| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Larotrectinib sulfate perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Larotrectinib sulfate_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.21483 |
| LAMB3 | laminin, beta 3 | 0.185802 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.151152 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.106338 |
| GRB10 | growth factor receptor-bound protein 10 | 0.095206 |
| LAMC2 | laminin, gamma 2 | 0.0951134 |
| NDRG1 | N-myc downstream regulated 1 | 0.0940588 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0936772 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0888032 |
| NAV2 | neuron navigator 2 | 0.0875925 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0867048 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0855561 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0838878 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0821667 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0813907 |
| DSPP | dentin sialophosphoprotein | 0.0783673 |
| PLEC | plectin | 0.0750652 |
| VEGFA | vascular endothelial growth factor A | 0.0697449 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0687896 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.060496 |
| FBXO32 | F-box protein 32 | 0.0603665 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.059935 |
| FAM13A | family with sequence similarity 13, member A | 0.0571334 |
| EFNA5 | ephrin-A5 | 0.056747 |
| ARRDC3 | arrestin domain containing 3 | 0.0551999 |
| CTSB | cathepsin B | 0.0546339 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0533959 |
| MSN | moesin | 0.0529387 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0514117 |
| FLNB | filamin B, beta | 0.0509187 |
| AHNAK | AHNAK nucleoprotein | 0.0504689 |
| SMAD3 | SMAD family member 3 | 0.050454 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0486034 |
| RAI14 | retinoic acid induced 14 | 0.0462649 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0460221 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0447393 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0438098 |
| EZR | ezrin | 0.0437492 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.043591 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0426072 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0425344 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0422418 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0420989 |
| RPS3 | ribosomal protein S3 | 0.0411172 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0407287 |
| TMF1 | TATA element modulatory factor 1 | 0.0403063 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0393055 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.037742 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0374611 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0366155 |
| CANX | calnexin | 0.0364322 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0363722 |
| TPM3 | tropomyosin 3 | 0.0359568 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0358884 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0358361 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.0357651 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0352793 |
| RPL14 | ribosomal protein L14 | 0.034971 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0345249 |
| FAM107B | family with sequence similarity 107, member B | 0.0335368 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0333887 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0333887 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0332067 |
| UBC | ubiquitin C | 0.0329211 |
| SBF2 | SET binding factor 2 | 0.0328976 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.032879 |
| CALR | calreticulin | 0.0326886 |
| KRT18 | keratin 18, type I | 0.032647 |
| PGK1 | phosphoglycerate kinase 1 | 0.0325448 |
| VIM | vimentin | 0.0323442 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 0.0314512 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | 0.0309292 |
| SEPTIN9 | septin 9 | 0.0305231 |
| TMSB4X | thymosin beta 4, X-linked | 0.0302157 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0301819 |
| CCNY | cyclin Y | 0.0298727 |
| APP | amyloid beta (A4) precursor protein | 0.0294126 |
| UPP1 | uridine phosphorylase 1 | 0.0293597 |
| ASPH | aspartate beta-hydroxylase | 0.028797 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0287587 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0282423 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0281956 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.028136 |
| PCBP2 | poly(rC) binding protein 2 | 0.0279008 |
| SQSTM1 | sequestosome 1 | 0.0275198 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0273948 |
| ATXN1 | ataxin 1 | 0.0273422 |
| SOX4 | SRY (sex determining region Y)-box 4 | 0.0273321 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0272639 |
| FLNA | filamin A, alpha | 0.0271431 |
| DUSP6 | dual specificity phosphatase 6 | 0.0271255 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0270288 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.0267417 |
| OPTN | optineurin | 0.0266797 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0265998 |
| FHIT | fragile histidine triad | 0.0264566 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0264284 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0259129 |
| ADAR | adenosine deaminase, RNA-specific | 0.0256247 |
