| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Larotrectinib sulfate perturbation in SK-MEL-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Larotrectinib sulfate_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NRG3 | neuregulin 3 | 0.118604 |
| FNDC3B | fibronectin type III domain containing 3B | 0.101698 |
| MSN | moesin | 0.0985288 |
| NAV2 | neuron navigator 2 | 0.0939579 |
| SPAG9 | sperm associated antigen 9 | 0.0886419 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0847807 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0793317 |
| DST | dystonin | 0.0576431 |
| NOTCH2 | notch 2 | 0.0531705 |
| PRELID2 | PRELI domain containing 2 | 0.0506707 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0504473 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0493236 |
| CLIP4 | CAP-GLY domain containing linker protein family, member 4 | 0.0488859 |
| FLNB | filamin B, beta | 0.0480728 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.048042 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0472888 |
| FMNL2 | formin-like 2 | 0.047285 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0471253 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0465665 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0446475 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0445659 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0434915 |
| PTK2 | protein tyrosine kinase 2 | 0.0428994 |
| FLNA | filamin A, alpha | 0.0422952 |
| RPS3 | ribosomal protein S3 | 0.0416998 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.041371 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0393496 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0388625 |
| CENPF | centromere protein F, 350/400kDa | 0.0388508 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.038666 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0379139 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0378534 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0364723 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0361744 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | 0.0360154 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0358944 |
| PCBP2 | poly(rC) binding protein 2 | 0.0354965 |
| TPM3 | tropomyosin 3 | 0.0352978 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0351651 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0337373 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0330384 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0329571 |
| NGLY1 | N-glycanase 1 | 0.0326693 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.032262 |
| SETD5 | SET domain containing 5 | 0.0316788 |
| CD44 | CD44 molecule (Indian blood group) | 0.031544 |
| FAM13A | family with sequence similarity 13, member A | 0.0299236 |
| FAM219A | family with sequence similarity 219, member A | 0.0294238 |
| AMOTL1 | angiomotin like 1 | 0.0290574 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.0285433 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0284277 |
| PDE8A | phosphodiesterase 8A | 0.0282283 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0282071 |
| RPL14 | ribosomal protein L14 | 0.027878 |
| ATXN1 | ataxin 1 | 0.0277382 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0275885 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0275762 |
| SLC39A11 | solute carrier family 39, member 11 | 0.0274335 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0273655 |
| BBX | bobby sox homolog (Drosophila) | 0.0272442 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.026913 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0267297 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0264753 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.026424 |
| CPEB2 | cytoplasmic polyadenylation element binding protein 2 | 0.0261828 |
| CDK19 | cyclin-dependent kinase 19 | 0.0259911 |
| CORO1C | coronin, actin binding protein, 1C | 0.0255003 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0253231 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0252417 |
| ARRDC3 | arrestin domain containing 3 | 0.0250214 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.0248 |
| VEGFA | vascular endothelial growth factor A | 0.0247697 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.0247379 |
| BCKDHB | branched chain keto acid dehydrogenase E1, beta polypeptide | 0.0246856 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0246401 |
| WWOX | WW domain containing oxidoreductase | 0.0246331 |
| CTTN | cortactin | 0.0244999 |
| CFAP20DC | CFAP20 domain containing | 0.0244654 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0242137 |
| EZR | ezrin | 0.0235542 |
| NCKAP1 | NCK-associated protein 1 | 0.0232276 |
| CABIN1 | calcineurin binding protein 1 | 0.023217 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.023029 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0230214 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.022832 |
| ZNRF1 | zinc and ring finger 1, E3 ubiquitin protein ligase | 0.0228112 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0227761 |
| ECPAS | Ecm29 proteasome adaptor and scaffold | 0.0225893 |
| ZNF292 | zinc finger protein 292 | 0.0223588 |
| TPD52 | tumor protein D52 | 0.0223361 |
| NRP2 | neuropilin 2 | 0.0221541 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0220952 |
| AFDN | afadin, adherens junction formation factor | 0.0219681 |
| RPL3 | ribosomal protein L3 | 0.0219236 |
| RANGAP1 | Ran GTPase activating protein 1 | 0.0218436 |
| ITGB5 | integrin, beta 5 | 0.0217623 |
| TAC4 | tachykinin 4 (hemokinin) | 0.0216782 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.021646 |
