| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Larotrectinib sulfate perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Larotrectinib sulfate_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.124697 |
| COL5A2 | collagen, type V, alpha 2 | 0.103496 |
| DST | dystonin | 0.0986771 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | 0.0896843 |
| ZNF292 | zinc finger protein 292 | 0.0840099 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0671599 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | 0.0649811 |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | 0.0645247 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.064253 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0600881 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | 0.0569495 |
| GPC3 | glypican 3 | 0.0564304 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0530657 |
| COL11A1 | collagen, type XI, alpha 1 | 0.049755 |
| CFL2 | cofilin 2 (muscle) | 0.0496057 |
| MYO10 | myosin X | 0.0483264 |
| ITGAV | integrin, alpha V | 0.0480258 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0474302 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.0471249 |
| SHROOM3 | shroom family member 3 | 0.0467641 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.045034 |
| FOXG1 | forkhead box G1 | 0.0448374 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0437486 |
| JMJD1C | jumonji domain containing 1C | 0.0430948 |
| COL3A1 | collagen, type III, alpha 1 | 0.041223 |
| PCBP2 | poly(rC) binding protein 2 | 0.038486 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0372818 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0372017 |
| NCKAP1 | NCK-associated protein 1 | 0.0371608 |
| GASK1B | golgi associated kinase 1B | 0.0368155 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0366139 |
| MB21D2 | Mab-21 domain containing 2 | 0.0359889 |
| KCTD16 | potassium channel tetramerization domain containing 16 | 0.0350911 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | 0.0350315 |
| KIF1B | kinesin family member 1B | 0.0347708 |
| CABLES1 | Cdk5 and Abl enzyme substrate 1 | 0.0344128 |
| SKIC3 | SKI3 subunit of superkiller complex | 0.0343557 |
| ZC3H12B | zinc finger CCCH-type containing 12B | 0.034305 |
| PLEKHB2 | pleckstrin homology domain containing, family B (evectins) member 2 | 0.0340246 |
| NCOA2 | nuclear receptor coactivator 2 | 0.033906 |
| PCDH18 | protocadherin 18 | 0.032731 |
| PARD3B | par-3 family cell polarity regulator beta | 0.0327146 |
| SERINC1 | serine incorporator 1 | 0.0324679 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0320683 |
| CADM2 | cell adhesion molecule 2 | 0.0319397 |
| SMYD3 | SET and MYND domain containing 3 | 0.0309811 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0309424 |
| QKI | QKI, KH domain containing, RNA binding | 0.0307522 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0300834 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0297405 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0295804 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.0294417 |
| ARHGAP15 | Rho GTPase activating protein 15 | 0.0292637 |
| LRRC4C | leucine rich repeat containing 4C | 0.0292177 |
| SPAG9 | sperm associated antigen 9 | 0.0287309 |
| CAMKMT | calmodulin-lysine N-methyltransferase | 0.0285554 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0279362 |
| H1-4 | H1.4 linker histone, cluster member | 0.0278428 |
| VGLL4 | vestigial-like family member 4 | 0.0275717 |
| WDR43 | WD repeat domain 43 | 0.0270938 |
| PPM1B | protein phosphatase, Mg2+/Mn2+ dependent, 1B | 0.0268032 |
| SLK | STE20-like kinase | 0.0267672 |
| CALCR | calcitonin receptor | 0.026416 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.026256 |
| RHOH | ras homolog family member H | 0.0262542 |
| UTRN | utrophin | 0.0259712 |
| FNIP1 | folliculin interacting protein 1 | 0.0257684 |
| SEMA3E | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E | 0.0254973 |
| TENM3 | teneurin transmembrane protein 3 | 0.0253183 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0252233 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0250834 |
| STT3B | STT3B, subunit of the oligosaccharyltransferase complex (catalytic) | 0.0249549 |
| APP | amyloid beta (A4) precursor protein | 0.0249324 |
| KLHL5 | kelch-like family member 5 | 0.024599 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0245649 |
| NCOA1 | nuclear receptor coactivator 1 | 0.0243722 |
| EXOC6B | exocyst complex component 6B | 0.0243081 |
| MSN | moesin | 0.0242656 |
| PDS5B | PDS5 cohesin associated factor B | 0.0242407 |
| XPO1 | exportin 1 | 0.0242191 |
| PGK1 | phosphoglycerate kinase 1 | 0.024179 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0240865 |
| EXOC4 | exocyst complex component 4 | 0.024004 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0237598 |
| YAP1 | Yes-associated protein 1 | 0.0234179 |
| CASC3 | cancer susceptibility candidate 3 | 0.0233769 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0233578 |
| ATP11B | ATPase, class VI, type 11B | 0.0232183 |
| DMXL1 | Dmx-like 1 | 0.0230698 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0230509 |
| LCA5 | Leber congenital amaurosis 5 | 0.0230288 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0229471 |
| MIER1 | mesoderm induction early response 1, transcriptional regulator | 0.0229256 |
| TBC1D12 | TBC1 domain family, member 12 | 0.0228232 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0227446 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0225742 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | 0.0225607 |
