| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Larotrectinib sulfate perturbation in SW 1088 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Larotrectinib sulfate_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MYH9 | myosin, heavy chain 9, non-muscle | 0.114451 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0860963 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0609962 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0474784 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0461737 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0460516 |
| NAV2 | neuron navigator 2 | 0.0423752 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0422565 |
| AVL9 | AVL9 homolog (S. cerevisiase) | 0.0406208 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0392732 |
| SKIC3 | SKI3 subunit of superkiller complex | 0.0388114 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0386521 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0384107 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0381151 |
| ATP13A3 | ATPase type 13A3 | 0.0372793 |
| GOLGA4 | golgin A4 | 0.0372239 |
| PRRC2C | proline-rich coiled-coil 2C | 0.036996 |
| FAM13A | family with sequence similarity 13, member A | 0.0369933 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.0362958 |
| FRMD6 | FERM domain containing 6 | 0.0360261 |
| CD44 | CD44 molecule (Indian blood group) | 0.0358841 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0349497 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0342286 |
| TPM1 | tropomyosin 1 (alpha) | 0.0331058 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0330058 |
| THBS1 | thrombospondin 1 | 0.0326985 |
| PLEC | plectin | 0.0317528 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0315383 |
| MMP12 | matrix metallopeptidase 12 | 0.0315308 |
| CD109 | CD109 molecule | 0.0311624 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0309932 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0305081 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0291972 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0289841 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.02889 |
| DYNC2I1 | dynein 2 intermediate chain 1 | 0.0282556 |
| FAM20C | family with sequence similarity 20, member C | 0.0281642 |
| HDAC9 | histone deacetylase 9 | 0.0279171 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0272717 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.026985 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0267424 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | 0.026618 |
| CENPF | centromere protein F, 350/400kDa | 0.0265842 |
| STC1 | stanniocalcin 1 | 0.0257871 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0256799 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0256783 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0253619 |
| NAV1 | neuron navigator 1 | 0.0250804 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.024721 |
| FLNA | filamin A, alpha | 0.0238166 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0236857 |
| COL4A2 | collagen, type IV, alpha 2 | 0.0236274 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0234403 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0231457 |
| VEGFA | vascular endothelial growth factor A | 0.0229644 |
| ARRDC3 | arrestin domain containing 3 | 0.0229304 |
| RUNX1 | runt-related transcription factor 1 | 0.022572 |
| DST | dystonin | 0.0223977 |
| ANO6 | anoctamin 6 | 0.0222627 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0222569 |
| NPTN | neuroplastin | 0.0222297 |
| TENM3 | teneurin transmembrane protein 3 | 0.0221746 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0220226 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0219984 |
| PDE10A | phosphodiesterase 10A | 0.021992 |
| PCNX1 | pecanex 1 | 0.0219684 |
| FMNL2 | formin-like 2 | 0.0219529 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0218365 |
| SSH1 | slingshot protein phosphatase 1 | 0.0216237 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.021429 |
| RAB8B | RAB8B, member RAS oncogene family | 0.0213687 |
| ZNF148 | zinc finger protein 148 | 0.0212477 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0209548 |
| UBE2O | ubiquitin-conjugating enzyme E2O | 0.0209047 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0208904 |
| RIOK3 | RIO kinase 3 | 0.0208634 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0208339 |
| IRAK2 | interleukin-1 receptor-associated kinase 2 | 0.0207149 |
| TCP11L1 | t-complex 11, testis-specific-like 1 | 0.0206333 |
| DPYSL2 | dihydropyrimidinase-like 2 | 0.0205894 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0205469 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0205219 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0204934 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0204874 |
| LSM14A | LSM14A, SCD6 homolog A (S. cerevisiae) | 0.0204818 |
| PAPOLA | poly(A) polymerase alpha | 0.0204709 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0204577 |
| FAM13B | family with sequence similarity 13, member B | 0.0203757 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0201775 |
| ZNF292 | zinc finger protein 292 | 0.020091 |
| SMYD3 | SET and MYND domain containing 3 | 0.0199993 |
| JAK1 | Janus kinase 1 | 0.0198689 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0198455 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.01978 |
| FBXO32 | F-box protein 32 | 0.0197454 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0197398 |
| CHMP4B | charged multivesicular body protein 4B | 0.0197116 |
| WDFY2 | WD repeat and FYVE domain containing 2 | 0.019698 |