| CLEC2D | C-type lectin domain family 2, member D | 0.0215757 |
| MTR | 5-methyltetrahydrofolate-homocysteine methyltransferase | 0.0215725 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.23649 |
| FMN1 | formin 1 | -0.201418 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0819454 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0801307 |
| PMEL | premelanosome protein | -0.073636 |
| FRMD4A | FERM domain containing 4A | -0.069456 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0692469 |
| ACTG1 | actin gamma 1 | -0.0586563 |
| TMSB10 | thymosin beta 10 | -0.0578461 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0546717 |
| CCND1 | cyclin D1 | -0.0523855 |
| FTL | ferritin, light polypeptide | -0.0520779 |
| RPLP1 | ribosomal protein, large, P1 | -0.0497662 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.048134 |
| FN1 | fibronectin 1 | -0.0477417 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0442957 |
| NLGN1 | neuroligin 1 | -0.0441175 |
| RPL35A | ribosomal protein L35a | -0.0425327 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0423407 |
| KPNB1 | karyopherin (importin) beta 1 | -0.042045 |
| RAB7A | RAB7A, member RAS oncogene family | -0.040439 |
| APOD | apolipoprotein D | -0.0399902 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0384034 |
| MT2A | metallothionein 2A | -0.0383349 |
| RPL38 | ribosomal protein L38 | -0.038023 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0371426 |
| NF1 | neurofibromin 1 | -0.035517 |
| BPTF | bromodomain PHD finger transcription factor | -0.0341881 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0339714 |
| ENO1 | enolase 1, (alpha) | -0.0337357 |
| LINC02798 | long intergenic non-protein coding RNA 2798 | -0.0337119 |
| RPS24 | ribosomal protein S24 | -0.0336055 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.0335385 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0333209 |
| HLA-B | major histocompatibility complex, class I, B | -0.0332205 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.033219 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | -0.0330067 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0329238 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0325516 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0316954 |
| WNT2B | wingless-type MMTV integration site family, member 2B | -0.0316723 |
| SFTPA2 | surfactant protein A2 | -0.0314104 |
| FRMD5 | FERM domain containing 5 | -0.0313113 |
| PRAME | preferentially expressed antigen in melanoma | -0.031061 |
| IER3 | immediate early response 3 | -0.0306345 |
| ST13 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) | -0.0305744 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0298736 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0289285 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0285785 |
| RPLP2 | ribosomal protein, large, P2 | -0.0278365 |
| ERBIN | erbb2 interacting protein | -0.0277129 |
| TFRC | transferrin receptor | -0.0274542 |
| TPTEP2-CSNK1E | TPTEP2-CSNK1E readthrough | -0.0273153 |
| RPL32 | ribosomal protein L32 | -0.0271686 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0270565 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.027052 |
| TP63 | tumor protein p63 | -0.0270073 |
| RPL36A | ribosomal protein L36a | -0.0269086 |
| MT1X | metallothionein 1X | -0.0264025 |
| SOX6 | SRY (sex determining region Y)-box 6 | -0.0259505 |
| CDK13 | cyclin-dependent kinase 13 | -0.0258171 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0257595 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0256844 |
| CTSD | cathepsin D | -0.0256802 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0252247 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.025171 |
| S100A9 | S100 calcium binding protein A9 | -0.0251253 |
| RPS27A | ribosomal protein S27a | -0.0250243 |
| GPATCH8 | G patch domain containing 8 | -0.0250035 |
| PHF14 | PHD finger protein 14 | -0.0249604 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0244637 |
| COMMD10 | COMM domain containing 10 | -0.0243102 |
| HDAC9 | histone deacetylase 9 | -0.0241655 |
| ARF1 | ADP-ribosylation factor 1 | -0.0241092 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0240034 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0239791 |
| GNAI2 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 | -0.0239404 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0238741 |
| SP100 | SP100 nuclear antigen | -0.0235144 |
| RPL31 | ribosomal protein L31 | -0.0234184 |
| AHCYL1 | adenosylhomocysteinase-like 1 | -0.0233293 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0232291 |
| GNS | glucosamine (N-acetyl)-6-sulfatase | -0.0231974 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0228743 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0228366 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0228158 |
| EHBP1 | EH domain binding protein 1 | -0.0228096 |
| NPR2 | natriuretic peptide receptor 2 | -0.022726 |
| RPL34 | ribosomal protein L34 | -0.0224478 |
| TPI1 | triosephosphate isomerase 1 | -0.0224201 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0223688 |
| RPS5 | ribosomal protein S5 | -0.0222932 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0222681 |
| NRXN3 | neurexin 3 | -0.022226 |
| FGF13 | fibroblast growth factor 13 | -0.0222018 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0221947 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0219232 |
| CADM1 | cell adhesion molecule 1 | -0.0218216 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.0217204 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0216725 |
