| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Larotrectinib sulfate perturbation in SW480 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Larotrectinib sulfate_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.317542 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.115869 |
| WWOX | WW domain containing oxidoreductase | 0.0919384 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0737441 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0708156 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.0612845 |
| RAD51B | RAD51 paralog B | 0.0557416 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.055335 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0491172 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0469559 |
| FHIT | fragile histidine triad | 0.0452771 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0451089 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0441786 |
| OXR1 | oxidation resistance 1 | 0.0432055 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0419967 |
| RPS3 | ribosomal protein S3 | 0.038785 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.038004 |
| EXOC4 | exocyst complex component 4 | 0.0368872 |
| TNS3 | tensin 3 | 0.0363576 |
| SPATA13 | spermatogenesis associated 13 | 0.035922 |
| IGF1R | insulin-like growth factor 1 receptor | 0.035859 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0355818 |
| DST | dystonin | 0.0344225 |
| RUNX1 | runt-related transcription factor 1 | 0.0333254 |
| HDAC4 | histone deacetylase 4 | 0.0331392 |
| HSPA8 | heat shock 70kDa protein 8 | 0.032106 |
| RPL14 | ribosomal protein L14 | 0.0317958 |
| DNAH14 | dynein, axonemal, heavy chain 14 | 0.030518 |
| AOPEP | aminopeptidase O (putative) | 0.0304095 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0302001 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | 0.030131 |
| KIZ | kizuna centrosomal protein | 0.0294565 |
| CDH13 | cadherin 13 | 0.0288762 |
| FNIP1 | folliculin interacting protein 1 | 0.0282021 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0277765 |
| KRT5 | keratin 5, type II | 0.0269073 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0265606 |
| NAV2 | neuron navigator 2 | 0.0260781 |
| SYK | spleen tyrosine kinase | 0.0255221 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0253885 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0252006 |
| RPL4 | ribosomal protein L4 | 0.0247144 |
| PRELID2 | PRELI domain containing 2 | 0.0247017 |
| KLF6 | Kruppel-like factor 6 | 0.0245802 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0242305 |
| DIAPH2 | diaphanous-related formin 2 | 0.0241607 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0239519 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0239437 |
| ARHGAP9 | Rho GTPase activating protein 9 | 0.0236752 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0235969 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0235513 |
| FYN | FYN proto-oncogene, Src family tyrosine kinase | 0.0234674 |
| NUDT4 | nudix (nucleoside diphosphate linked moiety X)-type motif 4 | 0.0233867 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0232274 |
| DSPP | dentin sialophosphoprotein | 0.0229911 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.022845 |
| MYO1D | myosin ID | 0.0228004 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0227257 |
| KLF12 | Kruppel-like factor 12 | 0.0220722 |
| PCDH9 | protocadherin 9 | 0.0219569 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.021914 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | 0.0218564 |
| ACTN4 | actinin, alpha 4 | 0.0217725 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0215985 |
| TMEM163 | transmembrane protein 163 | 0.0209907 |
| SMYD3 | SET and MYND domain containing 3 | 0.0208943 |
| FRMD5 | FERM domain containing 5 | 0.0205717 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0204351 |
| RPS4X | ribosomal protein S4, X-linked | 0.0204188 |
| PHF3 | PHD finger protein 3 | 0.0203812 |
| NPAS3 | neuronal PAS domain protein 3 | 0.0202612 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0198443 |
| RPL13A | ribosomal protein L13a | 0.0198035 |
| SERINC1 | serine incorporator 1 | 0.0198034 |
| ATXN1 | ataxin 1 | 0.019693 |
| CTSB | cathepsin B | 0.0196005 |
| AHNAK | AHNAK nucleoprotein | 0.0195687 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | 0.0195371 |
| CTDSPL | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like | 0.0194725 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0193322 |
| AXIN2 | axin 2 | 0.019212 |
| SEPTIN9 | septin 9 | 0.0189594 |
| CEP112 | centrosomal protein 112kDa | 0.0189314 |
| CNKSR3 | CNKSR family member 3 | 0.0188688 |
| VOPP1 | vesicular, overexpressed in cancer, prosurvival protein 1 | 0.0188077 |
| ZNF292 | zinc finger protein 292 | 0.0187644 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0182691 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0181665 |
| UTRN | utrophin | 0.0180166 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0178572 |
| SCN5A | sodium channel, voltage gated, type V alpha subunit | 0.0177175 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.0176888 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0174042 |
| MSI2 | musashi RNA-binding protein 2 | 0.0172849 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | 0.0171172 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.016965 |
| CD46 | CD46 molecule, complement regulatory protein | 0.0169547 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0167379 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0163167 |
