| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Larotrectinib sulfate perturbation in NCI-H596 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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140 genes differentially expressed following the Larotrectinib sulfate_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.246181 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.189854 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.175957 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.171896 |
| DST | dystonin | 0.132695 |
| FMNL2 | formin-like 2 | 0.121775 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.11572 |
| PGK1 | phosphoglycerate kinase 1 | 0.115348 |
| NAV2 | neuron navigator 2 | 0.114723 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.105861 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.103378 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0916987 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0909037 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0908982 |
| EFNA5 | ephrin-A5 | 0.0802207 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0714506 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0652048 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0646834 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0644001 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0631371 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0610306 |
| RORA | RAR-related orphan receptor A | 0.060687 |
| SMAD3 | SMAD family member 3 | 0.0589734 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0538858 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0527924 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0519653 |
| LRCH3 | leucine-rich repeats and calponin homology (CH) domain containing 3 | 0.0506657 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0467291 |
| PDE8A | phosphodiesterase 8A | 0.045863 |
| GNAQ | guanine nucleotide binding protein (G protein), q polypeptide | 0.0455966 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0448216 |
| PRELID2 | PRELI domain containing 2 | 0.0444924 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0443038 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0442151 |
| CDC73 | cell division cycle 73 | 0.0438507 |
| MT2A | metallothionein 2A | 0.0435386 |
| PRRC2C | proline-rich coiled-coil 2C | 0.042755 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0420631 |
| PCDH7 | protocadherin 7 | 0.0417339 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0406442 |
| NR6A1 | nuclear receptor subfamily 6, group A, member 1 | 0.0399784 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0394317 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0381442 |
| RBM33 | RNA binding motif protein 33 | 0.0350245 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0343062 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0303582 |
| GOLGA4 | golgin A4 | 0.0290316 |
| ASPH | aspartate beta-hydroxylase | 0.02875 |
| EGFR | epidermal growth factor receptor | 0.028645 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0277486 |
| PDGFC | platelet derived growth factor C | 0.0255518 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.023638 |
| VCL | vinculin | 0.0220525 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0206137 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0196529 |
| KMT2A | lysine (K)-specific methyltransferase 2A | 0.0192218 |
| CCNY | cyclin Y | 0.0175865 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0169467 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.016946 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | 0.0166464 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0153207 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | 0.010978 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.00853235 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.00707068 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.00706688 |
| GRB10 | growth factor receptor-bound protein 10 | 0.00590457 |
| USP34 | ubiquitin specific peptidase 34 | 0.00573487 |
| CADM2 | cell adhesion molecule 2 | 0.00565947 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.00436022 |
| ARRDC3 | arrestin domain containing 3 | 0.00277946 |
| CD44 | CD44 molecule (Indian blood group) | 0.00261154 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.00148999 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.259626 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.204802 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.179403 |
| NDRG1 | N-myc downstream regulated 1 | -0.174763 |
| FN1 | fibronectin 1 | -0.17045 |
| JMJD1C | jumonji domain containing 1C | -0.130235 |
| MYO1E | myosin IE | -0.12653 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | -0.117507 |
| STC1 | stanniocalcin 1 | -0.113325 |
| PTMA | prothymosin, alpha | -0.107361 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.101422 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.101166 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0908353 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0883765 |
| GOLGB1 | golgin B1 | -0.0865999 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.085822 |
| PARD3 | par-3 family cell polarity regulator | -0.0838161 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0831145 |
| IGF2 | insulin-like growth factor 2 | -0.0806398 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0690917 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0683546 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.060521 |
| INHBA | inhibin, beta A | -0.0603502 |
| HMGA2 | high mobility group AT-hook 2 | -0.0583436 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | -0.0559162 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0557894 |
| ATP11A | ATPase, class VI, type 11A | -0.0509326 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0506344 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0461304 |
| PKM | pyruvate kinase, muscle | -0.0423818 |
| PTK2 | protein tyrosine kinase 2 | -0.0399292 |
| PDE10A | phosphodiesterase 10A | -0.0392884 |
| SMYD3 | SET and MYND domain containing 3 | -0.0381833 |
| TMSB10 | thymosin beta 10 | -0.0378068 |
| SETD5 | SET domain containing 5 | -0.0363013 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0350158 |
| GPC6 | glypican 6 | -0.0347065 |
| NF1 | neurofibromin 1 | -0.0328077 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0326591 |
| ATXN1 | ataxin 1 | -0.0320165 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0316161 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | -0.0299814 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0295421 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0258078 |
| COPA | coatomer protein complex, subunit alpha | -0.0254963 |
| SHB | Src homology 2 domain containing adaptor protein B | -0.0240351 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0237437 |
| HPCAL1 | hippocalcin-like 1 | -0.0208933 |
| FAM13A | family with sequence similarity 13, member A | -0.0203834 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0195892 |
| ZNF292 | zinc finger protein 292 | -0.0187218 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0180983 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0172413 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0171438 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0165662 |
| NLGN1 | neuroligin 1 | -0.0152446 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0151423 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0145692 |
| BBX | bobby sox homolog (Drosophila) | -0.0139256 |
| PRKCA | protein kinase C, alpha | -0.00918288 |
| ANXA2 | annexin A2 | -0.00825488 |
| ERBIN | erbb2 interacting protein | -0.00754232 |
| UBE2O | ubiquitin-conjugating enzyme E2O | -0.00738437 |
| ZNF608 | zinc finger protein 608 | -0.00687267 |
| RRBP1 | ribosome binding protein 1 | -0.00661514 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.00346111 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.00312726 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0013803 |
