| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Larotrectinib sulfate perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Larotrectinib sulfate_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GRAMD1B | GRAM domain containing 1B | 0.100092 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0857087 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0674546 |
| EFNA5 | ephrin-A5 | 0.0630611 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | 0.0618362 |
| ASPH | aspartate beta-hydroxylase | 0.0601952 |
| PCBP3 | poly(rC) binding protein 3 | 0.058063 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0568448 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0504643 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0469766 |
| PDE10A | phosphodiesterase 10A | 0.0439103 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.0424555 |
| FLNB | filamin B, beta | 0.0414255 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0407659 |
| PYGL | phosphorylase, glycogen, liver | 0.0403387 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0400761 |
| FNIP1 | folliculin interacting protein 1 | 0.0394785 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0382221 |
| NRCAM | neuronal cell adhesion molecule | 0.0363582 |
| FMNL2 | formin-like 2 | 0.0325627 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0313187 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0301192 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0288075 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0276717 |
| EXOC4 | exocyst complex component 4 | 0.0274586 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0267283 |
| NEK7 | NIMA-related kinase 7 | 0.0245386 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0240294 |
| ANTXR1 | anthrax toxin receptor 1 | 0.0224369 |
| PRELID2 | PRELI domain containing 2 | 0.0217595 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.021749 |
| SLC16A6 | solute carrier family 16, member 6 | 0.0215285 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0214545 |
| NONO | non-POU domain containing, octamer-binding | 0.021169 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0209434 |
| VPS13C | vacuolar protein sorting 13 homolog C (S. cerevisiae) | 0.0205969 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | 0.0200093 |
| MLKL | mixed lineage kinase domain-like | 0.0199177 |
| SQSTM1 | sequestosome 1 | 0.019671 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0193508 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0190068 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0189538 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0188936 |
| AHNAK | AHNAK nucleoprotein | 0.0187821 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0184938 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0184608 |
| AVL9 | AVL9 homolog (S. cerevisiase) | 0.0178515 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0177878 |
| SDCCAG8 | serologically defined colon cancer antigen 8 | 0.0175037 |
| APP | amyloid beta (A4) precursor protein | 0.0174155 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0170422 |
| DNAH14 | dynein, axonemal, heavy chain 14 | 0.0170284 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.0167769 |
| SEPTIN10 | septin 10 | 0.0165076 |
| VPS41 | vacuolar protein sorting 41 homolog (S. cerevisiae) | 0.0164491 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0161346 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0160558 |
| ANO6 | anoctamin 6 | 0.0157494 |
| TGFBR1 | transforming growth factor, beta receptor 1 | 0.0156376 |
| HDAC4 | histone deacetylase 4 | 0.0154405 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | 0.0153794 |
| GDA | guanine deaminase | 0.0153226 |
| DST | dystonin | 0.0153185 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0149508 |
| H1-4 | H1.4 linker histone, cluster member | 0.0148734 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0148427 |
| AOPEP | aminopeptidase O (putative) | 0.0145638 |
| PPFIA4 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 | 0.0145609 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | 0.01451 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0144195 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | 0.0142344 |
| UMAD1 | UBAP1-MVB12-associated (UMA) domain containing 1 | 0.0139513 |
| NBEAL1 | neurobeachin-like 1 | 0.0137456 |
| MSN | moesin | 0.0134037 |
| IGF2R | insulin-like growth factor 2 receptor | 0.0132474 |
| ANKRD36C | ankyrin repeat domain 36C | 0.013215 |
| MYOF | myoferlin | 0.0131331 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0131127 |
| RAD51B | RAD51 paralog B | 0.0130084 |
| FAM219A | family with sequence similarity 219, member A | 0.0129352 |
| UTY | ubiquitously transcribed tetratricopeptide repeat containing, Y-linked | 0.0129045 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0128524 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0128048 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0127858 |
| RPL3 | ribosomal protein L3 | 0.0127765 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0127084 |
| NHSL1 | NHS-like 1 | 0.0127029 |
| TNFRSF19 | tumor necrosis factor receptor superfamily, member 19 | 0.0126157 |
| CEP170 | centrosomal protein 170kDa | 0.0124184 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0123636 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0122975 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0121758 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.0121015 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.0120613 |