| UBE3A | ubiquitin protein ligase E3A | 0.0225507 |
| TARS1 | threonyl-tRNA synthetase 1 | 0.0224603 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0224241 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.184046 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.165487 |
| TMSB10 | thymosin beta 10 | -0.139852 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.11133 |
| ACTG1 | actin gamma 1 | -0.109555 |
| RPS8 | ribosomal protein S8 | -0.107995 |
| PTMA | prothymosin, alpha | -0.103448 |
| RPS16 | ribosomal protein S16 | -0.0935489 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0922425 |
| RPLP1 | ribosomal protein, large, P1 | -0.0847269 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0812784 |
| RPS6 | ribosomal protein S6 | -0.0742345 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0665726 |
| GNAS | GNAS complex locus | -0.0589945 |
| PCDH9 | protocadherin 9 | -0.0575885 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.057536 |
| NOP58 | NOP58 ribonucleoprotein | -0.0572069 |
| RPL35A | ribosomal protein L35a | -0.0567878 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0564496 |
| RPS24 | ribosomal protein S24 | -0.0557794 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0551353 |
| HSPB1 | heat shock 27kDa protein 1 | -0.050688 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0504676 |
| FOXP2 | forkhead box P2 | -0.0482459 |
| FTL | ferritin, light polypeptide | -0.047797 |
| FBL | fibrillarin | -0.0475859 |
| RPL12 | ribosomal protein L12 | -0.0470244 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0466941 |
| POTEF | POTE ankyrin domain family, member F | -0.0465703 |
| RBM25 | RNA binding motif protein 25 | -0.046389 |
| RPL31 | ribosomal protein L31 | -0.0457999 |
| S100A10 | S100 calcium binding protein A10 | -0.0456387 |
| RPL30 | ribosomal protein L30 | -0.0444262 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0443474 |
| RPS19 | ribosomal protein S19 | -0.0438845 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0433435 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0427204 |
| RPS25 | ribosomal protein S25 | -0.0426393 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0417282 |
| DEK | DEK proto-oncogene | -0.0414667 |
| GOLGA4 | golgin A4 | -0.04129 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0409675 |
| MKI67 | marker of proliferation Ki-67 | -0.0400007 |
| RPL37 | ribosomal protein L37 | -0.038594 |
| RPS21 | ribosomal protein S21 | -0.0383177 |
| MRPS30 | mitochondrial ribosomal protein S30 | -0.0382573 |
| THBS1 | thrombospondin 1 | -0.0379389 |
| ARF1 | ADP-ribosylation factor 1 | -0.0378986 |
| RPL8 | ribosomal protein L8 | -0.037632 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0374761 |
| RLF | rearranged L-myc fusion | -0.0373363 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.0371358 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | -0.0367606 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.0367285 |
| RPL38 | ribosomal protein L38 | -0.0361674 |
| RPL19 | ribosomal protein L19 | -0.0354699 |
| CAVIN1 | caveolae associated protein 1 | -0.0352772 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0352721 |
| PFN1 | profilin 1 | -0.0352068 |
| PUM1 | pumilio RNA-binding family member 1 | -0.0347673 |
| APOE | apolipoprotein E | -0.0347574 |
| HMGB1 | high mobility group box 1 | -0.0346192 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0341255 |
| SERF2 | small EDRK-rich factor 2 | -0.033979 |
| RPS15 | ribosomal protein S15 | -0.0338978 |
| RPS27 | ribosomal protein S27 | -0.0332942 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0330862 |
| INTS6 | integrator complex subunit 6 | -0.0330426 |
| SRP72 | signal recognition particle 72kDa | -0.0329026 |
| RPLP2 | ribosomal protein, large, P2 | -0.032833 |
| TXNRD1 | thioredoxin reductase 1 | -0.0327966 |
| RPS3 | ribosomal protein S3 | -0.0327345 |
| RACK1 | receptor for activated C kinase 1 | -0.032423 |
| BPTF | bromodomain PHD finger transcription factor | -0.0323693 |
| RPL28 | ribosomal protein L28 | -0.0323621 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0323467 |
| RPLP0 | ribosomal protein, large, P0 | -0.0318642 |
| RPS27A | ribosomal protein S27a | -0.0318138 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.0317479 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0316058 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.031404 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | -0.0311456 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0311293 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0309109 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0307112 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | -0.0304824 |
| RPL34 | ribosomal protein L34 | -0.0304362 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0302637 |
| SNX6 | sorting nexin 6 | -0.0301527 |
| FAM171B | family with sequence similarity 171, member B | -0.0301026 |
| URI1 | URI1, prefoldin-like chaperone | -0.0297679 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0296911 |
| RPL9 | ribosomal protein L9 | -0.0295723 |
| RPL11 | ribosomal protein L11 | -0.029537 |
| BSG | basigin (Ok blood group) | -0.0294729 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0294689 |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) | -0.0294547 |
| ACTN4 | actinin, alpha 4 | -0.0290466 |
| CDH19 | cadherin 19, type 2 | -0.0289457 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.028894 |
