Larotrectinib sulfate_SW48 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Larotrectinib sulfate perturbation in SW48 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Larotrectinib sulfate_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha 0.104785
LAMB3 laminin, beta 3 0.102232
CD36 CD36 molecule (thrombospondin receptor) 0.102074
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0935756
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0873957
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0869368
HSPA8 heat shock 70kDa protein 8 0.0852311
IER3 immediate early response 3 0.0829465
ACTG1 actin gamma 1 0.0785077
AREG amphiregulin 0.0771979
MYH9 myosin, heavy chain 9, non-muscle 0.0702435
FLOT1 flotillin 1 0.0654067
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0650982
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0646781
EZR ezrin 0.064356
AHNAK AHNAK nucleoprotein 0.0594331
TPT1 tumor protein, translationally-controlled 1 0.0585705
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0581817
ANXA1 annexin A1 0.0568416
RPS3 ribosomal protein S3 0.056397
HMGA2 high mobility group AT-hook 2 0.0556307
LAMC2 laminin, gamma 2 0.0553646
DSPP dentin sialophosphoprotein 0.0501084
SQSTM1 sequestosome 1 0.0480368
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0470697
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0461132
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0439677
AKAP12 A kinase (PRKA) anchor protein 12 0.0429724
APP amyloid beta (A4) precursor protein 0.0422542
FHIT fragile histidine triad 0.0419327
KTN1 kinectin 1 (kinesin receptor) 0.0392649
SNX9 sorting nexin 9 0.0382495
CPOX coproporphyrinogen oxidase 0.03697
RPL26 ribosomal protein L26 0.0362192
GPC5 glypican 5 0.0358498
RPS27A ribosomal protein S27a 0.0353208
SYNE2 spectrin repeat containing, nuclear envelope 2 0.03521
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0351103
KLF5 Kruppel-like factor 5 (intestinal) 0.0343227
RPS12 ribosomal protein S12 0.0340984
RPS8 ribosomal protein S8 0.0337473
RPL37A ribosomal protein L37a 0.0334449
NDRG1 N-myc downstream regulated 1 0.033345
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0328725
MACF1 microtubule-actin crosslinking factor 1 0.0327858
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0322302
DDIT4 DNA-damage-inducible transcript 4 0.0311992
KLF6 Kruppel-like factor 6 0.03045
RPL19 ribosomal protein L19 0.0301856
SRRM2 serine/arginine repetitive matrix 2 0.0298838
NAP1L1 nucleosome assembly protein 1-like 1 0.0297844
DST dystonin 0.0288674
SDC4 syndecan 4 0.0288394
TRIO trio Rho guanine nucleotide exchange factor 0.0287271
RPL7A ribosomal protein L7a 0.0286235
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0285909
AXIN2 axin 2 0.0285108
PGK1 phosphoglycerate kinase 1 0.0285022
CTSB cathepsin B 0.028314
SMYD3 SET and MYND domain containing 3 0.0279682
RPS13 ribosomal protein S13 0.027685
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0271003
EXOC4 exocyst complex component 4 0.027043
RPL3 ribosomal protein L3 0.0267399
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.0267253
EMP1 epithelial membrane protein 1 0.026687
PDE4B phosphodiesterase 4B, cAMP-specific 0.0262452
RPL31 ribosomal protein L31 0.026243
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0262289
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0260023
SET SET nuclear proto-oncogene 0.0259173
RPL4 ribosomal protein L4 0.0258568
KLC1 kinesin light chain 1 0.0257469
ESYT2 extended synaptotagmin-like protein 2 0.0256657
RNF43 ring finger protein 43 0.0250608
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0250206
RPL34 ribosomal protein L34 0.0249152
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) 0.024682
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0244573
H1-4 H1.4 linker histone, cluster member 0.0242275
GNAT3 guanine nucleotide binding protein, alpha transducing 3 0.0241043
APLP2 amyloid beta (A4) precursor-like protein 2 0.0238932
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0232305
KITLG KIT ligand 0.0226831
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0225437
DOCK1 dedicator of cytokinesis 1 0.0221706
CTTN cortactin 0.0219651
EREG epiregulin 0.0218918
RPL14 ribosomal protein L14 0.0218129
LMO7 LIM domain 7 0.0215794
LDHA lactate dehydrogenase A 0.0214922
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 0.0214128
RPL5 ribosomal protein L5 0.0212821
RPS6 ribosomal protein S6 0.0211531
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0208692
CALR calreticulin 0.0208203
RPL35 ribosomal protein L35 0.0207503
KDM3A lysine (K)-specific demethylase 3A 0.0206932
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0205929
NAMPT nicotinamide phosphoribosyltransferase 0.0205889

decreased expression

Symbol Name Standardized Value
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0666609
NCEH1 neutral cholesterol ester hydrolase 1 -0.0625515
