Larotrectinib sulfate_PANC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Larotrectinib sulfate perturbation in PANC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Larotrectinib sulfate_PANC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.26587
TRIO trio Rho guanine nucleotide exchange factor 0.148602
VIM vimentin 0.141006
ERRFI1 ERBB receptor feedback inhibitor 1 0.11893
MYH9 myosin, heavy chain 9, non-muscle 0.116038
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.115874
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.10661
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.104409
SEPTIN9 septin 9 0.0988001
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0983916
FNDC3B fibronectin type III domain containing 3B 0.0904984
SMAD3 SMAD family member 3 0.088696
MACF1 microtubule-actin crosslinking factor 1 0.0821455
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0794287
CD44 CD44 molecule (Indian blood group) 0.0710529
AFAP1 actin filament associated protein 1 0.0627885
DST dystonin 0.0613905
ITGAV integrin, alpha V 0.0575704
BIRC2 baculoviral IAP repeat containing 2 0.0564088
NAP1L1 nucleosome assembly protein 1-like 1 0.0563383
OGA O-GlcNAcase 0.0553037
ACTN4 actinin, alpha 4 0.0551907
MYOF myoferlin 0.0511286
JMJD1C jumonji domain containing 1C 0.0506123
IGF1R insulin-like growth factor 1 receptor 0.0483065
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0482797
FMNL2 formin-like 2 0.0481087
AHNAK AHNAK nucleoprotein 0.0478952
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0476191
SFTPA2 surfactant protein A2 0.0475452
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0471052
THSD4 thrombospondin, type I, domain containing 4 0.0468654
DGKD diacylglycerol kinase, delta 130kDa 0.0437479
TPM1 tropomyosin 1 (alpha) 0.0434939
SPAG9 sperm associated antigen 9 0.0431068
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0421048
NAV2 neuron navigator 2 0.0405228
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0403157
PTMA prothymosin, alpha 0.040048
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0399057
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0385113
SYNJ2 synaptojanin 2 0.0377452
SBF2 SET binding factor 2 0.0375259
DNMBP dynamin binding protein 0.0375011
RPS3 ribosomal protein S3 0.037454
APP amyloid beta (A4) precursor protein 0.0372752
ANO6 anoctamin 6 0.0370162
RTN4 reticulon 4 0.035859
APLP2 amyloid beta (A4) precursor-like protein 2 0.0354777
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0354276
AHNAK2 AHNAK nucleoprotein 2 0.0349768
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 0.0348366
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0346915
SQSTM1 sequestosome 1 0.0345858
TMEM41B transmembrane protein 41B 0.0338413
AFDN afadin, adherens junction formation factor 0.0336584
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0333698
RB1CC1 RB1-inducible coiled-coil 1 0.0322768
ANGPTL4 angiopoietin-like 4 0.0322062
SERINC1 serine incorporator 1 0.0317335
KMT2A lysine (K)-specific methyltransferase 2A 0.030987
MED13L mediator complex subunit 13-like 0.0308414
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0308182
CDK19 cyclin-dependent kinase 19 0.0304419
COL18A1 collagen, type XVIII, alpha 1 0.0304408
RAP1B RAP1B, member of RAS oncogene family 0.0300776
IPO7 importin 7 0.0297629
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0291091
EGFR epidermal growth factor receptor 0.0289886
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0285314
CACNG8 calcium channel, voltage-dependent, gamma subunit 8 0.0280631
EPAS1 endothelial PAS domain protein 1 0.0277768
RNF213 ring finger protein 213 0.0271482
KTN1 kinectin 1 (kinesin receptor) 0.0271049
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0267362
TNIP1 TNFAIP3 interacting protein 1 0.0266324
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.026474
DHX32 DEAH (Asp-Glu-Ala-His) box polypeptide 32 0.0262679
ARRDC3 arrestin domain containing 3 0.0260981
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0260394
PRRC2C proline-rich coiled-coil 2C 0.0260271
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0259766
SMYD3 SET and MYND domain containing 3 0.0258197
ZNF780B zinc finger protein 780B 0.0256769
MCTP1 multiple C2 domains, transmembrane 1 0.0255551
FNIP1 folliculin interacting protein 1 0.025526
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0254237
KLF6 Kruppel-like factor 6 0.0252587
SRRM2 serine/arginine repetitive matrix 2 0.025087
PDE10A phosphodiesterase 10A 0.0248175
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0246639
CTTN cortactin 0.0246128
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 0.0245754
AKAP13 A kinase (PRKA) anchor protein 13 0.024571
ANKRD11 ankyrin repeat domain 11 0.024537
ACTG1 actin gamma 1 0.0244369
GRK5 G protein-coupled receptor kinase 5 0.0243823
PLEC plectin 0.0243702
KDM3A lysine (K)-specific demethylase 3A 0.0243035
ANXA2 annexin A2 0.0242106

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.165389
RPS16 ribosomal protein S16 -0.0723461
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0529389