| CCNG2 | cyclin G2 | 0.0255029 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.196225 |
| POTEF | POTE ankyrin domain family, member F | -0.111743 |
| TMSB10 | thymosin beta 10 | -0.090786 |
| RPL35A | ribosomal protein L35a | -0.0666675 |
| ACTG1 | actin gamma 1 | -0.0666264 |
| HMGA1 | high mobility group AT-hook 1 | -0.0621616 |
| FTL | ferritin, light polypeptide | -0.0589882 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0581602 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0512798 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0507345 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0486436 |
| RPL34 | ribosomal protein L34 | -0.0453839 |
| RPLP1 | ribosomal protein, large, P1 | -0.0447423 |
| S100A6 | S100 calcium binding protein A6 | -0.0405852 |
| CCND1 | cyclin D1 | -0.0405835 |
| ARF1 | ADP-ribosylation factor 1 | -0.0354705 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0330348 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0330144 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0326185 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0316176 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0314037 |
| ERBIN | erbb2 interacting protein | -0.0304063 |
| S100A10 | S100 calcium binding protein A10 | -0.0301763 |
| RPL8 | ribosomal protein L8 | -0.0298999 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0294178 |
| RPS24 | ribosomal protein S24 | -0.0286631 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.02794 |
| RPL30 | ribosomal protein L30 | -0.0276838 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0271908 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.026705 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0265361 |
| GNAS | GNAS complex locus | -0.0265311 |
| RPL23 | ribosomal protein L23 | -0.0264322 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0242681 |
| RPLP2 | ribosomal protein, large, P2 | -0.024181 |
| CRABP2 | cellular retinoic acid binding protein 2 | -0.024028 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0230632 |
| RPLP0 | ribosomal protein, large, P0 | -0.0227135 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0226937 |
| USP15 | ubiquitin specific peptidase 15 | -0.0221973 |
| PALLD | palladin, cytoskeletal associated protein | -0.0220389 |
| HMGB1 | high mobility group box 1 | -0.0218913 |
| CTSD | cathepsin D | -0.0215534 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0210689 |
| OCLN | occludin | -0.0209622 |
| PPP2CA | protein phosphatase 2, catalytic subunit, alpha isozyme | -0.0208976 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0208585 |
| EGR1 | early growth response 1 | -0.0206639 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0203937 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0203305 |
| TMEM123 | transmembrane protein 123 | -0.0203215 |
| RPS5 | ribosomal protein S5 | -0.0203139 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0202713 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | -0.0201924 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0200516 |
| ZNF644 | zinc finger protein 644 | -0.019769 |
| RHEB | Ras homolog enriched in brain | -0.0197651 |
| TXNRD1 | thioredoxin reductase 1 | -0.0195571 |
| S100A9 | S100 calcium binding protein A9 | -0.0194904 |
| RLF | rearranged L-myc fusion | -0.0193972 |
| PEG10 | paternally expressed 10 | -0.0193475 |
| FBXO11 | F-box protein 11 | -0.0192315 |
| FBXO34 | F-box protein 34 | -0.0191845 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0191695 |
| IFRD1 | interferon-related developmental regulator 1 | -0.019117 |
| PLAU | plasminogen activator, urokinase | -0.018899 |
| RYBP | RING1 and YY1 binding protein | -0.0186789 |
| WWC1 | WW and C2 domain containing 1 | -0.0181682 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0180965 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0180511 |
| RPS25 | ribosomal protein S25 | -0.018045 |
| RPL28 | ribosomal protein L28 | -0.0179138 |
| OSMR | oncostatin M receptor | -0.0179081 |
| RPS13 | ribosomal protein S13 | -0.0178655 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | -0.0178188 |
| ZNF207 | zinc finger protein 207 | -0.0178108 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0176533 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0176239 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0175111 |
| TJP1 | tight junction protein 1 | -0.0174665 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0174115 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0172231 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0170612 |
| ZNF292 | zinc finger protein 292 | -0.0167205 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0166561 |
| RPS21 | ribosomal protein S21 | -0.0164736 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.016465 |
| RPS15 | ribosomal protein S15 | -0.0161699 |
| RPS23 | ribosomal protein S23 | -0.0159677 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0159203 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0159077 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0158299 |
| DEK | DEK proto-oncogene | -0.0158251 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.0157679 |
| RPL9 | ribosomal protein L9 | -0.0156595 |
| RPS19 | ribosomal protein S19 | -0.015385 |
| PFN1 | profilin 1 | -0.0153601 |
| RPL31 | ribosomal protein L31 | -0.0152169 |
| OSBPL3 | oxysterol binding protein-like 3 | -0.0152117 |
| CERT1 | ceramide transporter 1 | -0.015009 |
