| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Larotrectinib sulfate perturbation in SW 900 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Larotrectinib sulfate_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 0.186553 |
| HMGA2 | high mobility group AT-hook 2 | 0.100731 |
| ITGA1 | integrin, alpha 1 | 0.0983278 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0894895 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0709645 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0705514 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0564047 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0531903 |
| SQSTM1 | sequestosome 1 | 0.0515677 |
| TMEM156 | transmembrane protein 156 | 0.0409274 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.0397906 |
| GLIS3 | GLIS family zinc finger 3 | 0.0389228 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0371199 |
| CD109 | CD109 molecule | 0.0360029 |
| RUNX2 | runt-related transcription factor 2 | 0.0355334 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0350938 |
| FBXO32 | F-box protein 32 | 0.0341649 |
| EFNA5 | ephrin-A5 | 0.0335456 |
| RAI14 | retinoic acid induced 14 | 0.0332979 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0331171 |
| GPC6 | glypican 6 | 0.0329198 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0319919 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0306093 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0296506 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0293416 |
| ETV6 | ets variant 6 | 0.0291937 |
| PRELID2 | PRELI domain containing 2 | 0.0263137 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0260552 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | 0.0258106 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.02566 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0255833 |
| SMAD3 | SMAD family member 3 | 0.0250264 |
| BICC1 | BicC family RNA binding protein 1 | 0.0229682 |
| CNIH3 | cornichon family AMPA receptor auxiliary protein 3 | 0.0214843 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0210232 |
| TPR | translocated promoter region, nuclear basket protein | 0.0208018 |
| AFDN | afadin, adherens junction formation factor | 0.0202662 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0201501 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.0198322 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0197949 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0196329 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0196078 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0192278 |
| FNIP1 | folliculin interacting protein 1 | 0.0191368 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0189751 |
| ATXN1 | ataxin 1 | 0.018641 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.018441 |
| FAM20C | family with sequence similarity 20, member C | 0.0181076 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0179881 |
| TSC22D1 | TSC22 domain family, member 1 | 0.0174539 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0165407 |
| NAV2 | neuron navigator 2 | 0.0161969 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.016023 |
| KLHL24 | kelch-like family member 24 | 0.0156264 |
| CTSB | cathepsin B | 0.0155903 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0155702 |
| VCAN | versican | 0.0154997 |
| FHIT | fragile histidine triad | 0.0150163 |
| OSMR | oncostatin M receptor | 0.0148578 |
| CENPF | centromere protein F, 350/400kDa | 0.0145158 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0144215 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0141542 |
| IRAK3 | interleukin-1 receptor-associated kinase 3 | 0.0139526 |
| WDR26 | WD repeat domain 26 | 0.0139338 |
| SMOX | spermine oxidase | 0.013894 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | 0.0138153 |
| CREBRF | CREB3 regulatory factor | 0.013602 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0135366 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.013524 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0134835 |
| PCBP3 | poly(rC) binding protein 3 | 0.0133102 |
| TAPBP | TAP binding protein (tapasin) | 0.0130573 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0129307 |
| BAZ2B | bromodomain adjacent to zinc finger domain, 2B | 0.0128016 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0126939 |
| RAB31 | RAB31, member RAS oncogene family | 0.0126336 |
| PRKCSH | protein kinase C substrate 80K-H | 0.0123759 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0123747 |
| DST | dystonin | 0.0123724 |
| FBXL5 | F-box and leucine-rich repeat protein 5 | 0.0123199 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0122622 |
| LOXL2 | lysyl oxidase-like 2 | 0.0121183 |
| NTN4 | netrin 4 | 0.0120242 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0120095 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0119841 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0119162 |
| WDR33 | WD repeat domain 33 | 0.0118993 |
| ZFAND5 | zinc finger, AN1-type domain 5 | 0.0116035 |
| SKAP2 | src kinase associated phosphoprotein 2 | 0.0115909 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0115167 |
| FOXP1 | forkhead box P1 | 0.0114936 |
| ANO6 | anoctamin 6 | 0.0114597 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0114525 |
| TGFB2 | transforming growth factor, beta 2 | 0.0114309 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0114187 |
| FAM13A | family with sequence similarity 13, member A | 0.0114089 |
