| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Larotrectinib sulfate perturbation in SW1417 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Larotrectinib sulfate_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.120592 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0793799 |
| H1-0 | H1.0 linker histone | 0.0644653 |
| DSPP | dentin sialophosphoprotein | 0.0582915 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0552743 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0505249 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0504868 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0498399 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0497195 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0488383 |
| AHNAK | AHNAK nucleoprotein | 0.0483332 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0472789 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0470667 |
| WWOX | WW domain containing oxidoreductase | 0.0465282 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0458298 |
| STT3B | STT3B, subunit of the oligosaccharyltransferase complex (catalytic) | 0.045235 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0449536 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0438587 |
| NCKAP1 | NCK-associated protein 1 | 0.0421773 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0390735 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0379806 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0373406 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0364286 |
| BCL2L1 | BCL2-like 1 | 0.0363996 |
| SDC4 | syndecan 4 | 0.0355284 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0354472 |
| PRELID2 | PRELI domain containing 2 | 0.0349944 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0347812 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0346921 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0341636 |
| VCL | vinculin | 0.0340258 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0338889 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0337831 |
| RPS3 | ribosomal protein S3 | 0.0337227 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0334952 |
| SKAP2 | src kinase associated phosphoprotein 2 | 0.0334114 |
| ZNF292 | zinc finger protein 292 | 0.0311598 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0305876 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0304207 |
| RPL14 | ribosomal protein L14 | 0.0302832 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.030254 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0296094 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0293744 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.0292338 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0290608 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0290604 |
| NKTR | natural killer cell triggering receptor | 0.0289493 |
| FHIT | fragile histidine triad | 0.0287984 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0278847 |
| RPS6 | ribosomal protein S6 | 0.0276094 |
| SNX9 | sorting nexin 9 | 0.0275718 |
| AFDN | afadin, adherens junction formation factor | 0.0271341 |
| SUCO | SUN domain containing ossification factor | 0.0266363 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.0264981 |
| DST | dystonin | 0.026014 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0255001 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0254815 |
| TMA7 | translation machinery associated 7 homolog (S. cerevisiae) | 0.0254426 |
| MYO5B | myosin VB | 0.0244636 |
| PARD3B | par-3 family cell polarity regulator beta | 0.0241153 |
| UBQLN1 | ubiquilin 1 | 0.0239844 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | 0.0239763 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0238462 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0237509 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0237412 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | 0.0236986 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0236928 |
| XPO1 | exportin 1 | 0.0236503 |
| VMP1 | vacuole membrane protein 1 | 0.0236094 |
| FAM3C | family with sequence similarity 3, member C | 0.0235252 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0230805 |
| XRN2 | 5'-3' exoribonuclease 2 | 0.0229239 |
| MED13L | mediator complex subunit 13-like | 0.0228535 |
| TRIM44 | tripartite motif containing 44 | 0.0227413 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.022706 |
| ZFP36 | ZFP36 ring finger protein | 0.0226654 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | 0.0225967 |
| LAMP2 | lysosomal-associated membrane protein 2 | 0.0225255 |
| MKI67 | marker of proliferation Ki-67 | 0.0224369 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.0223069 |
| MYO10 | myosin X | 0.0222729 |
| ARRDC3 | arrestin domain containing 3 | 0.0222668 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0221852 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0221171 |
| CDCP1 | CUB domain containing protein 1 | 0.0217042 |
| KAT6A | K(lysine) acetyltransferase 6A | 0.0214334 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.021382 |
| RBM39 | RNA binding motif protein 39 | 0.0213725 |
| YAP1 | Yes-associated protein 1 | 0.0211645 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0211126 |
| NONO | non-POU domain containing, octamer-binding | 0.0210332 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | 0.0209679 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.0208856 |
| SET | SET nuclear proto-oncogene | 0.0208855 |
| FAR1 | fatty acyl CoA reductase 1 | 0.0208568 |
| ACTN4 | actinin, alpha 4 | 0.0208097 |
