Larotrectinib sulfate_hTERT-HPNE Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Larotrectinib sulfate perturbation in hTERT-HPNE cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Larotrectinib sulfate_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.197722
HMGA2 high mobility group AT-hook 2 0.156755
MYH9 myosin, heavy chain 9, non-muscle 0.135682
INHBA inhibin, beta A 0.0899519
JARID2 jumonji, AT rich interactive domain 2 0.0555016
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0496888
NALF1 NALCN channel auxiliary factor 1 0.0495178
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0466758
SOD2 superoxide dismutase 2, mitochondrial 0.0453485
ARHGAP21 Rho GTPase activating protein 21 0.0449207
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.044387
MYO10 myosin X 0.0439312
PRKG1 protein kinase, cGMP-dependent, type I 0.0435356
NAV1 neuron navigator 1 0.0397952
DST dystonin 0.0380647
NAV2 neuron navigator 2 0.0357847
FMNL2 formin-like 2 0.0344972
FAM13A family with sequence similarity 13, member A 0.0344684
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0332934
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0328343
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 0.0323227
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0301918
HIPK2 homeodomain interacting protein kinase 2 0.0301652
PDE4D phosphodiesterase 4D, cAMP-specific 0.0291286
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.029053
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0278111
ZBTB38 zinc finger and BTB domain containing 38 0.0277332
MEIS1 Meis homeobox 1 0.0270894
SMAD3 SMAD family member 3 0.0266936
ATP13A3 ATPase type 13A3 0.0264512
RAI14 retinoic acid induced 14 0.0264351
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0262414
MMP12 matrix metallopeptidase 12 0.0258304
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0255036
HDAC9 histone deacetylase 9 0.0254024
GREM1 gremlin 1, DAN family BMP antagonist 0.0252815
DNER delta/notch-like EGF repeat containing 0.0251181
COL6A2 collagen, type VI, alpha 2 0.0248192
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0246242
COL6A1 collagen, type VI, alpha 1 0.0237483
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0237046
FNIP1 folliculin interacting protein 1 0.0229184
APOLD1 apolipoprotein L domain containing 1 0.0226853
OXR1 oxidation resistance 1 0.0225763
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0225323
TNS1 tensin 1 0.0224564
MACF1 microtubule-actin crosslinking factor 1 0.0218462
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0217007
RFX8 RFX family member 8, lacking RFX DNA binding domain 0.0216946
ABI3BP ABI family, member 3 (NESH) binding protein 0.0209099
FRMD6 FERM domain containing 6 0.0206643
SEPTIN9 septin 9 0.0206088
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0202386
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0201216
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0201213
RAD51B RAD51 paralog B 0.0196053
AMPD3 adenosine monophosphate deaminase 3 0.0190183
GLIS3 GLIS family zinc finger 3 0.0188309
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0187164
APP amyloid beta (A4) precursor protein 0.018693
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0186446
COL4A2 collagen, type IV, alpha 2 0.0185525
LOXL2 lysyl oxidase-like 2 0.0185257
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0179683
NGLY1 N-glycanase 1 0.0175752
ERRFI1 ERBB receptor feedback inhibitor 1 0.0173016
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 0.0171625
MMP1 matrix metallopeptidase 1 0.01701
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.016799
WNT5A wingless-type MMTV integration site family, member 5A 0.0166509
TRIO trio Rho guanine nucleotide exchange factor 0.0166097
COL4A1 collagen, type IV, alpha 1 0.0165838
VEGFA vascular endothelial growth factor A 0.0163187
EGFR epidermal growth factor receptor 0.0161058
AKAP12 A kinase (PRKA) anchor protein 12 0.0159786
FLNA filamin A, alpha 0.0158006
HSPA8 heat shock 70kDa protein 8 0.015724
AHNAK AHNAK nucleoprotein 0.0156822
AFF3 AF4/FMR2 family, member 3 0.0156036
DOCK5 dedicator of cytokinesis 5 0.015333
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0153277
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0152761
IGF2R insulin-like growth factor 2 receptor 0.0147967
DIAPH2 diaphanous-related formin 2 0.0147473
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0146565
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 0.0146047
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0145962
CAMTA1 calmodulin binding transcription activator 1 0.0145664
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0145468
ANKRD36 ankyrin repeat domain 36 0.014523
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0144928
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0139793
SMYD3 SET and MYND domain containing 3 0.013966
DSCAM Down syndrome cell adhesion molecule 0.0139104