| VPS13C | vacuolar protein sorting 13 homolog C (S. cerevisiae) | 0.016157 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.21837 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0814356 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0806564 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0787154 |
| TMSB10 | thymosin beta 10 | -0.0673995 |
| EGR1 | early growth response 1 | -0.0663541 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0610735 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0521224 |
| PKM | pyruvate kinase, muscle | -0.0494629 |
| GLG1 | golgi glycoprotein 1 | -0.0480012 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0479961 |
| HMGA1 | high mobility group AT-hook 1 | -0.0471325 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0470371 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0463033 |
| SLC38A2 | solute carrier family 38, member 2 | -0.042307 |
| ARF4 | ADP-ribosylation factor 4 | -0.0404447 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0403092 |
| PIBF1 | progesterone immunomodulatory binding factor 1 | -0.040231 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0395815 |
| MORF4L2 | mortality factor 4 like 2 | -0.0395516 |
| PFN1 | profilin 1 | -0.0371763 |
| MKI67 | marker of proliferation Ki-67 | -0.0363329 |
| ENO1 | enolase 1, (alpha) | -0.0361384 |
| ANLN | anillin, actin binding protein | -0.0359829 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0355383 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0352738 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.034726 |
| SETD5 | SET domain containing 5 | -0.0344533 |
| MED13 | mediator complex subunit 13 | -0.0334836 |
| ANXA2 | annexin A2 | -0.0328931 |
| HM13 | histocompatibility (minor) 13 | -0.0323751 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0318415 |
| COG5 | component of oligomeric golgi complex 5 | -0.0315773 |
| TPM4 | tropomyosin 4 | -0.0309831 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0308996 |
| EMP1 | epithelial membrane protein 1 | -0.0306159 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0298997 |
| USP34 | ubiquitin specific peptidase 34 | -0.0298273 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0284892 |
| TPX2 | TPX2, microtubule-associated | -0.0283035 |
| DIAPH3 | diaphanous-related formin 3 | -0.0281035 |
| DCAF7 | DDB1 and CUL4 associated factor 7 | -0.0278637 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0275909 |
| S100A10 | S100 calcium binding protein A10 | -0.0273515 |
| WNK1 | WNK lysine deficient protein kinase 1 | -0.0273002 |
| RPL7A | ribosomal protein L7a | -0.0271323 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.0268246 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0267957 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0262743 |
| TMEM123 | transmembrane protein 123 | -0.025586 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.0250038 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0247515 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0246921 |
| RPS5 | ribosomal protein S5 | -0.0246587 |
| TARS1 | threonyl-tRNA synthetase 1 | -0.0245739 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0245139 |
| ACTG1 | actin gamma 1 | -0.0244108 |
| GOLGA4 | golgin A4 | -0.0243848 |
| ZNF207 | zinc finger protein 207 | -0.024252 |
| RPS24 | ribosomal protein S24 | -0.0241808 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0241751 |
| CBFB | core-binding factor, beta subunit | -0.0241477 |
| TMEM41B | transmembrane protein 41B | -0.0241113 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | -0.0240499 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0235794 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0234431 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0233756 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0230747 |
| TUBA1B | tubulin, alpha 1b | -0.023032 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0229748 |
| ERBIN | erbb2 interacting protein | -0.0227471 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0226503 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.022624 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0225129 |
| CARS1 | cysteinyl-tRNA synthetase 1 | -0.0222362 |
| RPL3 | ribosomal protein L3 | -0.0218428 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0218259 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0216545 |
| YARS1 | tyrosyl-tRNA synthetase 1 | -0.0215637 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0215326 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0215259 |
| TPI1 | triosephosphate isomerase 1 | -0.0214106 |
| H3-3B | H3.3 histone B | -0.0213351 |
| WASF2 | WAS protein family, member 2 | -0.0211407 |
| ITGA6 | integrin, alpha 6 | -0.0211327 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0211106 |
| CKAP2 | cytoskeleton associated protein 2 | -0.0211062 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0210953 |
| ITGB4 | integrin, beta 4 | -0.0209611 |
| FLNB | filamin B, beta | -0.0208134 |
| KIF4A | kinesin family member 4A | -0.0208043 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0207581 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0207479 |
| RPLP1 | ribosomal protein, large, P1 | -0.0205961 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0204797 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0201734 |
| INTS6 | integrator complex subunit 6 | -0.0200968 |
| TXNIP | thioredoxin interacting protein | -0.0199979 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0199741 |
| EFNB2 | ephrin-B2 | -0.0199307 |
