| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Larotrectinib sulfate perturbation in RKO cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Larotrectinib sulfate_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LAMB3 | laminin, beta 3 | 0.174403 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.109852 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.075997 |
| AHNAK | AHNAK nucleoprotein | 0.0756761 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0674268 |
| ARHGAP22 | Rho GTPase activating protein 22 | 0.0669758 |
| RPS3 | ribosomal protein S3 | 0.0650344 |
| FLNA | filamin A, alpha | 0.0574972 |
| RPL14 | ribosomal protein L14 | 0.0567989 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0555081 |
| NAV2 | neuron navigator 2 | 0.0553723 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0539522 |
| CORO1C | coronin, actin binding protein, 1C | 0.0533817 |
| S100A2 | S100 calcium binding protein A2 | 0.0516063 |
| RPS4X | ribosomal protein S4, X-linked | 0.0509158 |
| RPL13A | ribosomal protein L13a | 0.0453169 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0448679 |
| EXOC4 | exocyst complex component 4 | 0.0442009 |
| SP100 | SP100 nuclear antigen | 0.0434037 |
| RPL7 | ribosomal protein L7 | 0.041089 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.04108 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0406397 |
| RPL4 | ribosomal protein L4 | 0.0405235 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0404408 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.039665 |
| PHC2 | polyhomeotic homolog 2 (Drosophila) | 0.0396002 |
| RIGI | RNA sensor RIG-I | 0.0388024 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0380712 |
| DST | dystonin | 0.0374034 |
| CAPRIN2 | caprin family member 2 | 0.0369962 |
| FHL2 | four and a half LIM domains 2 | 0.0365295 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0358117 |
| VIM | vimentin | 0.0357443 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0356572 |
| RPL26 | ribosomal protein L26 | 0.0346468 |
| CD44 | CD44 molecule (Indian blood group) | 0.0344586 |
| VCL | vinculin | 0.0337438 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0332658 |
| DLC1 | DLC1 Rho GTPase activating protein | 0.0326776 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | 0.0324777 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0322533 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.032182 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0311868 |
| FHIT | fragile histidine triad | 0.0306367 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0301354 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | 0.0290368 |
| FMNL2 | formin-like 2 | 0.0282447 |
| SERINC1 | serine incorporator 1 | 0.0277971 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0275464 |
| RPL12 | ribosomal protein L12 | 0.0271926 |
| ADAR | adenosine deaminase, RNA-specific | 0.0271627 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0266836 |
| RGMB | repulsive guidance molecule family member b | 0.0265451 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0264124 |
| TRAPPC9 | trafficking protein particle complex 9 | 0.026322 |
| HMGA2 | high mobility group AT-hook 2 | 0.0259287 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0258153 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0257991 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0254569 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0254398 |
| FEZ2 | fasciculation and elongation protein zeta 2 (zygin II) | 0.0254126 |
| ANXA2 | annexin A2 | 0.0252725 |
| OGA | O-GlcNAcase | 0.0251167 |
| RPS8 | ribosomal protein S8 | 0.0248975 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0247971 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0240342 |
| APP | amyloid beta (A4) precursor protein | 0.0233743 |
| POU2F1 | POU class 2 homeobox 1 | 0.0230274 |
| ZNF438 | zinc finger protein 438 | 0.0228225 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0225899 |
| EMP1 | epithelial membrane protein 1 | 0.0224583 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0222666 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | 0.0220162 |
| DGKI | diacylglycerol kinase, iota | 0.0219496 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0218749 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0216209 |
| RPL23 | ribosomal protein L23 | 0.0215246 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0212254 |
| ADTRP | androgen-dependent TFPI-regulating protein | 0.0211179 |
| CASC3 | cancer susceptibility candidate 3 | 0.0210516 |
| TDRD7 | tudor domain containing 7 | 0.0210251 |
| PCMTD1 | protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 | 0.0206439 |
| DNAH14 | dynein, axonemal, heavy chain 14 | 0.0205372 |
| MTAP | methylthioadenosine phosphorylase | 0.0204919 |
| EZR | ezrin | 0.0202245 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0201618 |
| GNAQ | guanine nucleotide binding protein (G protein), q polypeptide | 0.0200286 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0199808 |
| EGFR | epidermal growth factor receptor | 0.0198623 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.019618 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | 0.0194862 |
| GLIPR1 | GLI pathogenesis-related 1 | 0.0193476 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0192454 |
| PTMA | prothymosin, alpha | 0.0191425 |
| SMAD3 | SMAD family member 3 | 0.0190834 |
| ATP6V1C1 | ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 | 0.0190761 |
| FAM13A | family with sequence similarity 13, member A | 0.0190698 |
| ST13 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) | 0.0190401 |