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0138835
PRELID2 PRELI domain containing 2 0.0138241
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0137486
FRMD4A FERM domain containing 4A 0.0136468
PLEC plectin 0.0135377
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0134388

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.426992
TMSB10 thymosin beta 10 -0.127964
FTL ferritin, light polypeptide -0.107
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.10013
VIM vimentin -0.0906118
B2M beta-2-microglobulin -0.0880167
HLA-B major histocompatibility complex, class I, B -0.0859619
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0826702
MT2A metallothionein 2A -0.0794991
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0719115
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0701716
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0614838
RPLP1 ribosomal protein, large, P1 -0.0600542
RPS6 ribosomal protein S6 -0.0564326
POTEF POTE ankyrin domain family, member F -0.0561597
COL1A1 collagen, type I, alpha 1 -0.0556207
ACTG1 actin gamma 1 -0.0516833
NDRG1 N-myc downstream regulated 1 -0.0510023
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0481665
TPT1 tumor protein, translationally-controlled 1 -0.0462112
COL1A2 collagen, type I, alpha 2 -0.0449555
ADM adrenomedullin -0.044867
CXCL8 chemokine (C-X-C motif) ligand 8 -0.044141
PKM pyruvate kinase, muscle -0.0438644
RPL35A ribosomal protein L35a -0.0437708
LDHA lactate dehydrogenase A -0.0424449
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0415111
RPS19 ribosomal protein S19 -0.0404704
ENO1 enolase 1, (alpha) -0.04041
EIF1 eukaryotic translation initiation factor 1 -0.038689
RPS8 ribosomal protein S8 -0.0386774
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0385872
LOC112694756 uncharaterized LOC112694756 -0.0381169
HLA-A major histocompatibility complex, class I, A -0.0346561
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0342977
PFN1 profilin 1 -0.0340611
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0333363
PDIA3 protein disulfide isomerase family A, member 3 -0.0331536
RPL37A ribosomal protein L37a -0.0327826
PTMA prothymosin, alpha -0.0316905
IER3 immediate early response 3 -0.0316255
RPL28 ribosomal protein L28 -0.0306187
HILPDA hypoxia inducible lipid droplet-associated -0.0293574
RPL34 ribosomal protein L34 -0.0293066
GOLGA4 golgin A4 -0.0288528
MAP1B microtubule-associated protein 1B -0.0285495
CALU calumenin -0.0283023
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0279911
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0277748
S100A6 S100 calcium binding protein A6 -0.0276282
RPLP2 ribosomal protein, large, P2 -0.0268275
RPLP0 ribosomal protein, large, P0 -0.0262337
RPL12 ribosomal protein L12 -0.0259724
RPL23 ribosomal protein L23 -0.0259527
S100A9 S100 calcium binding protein A9 -0.0256761
TPM4 tropomyosin 4 -0.0255075
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0253976
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0249196
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0247659
RPS13 ribosomal protein S13 -0.0237606
VDAC1 voltage-dependent anion channel 1 -0.0234979
RPL31 ribosomal protein L31 -0.0232104
TPI1 triosephosphate isomerase 1 -0.022997
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0229592
RPS14 ribosomal protein S14 -0.0226121
RPS16 ribosomal protein S16 -0.0224184
RPS12 ribosomal protein S12 -0.0221221
ANXA2 annexin A2 -0.0221206
RPL8 ribosomal protein L8 -0.0219483
HMGA1 high mobility group AT-hook 1 -0.0218145
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0217939
RPL32 ribosomal protein L32 -0.0216023
ENO2 enolase 2 (gamma, neuronal) -0.0214326
CYB5R3 cytochrome b5 reductase 3 -0.0211717
ALCAM activated leukocyte cell adhesion molecule -0.021097
EGR1 early growth response 1 -0.0208901
RPL5 ribosomal protein L5 -0.0205727
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0205204
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0202663
LMAN1 lectin, mannose-binding, 1 -0.0202168
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0201142
CD44 CD44 molecule (Indian blood group) -0.020013
RACK1 receptor for activated C kinase 1 -0.0196597
RPS23 ribosomal protein S23 -0.019536
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0192099
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0191606
S100A10 S100 calcium binding protein A10 -0.0189443
RPL30 ribosomal protein L30 -0.018941
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0188097
CALR calreticulin -0.0187693
FTH1 ferritin, heavy polypeptide 1 -0.0186359
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0185517
WDR45B WD repeat domain 45B -0.0183335
RPS25 ribosomal protein S25 -0.0181735
LMNA lamin A/C -0.0180056
WSB1 WD repeat and SOCS box containing 1 -0.0179513
BSG basigin (Ok blood group) -0.0179175
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0178651
YBX1 Y box binding protein 1 -0.0176548
LOX lysyl oxidase -0.0176337