| CANX | calnexin | 0.0195982 |
| TANK | TRAF family member-associated NFKB activator | 0.0193599 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.34799 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.231472 |
| TMSB10 | thymosin beta 10 | -0.198561 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.191621 |
| HLA-B | major histocompatibility complex, class I, B | -0.126613 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0764795 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0761033 |
| MT2A | metallothionein 2A | -0.0742888 |
| FTL | ferritin, light polypeptide | -0.0713779 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0667517 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0655388 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0618537 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0610963 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | -0.0595676 |
| CALU | calumenin | -0.0552397 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0545884 |
| CADM1 | cell adhesion molecule 1 | -0.0528314 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0514128 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0504375 |
| GLIS3 | GLIS family zinc finger 3 | -0.0500041 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0463274 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0438455 |
| HLA-C | major histocompatibility complex, class I, C | -0.0426787 |
| CDH13 | cadherin 13 | -0.0416148 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0414075 |
| NRP1 | neuropilin 1 | -0.0411947 |
| PRSS23 | protease, serine, 23 | -0.0411442 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0404805 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0398267 |
| POTEF | POTE ankyrin domain family, member F | -0.039756 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0395191 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0391867 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0387652 |
| RPL35A | ribosomal protein L35a | -0.0386079 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0381263 |
| COL1A1 | collagen, type I, alpha 1 | -0.0375646 |
| HIPK2 | homeodomain interacting protein kinase 2 | -0.0375346 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0363238 |
| VCL | vinculin | -0.0362358 |
| S100A6 | S100 calcium binding protein A6 | -0.0352397 |
| S100A9 | S100 calcium binding protein A9 | -0.034854 |
| LOX | lysyl oxidase | -0.0347174 |
| S100A10 | S100 calcium binding protein A10 | -0.0336438 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.033579 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0330579 |
| GOLGB1 | golgin B1 | -0.0329687 |
| HLA-A | major histocompatibility complex, class I, A | -0.0325782 |
| SRPK2 | SRSF protein kinase 2 | -0.0323548 |
| COL5A1 | collagen, type V, alpha 1 | -0.0321591 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0319945 |
| RRBP1 | ribosome binding protein 1 | -0.031716 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0313863 |
| CUL3 | cullin 3 | -0.0313483 |
| RPL34 | ribosomal protein L34 | -0.0309114 |
| TAGLN2 | transgelin 2 | -0.0300994 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0300024 |
| EFNA5 | ephrin-A5 | -0.0299273 |
| RAB10 | RAB10, member RAS oncogene family | -0.0297067 |
| PALLD | palladin, cytoskeletal associated protein | -0.0291653 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0286793 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0283658 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0283105 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0277727 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0277263 |
| CDK6 | cyclin-dependent kinase 6 | -0.0275699 |
| RTN4 | reticulon 4 | -0.0273582 |
| RPS19 | ribosomal protein S19 | -0.0272691 |
| HM13 | histocompatibility (minor) 13 | -0.0266729 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.0266386 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0264419 |
| ENO1 | enolase 1, (alpha) | -0.0263021 |
| PXMP2 | peroxisomal membrane protein 2, 22kDa | -0.0261532 |
| FBXO11 | F-box protein 11 | -0.0260574 |
| LMNA | lamin A/C | -0.0252712 |
| MAP4 | microtubule-associated protein 4 | -0.0251394 |
| FKBP10 | FK506 binding protein 10, 65 kDa | -0.0250638 |
| LOXL2 | lysyl oxidase-like 2 | -0.0249467 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0248052 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.0247844 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0246747 |
| USP9X | ubiquitin specific peptidase 9, X-linked | -0.0246383 |
| TPM4 | tropomyosin 4 | -0.0245213 |
| MT1X | metallothionein 1X | -0.0244597 |
| PKM | pyruvate kinase, muscle | -0.0242627 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0242142 |
| SERF2 | small EDRK-rich factor 2 | -0.0241387 |
| RAB5A | RAB5A, member RAS oncogene family | -0.0239495 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0238431 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.023572 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0233553 |
| RPLP1 | ribosomal protein, large, P1 | -0.02319 |
| EGFR | epidermal growth factor receptor | -0.0231208 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0230799 |
| RASAL2 | RAS protein activator like 2 | -0.0230768 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0229102 |
| SCARB2 | scavenger receptor class B, member 2 | -0.022585 |
| RBM25 | RNA binding motif protein 25 | -0.0225586 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0225581 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0225041 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0224976 |
