Larotrectinib sulfate_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Larotrectinib sulfate perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Larotrectinib sulfate_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SOD2 superoxide dismutase 2, mitochondrial 0.28427
MYH9 myosin, heavy chain 9, non-muscle 0.177413
COL6A3 collagen, type VI, alpha 3 0.116125
FNDC3B fibronectin type III domain containing 3B 0.0952686
NAV2 neuron navigator 2 0.0906503
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0865919
VCAN versican 0.0787561
NAMPT nicotinamide phosphoribosyltransferase 0.0732701
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0713899
TRIO trio Rho guanine nucleotide exchange factor 0.0689861
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0627017
DST dystonin 0.0610335
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0556851
SMAD3 SMAD family member 3 0.0526385
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0456081
RND3 Rho family GTPase 3 0.0444128
MYOF myoferlin 0.0434722
IGF2R insulin-like growth factor 2 receptor 0.0409247
TNS3 tensin 3 0.0408542
ELL2 elongation factor, RNA polymerase II, 2 0.0402993
MSN moesin 0.0398591
FMNL2 formin-like 2 0.0380901
MLPH melanophilin 0.0374314
BICC1 BicC family RNA binding protein 1 0.0369446
FBXO32 F-box protein 32 0.0352051
AKAP12 A kinase (PRKA) anchor protein 12 0.0350456
HDAC9 histone deacetylase 9 0.0347765
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0342408
RNF213 ring finger protein 213 0.0335222
MACF1 microtubule-actin crosslinking factor 1 0.0334518
CEP250 centrosomal protein 250kDa 0.0330005
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0327249
TNIP1 TNFAIP3 interacting protein 1 0.0311759
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0307108
FNIP1 folliculin interacting protein 1 0.0294301
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0287792
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0286922
PPARD peroxisome proliferator-activated receptor delta 0.0277323
APP amyloid beta (A4) precursor protein 0.0255921
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0249926
ZMIZ1 zinc finger, MIZ-type containing 1 0.0240924
VCL vinculin 0.0240437
RAD51B RAD51 paralog B 0.0232588
RUNX1 runt-related transcription factor 1 0.0229943
AMPD3 adenosine monophosphate deaminase 3 0.0229571
SPAG9 sperm associated antigen 9 0.0228771
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0228442
SEPTIN9 septin 9 0.0225315
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0223047
RB1CC1 RB1-inducible coiled-coil 1 0.0222508
PRKCSH protein kinase C substrate 80K-H 0.0220528
CTSB cathepsin B 0.021948
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.021717
EPAS1 endothelial PAS domain protein 1 0.0216451
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0216138
PHF3 PHD finger protein 3 0.0215711
VEGFA vascular endothelial growth factor A 0.0213943
USP9X ubiquitin specific peptidase 9, X-linked 0.0213312
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0212023
PDE10A phosphodiesterase 10A 0.0209523
OPTN optineurin 0.0208886
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0208268
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0207494
DUSP10 dual specificity phosphatase 10 0.0206847
ZBTB38 zinc finger and BTB domain containing 38 0.0205366
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.0201839
FNIP2 folliculin interacting protein 2 0.0201101
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0198608
BCAR3 breast cancer anti-estrogen resistance 3 0.0197947
NAV1 neuron navigator 1 0.0196426
RIGI RNA sensor RIG-I 0.0194866
SQSTM1 sequestosome 1 0.0194425
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0193829
AHNAK AHNAK nucleoprotein 0.0190727
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0190381
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0189198
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.0189089
ANO6 anoctamin 6 0.0188375
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0187312
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0187091
LOXL2 lysyl oxidase-like 2 0.0186736
FMN1 formin 1 0.0186252
VAC14 Vac14 homolog (S. cerevisiae) 0.0186054
FHIT fragile histidine triad 0.0185253
EVC Ellis van Creveld protein 0.0181437
KYNU kynureninase 0.0180909
NCKAP1 NCK-associated protein 1 0.0180439
PLSCR1 phospholipid scramblase 1 0.0179431
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0179243
JAK1 Janus kinase 1 0.0178605
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0178088
TMEM132D transmembrane protein 132D 0.0178002
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0176828
HSPA8 heat shock 70kDa protein 8 0.0176769
AFDN afadin, adherens junction formation factor 0.0176608
