Larotrectinib sulfate_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Larotrectinib sulfate perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Larotrectinib sulfate_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.13143
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0786523
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0764409
NAP1L1 nucleosome assembly protein 1-like 1 0.0712251
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0660327
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0530717
MYH9 myosin, heavy chain 9, non-muscle 0.0490101
CEP250 centrosomal protein 250kDa 0.0490029
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0487808
APOLD1 apolipoprotein L domain containing 1 0.0479288
CENPF centromere protein F, 350/400kDa 0.0464189
CANX calnexin 0.0456573
APLP2 amyloid beta (A4) precursor-like protein 2 0.0447306
TRIO trio Rho guanine nucleotide exchange factor 0.0438485
TBC1D5 TBC1 domain family, member 5 0.0420741
CDCP1 CUB domain containing protein 1 0.0415506
TPX2 TPX2, microtubule-associated 0.0399474
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0399317
SET SET nuclear proto-oncogene 0.0394893
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0387118
HSPA8 heat shock 70kDa protein 8 0.0378112
PYGL phosphorylase, glycogen, liver 0.036257
BHLHE40 basic helix-loop-helix family, member e40 0.0353434
SOD2 superoxide dismutase 2, mitochondrial 0.0342306
MKI67 marker of proliferation Ki-67 0.034137
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0339804
OGA O-GlcNAcase 0.0336997
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0326426
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0323862
KMT2C lysine (K)-specific methyltransferase 2C 0.0323714
DNER delta/notch-like EGF repeat containing 0.0317753
AKAP13 A kinase (PRKA) anchor protein 13 0.0315308
BASP1 brain abundant, membrane attached signal protein 1 0.0315035
SMC4 structural maintenance of chromosomes 4 0.0311266
PNISR PNN-interacting serine/arginine-rich protein 0.0311168
UBE2O ubiquitin-conjugating enzyme E2O 0.0310698
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0303965
PDE4D phosphodiesterase 4D, cAMP-specific 0.0303914
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 0.0298397
PIKFYVE phosphoinositide kinase, FYVE finger containing 0.0294022
ZNF292 zinc finger protein 292 0.0291657
XPO1 exportin 1 0.0290008
MAP2K1 mitogen-activated protein kinase kinase 1 0.0286973
CALR calreticulin 0.0285364
TNPO1 transportin 1 0.0285041
KIF5B kinesin family member 5B 0.0283706
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 0.0282103
RBM26 RNA binding motif protein 26 0.0277374
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0275425
NUP58 nucleoporin 58 0.0275405
TRIP12 thyroid hormone receptor interactor 12 0.0274226
SERINC1 serine incorporator 1 0.0273808
PRELID2 PRELI domain containing 2 0.0272015
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0270532
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.02693
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.026916
NCAPD2 non-SMC condensin I complex, subunit D2 0.0269015
RPS3 ribosomal protein S3 0.0268258
ZBTB1 zinc finger and BTB domain containing 1 0.0265539
CKAP5 cytoskeleton associated protein 5 0.0265488
FNDC3B fibronectin type III domain containing 3B 0.026218
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0261039
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0259445
RB1CC1 RB1-inducible coiled-coil 1 0.0259229
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0258782
ANLN anillin, actin binding protein 0.0255614
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0252157
NUMA1 nuclear mitotic apparatus protein 1 0.0249263
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0245876
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0244902
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0244848
TOP2B topoisomerase (DNA) II beta 180kDa 0.0243594
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0242186
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0241338
PRR11 proline rich 11 0.0238492
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0235068
MIB1 mindbomb E3 ubiquitin protein ligase 1 0.0233981
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0233908
RNF145 ring finger protein 145 0.023365
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0232647
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0229771
RPL7 ribosomal protein L7 0.0229044
NBAS neuroblastoma amplified sequence 0.0226787
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0226306
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0223195
RPL23 ribosomal protein L23 0.0221572
SNX14 sorting nexin 14 0.0217424
NCKAP1 NCK-associated protein 1 0.021715
MYEF2 myelin expression factor 2 0.0216726
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0216542
LCORL ligand dependent nuclear receptor corepressor-like 0.0215131
NAMPT nicotinamide phosphoribosyltransferase 0.0215127
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0213064
ZNF670 zinc finger protein 670 0.021145
KMT2A lysine (K)-specific methyltransferase 2A 0.0210975
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.0210231
FLNA filamin A, alpha 0.0209426
PRRC2B proline-rich coiled-coil 2B 0.0207875