RCOR1 REST corepressor 1 -0.0578292
EGR1 early growth response 1 -0.0512126
STRN3 striatin, calmodulin binding protein 3 -0.042074
EGFR epidermal growth factor receptor -0.0418391
RAB10 RAB10, member RAS oncogene family -0.0410474
ITPKC inositol-trisphosphate 3-kinase C -0.0391254
TSC22D2 TSC22 domain family, member 2 -0.0349087
VCL vinculin -0.0347879
LAMA4 laminin, alpha 4 -0.0337932
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0337244
WAC WW domain containing adaptor with coiled-coil -0.0333463
HDAC2 histone deacetylase 2 -0.0331406
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0322679
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0311783
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.026807
SCFD1 sec1 family domain containing 1 -0.0265185
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0261022
PUM2 pumilio RNA-binding family member 2 -0.0256121
SGPP2 sphingosine-1-phosphate phosphatase 2 -0.0254763
PHF14 PHD finger protein 14 -0.0239455
TNS3 tensin 3 -0.0239353
IARS1 isoleucyl-tRNA synthetase 1 -0.0234311
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0231727
HMGA1 high mobility group AT-hook 1 -0.0230755
RNF145 ring finger protein 145 -0.0230722
PDLIM5 PDZ and LIM domain 5 -0.0225422
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0222643
NTSR1 neurotensin receptor 1 (high affinity) -0.0219704
ATXN1 ataxin 1 -0.0218848
YAP1 Yes-associated protein 1 -0.0215497
RBM25 RNA binding motif protein 25 -0.0211033
UBE2R2 ubiquitin-conjugating enzyme E2R 2 -0.0206389
FNDC3A fibronectin type III domain containing 3A -0.0204858
FTH1 ferritin, heavy polypeptide 1 -0.0204736
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0202711
FAT1 FAT atypical cadherin 1 -0.0199708
NEK7 NIMA-related kinase 7 -0.0198641
ECT2 epithelial cell transforming 2 -0.0196007
KCMF1 potassium channel modulatory factor 1 -0.0192079
WDR43 WD repeat domain 43 -0.0190732
ARL5B ADP-ribosylation factor-like 5B -0.0190627
BIRC6 baculoviral IAP repeat containing 6 -0.0190298
MED14 mediator complex subunit 14 -0.0189694
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.018839
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0186928
YLPM1 YLP motif containing 1 -0.0185973
RFX7 regulatory factor X, 7 -0.0178143
POTEF POTE ankyrin domain family, member F -0.0178077
MED13L mediator complex subunit 13-like -0.0176673
EVA1C eva-1 homolog C (C. elegans) -0.0175496
PPP1R9A protein phosphatase 1, regulatory subunit 9A -0.0174841
PTBP2 polypyrimidine tract binding protein 2 -0.017376
RAB7A RAB7A, member RAS oncogene family -0.0172335
COG5 component of oligomeric golgi complex 5 -0.0172303
BRWD1 bromodomain and WD repeat domain containing 1 -0.0169737
CARD16 caspase recruitment domain family, member 16 -0.0169626
SFPQ splicing factor proline/glutamine-rich -0.0165539
KDM6A lysine (K)-specific demethylase 6A -0.0165442
UBE2H ubiquitin-conjugating enzyme E2H -0.0163126
LOC102724023 ES1 protein homolog, mitochondrial -0.0161766
PTEN phosphatase and tensin homolog -0.0161613
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0160077
SH3RF2 SH3 domain containing ring finger 2 -0.015864
NF1 neurofibromin 1 -0.0157785
FAR1 fatty acyl CoA reductase 1 -0.015778
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0157689
NUP58 nucleoporin 58 -0.015692
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 -0.0155543
SEC31A SEC31 homolog A (S. cerevisiae) -0.015461
ADNP activity-dependent neuroprotector homeobox -0.0153598
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0152732
SEC24D SEC24 family member D -0.0152004
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 -0.0146339
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0146236
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0145952
INO80 INO80 complex subunit -0.0145221
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) -0.0144198
MNAT1 MNAT CDK-activating kinase assembly factor 1 -0.0144027
ZNF207 zinc finger protein 207 -0.0143429
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0143256
ATP5F1B ATP synthase F1 subunit beta -0.0143217
SPRED2 sprouty-related, EVH1 domain containing 2 -0.014237
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0141676
UBAP2 ubiquitin associated protein 2 -0.0140864
SFSWAP splicing factor, suppressor of white-apricot family -0.0139537
USP6NL USP6 N-terminal like -0.0138788
ETNK1 ethanolamine kinase 1 -0.0138642
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.0137391
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0137118
PCNX1 pecanex 1 -0.0137109
MAP2K4 mitogen-activated protein kinase kinase 4 -0.0137054
MEMO1 mediator of cell motility 1 -0.0136356
CDC73 cell division cycle 73 -0.0135099
ABR active BCR-related -0.0134842
SETX senataxin -0.0134705
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0134521
SRP54 signal recognition particle 54kDa -0.0134316
GARS1 glycyl-tRNA synthetase 1 -0.0133285