Larotrectinib sulfate_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Larotrectinib sulfate perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Larotrectinib sulfate_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FLNB filamin B, beta 0.1552
TJP1 tight junction protein 1 0.127159
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.11722
VCL vinculin 0.110326
PDE4B phosphodiesterase 4B, cAMP-specific 0.098031
EZR ezrin 0.0909957
TXNRD1 thioredoxin reductase 1 0.0875092
SOX6 SRY (sex determining region Y)-box 6 0.0869074
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0841303
PDE4D phosphodiesterase 4D, cAMP-specific 0.0798304
PYGB phosphorylase, glycogen; brain 0.0791992
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0777055
NBEA neurobeachin 0.0761885
EGFR epidermal growth factor receptor 0.0761462
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0730426
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0707069
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0676612
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0666782
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0630903
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 0.0607952
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0598425
ENOX1 ecto-NOX disulfide-thiol exchanger 1 0.0569775
PCBP2 poly(rC) binding protein 2 0.055076
DUSP4 dual specificity phosphatase 4 0.0547682
ZBTB20 zinc finger and BTB domain containing 20 0.0545842
ADAM10 ADAM metallopeptidase domain 10 0.0523473
ZEB1 zinc finger E-box binding homeobox 1 0.0514605
LOXL3 lysyl oxidase-like 3 0.0514516
DSTN destrin (actin depolymerizing factor) 0.0511587
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0502389
GLI2 GLI family zinc finger 2 0.0469699
FBLN2 fibulin 2 0.0462801
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0454112
GSE1 Gse1 coiled-coil protein 0.0446393
HEG1 heart development protein with EGF-like domains 1 0.0445857
TMEM65 transmembrane protein 65 0.0427503
SMAD6 SMAD family member 6 0.0425471
EFNA5 ephrin-A5 0.0425174
ZNF292 zinc finger protein 292 0.042332
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0419009
NCKAP1 NCK-associated protein 1 0.041567
KTN1 kinectin 1 (kinesin receptor) 0.0415566
FAM91A1 family with sequence similarity 91, member A1 0.0397383
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0396023
LDHA lactate dehydrogenase A 0.0379569
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0373512
GLI3 GLI family zinc finger 3 0.0360063
PGK1 phosphoglycerate kinase 1 0.0357327
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0355608
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0348403
KDM3A lysine (K)-specific demethylase 3A 0.0338733
EPS8 epidermal growth factor receptor pathway substrate 8 0.0338109
CCNL1 cyclin L1 0.0335399
RTN4 reticulon 4 0.0332524
WAC WW domain containing adaptor with coiled-coil 0.0330361
IGF1R insulin-like growth factor 1 receptor 0.0328481
EIF4B eukaryotic translation initiation factor 4B 0.0328473
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.032723
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0321283
ADAM9 ADAM metallopeptidase domain 9 0.0320514
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.0318225
CD47 CD47 molecule 0.0316317
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0314103
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.0313196
CCDC68 coiled-coil domain containing 68 0.0312869
TGFBR3 transforming growth factor, beta receptor III 0.0308978
CANX calnexin 0.0305649
EML4 echinoderm microtubule associated protein like 4 0.0300974
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0298462
HSPA8 heat shock 70kDa protein 8 0.0288999
SETD5 SET domain containing 5 0.0288912
PTPRG protein tyrosine phosphatase, receptor type, G 0.0288799
TMSB4X thymosin beta 4, X-linked 0.0288306
SAMD4A sterile alpha motif domain containing 4A 0.028786
CAMTA1 calmodulin binding transcription activator 1 0.0285086
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0283734
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0283094
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0283041
BCLAF1 BCL2-associated transcription factor 1 0.028252
PTBP2 polypyrimidine tract binding protein 2 0.0281832
GOLGA4 golgin A4 0.0279384
IPO7 importin 7 0.0278481
PARD3 par-3 family cell polarity regulator 0.0277447
PICALM phosphatidylinositol binding clathrin assembly protein 0.0277434
SERINC1 serine incorporator 1 0.0276129
CSF1 colony stimulating factor 1 (macrophage) 0.027525
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0274683
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0273916
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0268414
SET SET nuclear proto-oncogene 0.0268031
PDGFC platelet derived growth factor C 0.0267538
RBMS2 RNA binding motif, single stranded interacting protein 2 0.026134
TOP2B topoisomerase (DNA) II beta 180kDa 0.0260414