| H1-0 | H1.0 linker histone | 0.0190176 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.018403 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | -0.143858 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.141463 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.118194 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.112784 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0970542 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0959824 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0894641 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0874009 |
| HDAC9 | histone deacetylase 9 | -0.0741727 |
| PTK2 | protein tyrosine kinase 2 | -0.0697484 |
| NAV3 | neuron navigator 3 | -0.0692399 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0681632 |
| ERBIN | erbb2 interacting protein | -0.0669599 |
| SETD5 | SET domain containing 5 | -0.0617147 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0614245 |
| CALU | calumenin | -0.0612782 |
| ACTG1 | actin gamma 1 | -0.0597453 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0575131 |
| PKM | pyruvate kinase, muscle | -0.0573983 |
| POTEF | POTE ankyrin domain family, member F | -0.0567836 |
| SEC24A | SEC24 family member A | -0.0551735 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0547163 |
| NUP58 | nucleoporin 58 | -0.0538618 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0535532 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0523412 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.051918 |
| RRBP1 | ribosome binding protein 1 | -0.0510687 |
| ATAD2 | ATPase family, AAA domain containing 2 | -0.0507416 |
| SRPK2 | SRSF protein kinase 2 | -0.0501273 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0500991 |
| NF1 | neurofibromin 1 | -0.0500293 |
| ZNF207 | zinc finger protein 207 | -0.0500269 |
| GOLGA4 | golgin A4 | -0.0499916 |
| JMJD1C | jumonji domain containing 1C | -0.0495344 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0489117 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0481263 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0477875 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0474953 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0473302 |
| PFN1 | profilin 1 | -0.047159 |
| TXNRD1 | thioredoxin reductase 1 | -0.0463782 |
| CREB5 | cAMP responsive element binding protein 5 | -0.0462978 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0462735 |
| DIAPH3 | diaphanous-related formin 3 | -0.0460783 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0441816 |
| HM13 | histocompatibility (minor) 13 | -0.0439568 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.043462 |
| FBXO11 | F-box protein 11 | -0.0433206 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0420419 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0416653 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0392392 |
| RPL8 | ribosomal protein L8 | -0.0391895 |
| HMGA1 | high mobility group AT-hook 1 | -0.0391321 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0390638 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0390071 |
| SET | SET nuclear proto-oncogene | -0.0387844 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0387566 |
| EGR1 | early growth response 1 | -0.0386294 |
| NDRG1 | N-myc downstream regulated 1 | -0.0382467 |
| ADNP | activity-dependent neuroprotector homeobox | -0.0382239 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0381616 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0380273 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0378293 |
| USP34 | ubiquitin specific peptidase 34 | -0.037574 |
| SEC24D | SEC24 family member D | -0.0369319 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.0368994 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0366307 |
| KRR1 | KRR1, small subunit (SSU) processome component, homolog (yeast) | -0.0365821 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0363411 |
| COG5 | component of oligomeric golgi complex 5 | -0.0362776 |
| SON | SON DNA binding protein | -0.0357081 |
| RBM25 | RNA binding motif protein 25 | -0.0356797 |
| FTL | ferritin, light polypeptide | -0.0355865 |
| RPL35 | ribosomal protein L35 | -0.035576 |
| STC1 | stanniocalcin 1 | -0.0354998 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | -0.0354091 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0351612 |
| CCDC88A | coiled-coil domain containing 88A | -0.0351066 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0350721 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | -0.0348303 |
| ANXA5 | annexin A5 | -0.0346237 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0343348 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | -0.0340843 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0338744 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | -0.0338517 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0338456 |
| UBE3C | ubiquitin protein ligase E3C | -0.0337888 |
| BRD4 | bromodomain containing 4 | -0.0337604 |
| WDR43 | WD repeat domain 43 | -0.0334739 |
| SRPK1 | SRSF protein kinase 1 | -0.0330042 |
| ZNF644 | zinc finger protein 644 | -0.0328698 |
| WNK1 | WNK lysine deficient protein kinase 1 | -0.0327056 |
| OLA1 | Obg-like ATPase 1 | -0.0326793 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0321581 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.032157 |
| OSBPL8 | oxysterol binding protein-like 8 | -0.0321439 |
| FUBP3 | far upstream element (FUSE) binding protein 3 | -0.0321034 |
| NABP1 | nucleic acid binding protein 1 | -0.0308648 |
| YARS1 | tyrosyl-tRNA synthetase 1 | -0.0308631 |
| MT1X | metallothionein 1X | -0.0307334 |
