| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Larotrectinib sulfate perturbation in RPMI-7951 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Larotrectinib sulfate_RPMI-7951 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | 0.415658 |
| FN1 | fibronectin 1 | 0.383059 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0644994 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0634409 |
| NAV2 | neuron navigator 2 | 0.0629991 |
| COL7A1 | collagen, type VII, alpha 1 | 0.0557704 |
| PGK1 | phosphoglycerate kinase 1 | 0.0525046 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0479083 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0475499 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0458552 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.04418 |
| ANTXR1 | anthrax toxin receptor 1 | 0.0435465 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0422094 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0402803 |
| HMGA2 | high mobility group AT-hook 2 | 0.0393975 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.039015 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0366483 |
| CD109 | CD109 molecule | 0.0359753 |
| FMNL2 | formin-like 2 | 0.0347246 |
| TGFBR1 | transforming growth factor, beta receptor 1 | 0.0338954 |
| FNIP1 | folliculin interacting protein 1 | 0.0326731 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.03142 |
| CENPF | centromere protein F, 350/400kDa | 0.031308 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0308903 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0308273 |
| APOLD1 | apolipoprotein L domain containing 1 | 0.030417 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0299549 |
| FLNA | filamin A, alpha | 0.029908 |
| AHNAK | AHNAK nucleoprotein | 0.0297688 |
| RAD51B | RAD51 paralog B | 0.0297181 |
| MMP14 | matrix metallopeptidase 14 (membrane-inserted) | 0.0296225 |
| CANX | calnexin | 0.0286444 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0272417 |
| CLIP4 | CAP-GLY domain containing linker protein family, member 4 | 0.0270453 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0270386 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | 0.0250026 |
| KYNU | kynureninase | 0.0249999 |
| COL4A2 | collagen, type IV, alpha 2 | 0.0245305 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0235952 |
| CTSB | cathepsin B | 0.0224262 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0222972 |
| FLNB | filamin B, beta | 0.0222288 |
| PLIN2 | perilipin 2 | 0.0220704 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0219884 |
| PRKCSH | protein kinase C substrate 80K-H | 0.0217895 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0217738 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0217288 |
| SERINC1 | serine incorporator 1 | 0.0216422 |
| TULP4 | tubby like protein 4 | 0.0212899 |
| MLPH | melanophilin | 0.0211813 |
| RFX8 | RFX family member 8, lacking RFX DNA binding domain | 0.0204772 |
| SKAP2 | src kinase associated phosphoprotein 2 | 0.0204671 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0204577 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0204333 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0203697 |
| CD44 | CD44 molecule (Indian blood group) | 0.0202653 |
| VCL | vinculin | 0.0200039 |
| PCBP3 | poly(rC) binding protein 3 | 0.0198872 |
| IFI44 | interferon-induced protein 44 | 0.0198405 |
| SUMF1 | sulfatase modifying factor 1 | 0.0198397 |
| RPL4 | ribosomal protein L4 | 0.0194709 |
| ATXN1 | ataxin 1 | 0.0192433 |
| SLC14A2 | solute carrier family 14 (urea transporter), member 2 | 0.0191434 |
| FBXO32 | F-box protein 32 | 0.0190635 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0187087 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0185047 |
| SYTL3 | synaptotagmin-like 3 | 0.0184472 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0182003 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0181873 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.0181848 |
| HDAC9 | histone deacetylase 9 | 0.0179335 |
| CUX1 | cut-like homeobox 1 | 0.0179034 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0178636 |
| MKI67 | marker of proliferation Ki-67 | 0.0178391 |
| RND3 | Rho family GTPase 3 | 0.0176313 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0174806 |
| TMEM178B | transmembrane protein 178B | 0.0174417 |
| DNER | delta/notch-like EGF repeat containing | 0.0173453 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0172885 |
| NCAM1 | neural cell adhesion molecule 1 | 0.0171447 |
| TNS3 | tensin 3 | 0.0169951 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0169185 |
| SNAPC1 | small nuclear RNA activating complex, polypeptide 1, 43kDa | 0.0168577 |
| FHIT | fragile histidine triad | 0.0168311 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0167707 |
| ANXA2 | annexin A2 | 0.016748 |
| OGA | O-GlcNAcase | 0.0167095 |
| LCORL | ligand dependent nuclear receptor corepressor-like | 0.0166358 |
| COL5A1 | collagen, type V, alpha 1 | 0.0165869 |
| SQSTM1 | sequestosome 1 | 0.0163659 |
| CKAP2L | cytoskeleton associated protein 2-like | 0.0162456 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0162258 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0159543 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0158375 |
| NAV1 | neuron navigator 1 | 0.0157105 |
| DIAPH3 | diaphanous-related formin 3 | 0.015635 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0155865 |
| CAVIN1 | caveolae associated protein 1 | 0.0153141 |
| SMOX | spermine oxidase | 0.0152017 |
