
| ZFR | zinc finger RNA binding protein | 0.0390806 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0390635 |
| KIF5B | kinesin family member 5B | 0.0387708 |
| SET | SET nuclear proto-oncogene | 0.038047 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0371078 |
| TMEM41B | transmembrane protein 41B | 0.0369846 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0359507 |
| IPO7 | importin 7 | 0.0357544 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.0354278 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0349867 |
| PPME1 | protein phosphatase methylesterase 1 | 0.0341457 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.033831 |
| RNF145 | ring finger protein 145 | 0.0338121 |
| GRAMD1B | GRAM domain containing 1B | 0.0334263 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0332835 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | 0.0332131 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.033007 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0327826 |
| JMJD1C | jumonji domain containing 1C | 0.0327689 |
| PCBP2 | poly(rC) binding protein 2 | 0.0321849 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0320863 |
| OGA | O-GlcNAcase | 0.0320536 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0319481 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.0318869 |
| XPO1 | exportin 1 | 0.0318 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0317127 |
| GATAD2B | GATA zinc finger domain containing 2B | 0.0316699 |
| PGK1 | phosphoglycerate kinase 1 | 0.0314663 |
| ANO6 | anoctamin 6 | 0.0311572 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0311032 |
| ZNF292 | zinc finger protein 292 | 0.0309234 |
| RUSC2 | RUN and SH3 domain containing 2 | 0.0308475 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0308381 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0307376 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | 0.0303864 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0303814 |
| DENR | density-regulated protein | 0.0298316 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0298309 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0295161 |
| GOLGA4 | golgin A4 | 0.0294337 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0292734 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0291662 |
| LATS2 | large tumor suppressor kinase 2 | 0.0290686 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.029048 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0284807 |
| CENPF | centromere protein F, 350/400kDa | 0.0277859 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0277478 |
| SINHCAF | SIN3-HDAC complex associated factor | 0.0276601 |
| RNF38 | ring finger protein 38 | 0.0276522 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0274741 |
| SQSTM1 | sequestosome 1 | 0.0273733 |
| TAB2 | TGF-beta activated kinase 1/MAP3K7 binding protein 2 | 0.0273616 |
| SMAP1 | small ArfGAP 1 | 0.027183 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0271556 |
| RUNX1 | runt-related transcription factor 1 | 0.0268224 |
| COG5 | component of oligomeric golgi complex 5 | 0.0268029 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | 0.0266858 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0266734 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | 0.0265528 |
| CTTNBP2NL | CTTNBP2 N-terminal like | 0.0261202 |
| CLTC | clathrin, heavy chain (Hc) | 0.0261074 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0259874 |
| PNN | pinin, desmosome associated protein | 0.0259497 |
| TPR | translocated promoter region, nuclear basket protein | 0.0259424 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0258437 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0258183 |
| UBC | ubiquitin C | 0.0256524 |
| PLCB4 | phospholipase C, beta 4 | 0.0255605 |
| MAP3K14 | mitogen-activated protein kinase kinase kinase 14 | 0.0255334 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.177214 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.146843 |
| RAD51B | RAD51 paralog B | -0.116837 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0982278 |
| TMSB10 | thymosin beta 10 | -0.0908281 |
| MCL1 | myeloid cell leukemia 1 | -0.0800466 |
| PDE10A | phosphodiesterase 10A | -0.0752022 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0732788 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0731432 |
| AEBP2 | AE binding protein 2 | -0.0647439 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0638169 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0633343 |
| OSMR | oncostatin M receptor | -0.0626088 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0583423 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0577325 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0568763 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0522201 |
| ATXN1 | ataxin 1 | -0.0518109 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0516584 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0502518 |
| VCL | vinculin | -0.0498397 |
| RYR3 | ryanodine receptor 3 | -0.0469312 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | -0.0467534 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0463404 |
| HLA-B | major histocompatibility complex, class I, B | -0.0458331 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0452169 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0430367 |
| HMGA2 | high mobility group AT-hook 2 | -0.0428809 |
| INTS6 | integrator complex subunit 6 | -0.0428458 |
| WNT2B | wingless-type MMTV integration site family, member 2B | -0.0427191 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0425143 |
| PYGL | phosphorylase, glycogen, liver | -0.0421992 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | -0.0416054 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0413519 |
| EGFR | epidermal growth factor receptor | -0.0407188 |
| NF1 | neurofibromin 1 | -0.0404165 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0398808 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.039824 |
| RNF213 | ring finger protein 213 | -0.0398127 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0395737 |
| EGR1 | early growth response 1 | -0.0386501 |
| USP34 | ubiquitin specific peptidase 34 | -0.0382385 |
| NABP1 | nucleic acid binding protein 1 | -0.0369123 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0368165 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0367938 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0336182 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0332222 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | -0.0315348 |
| PRELID2 | PRELI domain containing 2 | -0.0309093 |
| DIAPH2 | diaphanous-related formin 2 | -0.0308943 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0307214 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0305873 |
| PRKCE | protein kinase C, epsilon | -0.0305459 |
| CUX1 | cut-like homeobox 1 | -0.0304225 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0298525 |
| WWOX | WW domain containing oxidoreductase | -0.0295866 |
| E2F3 | E2F transcription factor 3 | -0.0294437 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0282971 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0280707 |
| PPP1R10 | protein phosphatase 1, regulatory subunit 10 | -0.0278047 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0274787 |
| NLGN1 | neuroligin 1 | -0.0268887 |
| ATG7 | autophagy related 7 | -0.0268611 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | -0.0264515 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0252907 |
| MT2A | metallothionein 2A | -0.0252639 |
| TRMT11 | tRNA methyltransferase 11 homolog (S. cerevisiae) | -0.0249661 |
| TPM4 | tropomyosin 4 | -0.0248356 |
| CACNA1A | calcium channel, voltage-dependent, P/Q type, alpha 1A subunit | -0.0247781 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0247562 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0242692 |
| GPATCH2L | G patch domain containing 2-like | -0.0240778 |
| CDK12 | cyclin-dependent kinase 12 | -0.0239644 |
| NEK10 | NIMA-related kinase 10 | -0.0239467 |
| FARS2 | phenylalanyl-tRNA synthetase 2, mitochondrial | -0.0237288 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0236521 |
| FMNL2 | formin-like 2 | -0.0235667 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0233991 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0231319 |
| EHBP1 | EH domain binding protein 1 | -0.0228814 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | -0.0227854 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0227814 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0226901 |
| TPM2 | tropomyosin 2 (beta) | -0.0226168 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0220834 |
| HELZ2 | helicase with zinc finger 2, transcriptional coactivator | -0.0219813 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0219358 |
| BPTF | bromodomain PHD finger transcription factor | -0.0217257 |
| LOXL2 | lysyl oxidase-like 2 | -0.0216116 |
| FMN1 | formin 1 | -0.0215957 |
| GNAS | GNAS complex locus | -0.0214357 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0214132 |
| IER3 | immediate early response 3 | -0.0210145 |
| SCFD2 | sec1 family domain containing 2 | -0.0209498 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0208365 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0207832 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0206178 |
| CPNE1 | copine I | -0.0205438 |
| ETV6 | ets variant 6 | -0.0204827 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0200739 |