| PLEC | plectin | 0.0120148 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0119434 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0117913 |
| PHF3 | PHD finger protein 3 | 0.011784 |
| NGLY1 | N-glycanase 1 | 0.0117417 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0117226 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.402186 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.201654 |
| TMSB10 | thymosin beta 10 | -0.145141 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.127394 |
| VIM | vimentin | -0.116811 |
| FTL | ferritin, light polypeptide | -0.106113 |
| RPLP1 | ribosomal protein, large, P1 | -0.104336 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0954176 |
| RPS6 | ribosomal protein S6 | -0.0874478 |
| PTMA | prothymosin, alpha | -0.0847889 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.080273 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0758774 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0702592 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.070001 |
| RPL35A | ribosomal protein L35a | -0.0680258 |
| RPS19 | ribosomal protein S19 | -0.0666307 |
| B2M | beta-2-microglobulin | -0.0636017 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0599475 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0590483 |
| RPS8 | ribosomal protein S8 | -0.0589854 |
| RPL31 | ribosomal protein L31 | -0.0584988 |
| RPS23 | ribosomal protein S23 | -0.0570018 |
| GNAS | GNAS complex locus | -0.0559361 |
| RPS24 | ribosomal protein S24 | -0.0528291 |
| S100A6 | S100 calcium binding protein A6 | -0.0518194 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.051634 |
| RPLP0 | ribosomal protein, large, P0 | -0.0515511 |
| RPL12 | ribosomal protein L12 | -0.0515308 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0512379 |
| HLA-A | major histocompatibility complex, class I, A | -0.0505356 |
| PM20D1 | peptidase M20 domain containing 1 | -0.0499328 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.0486307 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0483898 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0472671 |
| RPS12 | ribosomal protein S12 | -0.0470176 |
| S100A10 | S100 calcium binding protein A10 | -0.046886 |
| PKM | pyruvate kinase, muscle | -0.046864 |
| RPS14 | ribosomal protein S14 | -0.0457314 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0455102 |
| LDHA | lactate dehydrogenase A | -0.0452609 |
| RPL37A | ribosomal protein L37a | -0.0440372 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.043691 |
| EGR1 | early growth response 1 | -0.0425147 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0415983 |
| RPL19 | ribosomal protein L19 | -0.0410084 |
| RPL23 | ribosomal protein L23 | -0.0408768 |
| DPP10 | dipeptidyl-peptidase 10 (non-functional) | -0.0407242 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.0407014 |
| UBC | ubiquitin C | -0.0404246 |
| RPLP2 | ribosomal protein, large, P2 | -0.0402885 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0399297 |
| RPS16 | ribosomal protein S16 | -0.0396051 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0393121 |
| HLA-B | major histocompatibility complex, class I, B | -0.0393028 |
| ENO1 | enolase 1, (alpha) | -0.0389401 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0383297 |
| RPL34 | ribosomal protein L34 | -0.0380293 |
| RPL36 | ribosomal protein L36 | -0.0370402 |
| RPS25 | ribosomal protein S25 | -0.0368557 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0368042 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0367749 |
| RPL26 | ribosomal protein L26 | -0.0366167 |
| CANX | calnexin | -0.0362048 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0361278 |
| COL5A2 | collagen, type V, alpha 2 | -0.0360905 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0359495 |
| RPL36A | ribosomal protein L36a | -0.0357596 |
| RPS27 | ribosomal protein S27 | -0.0352868 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0352331 |
| RPS29 | ribosomal protein S29 | -0.0350336 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0346412 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0344148 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0334941 |
| RPS21 | ribosomal protein S21 | -0.0332318 |
| NUP58 | nucleoporin 58 | -0.0332047 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.033154 |
| RPL9 | ribosomal protein L9 | -0.0328633 |
| VCL | vinculin | -0.0325877 |
| RPS13 | ribosomal protein S13 | -0.0322885 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0321751 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | -0.0320452 |
| RPL28 | ribosomal protein L28 | -0.0312501 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0309583 |
| MT2A | metallothionein 2A | -0.0308055 |
| ASTN2 | astrotactin 2 | -0.030605 |
| RPL11 | ribosomal protein L11 | -0.0302701 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.030269 |
| PCBP2 | poly(rC) binding protein 2 | -0.0302363 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0302319 |
| RPL37 | ribosomal protein L37 | -0.0298801 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0298764 |
| PFN1 | profilin 1 | -0.0297364 |
| RPS27A | ribosomal protein S27a | -0.0297199 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0296872 |
| STC1 | stanniocalcin 1 | -0.0294442 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0293154 |
| ANXA2 | annexin A2 | -0.0287495 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -0.0286609 |
| POTEF | POTE ankyrin domain family, member F | -0.028443 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0284281 |