SEPTIN9 septin 9 0.0207707
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0206264

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.354115
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0810734
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0797583
LOC112694756 uncharaterized LOC112694756 -0.0723405
TMSB10 thymosin beta 10 -0.0643537
RIGI RNA sensor RIG-I -0.0642651
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0569382
IGF2 insulin-like growth factor 2 -0.0491949
LDHA lactate dehydrogenase A -0.0490348
EGR1 early growth response 1 -0.0480608
TPT1 tumor protein, translationally-controlled 1 -0.0444782
DSCAM Down syndrome cell adhesion molecule -0.0421855
SAMD4A sterile alpha motif domain containing 4A -0.0403035
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0398929
MBNL2 muscleblind-like splicing regulator 2 -0.0397199
NCEH1 neutral cholesterol ester hydrolase 1 -0.038865
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0383524
SLC38A2 solute carrier family 38, member 2 -0.0379601
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0377727
NALCN sodium leak channel, non selective -0.0366137
OSMR oncostatin M receptor -0.0364536
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0359905
INTS6 integrator complex subunit 6 -0.0358946
ANXA2 annexin A2 -0.035859
B2M beta-2-microglobulin -0.0357967
EXT1 exostosin glycosyltransferase 1 -0.0353808
FUS FUS RNA binding protein -0.034673
TM4SF1 transmembrane 4 L six family member 1 -0.0336076
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0330704
IGFBP3 insulin-like growth factor binding protein 3 -0.0324514
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0323946
ACTG1 actin gamma 1 -0.0319782
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0318552
BCAR3 breast cancer anti-estrogen resistance 3 -0.0316485
FMN1 formin 1 -0.0309761
IARS1 isoleucyl-tRNA synthetase 1 -0.0308281
JUN jun proto-oncogene -0.0297879
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0295758
H3-3B H3.3 histone B -0.0295617
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0290529
ELL2 elongation factor, RNA polymerase II, 2 -0.0286429
SASH1 SAM and SH3 domain containing 1 -0.0285303
GLG1 golgi glycoprotein 1 -0.0285121
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0282307
NDRG1 N-myc downstream regulated 1 -0.0278217
BPTF bromodomain PHD finger transcription factor -0.027808
RBMS1 RNA binding motif, single stranded interacting protein 1 -0.027232
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0270547
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0264615
SENP6 SUMO1/sentrin specific peptidase 6 -0.0264205
IL1RAP interleukin 1 receptor accessory protein -0.0264028
NAV3 neuron navigator 3 -0.0262799
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0259545
POTEF POTE ankyrin domain family, member F -0.0257907
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.025698
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0255685
MT2A metallothionein 2A -0.0254582
VCL vinculin -0.0253554
AFF4 AF4/FMR2 family, member 4 -0.0253028
SLC36A4 solute carrier family 36 (proton/amino acid symporter), member 4 -0.0249947
OXSR1 oxidative stress responsive 1 -0.0249743
PRSS23 protease, serine, 23 -0.0248679
EFNA5 ephrin-A5 -0.0247821
ELOF1 elongation factor 1 homolog (S. cerevisiae) -0.0242968
SVIL supervillin -0.023987
FNDC3A fibronectin type III domain containing 3A -0.023868
PTMA prothymosin, alpha -0.0237613
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.023732
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0231106
ZBTB20 zinc finger and BTB domain containing 20 -0.0230351
MBNL1 muscleblind-like splicing regulator 1 -0.0230334
NABP1 nucleic acid binding protein 1 -0.023012
UGCG UDP-glucose ceramide glucosyltransferase -0.0228998
RBM39 RNA binding motif protein 39 -0.0228667
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0228256
COPB1 coatomer protein complex, subunit beta 1 -0.0227765
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0225419
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0219328
RPLP1 ribosomal protein, large, P1 -0.0216077
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0212975
RAB7A RAB7A, member RAS oncogene family -0.0212699
ANKRD28 ankyrin repeat domain 28 -0.0211801
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0211033
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0210316
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0207186
NF1 neurofibromin 1 -0.0206067
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0204186
PLEK2 pleckstrin 2 -0.0203817
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa -0.0203401
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0201774
VDAC1 voltage-dependent anion channel 1 -0.020154
CD2AP CD2-associated protein -0.02011
UBE2Z ubiquitin-conjugating enzyme E2Z -0.0200416
LPP LIM domain containing preferred translocation partner in lipoma -0.0198313
ZBTB38 zinc finger and BTB domain containing 38 -0.0197448
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0197325
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) -0.0195774
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0195116
RPS13 ribosomal protein S13 -0.0193911
TBCA tubulin folding cofactor A -0.0193286