Larotrectinib sulfate_SHP-77 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Larotrectinib sulfate perturbation in SHP-77 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Larotrectinib sulfate_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE10A phosphodiesterase 10A 0.178446
SMOC1 SPARC related modular calcium binding 1 0.0861763
CENPF centromere protein F, 350/400kDa 0.0482049
SINHCAF SIN3-HDAC complex associated factor 0.040797
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0384777
BHLHE40 basic helix-loop-helix family, member e40 0.0338727
KDM3A lysine (K)-specific demethylase 3A 0.0324098
BTBD3 BTB (POZ) domain containing 3 0.0288504
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0280856
ELL2 elongation factor, RNA polymerase II, 2 0.0280622
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.026607
TOP2B topoisomerase (DNA) II beta 180kDa 0.0259419
JAM3 junctional adhesion molecule 3 0.0251476
CAMTA1 calmodulin binding transcription activator 1 0.0244459
ZNF292 zinc finger protein 292 0.0239109
CHD7 chromodomain helicase DNA binding protein 7 0.0238377
FAT1 FAT atypical cadherin 1 0.0236121
NCKAP1 NCK-associated protein 1 0.0230258
SSBP2 single-stranded DNA binding protein 2 0.0224299
RAD21 RAD21 homolog (S. pombe) 0.0223357
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0220321
AUH AU RNA binding protein/enoyl-CoA hydratase 0.021537
PCSK1 proprotein convertase subtilisin/kexin type 1 0.0214466
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0213842
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0213796
SYT13 synaptotagmin XIII 0.021307
CCNY cyclin Y 0.0209043
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.020611
PDS5B PDS5 cohesin associated factor B 0.0202825
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0200934
RNF145 ring finger protein 145 0.0199917
PDK4 pyruvate dehydrogenase kinase, isozyme 4 0.0198788
PUM2 pumilio RNA-binding family member 2 0.0196721
XPO1 exportin 1 0.0196702
NCAM1 neural cell adhesion molecule 1 0.0196044
MKI67 marker of proliferation Ki-67 0.0195733
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0194157
NAMPT nicotinamide phosphoribosyltransferase 0.0191568
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0190329
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0186559
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0186554
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0182133
KLHL24 kelch-like family member 24 0.0175794
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae) 0.0173323
BCLAF1 BCL2-associated transcription factor 1 0.0173034
PPME1 protein phosphatase methylesterase 1 0.0172337
PRKD1 protein kinase D1 0.0172285
ARHGAP32 Rho GTPase activating protein 32 0.0169681
KAT6A K(lysine) acetyltransferase 6A 0.016965
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0167884
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.016435
MIS18BP1 MIS18 binding protein 1 0.0160411
CKAP5 cytoskeleton associated protein 5 0.0159475
DPYSL3 dihydropyrimidinase-like 3 0.0159357
FNBP1L formin binding protein 1-like 0.0155821
SERINC1 serine incorporator 1 0.0153482
RB1CC1 RB1-inducible coiled-coil 1 0.0153328
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0151871
USP3 ubiquitin specific peptidase 3 0.0149879
PHIP pleckstrin homology domain interacting protein 0.0148873
MATR3 matrin 3 0.0147043
EMSY EMSY transcriptional repressor, BRCA2 interacting 0.014624
HP1BP3 heterochromatin protein 1, binding protein 3 0.0146128
H1-4 H1.4 linker histone, cluster member 0.0145299
DGKD diacylglycerol kinase, delta 130kDa 0.0144835
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0144416
ZDHHC20 zinc finger, DHHC-type containing 20 0.0142951
OGA O-GlcNAcase 0.013913
CDK8 cyclin-dependent kinase 8 0.0139086
FCHSD2 FCH and double SH3 domains 2 0.0138771
FMNL2 formin-like 2 0.0138515
IRS2 insulin receptor substrate 2 0.013818
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0137189
NR1D2 nuclear receptor subfamily 1, group D, member 2 0.0137046
PELI2 pellino E3 ubiquitin protein ligase family member 2 0.0133815
NUMA1 nuclear mitotic apparatus protein 1 0.0133168
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0133141
PHF3 PHD finger protein 3 0.0132682
BCL6 B-cell CLL/lymphoma 6 0.0131645
USP24 ubiquitin specific peptidase 24 0.0130696
ARGLU1 arginine and glutamate rich 1 0.0129608
MXI1 MAX interactor 1, dimerization protein 0.0128399
HMGN2 high mobility group nucleosomal binding domain 2 0.0128091
ANKRD28 ankyrin repeat domain 28 0.0127986
RSRC2 arginine/serine-rich coiled-coil 2 0.0127865
FNIP1 folliculin interacting protein 1 0.0127169
CASC3 cancer susceptibility candidate 3 0.0125314
MYEF2 myelin expression factor 2 0.012525
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) 0.0124914
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0124276
ANKH ANKH inorganic pyrophosphate transport regulator 0.0122679
CREBRF CREB3 regulatory factor 0.0122313
NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3 0.0122069
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 0.0121701