| SFTPA2 | surfactant protein A2 | 0.0207581 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0206972 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0206733 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0203996 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | -0.117596 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.106627 |
| FTL | ferritin, light polypeptide | -0.104123 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0982787 |
| TMSB10 | thymosin beta 10 | -0.0914423 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0574701 |
| PKM | pyruvate kinase, muscle | -0.0505643 |
| NDRG1 | N-myc downstream regulated 1 | -0.0502733 |
| EGR1 | early growth response 1 | -0.0483369 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0482952 |
| S100A6 | S100 calcium binding protein A6 | -0.0443693 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.044214 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0436868 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0436438 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0432264 |
| GNAS | GNAS complex locus | -0.0419421 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0401093 |
| CLDN4 | claudin 4 | -0.038208 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0379143 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0375785 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | -0.0372708 |
| HM13 | histocompatibility (minor) 13 | -0.0371682 |
| HLA-A | major histocompatibility complex, class I, A | -0.0370883 |
| TMEM123 | transmembrane protein 123 | -0.0360354 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0355802 |
| HMGA1 | high mobility group AT-hook 1 | -0.0355393 |
| FBXO11 | F-box protein 11 | -0.0345413 |
| KRT18 | keratin 18, type I | -0.0339787 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0338 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0337699 |
| GTF2IRD1 | GTF2I repeat domain containing 1 | -0.0336685 |
| CDK13 | cyclin-dependent kinase 13 | -0.0326085 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | -0.0323259 |
| ARHGAP12 | Rho GTPase activating protein 12 | -0.0321784 |
| RPS24 | ribosomal protein S24 | -0.0320652 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0319917 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0316815 |
| CTSD | cathepsin D | -0.0303511 |
| RPL35A | ribosomal protein L35a | -0.0303201 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0300665 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0300144 |
| EHBP1 | EH domain binding protein 1 | -0.0299285 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0297655 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0297544 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0295659 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0293142 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0286881 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.028535 |
| MYH14 | myosin, heavy chain 14, non-muscle | -0.0282984 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0270891 |
| BZW2 | basic leucine zipper and W2 domains 2 | -0.027055 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0268792 |
| MED13 | mediator complex subunit 13 | -0.0263197 |
| RPL27A | ribosomal protein L27a | -0.0261491 |
| LOC112694756 | uncharaterized LOC112694756 | -0.026111 |
| ZNF207 | zinc finger protein 207 | -0.0260531 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0258291 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0253795 |
| FNBP4 | formin binding protein 4 | -0.0250908 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0245929 |
| TOB1 | transducer of ERBB2, 1 | -0.0244917 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0240699 |
| RPS25 | ribosomal protein S25 | -0.0240524 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0240193 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0239119 |
| RPS13 | ribosomal protein S13 | -0.0236907 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0235304 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0233172 |
| INTS6 | integrator complex subunit 6 | -0.0232236 |
| PERP | PERP, TP53 apoptosis effector | -0.0231387 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.023097 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0227858 |
| TNPO3 | transportin 3 | -0.0227809 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0227802 |
| HLA-B | major histocompatibility complex, class I, B | -0.0218779 |
| LMNA | lamin A/C | -0.0218222 |
| RCOR1 | REST corepressor 1 | -0.0217657 |
| UBAP2 | ubiquitin associated protein 2 | -0.0216561 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0216336 |
| IER3 | immediate early response 3 | -0.0215835 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0213151 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0212751 |
| PHACTR4 | phosphatase and actin regulator 4 | -0.0211259 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | -0.0210447 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0207156 |
| FRAS1 | Fraser extracellular matrix complex subunit 1 | -0.0206161 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0204492 |
| TUBB | tubulin, beta class I | -0.0203909 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0201568 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0197905 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0197432 |
| CD9 | CD9 molecule | -0.0197046 |
| RPL28 | ribosomal protein L28 | -0.0196481 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0196449 |
| RAB5A | RAB5A, member RAS oncogene family | -0.0194484 |
| RPL15 | ribosomal protein L15 | -0.0193389 |
| RPLP1 | ribosomal protein, large, P1 | -0.0193212 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0191219 |
| CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 | -0.0191018 |
| PITPNB | phosphatidylinositol transfer protein, beta | -0.0190288 |