| PHC2 | polyhomeotic homolog 2 (Drosophila) | 0.0112914 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0112811 |
| ATP9A | ATPase, class II, type 9A | 0.0111115 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0110349 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.541862 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.174069 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.145458 |
| PTMA | prothymosin, alpha | -0.142105 |
| TMSB10 | thymosin beta 10 | -0.114488 |
| MT2A | metallothionein 2A | -0.107651 |
| S100A6 | S100 calcium binding protein A6 | -0.0881467 |
| FTL | ferritin, light polypeptide | -0.0804077 |
| HLA-B | major histocompatibility complex, class I, B | -0.0789061 |
| VIM | vimentin | -0.0728723 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.066422 |
| UBC | ubiquitin C | -0.0631251 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0573971 |
| RPS27A | ribosomal protein S27a | -0.0547681 |
| ENO1 | enolase 1, (alpha) | -0.0525106 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0523167 |
| CANX | calnexin | -0.0521531 |
| S100A10 | S100 calcium binding protein A10 | -0.0513562 |
| B2M | beta-2-microglobulin | -0.0512021 |
| RPS19 | ribosomal protein S19 | -0.0507647 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0500454 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0489805 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0487109 |
| RPLP1 | ribosomal protein, large, P1 | -0.0483802 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0446111 |
| PKM | pyruvate kinase, muscle | -0.0445442 |
| LMNA | lamin A/C | -0.0439219 |
| RPL31 | ribosomal protein L31 | -0.0435718 |
| CALR | calreticulin | -0.0428616 |
| RACK1 | receptor for activated C kinase 1 | -0.0426531 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0422662 |
| RPL23 | ribosomal protein L23 | -0.0419503 |
| IER3 | immediate early response 3 | -0.041854 |
| CALU | calumenin | -0.0401947 |
| RPL37A | ribosomal protein L37a | -0.0401528 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0400715 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0400585 |
| RPS6 | ribosomal protein S6 | -0.0390028 |
| RPL26 | ribosomal protein L26 | -0.0389149 |
| ASPH | aspartate beta-hydroxylase | -0.0388197 |
| TXNIP | thioredoxin interacting protein | -0.0385154 |
| RPS24 | ribosomal protein S24 | -0.0379277 |
| RPS12 | ribosomal protein S12 | -0.0379131 |
| RPS5 | ribosomal protein S5 | -0.0369122 |
| RPL9 | ribosomal protein L9 | -0.0351468 |
| LOC112694756 | uncharaterized LOC112694756 | -0.035036 |
| TPI1 | triosephosphate isomerase 1 | -0.0343636 |
| POTEF | POTE ankyrin domain family, member F | -0.0342217 |
| RPL28 | ribosomal protein L28 | -0.0338185 |
| RPS25 | ribosomal protein S25 | -0.0331642 |
| RPL35A | ribosomal protein L35a | -0.0331336 |
| RPL8 | ribosomal protein L8 | -0.0331316 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0328083 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0324766 |
| ACTG1 | actin gamma 1 | -0.0319081 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0314774 |
| WDR45B | WD repeat domain 45B | -0.0314315 |
| RPS29 | ribosomal protein S29 | -0.0313133 |
| RPS27 | ribosomal protein S27 | -0.0310652 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0308888 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0304926 |
| RPS21 | ribosomal protein S21 | -0.0304698 |
| FN1 | fibronectin 1 | -0.0303972 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0301963 |
| RPS11 | ribosomal protein S11 | -0.0298165 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0297506 |
| RPL12 | ribosomal protein L12 | -0.02934 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0292578 |
| S100A9 | S100 calcium binding protein A9 | -0.0290462 |
| RPL19 | ribosomal protein L19 | -0.0289473 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0287287 |
| HMGA1 | high mobility group AT-hook 1 | -0.0286241 |
| GNAS | GNAS complex locus | -0.0285684 |
| HLA-A | major histocompatibility complex, class I, A | -0.0285498 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0275451 |
| RPS8 | ribosomal protein S8 | -0.0275447 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0275295 |
| RPS16 | ribosomal protein S16 | -0.0274025 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0270761 |
| RPS20 | ribosomal protein S20 | -0.0270101 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0267789 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0266458 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0258035 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0257159 |
| RPL37 | ribosomal protein L37 | -0.0256647 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0254834 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0253504 |
| RHEB | Ras homolog enriched in brain | -0.0252244 |
| RPL34 | ribosomal protein L34 | -0.0250829 |
| RPL30 | ribosomal protein L30 | -0.0249195 |
| NOP58 | NOP58 ribonucleoprotein | -0.0246551 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0240598 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0239035 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0237968 |
| RPLP2 | ribosomal protein, large, P2 | -0.023404 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0232673 |
| RPL36 | ribosomal protein L36 | -0.0230099 |
| TMSB4X | thymosin beta 4, X-linked | -0.022916 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0228093 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0227792 |