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0121558
CDK17 cyclin-dependent kinase 17 0.0121326
ADAM17 ADAM metallopeptidase domain 17 0.0121115
MARCHF6 membrane associated ring-CH-type finger 6 0.0120702
CCNL1 cyclin L1 0.011989
SPAG5 sperm associated antigen 5 0.0119828

decreased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.157095
GPC6 glypican 6 -0.139616
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.137857
ENO1 enolase 1, (alpha) -0.12667
NRG1 neuregulin 1 -0.108529
ACTG1 actin gamma 1 -0.0952136
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.083609
MCL1 myeloid cell leukemia 1 -0.0835609
IGFBP5 insulin-like growth factor binding protein 5 -0.0786146
EGR1 early growth response 1 -0.0777544
MAP1B microtubule-associated protein 1B -0.0681786
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0666786
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) -0.0650378
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2 -0.0630299
NKAIN2 Na+/K+ transporting ATPase interacting 2 -0.0607555
SNTG1 syntrophin, gamma 1 -0.0603979
LOC112694756 uncharaterized LOC112694756 -0.0603499
ESRRG estrogen-related receptor gamma -0.0600222
IGFBP2 insulin-like growth factor binding protein 2, 36kDa -0.0594366
TSHZ2 teashirt zinc finger homeobox 2 -0.0591321
FTL ferritin, light polypeptide -0.0563215
CALCA calcitonin-related polypeptide alpha -0.0560153
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.05501
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0535009
RIMS2 regulating synaptic membrane exocytosis 2 -0.0515958
NCKAP5 NCK-associated protein 5 -0.0502909
SMYD3 SET and MYND domain containing 3 -0.0498724
NBEA neurobeachin -0.0496292
MCTP1 multiple C2 domains, transmembrane 1 -0.0491495
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0489396
MT2A metallothionein 2A -0.047004
VGF VGF nerve growth factor inducible -0.0464566
ASPH aspartate beta-hydroxylase -0.046046
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0458787
PTMA prothymosin, alpha -0.045877
STC1 stanniocalcin 1 -0.0457709
EFNA5 ephrin-A5 -0.0453719
DTNA dystrobrevin, alpha -0.0446484
RPL8 ribosomal protein L8 -0.0433642
NALF1 NALCN channel auxiliary factor 1 -0.0417815
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0417812
CPE carboxypeptidase E -0.0417415
PTCHD4 patched domain containing 4 -0.0416513
INHBA inhibin, beta A -0.0412528
RPLP1 ribosomal protein, large, P1 -0.0404605
PDIA3 protein disulfide isomerase family A, member 3 -0.0390727
RORA RAR-related orphan receptor A -0.0388713
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0388267
NDRG1 N-myc downstream regulated 1 -0.0378303
TENM1 teneurin transmembrane protein 1 -0.0377682
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0374584
SETX senataxin -0.0367511
EYA2 EYA transcriptional coactivator and phosphatase 2 -0.0364176
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0362962
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0362875
POTEF POTE ankyrin domain family, member F -0.0360382
ZSWIM6 zinc finger, SWIM-type containing 6 -0.035419
RPS21 ribosomal protein S21 -0.0348096
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0344265
PKM pyruvate kinase, muscle -0.0342577
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0337371
KLHL29 kelch-like family member 29 -0.033418
S100A9 S100 calcium binding protein A9 -0.033356
CDK13 cyclin-dependent kinase 13 -0.0329863
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0327388
GMDS GDP-mannose 4,6-dehydratase -0.0320736
CNTNAP2 contactin associated protein-like 2 -0.0319177
RPS8 ribosomal protein S8 -0.0314393
SYT1 synaptotagmin I -0.0309838
LSAMP limbic system-associated membrane protein -0.0308777
ZNF804A zinc finger protein 804A -0.0308084
EPHA6 EPH receptor A6 -0.0307739
NLGN1 neuroligin 1 -0.0306723
RPL37A ribosomal protein L37a -0.0305759
PHF14 PHD finger protein 14 -0.030566
EEF2 eukaryotic translation elongation factor 2 -0.0302105
ANKRD17 ankyrin repeat domain 17 -0.0300395
SCG2 secretogranin II -0.0298477
RPS25 ribosomal protein S25 -0.0294731
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0294636
GPC5 glypican 5 -0.0294468
SSR2 signal sequence receptor, beta (translocon-associated protein beta) -0.029421
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0293161
HM13 histocompatibility (minor) 13 -0.0292914
PEG10 paternally expressed 10 -0.029159
CHGA chromogranin A -0.0291449
SDK1 sidekick cell adhesion molecule 1 -0.0289137
RPS16 ribosomal protein S16 -0.0289111
ISG15 ISG15 ubiquitin-like modifier -0.0286009
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0285402
RPS27A ribosomal protein S27a -0.0276379
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0275925
CRK v-crk avian sarcoma virus CT10 oncogene homolog -0.027534
RPL37 ribosomal protein L37 -0.0273852
PFN1 profilin 1 -0.0271608
TOP1 topoisomerase (DNA) I -0.0269417
TXNRD1 thioredoxin reductase 1 -0.0264855
NELL1 NEL-like 1 (chicken) -0.0264653
SCFD2 sec1 family domain containing 2 -0.0262359
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) -0.0261263