FAM20C family with sequence similarity 20, member C 0.0176376
ATXN1 ataxin 1 0.0172316
ANKRD36 ankyrin repeat domain 36 0.0168248
FLNA filamin A, alpha 0.0167407
DENND5A DENN/MADD domain containing 5A 0.0165461

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.240145
VIM vimentin -0.200721
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.159992
TMSB10 thymosin beta 10 -0.125338
HLA-B major histocompatibility complex, class I, B -0.124607
FTL ferritin, light polypeptide -0.108279
TPT1 tumor protein, translationally-controlled 1 -0.0805486
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0752047
IGFBP3 insulin-like growth factor binding protein 3 -0.0702656
MT2A metallothionein 2A -0.0688465
RPS6 ribosomal protein S6 -0.0634063
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0595155
RPS24 ribosomal protein S24 -0.0556665
IER3 immediate early response 3 -0.0553589
PTMA prothymosin, alpha -0.0549204
RPLP2 ribosomal protein, large, P2 -0.0546474
RPL35A ribosomal protein L35a -0.0544412
NDRG1 N-myc downstream regulated 1 -0.0507724
HLA-A major histocompatibility complex, class I, A -0.0501355
RPLP1 ribosomal protein, large, P1 -0.0494575
GLIS3 GLIS family zinc finger 3 -0.049095
EIF1 eukaryotic translation initiation factor 1 -0.0469607
RPS8 ribosomal protein S8 -0.0456785
PGK1 phosphoglycerate kinase 1 -0.0446333
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0445643
RPS23 ribosomal protein S23 -0.0438077
RPL23 ribosomal protein L23 -0.0422555
ENO1 enolase 1, (alpha) -0.042079
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0420275
VDAC1 voltage-dependent anion channel 1 -0.040841
EGR1 early growth response 1 -0.0405251
RPS19 ribosomal protein S19 -0.0402615
RPS12 ribosomal protein S12 -0.0401435
RPL36A ribosomal protein L36a -0.0401415
ACTG1 actin gamma 1 -0.039658
P4HB prolyl 4-hydroxylase, beta polypeptide -0.039291
LDHA lactate dehydrogenase A -0.0391504
B2M beta-2-microglobulin -0.0387962
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0386162
RPS13 ribosomal protein S13 -0.0381866
PKM pyruvate kinase, muscle -0.0372209
UGCG UDP-glucose ceramide glucosyltransferase -0.0371515
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0366886
GNAS GNAS complex locus -0.0362454
LOC112694756 uncharaterized LOC112694756 -0.0353441
RPL32 ribosomal protein L32 -0.0351023
RPLP0 ribosomal protein, large, P0 -0.0348782
RPL37A ribosomal protein L37a -0.0343231
HMGA1 high mobility group AT-hook 1 -0.0330601
RPL12 ribosomal protein L12 -0.0329721
IFITM3 interferon induced transmembrane protein 3 -0.0327422
LOX lysyl oxidase -0.0326359
BTG1 B-cell translocation gene 1, anti-proliferative -0.0325576
RPL19 ribosomal protein L19 -0.0322247
RPS21 ribosomal protein S21 -0.032196
FTH1 ferritin, heavy polypeptide 1 -0.0321123
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0320178
DEK DEK proto-oncogene -0.0318876
WSB1 WD repeat and SOCS box containing 1 -0.0318052
S100A9 S100 calcium binding protein A9 -0.0315879
RPL7A ribosomal protein L7a -0.0311139
RPL9 ribosomal protein L9 -0.0304098
RPL36 ribosomal protein L36 -0.030183
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0294241
RPL5 ribosomal protein L5 -0.0289308
RPS3 ribosomal protein S3 -0.0287974
RPL31 ribosomal protein L31 -0.0285623
CALR calreticulin -0.0276761
EEF2 eukaryotic translation elongation factor 2 -0.0276537
RPS25 ribosomal protein S25 -0.0276067
RPS14 ribosomal protein S14 -0.0274969
TXNIP thioredoxin interacting protein -0.0268691
ENO2 enolase 2 (gamma, neuronal) -0.0265317
RPL11 ribosomal protein L11 -0.0265073
COL1A1 collagen, type I, alpha 1 -0.0262564
RPS27A ribosomal protein S27a -0.0261975
RPL26 ribosomal protein L26 -0.026134
RPL8 ribosomal protein L8 -0.0258521
RPL28 ribosomal protein L28 -0.0256067
RACK1 receptor for activated C kinase 1 -0.0255445
COL1A2 collagen, type I, alpha 2 -0.0254334
RPL27A ribosomal protein L27a -0.0251559
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0249729
RPL37 ribosomal protein L37 -0.0248927
RPS10 ribosomal protein S10 -0.0244531
POTEF POTE ankyrin domain family, member F -0.0244238
DLG1 discs, large homolog 1 (Drosophila) -0.0239947
CADM1 cell adhesion molecule 1 -0.023975
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0238296
RPS16 ribosomal protein S16 -0.0235439
CD44 CD44 molecule (Indian blood group) -0.0234557
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0231148
ADM adrenomedullin -0.0227582
RPL34 ribosomal protein L34 -0.0227341
RPL38 ribosomal protein L38 -0.0223642
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0222508
KPNB1 karyopherin (importin) beta 1 -0.0222109
LMAN1 lectin, mannose-binding, 1 -0.0219678
TGFBI transforming growth factor, beta-induced, 68kDa -0.0219257
PFN1 profilin 1 -0.0218253