NBAS neuroblastoma amplified sequence 0.0259899
PLK2 polo-like kinase 2 0.025921
EIF4A2 eukaryotic translation initiation factor 4A2 0.0258584
PLXNA1 plexin A1 0.0256516
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0255839
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L 0.0255287
HDGF hepatoma-derived growth factor 0.0255269

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.408062
TPT1 tumor protein, translationally-controlled 1 -0.0853061
ACTG1 actin gamma 1 -0.0821516
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0755557
LOC112694756 uncharaterized LOC112694756 -0.0639202
RPLP1 ribosomal protein, large, P1 -0.0566399
RPS19 ribosomal protein S19 -0.0506141
RPL35A ribosomal protein L35a -0.0503844
RPLP2 ribosomal protein, large, P2 -0.0463737
RPL7A ribosomal protein L7a -0.0423773
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 -0.038333
INTS6 integrator complex subunit 6 -0.0382807
S100A6 S100 calcium binding protein A6 -0.0366781
MT2A metallothionein 2A -0.0358769
WSB1 WD repeat and SOCS box containing 1 -0.0357666
RPS13 ribosomal protein S13 -0.0357059
TMSB10 thymosin beta 10 -0.0348583
RPS6 ribosomal protein S6 -0.0339539
RPS23 ribosomal protein S23 -0.0338795
RPL34 ribosomal protein L34 -0.0335653
FUS FUS RNA binding protein -0.0334158
RPS8 ribosomal protein S8 -0.0323321
S100A9 S100 calcium binding protein A9 -0.0307719
RPL9 ribosomal protein L9 -0.03064
RPL8 ribosomal protein L8 -0.0305744
IFI16 interferon, gamma-inducible protein 16 -0.0305517
RFC3 replication factor C (activator 1) 3, 38kDa -0.0304358
RPS29 ribosomal protein S29 -0.0292944
RPL32 ribosomal protein L32 -0.0292902
RPS15 ribosomal protein S15 -0.0290404
RPL35 ribosomal protein L35 -0.0288796
RPS21 ribosomal protein S21 -0.0278301
RRBP1 ribosome binding protein 1 -0.0277112
EIF1 eukaryotic translation initiation factor 1 -0.0265505
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0263641
RPS25 ribosomal protein S25 -0.0259497
RPL31 ribosomal protein L31 -0.0255806
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0244608
RPS27 ribosomal protein S27 -0.0244261
RPL36 ribosomal protein L36 -0.0240924
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0236589
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0233791
ARL4C ADP-ribosylation factor-like 4C -0.0231833
RPL28 ribosomal protein L28 -0.0228977
RPS11 ribosomal protein S11 -0.0226691
DSCAM Down syndrome cell adhesion molecule -0.0226437
RPS24 ribosomal protein S24 -0.0219198
RPS5 ribosomal protein S5 -0.0217494
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0210713
RPL12 ribosomal protein L12 -0.0210421
RPS27A ribosomal protein S27a -0.0203306
PSPC1 paraspeckle component 1 -0.0195866
RPLP0 ribosomal protein, large, P0 -0.0193313
TXNIP thioredoxin interacting protein -0.0192943
AEBP2 AE binding protein 2 -0.0191494
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.0190516
NAV2 neuron navigator 2 -0.0189012
CREBBP CREB binding protein -0.0188503
RPL37 ribosomal protein L37 -0.0187944
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0185997
RPS16 ribosomal protein S16 -0.0184032
S100A10 S100 calcium binding protein A10 -0.01802
HLA-B major histocompatibility complex, class I, B -0.0177778
ATXN2 ataxin 2 -0.0175824
MON2 MON2 homolog (S. cerevisiae) -0.0172267
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0169827
RPL23 ribosomal protein L23 -0.0167183
CARS1 cysteinyl-tRNA synthetase 1 -0.0166241
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0166208
RPL38 ribosomal protein L38 -0.0165967
PNISR PNN-interacting serine/arginine-rich protein -0.0164726
SMC4 structural maintenance of chromosomes 4 -0.0164602
RPL26 ribosomal protein L26 -0.0163518
FER1L6 fer-1-like family member 6 -0.0162174
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) -0.0157335
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0157034
GPHN gephyrin -0.0156763
TARS1 threonyl-tRNA synthetase 1 -0.0156468
ZNF217 zinc finger protein 217 -0.0155013
PFN1 profilin 1 -0.0154293
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0154133
RPL36A ribosomal protein L36a -0.0153874
GARS1 glycyl-tRNA synthetase 1 -0.0151125
RPL11 ribosomal protein L11 -0.0150193
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) -0.0148323
CCDC138 coiled-coil domain containing 138 -0.0145394
ZNFX1 zinc finger, NFX1-type containing 1 -0.0144497
ALDOC aldolase C, fructose-bisphosphate -0.0143331
CENPE centromere protein E, 312kDa -0.0142924
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0141922
FTL ferritin, light polypeptide -0.0139248
SRP19 signal recognition particle 19kDa -0.0138541
RPS28 ribosomal protein S28 -0.0138426
RRM2 ribonucleotide reductase M2 -0.0138189
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0136643
RPS15A ribosomal protein S15a -0.0135246
YLPM1 YLP motif containing 1 -0.0134453
WDR45B WD repeat domain 45B -0.0133672
DDIT3 DNA-damage-inducible transcript 3 -0.0132972
SGMS2 sphingomyelin synthase 2 -0.0132948