| FOXN3 | forkhead box N3 | 0.0145883 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.188084 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.110651 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0766306 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0711902 |
| B2M | beta-2-microglobulin | -0.063628 |
| POTEF | POTE ankyrin domain family, member F | -0.0627698 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.0611646 |
| STC1 | stanniocalcin 1 | -0.0603961 |
| NDRG1 | N-myc downstream regulated 1 | -0.0587607 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0583006 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0564454 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0543476 |
| FRMD4A | FERM domain containing 4A | -0.0542517 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0495314 |
| EGR1 | early growth response 1 | -0.048519 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0450819 |
| GOLGA4 | golgin A4 | -0.0446103 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0409313 |
| COL1A1 | collagen, type I, alpha 1 | -0.0403648 |
| MEF2A | myocyte enhancer factor 2A | -0.0393781 |
| HLA-B | major histocompatibility complex, class I, B | -0.0392035 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0389168 |
| SEC24A | SEC24 family member A | -0.0359552 |
| CADM1 | cell adhesion molecule 1 | -0.0338494 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0337139 |
| NOP58 | NOP58 ribonucleoprotein | -0.0333674 |
| RBM39 | RNA binding motif protein 39 | -0.0320407 |
| TMSB10 | thymosin beta 10 | -0.0310177 |
| HM13 | histocompatibility (minor) 13 | -0.0310069 |
| RAB7A | RAB7A, member RAS oncogene family | -0.030362 |
| MT2A | metallothionein 2A | -0.0302334 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0300495 |
| FOSL1 | FOS-like antigen 1 | -0.0300172 |
| ECE1 | endothelin converting enzyme 1 | -0.0296801 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0292227 |
| MCTP2 | multiple C2 domains, transmembrane 2 | -0.0291369 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.028373 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0280845 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0280071 |
| TASOR2 | transcription activation suppressor family member 2 | -0.0278214 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0277451 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0274761 |
| KIF5B | kinesin family member 5B | -0.0264488 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0261652 |
| TFG | TRK-fused gene | -0.026155 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.0260362 |
| CLIC4 | chloride intracellular channel 4 | -0.0259278 |
| MED13L | mediator complex subunit 13-like | -0.0257345 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0256166 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0254647 |
| FTL | ferritin, light polypeptide | -0.025388 |
| SEPTIN7 | septin 7 | -0.0253134 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0253022 |
| PFN1 | profilin 1 | -0.025239 |
| RAB5A | RAB5A, member RAS oncogene family | -0.0248747 |
| RRBP1 | ribosome binding protein 1 | -0.0247506 |
| VEGFA | vascular endothelial growth factor A | -0.0246553 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | -0.0242686 |
| DENND4A | DENN/MADD domain containing 4A | -0.0242271 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0241524 |
| IL1B | interleukin 1, beta | -0.0240931 |
| LOX | lysyl oxidase | -0.024013 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0238347 |
| NUP58 | nucleoporin 58 | -0.0237675 |
| H1-0 | H1.0 linker histone | -0.023746 |
| CLINT1 | clathrin interactor 1 | -0.0235245 |
| MMP12 | matrix metallopeptidase 12 | -0.023508 |
| USP34 | ubiquitin specific peptidase 34 | -0.023438 |
| ZNF292 | zinc finger protein 292 | -0.0233912 |
| CHSY1 | chondroitin sulfate synthase 1 | -0.0231131 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0230404 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0229523 |
| MSR1 | macrophage scavenger receptor 1 | -0.0225778 |
| NF1 | neurofibromin 1 | -0.0224884 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0223992 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0222799 |
| ENO1 | enolase 1, (alpha) | -0.0219185 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.0214547 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0214228 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | -0.0214022 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0213265 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0212121 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0210649 |
| NBAS | neuroblastoma amplified sequence | -0.0209918 |
| SRP54 | signal recognition particle 54kDa | -0.0208277 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0207979 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.020694 |
| SENP5 | SUMO1/sentrin specific peptidase 5 | -0.0206631 |
| TNNC1 | troponin C type 1 (slow) | -0.0204316 |
| COG5 | component of oligomeric golgi complex 5 | -0.0204084 |
| GOLT1B | golgi transport 1B | -0.0203363 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0202909 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0200453 |
| DEK | DEK proto-oncogene | -0.0199973 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | -0.0199902 |
| PIBF1 | progesterone immunomodulatory binding factor 1 | -0.0199634 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | -0.0198561 |
| FBXO11 | F-box protein 11 | -0.0197997 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0197207 |
| TOP1 | topoisomerase (DNA) I | -0.0196857 |