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0447812
EGR1 early growth response 1 -0.0375327
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0371059
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0329544
PKM pyruvate kinase, muscle -0.0320189
MAP1B microtubule-associated protein 1B -0.0302342
HMGA1 high mobility group AT-hook 1 -0.0286801
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0286476
RPL35A ribosomal protein L35a -0.0250279
LOC112694756 uncharaterized LOC112694756 -0.024277
PDIA3 protein disulfide isomerase family A, member 3 -0.0229397
AKT2 v-akt murine thymoma viral oncogene homolog 2 -0.0228906
TMSB10 thymosin beta 10 -0.0222129
POTEF POTE ankyrin domain family, member F -0.0216096
FTL ferritin, light polypeptide -0.0207985
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 -0.0195616
EIF3K eukaryotic translation initiation factor 3, subunit K -0.0186364
PFN1 profilin 1 -0.0177014
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.0170495
INTS6 integrator complex subunit 6 -0.0168418
RPLP1 ribosomal protein, large, P1 -0.0166625
FTH1 ferritin, heavy polypeptide 1 -0.016575
IARS1 isoleucyl-tRNA synthetase 1 -0.0161184
LDHA lactate dehydrogenase A -0.0159693
HSPG2 heparan sulfate proteoglycan 2 -0.0157246
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0155162
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.015146
CTSD cathepsin D -0.014797
SPDYA speedy/RINGO cell cycle regulator family member A -0.0138536
MYADM myeloid-associated differentiation marker -0.0137215
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0136428
MAGT1 magnesium transporter 1 -0.0132556
NUP98 nucleoporin 98kDa -0.0130269
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0129597
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0128779
VDAC1 voltage-dependent anion channel 1 -0.0122922
ENO1 enolase 1, (alpha) -0.0122559
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0119787
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0114761
RNF220 ring finger protein 220 -0.0113547
ATP5F1B ATP synthase F1 subunit beta -0.0112046
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0110196
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) -0.010975
RAB7A RAB7A, member RAS oncogene family -0.0108841
TUBA1B tubulin, alpha 1b -0.010856
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0106654
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0105472
CARD18 caspase recruitment domain family, member 18 -0.0104363
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -0.0101366
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0100611
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0100528
SPINT2 serine peptidase inhibitor, Kunitz type, 2 -0.00996983
OSMR oncostatin M receptor -0.00989144
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.00981486
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.00976599
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.00974894
PPP1R10 protein phosphatase 1, regulatory subunit 10 -0.00971803
ATG7 autophagy related 7 -0.00959909
LAMA5 laminin, alpha 5 -0.00950053
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.00945872
ATF6 activating transcription factor 6 -0.0093813
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -0.00937608
IFITM3 interferon induced transmembrane protein 3 -0.0092879
HM13 histocompatibility (minor) 13 -0.0092403
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.00923152
RPL28 ribosomal protein L28 -0.00911874
ZNF546 zinc finger protein 546 -0.00910186
RPS24 ribosomal protein S24 -0.00902755
FBXO27 F-box protein 27 -0.00896007
SETX senataxin -0.00890951
COG5 component of oligomeric golgi complex 5 -0.00887709
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) -0.00883837
RPS25 ribosomal protein S25 -0.00880269
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.00878947
LGALS1 lectin, galactoside-binding, soluble, 1 -0.00876949
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) -0.00870933
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.00854964
SYNPO synaptopodin -0.00851608
BSG basigin (Ok blood group) -0.00838447
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.00832839
SRSF3 serine/arginine-rich splicing factor 3 -0.00831099
FASN fatty acid synthase -0.00812646
CAPZB capping protein (actin filament) muscle Z-line, beta -0.00802277
KRT19 keratin 19, type I -0.00799549
CRABP2 cellular retinoic acid binding protein 2 -0.00794583
RPL39 ribosomal protein L39 -0.00791294
CYCS cytochrome c, somatic -0.00783993
MYO1E myosin IE -0.00783905
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 -0.00778831
ZRANB3 zinc finger, RAN-binding domain containing 3 -0.00778267
S100A9 S100 calcium binding protein A9 -0.00778169
TWF1 twinfilin actin binding protein 1 -0.00777984
HCFC1 host cell factor C1 -0.00775272
C6ORF62 chromosome 6 open reading frame 62 -0.00763791
NFIX nuclear factor I/X (CCAAT-binding transcription factor) -0.0076278
ZNF207 zinc finger protein 207 -0.00760683
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.00754519