Larotrectinib sulfate_Panc 03.27 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Larotrectinib sulfate perturbation in Panc 03.27 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Larotrectinib sulfate_Panc 03.27 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LAMB3 laminin, beta 3 0.173029
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.15479
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.110257
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 0.0964229
LMO7 LIM domain 7 0.082124
EGFR epidermal growth factor receptor 0.0804773
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0788431
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0701456
MACF1 microtubule-actin crosslinking factor 1 0.0679771
C3 complement component 3 0.0616978
AKAP12 A kinase (PRKA) anchor protein 12 0.059974
DSPP dentin sialophosphoprotein 0.0597067
KTN1 kinectin 1 (kinesin receptor) 0.0587226
VEGFA vascular endothelial growth factor A 0.0571412
TGM2 transglutaminase 2 0.0569874
NAV2 neuron navigator 2 0.0560543
KRT18 keratin 18, type I 0.0545682
RPS3 ribosomal protein S3 0.0535242
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0517356
PCBP2 poly(rC) binding protein 2 0.0500267
MYH9 myosin, heavy chain 9, non-muscle 0.0490659
KRT17 keratin 17, type I 0.0489296
FTH1 ferritin, heavy polypeptide 1 0.0484057
CD47 CD47 molecule 0.0464956
FMNL2 formin-like 2 0.0456699
RIMKLB ribosomal modification protein rimK-like family member B 0.0440279
ARRDC3 arrestin domain containing 3 0.0420816
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0414305
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0411176
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0400836
BACE2 beta-site APP-cleaving enzyme 2 0.040066
SEPTIN9 septin 9 0.040019
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0399835
DSCAM Down syndrome cell adhesion molecule 0.039361
SOD2 superoxide dismutase 2, mitochondrial 0.0383528
KLHL24 kelch-like family member 24 0.0382882
RPS6 ribosomal protein S6 0.0381673
TMF1 TATA element modulatory factor 1 0.0374662
UGCG UDP-glucose ceramide glucosyltransferase 0.0369856
RIOK3 RIO kinase 3 0.0369288
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0369267
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0362927
THSD4 thrombospondin, type I, domain containing 4 0.0358701
EEF1G eukaryotic translation elongation factor 1 gamma 0.0354069
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0347779
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0344782
SAMD4A sterile alpha motif domain containing 4A 0.0334247
VIM vimentin 0.0327502
SET SET nuclear proto-oncogene 0.0314916
B2M beta-2-microglobulin 0.0312604
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0309417
KLF6 Kruppel-like factor 6 0.0308029
OPTN optineurin 0.0303595
EZR ezrin 0.0301066
CANX calnexin 0.0294188
DIAPH1 diaphanous-related formin 1 0.0291764
BRD4 bromodomain containing 4 0.0290773
ESYT2 extended synaptotagmin-like protein 2 0.0289502
SMOC1 SPARC related modular calcium binding 1 0.0287507
DUSP5 dual specificity phosphatase 5 0.0281224
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0277211
RICTOR RPTOR independent companion of MTOR, complex 2 0.0266791
RPL7 ribosomal protein L7 0.0264602
SYT14 synaptotagmin XIV 0.0264232
ZFP36L1 ZFP36 ring finger protein-like 1 0.0263758
GOLGB1 golgin B1 0.0257489
TIMP2 TIMP metallopeptidase inhibitor 2 0.0253332
APLP2 amyloid beta (A4) precursor-like protein 2 0.0252178
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.024982
FNIP1 folliculin interacting protein 1 0.0248387
SRRM2 serine/arginine repetitive matrix 2 0.0246079
AFF1 AF4/FMR2 family, member 1 0.0245608
HDGF hepatoma-derived growth factor 0.0234991
AKAP9 A kinase (PRKA) anchor protein 9 0.0232382
SOX4 SRY (sex determining region Y)-box 4 0.0231478
STC2 stanniocalcin 2 0.023139
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0231028
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0231024
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0230473
WWC1 WW and C2 domain containing 1 0.023002
SLK STE20-like kinase 0.0226956
DOCK5 dedicator of cytokinesis 5 0.0224586
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0224195
G0S2 G0/G1 switch 2 0.0224121
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0223975
DST dystonin 0.0223888
ERRFI1 ERBB receptor feedback inhibitor 1 0.0223654
PNN pinin, desmosome associated protein 0.0223519
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0222874
FRMD6 FERM domain containing 6 0.0221562
KYNU kynureninase 0.0219668
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0219238
CMIP c-Maf inducing protein 0.0217367
PHF3 PHD finger protein 3 0.0215024
SRI sorcin 0.0211815
SACK1A scaffolding CK1 anchoring protein A 0.0210948
FAM107B family with sequence similarity 107, member B 0.0210448
PDLIM5 PDZ and LIM domain 5 0.0206404
SVIL supervillin 0.0205615
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 0.0205601

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.336481
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.122444
TPT1 tumor protein, translationally-controlled 1 -0.111149
EMP1 epithelial membrane protein 1 -0.0847128
TM4SF1 transmembrane 4 L six family member 1 -0.0782756
EPS8 epidermal growth factor receptor pathway substrate 8 -0.071116
DLG1 discs, large homolog 1 (Drosophila) -0.0676574
ANXA2 annexin A2 -0.0664563
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0656655
LOC112694756 uncharaterized LOC112694756 -0.0625415
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0614953
ARHGAP26 Rho GTPase activating protein 26 -0.0610185
RBM39 RNA binding motif protein 39 -0.0593372
KRT8 keratin 8, type II -0.0593069
SMC4 structural maintenance of chromosomes 4 -0.0578374
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0569385
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0554043
RPS24 ribosomal protein S24 -0.0543459
NCOA7 nuclear receptor coactivator 7 -0.0529754
TMSB10 thymosin beta 10 -0.0528346
HLA-C major histocompatibility complex, class I, C -0.0511544
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0511243
TMSB4X thymosin beta 4, X-linked -0.0506354
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0498063
TMEM123 transmembrane protein 123 -0.0491733
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0473697
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0449686
RPL35A ribosomal protein L35a -0.0448666
EFNA5 ephrin-A5 -0.0443653
LAMA4 laminin, alpha 4 -0.0442874
EGR1 early growth response 1 -0.044203
CD2AP CD2-associated protein -0.0433364
FRMD5 FERM domain containing 5 -0.0419059
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0418126
RPLP1 ribosomal protein, large, P1 -0.0416858
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0414156
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0409629
VCL vinculin -0.04075
ECT2 epithelial cell transforming 2 -0.0399176
NF1 neurofibromin 1 -0.0397879
TSC22D2 TSC22 domain family, member 2 -0.038333
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0383094
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0377957
RUNX1 runt-related transcription factor 1 -0.0374021
ZFAND3 zinc finger, AN1-type domain 3 -0.0369462
NT5C2 5'-nucleotidase, cytosolic II -0.035744
SENP5 SUMO1/sentrin specific peptidase 5 -0.0357389
KDM3A lysine (K)-specific demethylase 3A -0.0356128
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0345912
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) -0.034393
WWTR1 WW domain containing transcription regulator 1 -0.0343745
MBNL1 muscleblind-like splicing regulator 1 -0.0343218
NRIP1 nuclear receptor interacting protein 1 -0.0338467
H1-0 H1.0 linker histone -0.0336428
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.03335
ANKRD10 ankyrin repeat domain 10 -0.0332244
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0326621
TFRC transferrin receptor -0.0324677
BIRC3 baculoviral IAP repeat containing 3 -0.0324605
ASPH aspartate beta-hydroxylase -0.0324226
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme -0.0320789
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0320308
OSBPL3 oxysterol binding protein-like 3 -0.0319532
HLA-B major histocompatibility complex, class I, B -0.0319109
SYNGAP1 synaptic Ras GTPase activating protein 1 -0.0318711
JMJD1C jumonji domain containing 1C -0.0318518
RYBP RING1 and YY1 binding protein -0.0314334
GPHN gephyrin -0.0314133
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.0312291
MACC1 metastasis associated in colon cancer 1 -0.0308195
RLF rearranged L-myc fusion -0.030765
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0306817
EHF ets homologous factor -0.0306128
ARF1 ADP-ribosylation factor 1 -0.0305023
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0304925
RTN4 reticulon 4 -0.0304085
RPL30 ribosomal protein L30 -0.0303922
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0295441
PTMA prothymosin, alpha -0.0294383
PLAT plasminogen activator, tissue -0.0293174
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0293142
ETV6 ets variant 6 -0.0292431
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0288122
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0287666
ARHGAP5 Rho GTPase activating protein 5 -0.0287625
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.028749
PTK2 protein tyrosine kinase 2 -0.0287277
RAD21 RAD21 homolog (S. pombe) -0.0286242
CSNK1A1 casein kinase 1, alpha 1 -0.0285416
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0284561
SPAG9 sperm associated antigen 9 -0.0282775
RPL34 ribosomal protein L34 -0.0282288
RPS5 ribosomal protein S5 -0.0277932
S100A6 S100 calcium binding protein A6 -0.0277923
TXNRD1 thioredoxin reductase 1 -0.027427
RRBP1 ribosome binding protein 1 -0.0269875
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.026807
SDC4 syndecan 4 -0.0267785
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0267039
CLTC clathrin, heavy chain (Hc) -0.0264882